Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona ...
382-598
4.59e-19
Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona pellucida. ZP domains are also present in multidomain transmembrane proteins such as glycoprotein GP2, uromodulin and TGF-beta receptor type III (betaglycan).
The actual alignment was detected with superfamily member smart00241:
Pssm-ID: 214579 Cd Length: 252 Bit Score: 87.44 E-value: 4.59e-19
Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen ...
131-210
2.49e-18
Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or protein-carbohydrate interactions.
:
Pssm-ID: 238532 Cd Length: 80 Bit Score: 79.82 E-value: 2.49e-18
PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some ...
236-327
6.55e-04
PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some members of the family there is an additional fourth disulphide bridge the links the N and C termini of the domain. The domain is found in diverse proteins, in some they mediate protein-protein interactions, in others they mediate protein-carbohydrate interactions.
:
Pssm-ID: 459635 Cd Length: 76 Bit Score: 39.07 E-value: 6.55e-04
Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona ...
382-598
4.59e-19
Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona pellucida. ZP domains are also present in multidomain transmembrane proteins such as glycoprotein GP2, uromodulin and TGF-beta receptor type III (betaglycan).
Pssm-ID: 214579 Cd Length: 252 Bit Score: 87.44 E-value: 4.59e-19
Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen ...
131-210
2.49e-18
Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or protein-carbohydrate interactions.
Pssm-ID: 238532 Cd Length: 80 Bit Score: 79.82 E-value: 2.49e-18
PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some ...
134-212
4.45e-13
PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some members of the family there is an additional fourth disulphide bridge the links the N and C termini of the domain. The domain is found in diverse proteins, in some they mediate protein-protein interactions, in others they mediate protein-carbohydrate interactions.
Pssm-ID: 459635 Cd Length: 76 Bit Score: 64.88 E-value: 4.45e-13
divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans ...
134-211
4.50e-10
divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans hypothetical ORFs and the extracellular portion of plant receptor-like protein kinases. Predicted to possess protein- and/or carbohydrate-binding functions.
Pssm-ID: 214680 Cd Length: 78 Bit Score: 56.43 E-value: 4.50e-10
PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some ...
236-327
6.55e-04
PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some members of the family there is an additional fourth disulphide bridge the links the N and C termini of the domain. The domain is found in diverse proteins, in some they mediate protein-protein interactions, in others they mediate protein-carbohydrate interactions.
Pssm-ID: 459635 Cd Length: 76 Bit Score: 39.07 E-value: 6.55e-04
Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona ...
382-598
4.59e-19
Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona pellucida. ZP domains are also present in multidomain transmembrane proteins such as glycoprotein GP2, uromodulin and TGF-beta receptor type III (betaglycan).
Pssm-ID: 214579 Cd Length: 252 Bit Score: 87.44 E-value: 4.59e-19
Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen ...
131-210
2.49e-18
Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or protein-carbohydrate interactions.
Pssm-ID: 238532 Cd Length: 80 Bit Score: 79.82 E-value: 2.49e-18
PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some ...
134-212
4.45e-13
PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some members of the family there is an additional fourth disulphide bridge the links the N and C termini of the domain. The domain is found in diverse proteins, in some they mediate protein-protein interactions, in others they mediate protein-carbohydrate interactions.
Pssm-ID: 459635 Cd Length: 76 Bit Score: 64.88 E-value: 4.45e-13
divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans ...
134-211
4.50e-10
divergent subfamily of APPLE domains; Apple-like domains present in Plasminogen, C. elegans hypothetical ORFs and the extracellular portion of plant receptor-like protein kinases. Predicted to possess protein- and/or carbohydrate-binding functions.
Pssm-ID: 214680 Cd Length: 78 Bit Score: 56.43 E-value: 4.50e-10
PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some ...
236-327
6.55e-04
PAN domain; The PAN domain contains a conserved core of three disulphide bridges. In some members of the family there is an additional fourth disulphide bridge the links the N and C termini of the domain. The domain is found in diverse proteins, in some they mediate protein-protein interactions, in others they mediate protein-carbohydrate interactions.
Pssm-ID: 459635 Cd Length: 76 Bit Score: 39.07 E-value: 6.55e-04
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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Functional characterization of the conserved domain architecture found on the query.
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This image shows a graphical summary of conserved domains identified on the query sequence.
The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits
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Domains are color coded according to superfamilies
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if a domain or superfamily has been annotated with functional sites (conserved features),
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click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.
The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
Click on the domain model's accession number to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.
To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page,
or click on the triangles, if present, that represent functional sites (conserved features)
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Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence.
(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
(labeled illustration) Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance.
(labeled illustration) Four types of hits can be shown, as available,
for each region on the query sequence:
specific hits meet or exceed a domain-specific e-value threshold
(illustrated example)
and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits
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the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains
Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool
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