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    Rpp21 Ribonuclease P/MRP subunit p21 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 318857, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Rpp21provided by FlyBase
    Official Full Name
    Ribonuclease P/MRP subunit p21provided by FlyBase
    Primary source
    FLYBASE:FBgn0053082
    Locus tag
    Dmel_CG33082
    See related
    AllianceGenome:FB:FBgn0053082
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG33082; Dmel\CG33082; Rpr2
    Summary
    Predicted to enable ribonuclease P RNA binding activity. Predicted to be involved in tRNA 5'-leader removal. Predicted to be part of nucleolar ribonuclease P complex. Orthologous to human RPP21 (ribonuclease P/MRP subunit p21). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See Rpp21 in Genome Data Viewer
    Location:
    1E1-1E1; 1-0.1 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (1030758..1033119)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (924791..925645)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene suppressor of white-apricot Neighboring gene uncharacterized protein Neighboring gene Cell division cycle 45 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44779 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biogenesis of RNase P RNA from an intron requires co-assembly with cognate protein subunits. Palsule G, et al. Nucleic Acids Res, 2019 Sep 19. PMID 31287870, Free PMC Article
    2. Inventory and analysis of the protein subunits of the ribonucleases P and MRP provides further evidence of homology between the yeast and human enzymes. Rosenblad MA, et al. Nucleic Acids Res, 2006. PMID 16998185, Free PMC Article
    3. Phylostratigraphic bias creates spurious patterns of genome evolution. Moyers BA, et al. Mol Biol Evol, 2015 Jan. PMID 25312911, Free PMC Article
    4. High-fidelity promoter profiling reveals widespread alternative promoter usage and transposon-driven developmental gene expression. Batut P, et al. Genome Res, 2013 Jan. PMID 22936248, Free PMC Article
    5. Landscape and evolution of tissue-specific alternative polyadenylation across Drosophila species. Sanfilippo P, et al. Genome Biol, 2017 Nov 30. PMID 29191225, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ribonuclease P RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA 5'-leader removal ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in tRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of multimeric ribonuclease P complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of nucleolar ribonuclease P complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ribonuclease P/MRP subunit p21
    Names
    CG33082-PA
    CG33082-PB
    Rpp21-PA
    Rpp21-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      1030758..1033119
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001316642.1 → NP_001303571.1  ribonuclease P/MRP subunit p21, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      C4IXS0, Q86B65
      Conserved Domains (1) summary
      pfam04032
      Location:18 → 83
      Rpr2; RNAse P Rpr2/Rpp21/SNM1 subunit domain

    2. NM_176680.4 → NP_788853.1  ribonuclease P/MRP subunit p21, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788853.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C4IXS0, Q86B65
      Related
      FBpp0070169
      Conserved Domains (1) summary
      pfam04032
      Location:18 → 83
      Rpr2; RNAse P Rpr2/Rpp21/SNM1 subunit domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86B65 Q86B65

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