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Conserved domains on  [gi|28571089|ref|NP_788853|]
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ribonuclease P/MRP subunit p21, isoform A [Drosophila melanogaster]

Protein Classification

ribonuclease P Rpr2/Rpp21/SNM1 subunit( domain architecture ID 10513160)

ribonuclease P (RNAse P) Rpr2/Rpp21/SNM1 subunit is a component of RNAse P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends; ribonuclease P protein component 4 is part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends

EC:  3.1.26.5
Gene Ontology:  GO:0046872|GO:0006278|GO:0004526|GO:0030677
PubMed:  21930585|14550630

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Rpr2 pfam04032
RNAse P Rpr2/Rpp21/SNM1 subunit domain; This family contains a ribonuclease P subunit of ...
 18-83 5.31e-19

RNAse P Rpr2/Rpp21/SNM1 subunit domain; This family contains a ribonuclease P subunit of humans and yeast. Other members of the family include the probable archaeal homologs. This family includes SNM1. It is a subunit of RNase MRP (mitochondrial RNA processing), a ribonucleoprotein endoribonuclease that has roles in both mitochondrial DNA replication and nuclear 5.8S rRNA processing. SNM1 is an RNA binding protein that binds the MRP RNA specifically. This subunit possibly binds the precursor tRNA.


:

Pssm-ID: 427665  Cd Length: 88  Bit Score: 76.95  E-value: 5.31e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 28571089    18 RMNYLFQASNLMAVGNQPKLAAYYGKLCRNVGTKAIMHMAPAVKRSLCRRCFLPLIPGVNTELHVE 83
Cdd:pfam04032   1 RLNFLYQAAHLLARPGNPELSRRYVSLLRAISKKAVLRLPPSIKRTICKKCGTLLIPGVTCTVRIE 66
 
Name Accession Description Interval E-value
Rpr2 pfam04032
RNAse P Rpr2/Rpp21/SNM1 subunit domain; This family contains a ribonuclease P subunit of ...
 18-83 5.31e-19

RNAse P Rpr2/Rpp21/SNM1 subunit domain; This family contains a ribonuclease P subunit of humans and yeast. Other members of the family include the probable archaeal homologs. This family includes SNM1. It is a subunit of RNase MRP (mitochondrial RNA processing), a ribonucleoprotein endoribonuclease that has roles in both mitochondrial DNA replication and nuclear 5.8S rRNA processing. SNM1 is an RNA binding protein that binds the MRP RNA specifically. This subunit possibly binds the precursor tRNA.


Pssm-ID: 427665  Cd Length: 88  Bit Score: 76.95  E-value: 5.31e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 28571089    18 RMNYLFQASNLMAVGNQPKLAAYYGKLCRNVGTKAIMHMAPAVKRSLCRRCFLPLIPGVNTELHVE 83
Cdd:pfam04032   1 RLNFLYQAAHLLARPGNPELSRRYVSLLRAISKKAVLRLPPSIKRTICKKCGTLLIPGVTCTVRIE 66
RPR2 COG2023
Ribonuclease P protein subunit RPR2 [Translation, ribosomal structure and biogenesis];
18-77 8.32e-09

Ribonuclease P protein subunit RPR2 [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441626  Cd Length: 90  Bit Score: 50.60  E-value: 8.32e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571089  18 RMNYLFQASNLMAVGNQPKLAAYYGKLCRNVGTKAIMHMAPAVKRSLCRRCFLPLIPGVN 77
Cdd:COG2023   5 RIEILFELAEEAAREGNPELARRYVELARRIAMKYRVRLPRELKRRFCKKCDAPLVPGVN 64
PRK03954 PRK03954
ribonuclease P protein component 4; Validated
 35-77 1.36e-04

ribonuclease P protein component 4; Validated


Pssm-ID: 235180  Cd Length: 121  Bit Score: 39.82  E-value: 1.36e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 28571089   35 PKLAAYYGKLCRNVGTKAIMHMAPAVKRSLCRRCFLPLIPGVN 77
Cdd:PRK03954  37 PELANRYVELALAVQQKAKVKLPRKWKRRYCKRCHSFLVPGVN 79
 
Name Accession Description Interval E-value
Rpr2 pfam04032
RNAse P Rpr2/Rpp21/SNM1 subunit domain; This family contains a ribonuclease P subunit of ...
 18-83 5.31e-19

RNAse P Rpr2/Rpp21/SNM1 subunit domain; This family contains a ribonuclease P subunit of humans and yeast. Other members of the family include the probable archaeal homologs. This family includes SNM1. It is a subunit of RNase MRP (mitochondrial RNA processing), a ribonucleoprotein endoribonuclease that has roles in both mitochondrial DNA replication and nuclear 5.8S rRNA processing. SNM1 is an RNA binding protein that binds the MRP RNA specifically. This subunit possibly binds the precursor tRNA.


Pssm-ID: 427665  Cd Length: 88  Bit Score: 76.95  E-value: 5.31e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 28571089    18 RMNYLFQASNLMAVGNQPKLAAYYGKLCRNVGTKAIMHMAPAVKRSLCRRCFLPLIPGVNTELHVE 83
Cdd:pfam04032   1 RLNFLYQAAHLLARPGNPELSRRYVSLLRAISKKAVLRLPPSIKRTICKKCGTLLIPGVTCTVRIE 66
RPR2 COG2023
Ribonuclease P protein subunit RPR2 [Translation, ribosomal structure and biogenesis];
18-77 8.32e-09

Ribonuclease P protein subunit RPR2 [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441626  Cd Length: 90  Bit Score: 50.60  E-value: 8.32e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571089  18 RMNYLFQASNLMAVGNQPKLAAYYGKLCRNVGTKAIMHMAPAVKRSLCRRCFLPLIPGVN 77
Cdd:COG2023   5 RIEILFELAEEAAREGNPELARRYVELARRIAMKYRVRLPRELKRRFCKKCDAPLVPGVN 64
PRK03954 PRK03954
ribonuclease P protein component 4; Validated
 35-77 1.36e-04

ribonuclease P protein component 4; Validated


Pssm-ID: 235180  Cd Length: 121  Bit Score: 39.82  E-value: 1.36e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 28571089   35 PKLAAYYGKLCRNVGTKAIMHMAPAVKRSLCRRCFLPLIPGVN 77
Cdd:PRK03954  37 PELANRYVELALAVQQKAKVKLPRKWKRRYCKRCHSFLVPGVN 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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