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    PIMT2 protein-l-isoaspartate methyltransferase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835089, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PIMT2
    Official Full Name
    protein-l-isoaspartate methyltransferase 2
    Primary source
    TAIR:AT5G50240
    Locus tag
    AT5G50240
    See related
    Araport:AT5G50240
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    Arabidopsis thaliana protein-l-isoaspartate methyltransferase 2; AtPIMT2; K6A12.10; K6A12_10; protein-l-isoaspartate methyltransferase 2
    Summary
    L-isoaspartyl methyltransferase 2 (PIMT2)gene, alternatively spliced.
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    Genomic context

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    See PIMT2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    5
    Sequence:
    Chromosome: 5; NC_003076.8 (20451228..20452569)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene F-box family protein Neighboring gene Transducin/WD40 repeat-like superfamily protein Neighboring gene chloroplast RNA-binding protein 31B Neighboring gene Cysteine proteinases superfamily protein Neighboring gene F-box/RNI-like/FBD-like domains-containing protein Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Changing transcriptional initiation sites and alternative 5'- and 3'-splice site selection of the first intron deploys Arabidopsis protein isoaspartyl methyltransferase2 variants to different subcellular compartments. Dinkins RD, et al. Plant J, 2008 Jul. PMID 18318686
    2. Arabidopsis Protein Repair L-Isoaspartyl Methyltransferases: Predominant Activities at Lethal Temperatures. Villa ST, et al. Physiol Plant, 2006 Dec. PMID 21076691, Free PMC Article
    3. A second protein L-isoaspartyl methyltransferase gene in Arabidopsis produces two transcripts whose products are sequestered in the nucleus. Xu Q, et al. Plant Physiol, 2004 Sep. PMID 15347786, Free PMC Article
    4. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    General gene information

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    NM_001085271.1
    NM_001125934.1
    NM_001344883.1
    NM_124403.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein-L-isoaspartate (D-aspartate) O-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-L-isoaspartate (D-aspartate) O-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein modification process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein repair TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein-l-isoaspartate methyltransferase 2
    NP_001078740.1
    • protein-l-isoaspartate methyltransferase 2 (PIMT2); FUNCTIONS IN: protein-L-isoaspartate (D-aspartate) O-methyltransferase activity; INVOLVED IN: protein modification process; LOCATED IN: cellular_component unknown; CONTAINS InterPro DOMAIN/s: Protein-L-isoaspartate(D-aspartate) O-methyltransferase (InterPro:IPR000682); BEST Arabidopsis thaliana protein match is: protein-l-isoaspartate methyltransferase 1 (TAIR:AT3G48330.2); Has 5551 Blast hits to 5550 proteins in 1430 species: Archae - 347; Bacteria - 3654; Metazoa - 345; Fungi - 95; Plants - 108; Viruses - 0; Other Eukaryotes - 1002 (source: NCBI BLink).
    NP_001119406.1
    • protein-l-isoaspartate methyltransferase 2 (PIMT2); FUNCTIONS IN: protein-L-isoaspartate (D-aspartate) O-methyltransferase activity; INVOLVED IN: protein modification process; LOCATED IN: cellular_component unknown; CONTAINS InterPro DOMAIN/s: Protein-L-isoaspartate(D-aspartate) O-methyltransferase (InterPro:IPR000682); BEST Arabidopsis thaliana protein match is: protein-l-isoaspartate methyltransferase 1 (TAIR:AT3G48330.2); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_199835.2
    • protein-l-isoaspartate methyltransferase 2 (PIMT2); FUNCTIONS IN: protein-L-isoaspartate (D-aspartate) O-methyltransferase activity; INVOLVED IN: protein modification process; LOCATED IN: cellular_component unknown; CONTAINS InterPro DOMAIN/s: Protein-L-isoaspartate(D-aspartate) O-methyltransferase (InterPro:IPR000682); BEST Arabidopsis thaliana protein match is: protein-l-isoaspartate methyltransferase 1 (TAIR:AT3G48330.2); Has 5558 Blast hits to 5557 proteins in 1434 species: Archae - 348; Bacteria - 3661; Metazoa - 345; Fungi - 95; Plants - 108; Viruses - 0; Other Eukaryotes - 1001 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      20451228..20452569
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_124403.2 → NP_199835.2  protein-l-isoaspartate methyltransferase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_199835.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q64J16, Q64J17, Q8GXQ4, Q9FGS1
      UniProtKB/TrEMBL
      A0A178UNE6
      Conserved Domains (2) summary
      pfam01135
      Location:92 → 299
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
      cl17173
      Location:95 → 304
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    2. NM_001085271.1 → NP_001078740.1  protein-l-isoaspartate methyltransferase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078740.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UNE6
      Conserved Domains (2) summary
      pfam01135
      Location:89 → 296
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
      cl17173
      Location:92 → 301
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    3. NM_001125934.1 → NP_001119406.1  protein-l-isoaspartate methyltransferase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001119406.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2FF22, F4K8W6
      Conserved Domains (2) summary
      pfam01135
      Location:1 → 205
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
      cl17173
      Location:1 → 210
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    4. NM_001344883.1 → NP_001331546.1  protein-l-isoaspartate methyltransferase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BE80
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q64J17.1

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