NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|145359074|ref|NP_199835|]
View 

protein-l-isoaspartate methyltransferase 2 [Arabidopsis thaliana]

Protein Classification

protein-L-isoaspartate O-methyltransferase( domain architecture ID 12014395)

protein-L-isoaspartate O-methyltransferase catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PCMT pfam01135
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
92-299 5.79e-105

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


:

Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 304.68  E-value: 5.79e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145359074   92 KRGMVENLKRYGVISSKRVAQVMEALDRGLFVPVG--SSAYVDTPVPIGYNATISAPHMHATCLQLLEdkLHPGMRALDV 169
Cdd:pfam01135   3 NEALIENLKNYGVIKSDKVAEAMLAVDREEFVPESfkSYAYEDIPLSIGYGQTISAPHMHAMMLELLE--LKPGMRVLEI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145359074  170 GSGTGYLTGCFALMVGAEGRVVGVDHIPELVDMSIKNIEKSVAASflkkgsLSLHVGDGRKGWQEFAPYDAIHVGAAASE 249
Cdd:pfam01135  81 GSGSGYLTACFARMVGEVGRVVSIEHIPELVEIARRNLEKLGLEN------VIVVVGDGRQGWPEFAPYDAIHVGAAAPE 154

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 145359074  250 IPQPLLDQLKPGGRMVIPLG-TYFQELKVIDKNEDGSIKVHTETSVRYVPL 299
Cdd:pfam01135 155 IPEALIDQLKEGGRLVIPVGpNGNQVLQQFDKRNDGSVVIKDLEGVRFVPL 205
 
Name Accession Description Interval E-value
PCMT pfam01135
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
92-299 5.79e-105

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 304.68  E-value: 5.79e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145359074   92 KRGMVENLKRYGVISSKRVAQVMEALDRGLFVPVG--SSAYVDTPVPIGYNATISAPHMHATCLQLLEdkLHPGMRALDV 169
Cdd:pfam01135   3 NEALIENLKNYGVIKSDKVAEAMLAVDREEFVPESfkSYAYEDIPLSIGYGQTISAPHMHAMMLELLE--LKPGMRVLEI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145359074  170 GSGTGYLTGCFALMVGAEGRVVGVDHIPELVDMSIKNIEKSVAASflkkgsLSLHVGDGRKGWQEFAPYDAIHVGAAASE 249
Cdd:pfam01135  81 GSGSGYLTACFARMVGEVGRVVSIEHIPELVEIARRNLEKLGLEN------VIVVVGDGRQGWPEFAPYDAIHVGAAAPE 154

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 145359074  250 IPQPLLDQLKPGGRMVIPLG-TYFQELKVIDKNEDGSIKVHTETSVRYVPL 299
Cdd:pfam01135 155 IPEALIDQLKEGGRLVIPVGpNGNQVLQQFDKRNDGSVVIKDLEGVRFVPL 205
pimt TIGR00080
protein-L-isoaspartate(D-aspartate) O-methyltransferase; This is an all-kingdom (but not all ...
 89-307 5.50e-78

protein-L-isoaspartate(D-aspartate) O-methyltransferase; This is an all-kingdom (but not all species) full-length ortholog enzyme for repairing aging proteins. Among the prokaryotes, the gene name is pcm. Among eukaryotes, pimt. [Protein fate, Protein modification and repair]


Pssm-ID: 272896 [Multi-domain]  Cd Length: 215  Bit Score: 236.65  E-value: 5.50e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145359074   89 SSGKRGMVENLKRYGVISSKRVAQVMEALDRGLFVP--VGSSAYVDTPVPIGYNATISAPHMHATCLQLLEdkLHPGMRA 166
Cdd:TIGR00080   4 ESQKKALIDKLINEGYIKSKRVIDALLSVPREEFVPehFKEYAYVDTPLEIGYGQTISAPHMVAMMTELLE--LKPGMKV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145359074  167 LDVGSGTGYLTGCFALMVGAEGRVVGVDHIPELVDMSIKNIEKsvaasfLKKGSLSLHVGDGRKGWQEFAPYDAIHVGAA 246
Cdd:TIGR00080  82 LEIGTGSGYQAAVLAEIVGRDGLVVSIERIPELAEKAERRLRK------LGLDNVIVIVGDGTQGWEPLAPYDRIYVTAA 155

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 145359074  247 ASEIPQPLLDQLKPGGRMVIPLGTYFQELKVIDKnEDGSIKVHTETSVRYVPLTSRVEQLG 307
Cdd:TIGR00080 156 GPKIPEALIDQLKEGGILVMPVGEYLQVLKRAEK-RGGEIIIKDVEPVAFVPLVGGEGFQG 215
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 96-300 4.74e-65

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 203.01  E-value: 4.74e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145359074  96 VENLKRYGvISSKRVAQVMEALDRGLFVPVG--SSAYVDTPVPIGYNATISAPHMHATCLQLLEdkLHPGMRALDVGSGT 173
Cdd:COG2518    1 VQQLRPRG-VTDPRVLDAMRAVPRELFVPEAlrELAYADRALPIGHGQTISQPYIVARMLEALD--LKPGDRVLEIGTGS 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145359074 174 GYLTGCFALMVGaegRVVGVDHIPELVDMsiknieksvAASFLKK---GSLSLHVGDGRKGWQEFAPYDAIHVGAAASEI 250
Cdd:COG2518   78 GYQAAVLARLAG---RVYSVERDPELAER---------ARERLAAlgyDNVTVRVGDGALGWPEHAPFDRIIVTAAAPEV 145

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 145359074 251 PQPLLDQLKPGGRMVIPLGT-YFQELKVIDKNEDGsikVHTET--SVRYVPLT 300
Cdd:COG2518  146 PEALLEQLAPGGRLVAPVGEgGVQRLVLITRTGDG---FERESlfEVRFVPLR 195
PRK13942 PRK13942
protein-L-isoaspartate O-methyltransferase; Provisional
 92-299 2.82e-61

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 184409  Cd Length: 212  Bit Score: 193.69  E-value: 2.82e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145359074  92 KRGMVENLKRYGVISSKRVAQVMEALDRGLFVP--VGSSAYVDTPVPIGYNATISAPHMHATCLQLLEdkLHPGMRALDV 169
Cdd:PRK13942   6 KRRVIEELIREGYIKSKKVIDALLKVPRHLFVPeyLEEYAYVDTPLEIGYGQTISAIHMVAIMCELLD--LKEGMKVLEI 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145359074 170 GSGTGYLTGCFALMVGAEGRVVGVDHIPELVDMSIKNIEKsvaasfLKKGSLSLHVGDGRKGWQEFAPYDAIHVGAAASE 249
Cdd:PRK13942  84 GTGSGYHAAVVAEIVGKSGKVVTIERIPELAEKAKKTLKK------LGYDNVEVIVGDGTLGYEENAPYDRIYVTAAGPD 157

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 145359074 250 IPQPLLDQLKPGGRMVIPLGTYFQELKVIDKNEDgsiKVHTET--SVRYVPL 299
Cdd:PRK13942 158 IPKPLIEQLKDGGIMVIPVGSYSQELIRVEKDNG---KIIKKKlgEVAFVPL 206
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 165-271 3.27e-07

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 47.81  E-value: 3.27e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145359074 165 RALDVGSGTGYLTgcFALMVGAEGRVVGVDhipeLVDMSIKNIEKSVAAsfLKKGSLSLHVGDGRKG-WQEFAPYDAIHV 243
Cdd:cd02440    1 RVLDLGCGTGALA--LALASGPGARVTGVD----ISPVALELARKAAAA--LLADNVEVLKGDAEELpPEADESFDVIIS 72

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 145359074 244 GAAAS---EIPQPLLDQ----LKPGGRMVIPLGTY 271
Cdd:cd02440   73 DPPLHhlvEDLARFLEEarrlLKPGGVLVLTLVLA 107
 
Name Accession Description Interval E-value
PCMT pfam01135
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
92-299 5.79e-105

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 304.68  E-value: 5.79e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145359074   92 KRGMVENLKRYGVISSKRVAQVMEALDRGLFVPVG--SSAYVDTPVPIGYNATISAPHMHATCLQLLEdkLHPGMRALDV 169
Cdd:pfam01135   3 NEALIENLKNYGVIKSDKVAEAMLAVDREEFVPESfkSYAYEDIPLSIGYGQTISAPHMHAMMLELLE--LKPGMRVLEI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145359074  170 GSGTGYLTGCFALMVGAEGRVVGVDHIPELVDMSIKNIEKSVAASflkkgsLSLHVGDGRKGWQEFAPYDAIHVGAAASE 249
Cdd:pfam01135  81 GSGSGYLTACFARMVGEVGRVVSIEHIPELVEIARRNLEKLGLEN------VIVVVGDGRQGWPEFAPYDAIHVGAAAPE 154

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 145359074  250 IPQPLLDQLKPGGRMVIPLG-TYFQELKVIDKNEDGSIKVHTETSVRYVPL 299
Cdd:pfam01135 155 IPEALIDQLKEGGRLVIPVGpNGNQVLQQFDKRNDGSVVIKDLEGVRFVPL 205
pimt TIGR00080
protein-L-isoaspartate(D-aspartate) O-methyltransferase; This is an all-kingdom (but not all ...
 89-307 5.50e-78

protein-L-isoaspartate(D-aspartate) O-methyltransferase; This is an all-kingdom (but not all species) full-length ortholog enzyme for repairing aging proteins. Among the prokaryotes, the gene name is pcm. Among eukaryotes, pimt. [Protein fate, Protein modification and repair]


Pssm-ID: 272896 [Multi-domain]  Cd Length: 215  Bit Score: 236.65  E-value: 5.50e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145359074   89 SSGKRGMVENLKRYGVISSKRVAQVMEALDRGLFVP--VGSSAYVDTPVPIGYNATISAPHMHATCLQLLEdkLHPGMRA 166
Cdd:TIGR00080   4 ESQKKALIDKLINEGYIKSKRVIDALLSVPREEFVPehFKEYAYVDTPLEIGYGQTISAPHMVAMMTELLE--LKPGMKV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145359074  167 LDVGSGTGYLTGCFALMVGAEGRVVGVDHIPELVDMSIKNIEKsvaasfLKKGSLSLHVGDGRKGWQEFAPYDAIHVGAA 246
Cdd:TIGR00080  82 LEIGTGSGYQAAVLAEIVGRDGLVVSIERIPELAEKAERRLRK------LGLDNVIVIVGDGTQGWEPLAPYDRIYVTAA 155

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 145359074  247 ASEIPQPLLDQLKPGGRMVIPLGTYFQELKVIDKnEDGSIKVHTETSVRYVPLTSRVEQLG 307
Cdd:TIGR00080 156 GPKIPEALIDQLKEGGILVMPVGEYLQVLKRAEK-RGGEIIIKDVEPVAFVPLVGGEGFQG 215
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 96-300 4.74e-65

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 203.01  E-value: 4.74e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145359074  96 VENLKRYGvISSKRVAQVMEALDRGLFVPVG--SSAYVDTPVPIGYNATISAPHMHATCLQLLEdkLHPGMRALDVGSGT 173
Cdd:COG2518    1 VQQLRPRG-VTDPRVLDAMRAVPRELFVPEAlrELAYADRALPIGHGQTISQPYIVARMLEALD--LKPGDRVLEIGTGS 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145359074 174 GYLTGCFALMVGaegRVVGVDHIPELVDMsiknieksvAASFLKK---GSLSLHVGDGRKGWQEFAPYDAIHVGAAASEI 250
Cdd:COG2518   78 GYQAAVLARLAG---RVYSVERDPELAER---------ARERLAAlgyDNVTVRVGDGALGWPEHAPFDRIIVTAAAPEV 145

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 145359074 251 PQPLLDQLKPGGRMVIPLGT-YFQELKVIDKNEDGsikVHTET--SVRYVPLT 300
Cdd:COG2518  146 PEALLEQLAPGGRLVAPVGEgGVQRLVLITRTGDG---FERESlfEVRFVPLR 195
PRK13942 PRK13942
protein-L-isoaspartate O-methyltransferase; Provisional
 92-299 2.82e-61

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 184409  Cd Length: 212  Bit Score: 193.69  E-value: 2.82e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145359074  92 KRGMVENLKRYGVISSKRVAQVMEALDRGLFVP--VGSSAYVDTPVPIGYNATISAPHMHATCLQLLEdkLHPGMRALDV 169
Cdd:PRK13942   6 KRRVIEELIREGYIKSKKVIDALLKVPRHLFVPeyLEEYAYVDTPLEIGYGQTISAIHMVAIMCELLD--LKEGMKVLEI 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145359074 170 GSGTGYLTGCFALMVGAEGRVVGVDHIPELVDMSIKNIEKsvaasfLKKGSLSLHVGDGRKGWQEFAPYDAIHVGAAASE 249
Cdd:PRK13942  84 GTGSGYHAAVVAEIVGKSGKVVTIERIPELAEKAKKTLKK------LGYDNVEVIVGDGTLGYEENAPYDRIYVTAAGPD 157

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 145359074 250 IPQPLLDQLKPGGRMVIPLGTYFQELKVIDKNEDgsiKVHTET--SVRYVPL 299
Cdd:PRK13942 158 IPKPLIEQLKDGGIMVIPVGSYSQELIRVEKDNG---KIIKKKlgEVAFVPL 206
pcm PRK00312
protein-L-isoaspartate(D-aspartate) O-methyltransferase;
95-304 1.43e-58

protein-L-isoaspartate(D-aspartate) O-methyltransferase;


Pssm-ID: 178974 [Multi-domain]  Cd Length: 212  Bit Score: 186.95  E-value: 1.43e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145359074  95 MVENLKRYGvISSKRVAQVMEALDRGLFVPVG--SSAYVDTPVPIGYNATISAPHMHATCLQLLEDKlhPGMRALDVGSG 172
Cdd:PRK00312  12 LVLRLRAEG-ILDERVLEAIEATPRELFVPEAfkHKAYENRALPIGCGQTISQPYMVARMTELLELK--PGDRVLEIGTG 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145359074 173 TGYLTGCFALMVGaegRVVGVDHIPELVDMSIKNIEKsvaasfLKKGSLSLHVGDGRKGWQEFAPYDAIHVGAAASEIPQ 252
Cdd:PRK00312  89 SGYQAAVLAHLVR---RVFSVERIKTLQWEAKRRLKQ------LGLHNVSVRHGDGWKGWPAYAPFDRILVTAAAPEIPR 159

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 145359074 253 PLLDQLKPGGRMVIPLGTYFQELKVIDKNEDGSIKVHTETSVRYVPLTSRVE 304
Cdd:PRK00312 160 ALLEQLKEGGILVAPVGGEEQQLLTRVRKRGGRFEREVLEEVRFVPLVKGEL 211
PRK13944 PRK13944
protein-L-isoaspartate O-methyltransferase; Provisional
 93-299 2.81e-44

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 140001  Cd Length: 205  Bit Score: 149.96  E-value: 2.81e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145359074  93 RGMVENLKRYGVISSKRVAQVMEALDRGLFVP--VGSSAYVDTPVPIGYNATISAPHMHATCLQLLEDKlhPGMRALDVG 170
Cdd:PRK13944   3 KRLVEELVREGIIKSERVKKAMLSVPREEFVMpeYRMMAYEDRPLPLFAGATISAPHMVAMMCELIEPR--PGMKILEVG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145359074 171 SGTGYLTGCFALMVGAEGRVVGVDHIPELVDMSIKNIEKsvaASFLkkGSLSLHVGDGRKGWQEFAPYDAIHVGAAASEI 250
Cdd:PRK13944  81 TGSGYQAAVCAEAIERRGKVYTVEIVKELAIYAAQNIER---LGYW--GVVEVYHGDGKRGLEKHAPFDAIIVTAAASTI 155

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 145359074 251 PQPLLDQLKPGGRMVIPLGTYF-QELKVIDKNEDGsIKVHTETSVRYVPL 299
Cdd:PRK13944 156 PSALVRQLKDGGVLVIPVEEGVgQVLYKVVKRGEK-VEKRAITYVLFVPL 204
methyltran_FxLD TIGR04364
methyltransferase, FxLD system; Members of this family resemble occur regularly in the ...
 95-268 1.27e-31

methyltransferase, FxLD system; Members of this family resemble occur regularly in the vicinity of lantibiotic biosynthesis enzymes and their probable target, the FxLD family of putative ribosomal natural product precursor (TIGR04363). Members resemble protein-L-isoaspartate O-methyltransferase (TIGR00080) and a predicted methyltranserase, TIGR04188, of another putative peptide modification system.


Pssm-ID: 275158  Cd Length: 394  Bit Score: 121.70  E-value: 1.27e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145359074   95 MVENLKRYGVISSKRVAQVMEALDRGLFVPvgssayvDTPVPIGYNA----------------TISAPHMHATCLQLLEd 158
Cdd:TIGR04364   8 LVDELREDGVIRSPRVEAAFRTVPRHLFAP-------GAPLEKAYAAnravvtkrdedgralsSVSAPHIQAMMLEQAG- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145359074  159 kLHPGMRALDVGSGtGYLTGCFALMVGAEGRVVGVDHIPELVDMsiknieksvAASFLKK-GSLSLHV--GDGRKGWQEF 235
Cdd:TIGR04364  80 -VEPGMRVLEIGSG-GYNAALLAELVGPSGEVTTVDIDEDVTDR---------ARACLAAaGYPQVTVvlADAEAGVPEL 148

                         170       180       190
                  ....*....|....*....|....*....|...
gi 145359074  236 APYDAIHVGAAASEIPQPLLDQLKPGGRMVIPL 268
Cdd:TIGR04364 149 APYDRIIVTVGAWDIPPAWLDQLAPGGRLVVPL 181
PRK13943 PRK13943
protein-L-isoaspartate O-methyltransferase; Provisional
 99-284 5.01e-20

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 237568 [Multi-domain]  Cd Length: 322  Bit Score: 88.36  E-value: 5.01e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145359074  99 LKRYGVisSKRVAQVMEALDRGLFVPVG---SSAYVDTpVPIGYN-----ATISAPHMHATCLQLLEdkLHPGMRALDVG 170
Cdd:PRK13943  14 LKKYGI--SDHIAKAFLEVPREEFLTKSyplSYVYEDI-VLVSYDdgeeySTSSQPSLMALFMEWVG--LDKGMRVLEIG 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145359074 171 SGTGYLTGCFALMVGAEGRVVGVDHIPELVDMSIKNIEKsvaasfLKKGSLSLHVGDGRKGWQEFAPYDAIHVGAAASEI 250
Cdd:PRK13943  89 GGTGYNAAVMSRVVGEKGLVVSVEYSRKICEIAKRNVRR------LGIENVIFVCGDGYYGVPEFAPYDVIFVTVGVDEV 162

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 145359074 251 PQPLLDQLKPGGRMVIPLGTYF---QELKVIDKNEDG 284
Cdd:PRK13943 163 PETWFTQLKEGGRVIVPINLKLsrrQPAFLFKKKDPY 199
methyltr_grsp TIGR04188
methyltransferase, ATP-grasp peptide maturase system; Members of this protein family are ...
 95-269 5.62e-14

methyltransferase, ATP-grasp peptide maturase system; Members of this protein family are predicted SAM-dependent methyltransferases that regularly occur in the context of a putative peptide modification ATP-grasp enzyme (TIGR04187, related to enzymes of microviridin maturation) and a putative ribosomal peptide modification target (TIGR04186).


Pssm-ID: 275041  Cd Length: 363  Bit Score: 71.62  E-value: 5.62e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145359074   95 MVENLKRYGVISSKRVAQVMEALDRGLFVP--------------VGSS----------AYVDTPVPIGYNATISAPH--- 147
Cdd:TIGR04188   1 LAARLAAAGVLTDPAWREAVEAVPRHLFLPgfftqlpdgrgwrpVTADrpdpdewlalVYSDETLVTQLDGDLAADAagg 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145359074  148 -----------MHATCLQLLED-KLHPGMRALDVGSGTGYLTGCFALMVGAEgRVVGVDHIPELVDMsiknieksvAASF 215
Cdd:TIGR04188  81 pvtgrptssstQPSLVARMLEAlDVEDGHRVLEIGTGTGYSAALLCHRLGDD-NVTSVEVDPGLAAR---------AASA 150

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 145359074  216 LKKG--SLSLHVGDGRKGWQEFAPYDAIHVGAAASEIPQPLLDQLKPGGRMVIPLG 269
Cdd:TIGR04188 151 LAAAgyAPTVVTGDGLLGHPPRAPYDRIIATCAVRRVPPAWLRQTRPGGVILTTLS 206
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 154-266 1.25e-11

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 60.80  E-value: 1.25e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145359074 154 QLLEDKLHPGMRALDVGSGTGYLTGCFALMvGAegRVVGVDHIPELVDmsiknieksVAASFLKKGSLSLHVGDGRKGWQ 233
Cdd:COG2227   16 ALLARLLPAGGRVLDVGCGTGRLALALARR-GA--DVTGVDISPEALE---------IARERAAELNVDFVQGDLEDLPL 83

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 145359074 234 EFAPYDAIHVGAAASEIPQP------LLDQLKPGGRMVI 266
Cdd:COG2227   84 EDGSFDLVICSEVLEHLPDPaallreLARLLKPGGLLLL 122
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 159-266 9.09e-11

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 58.85  E-value: 9.09e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145359074 159 KLHPGMRALDVGSGTGYLTgcfALMVGAEGRVVGVDHIPELVDMSIKNIEKsvaasflKKGSLSLHVGDGRKgwQEFAP- 237
Cdd:COG2226   19 GLRPGARVLDLGCGTGRLA---LALAERGARVTGVDISPEMLELARERAAE-------AGLNVEFVVGDAED--LPFPDg 86

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 145359074 238 -YDAIHVGAAASEIPQP------LLDQLKPGGRMVI 266
Cdd:COG2226   87 sFDLVISSFVLHHLPDPeralaeIARVLKPGGRLVV 122
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 160-266 9.57e-11

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 60.94  E-value: 9.57e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145359074 160 LHPGMRALDVGSGTGYLTGCFALMVGAEGRVVGVDHIPELVDMSIKNIEKsvaasFLKKGSLSLHVGDGRKGWQEfAPYD 239
Cdd:COG2519   89 IFPGARVLEAGTGSGALTLALARAVGPEGKVYSYERREDFAEIARKNLER-----FGLPDNVELKLGDIREGIDE-GDVD 162

                         90       100       110
                 ....*....|....*....|....*....|...
gi 145359074 240 AIHVgaaasEIPQP--LLDQ----LKPGGRMVI 266
Cdd:COG2519  163 AVFL-----DMPDPweALEAvakaLKPGGVLVA 190
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
162-266 1.91e-10

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 56.76  E-value: 1.91e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145359074 162 PGMRALDVGSGTGYLTgcfALMVGA--EGRVVGVDHIPELVDMSIKNIeksvaasflkkGSLSLHVGDGRkGWQEFAPYD 239
Cdd:COG4106    1 PPRRVLDLGCGTGRLT---ALLAERfpGARVTGVDLSPEMLARARARL-----------PNVRFVVADLR-DLDPPEPFD 65

                         90       100       110
                 ....*....|....*....|....*....|...
gi 145359074 240 AIHVGAAASEIPQP------LLDQLKPGGRMVI 266
Cdd:COG4106   66 LVVSNAALHWLPDHaallarLAAALAPGGVLAV 98
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 153-266 3.52e-09

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 54.94  E-value: 3.52e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145359074 153 LQLLEDKLH--PGMRALDVGSGTGYLTGCFALMVGAegRVVGVDHIPELVDmsikNIEKSVAASFLkKGSLSLHVGDGRK 230
Cdd:COG2230   40 LDLILRKLGlkPGMRVLDIGCGWGGLALYLARRYGV--RVTGVTLSPEQLE----YARERAAEAGL-ADRVEVRLADYRD 112

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 145359074 231 gWQEFAPYDAI-------HVGAAASEipqPLLDQ----LKPGGRMVI 266
Cdd:COG2230  113 -LPADGQFDAIvsigmfeHVGPENYP---AYFAKvarlLKPGGRLLL 155
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
149-265 4.92e-09

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 56.33  E-value: 4.92e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145359074 149 HAT---CLQLLEDKLHPGMRALDVGSGTGYLtGCFALMVGAeGRVVGVDHIPELVDMSIKNIEK-SVAasflkkGSLSLH 224
Cdd:COG2264  132 HPTtrlCLEALEKLLKPGKTVLDVGCGSGIL-AIAAAKLGA-KRVLAVDIDPVAVEAARENAELnGVE------DRIEVV 203

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 145359074 225 VGDGRKGwqefAPYD---A-IHVGAAASEIPQpLLDQLKPGGRMV 265
Cdd:COG2264  204 LGDLLED----GPYDlvvAnILANPLIELAPD-LAALLKPGGYLI 243
PRK08317 PRK08317
hypothetical protein; Provisional
 162-266 1.32e-08

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 54.56  E-value: 1.32e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145359074 162 PGMRALDVGSGTGYLTGCFALMVGAEGRVVGVDHIPELVDMSIKNIEKSVAASFLKKGSL-SLHVGDGRkgwqefapYDA 240
Cdd:PRK08317  19 PGDRVLDVGCGPGNDARELARRVGPEGRVVGIDRSEAMLALAKERAAGLGPNVEFVRGDAdGLPFPDGS--------FDA 90

                         90       100       110
                 ....*....|....*....|....*....|..
gi 145359074 241 IHVGAAASEIPQP--LLDQ----LKPGGRMVI 266
Cdd:PRK08317  91 VRSDRVLQHLEDParALAEiarvLRPGGRVVV 122
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 167-262 1.34e-08

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 51.41  E-value: 1.34e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145359074  167 LDVGSGTGYLTGCFALMVGAegRVVGVDHIPELVDMSIKNIEKSVAasflkkgSLSLHVGDGRKGWQEFAPYDAIHVGAA 246
Cdd:pfam13649   2 LDLGCGTGRLTLALARRGGA--RVTGVDLSPEMLERARERAAEAGL-------NVEFVQGDAEDLPFPDGSFDLVVSSGV 72

                          90       100
                  ....*....|....*....|....
gi 145359074  247 ASEIPQPLLDQ--------LKPGG 262
Cdd:pfam13649  73 LHHLPDPDLEAalreiarvLKPGG 96
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 160-266 1.77e-08

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 52.80  E-value: 1.77e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145359074  160 LHPGMRALDVGSGTGYLTGCFALMVGAEGRVVGVDHIPELVDMSIKNIEKsvaasfLKKGSLSLHVGDgrkgWQEF---- 235
Cdd:pfam13847   1 IDKGMRVLDLGCGTGHLSFELAEELGPNAEVVGIDISEEAIEKARENAQK------LGFDNVEFEQGD----IEELpell 70

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 145359074  236 --APYD------AIHVGAAASEIPQPLLDQLKPGGRMVI 266
Cdd:pfam13847  71 edDKFDvvisncVLNHIPDPDKVLQEILRVLKPGGRLII 109
cbiT PRK00377
cobalt-precorrin-6Y C(15)-methyltransferase; Provisional
 153-266 2.56e-08

cobalt-precorrin-6Y C(15)-methyltransferase; Provisional


Pssm-ID: 234740  Cd Length: 198  Bit Score: 53.26  E-value: 2.56e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145359074 153 LQLLEDKLHPGMRALDVGSGTGYLTGCFALMVGAEGRVVGVDHIPELVDMSIKNIEKsvaasFLKKGSLSLHVGDGRKGW 232
Cdd:PRK00377  31 LALSKLRLRKGDMILDIGCGTGSVTVEASLLVGETGKVYAVDKDEKAINLTRRNAEK-----FGVLNNIVLIKGEAPEIL 105

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 145359074 233 QEFAP-YDAIHVGAAASEIP---QPLLDQLKPGGRMVI 266
Cdd:PRK00377 106 FTINEkFDRIFIGGGSEKLKeiiSASWEIIKKGGRIVI 143
CbiT TIGR02469
precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; This model recognizes ...
 143-270 1.48e-07

precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; This model recognizes the CbiT methylase which is responsible, in part (along with CbiE), for methylating precorrin-6y (or cobalt-precorrin-6y) at both the 5 and 15 positions as well as the concomitant decarbozylation at C-12. In many organisms, this protein is fused to the CbiE subunit. The fused protein, when found in organisms catalyzing the oxidative version of the cobalamin biosynthesis pathway, is called CobL. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 274148 [Multi-domain]  Cd Length: 124  Bit Score: 49.25  E-value: 1.48e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145359074  143 ISAPHMHATCLQLLEdkLHPGMRALDVGSGTGYLTGCFALMVGaEGRVVGVDHIPELVDMSIKNIEKsvaasflkkgsls 222
Cdd:TIGR02469   2 MTKREVRALTLAKLR--LRPGDVLWDIGAGTGSVTIEAARLVP-NGRVYAIERNPEALDLIERNLRR------------- 65

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 145359074  223 LHVGDGR--KGWQEFAPY------DAIHVGAAASEIpQPLLD----QLKPGGRMVIPLGT 270
Cdd:TIGR02469  66 FGVSNIVivEGDAPEAPEallpdpDAVFVGGSGGLL-QEILEaverRLRPGGRIVLNAIT 124
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 165-271 3.27e-07

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 47.81  E-value: 3.27e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145359074 165 RALDVGSGTGYLTgcFALMVGAEGRVVGVDhipeLVDMSIKNIEKSVAAsfLKKGSLSLHVGDGRKG-WQEFAPYDAIHV 243
Cdd:cd02440    1 RVLDLGCGTGALA--LALASGPGARVTGVD----ISPVALELARKAAAA--LLADNVEVLKGDAEELpPEADESFDVIIS 72

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 145359074 244 GAAAS---EIPQPLLDQ----LKPGGRMVIPLGTY 271
Cdd:cd02440   73 DPPLHhlvEDLARFLEEarrlLKPGGVLVLTLVLA 107
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
149-208 3.72e-07

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 50.15  E-value: 3.72e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 145359074 149 HAT---CLQLLEDKLHPGMRALDVGSGTGYLtGCFALMVGAeGRVVGVDhIPEL-VDMSIKNIE 208
Cdd:PRK00517 103 HPTtrlCLEALEKLVLPGKTVLDVGCGSGIL-AIAAAKLGA-KKVLAVD-IDPQaVEAARENAE 163
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 161-266 4.97e-07

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 49.03  E-value: 4.97e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145359074 161 HPGMRALDVGSGTGYLtGCFALMVGAEGRVVGVDhipelVD-MSIKNIEKSVAASFLKKGslSLHVGDGRKGWQEfAPYD 239
Cdd:COG2813   48 PLGGRVLDLGCGYGVI-GLALAKRNPEARVTLVD-----VNaRAVELARANAAANGLENV--EVLWSDGLSGVPD-GSFD 118

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 145359074 240 AI------HVGAAAS-EIPQPLLDQ----LKPGGRMVI 266
Cdd:COG2813  119 LIlsnppfHAGRAVDkEVAHALIADaarhLRPGGELWL 156
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 148-262 1.34e-06

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 47.49  E-value: 1.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145359074 148 MHATcLQLLED--KLHPGMRALDVGSGTGYLTGCFALMVGAEGRVVGVDHIPELVDMSIKNIEKSVAASFLKkgslsLHV 225
Cdd:COG4122    1 MPEQ-GRLLYLlaRLLGAKRILEIGTGTGYSTLWLARALPDDGRLTTIEIDPERAAIARENFARAGLADRIR-----LIL 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 145359074 226 GDGRKGWQEFA--PYDAIHVGAAASEIPQPL---LDQLKPGG 262
Cdd:COG4122   75 GDALEVLPRLAdgPFDLVFIDADKSNYPDYLelaLPLLRPGG 116
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 139-266 2.69e-06

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 47.22  E-value: 2.69e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145359074 139 YNATISAPHMHATCLQLleDKLHPGMRALDVGSGTGYLTGCFALMVGaeGRVVGVDHIPELVDMSIKNIEKsvaasfLKK 218
Cdd:COG0500    5 YYSDELLPGLAALLALL--ERLPKGGRVLDLGCGTGRNLLALAARFG--GRVIGIDLSPEAIALARARAAK------AGL 74

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 145359074 219 GSLSLHVGDGRKGWQ-EFAPYDAI-------HVGAAA-SEIPQPLLDQLKPGGRMVI 266
Cdd:COG0500   75 GNVEFLVADLAELDPlPAESFDLVvafgvlhHLPPEErEALLRELARALKPGGVLLL 131
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 161-266 8.52e-06

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 46.10  E-value: 8.52e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145359074  161 HPGMRALDVGSGTGYLTGCFALMVGAEGRVVGVDHIPELVDMSIKNIEKSVAASFLKKGSLSLHVGDgrkgwqefAPYDA 240
Cdd:TIGR01934  38 FKGQKVLDVACGTGDLAIELAKSAPDRGKVTGVDFSSEMLEVAKKKSELPLNIEFIQADAEALPFED--------NSFDA 109

                          90       100       110
                  ....*....|....*....|....*....|..
gi 145359074  241 IHVGAA---ASEIPQPLLDQ---LKPGGRMVI 266
Cdd:TIGR01934 110 VTIAFGlrnVTDIQKALREMyrvLKPGGRLVI 141
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 149-209 1.30e-05

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 46.10  E-value: 1.30e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 145359074  149 HAT---CLQLLEDKLHPGMRALDVGSGTGYLTgCFALMVGAEgRVVGVDHIPELVDMSIKNIEK 209
Cdd:pfam06325 145 HPTtklCLEALERLVKPGESVLDVGCGSGILA-IAALKLGAK-KVVGVDIDPVAVRAAKENAEL 206
arsM PRK11873
arsenite methyltransferase;
159-210 2.37e-05

arsenite methyltransferase;


Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 44.94  E-value: 2.37e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 145359074 159 KLHPGMRALDVGSGTGYltGCF--ALMVGAEGRVVGVDHIPELVDMSIKNIEKS 210
Cdd:PRK11873  74 ELKPGETVLDLGSGGGF--DCFlaARRVGPTGKVIGVDMTPEMLAKARANARKA 125
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
147-266 3.83e-05

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 43.45  E-value: 3.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145359074 147 HMHATCLQLLEDklHPGMRALDVGSGTGYLTGCFALMVgaeGRVVGVDHIPELVDmsiknieksVAASflKKGSLSLHVG 226
Cdd:COG4976   33 LLAEELLARLPP--GPFGRVLDLGCGTGLLGEALRPRG---YRLTGVDLSEEMLA---------KARE--KGVYDRLLVA 96

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 145359074 227 DGRKGWQEFAPYDAI-------HVGAaaseiPQPLLDQ----LKPGGRMVI 266
Cdd:COG4976   97 DLADLAEPDGRFDLIvaadvltYLGD-----LAAVFAGvaraLKPGGLFIF 142
CobL COG2242
Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part ...
 160-266 9.42e-05

Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441843 [Multi-domain]  Cd Length: 403  Bit Score: 43.62  E-value: 9.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145359074 160 LHPGMRALDVGSGTGYLtGCFALMVGAEGRVVGVDHIPELVDMSIKNIEKsvaasfLKKGSLSLHVGDGRKGWQEFAPYD 239
Cdd:COG2242  245 LRPGDVLWDIGAGSGSV-SIEAARLAPGGRVYAIERDPERAALIRANARR------FGVPNVEVVEGEAPEALADLPDPD 317

                         90       100       110
                 ....*....|....*....|....*....|.
gi 145359074 240 AIHVGAAASEIPQpLLDQ----LKPGGRMVI 266
Cdd:COG2242  318 AVFIGGSGGNLPE-ILEAcwarLRPGGRLVA 347
PRK14968 PRK14968
putative methyltransferase; Provisional
 155-208 1.74e-04

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 41.81  E-value: 1.74e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 145359074 155 LLEDKLH--PGMRALDVGSGTGYLTGCFALMvgaEGRVVGVDHIPELVDMSIKNIE 208
Cdd:PRK14968  14 LLAENAVdkKGDRVLEVGTGSGIVAIVAAKN---GKKVVGVDINPYAVECAKCNAK 66
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
146-209 2.10e-04

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 41.95  E-value: 2.10e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 145359074 146 PHMHATCL----------QLLEDKLHPGMRALDVGSGTGYLTgCFALMVGAEgRVVGVDHIPELVDMSIKNIEK 209
Cdd:COG4076    9 PRWHHPMLndverndafkAAIERVVKPGDVVLDIGTGSGLLS-MLAARAGAK-KVYAVEVNPDIAAVARRIIAA 80
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 162-194 2.76e-04

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 41.68  E-value: 2.76e-04
                         10        20        30
                 ....*....|....*....|....*....|...
gi 145359074 162 PGMRALDVGSGTGYLTGCFALMVGAEGRVVGVD 194
Cdd:PRK00216  51 PGDKVLDLACGTGDLAIALAKAVGKTGEVVGLD 83
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 167-266 7.68e-04

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 38.03  E-value: 7.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145359074  167 LDVGSGTGYLTGCFALMVgaeGRVVGVDHIPELVDmsiknieksVAASFLKKGSLSLHVGDGRKgwQEFAP--YDAIHVG 244
Cdd:pfam08241   1 LDVGCGTGLLTELLARLG---ARVTGVDISPEMLE---------LAREKAPREGLTFVVGDAED--LPFPDnsFDLVLSS 66

                          90       100
                  ....*....|....*....|....*...
gi 145359074  245 AAASEIPQP--LLDQ----LKPGGRMVI 266
Cdd:pfam08241  67 EVLHHVEDPerALREiarvLKPGGILII 94
Methyltransf_3 pfam01596
O-methyltransferase; Members of this family are O-methyltransferases. The family includes ...
 165-266 8.02e-04

O-methyltransferase; Members of this family are O-methyltransferases. The family includes catechol o-methyltransferase, caffeoyl-CoA O-methyltransferase and a family of bacterial O-methyltransferases that may be involved in antibiotic production.


Pssm-ID: 396257 [Multi-domain]  Cd Length: 203  Bit Score: 39.79  E-value: 8.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145359074  165 RALDVGSGTGYLTGCFALMVGAEGRVVGVDHIPELVDMSIKNIEKsvaASFLKKgsLSLHVGDGRKGWQEF------APY 238
Cdd:pfam01596  46 NVLEIGVFTGYSALAMALALPEDGKITAIDIDPEAYEIAKKFIQK---AGVAHK--ISFILGPALKVLEQLtqdkplPEF 120

                          90       100       110
                  ....*....|....*....|....*....|.
gi 145359074  239 DAIHVGAAASEIP---QPLLDQLKPGGRMVI 266
Cdd:pfam01596 121 DFIFIDADKSNYPnyyERLLELLKVGGLMAI 151
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
162-209 1.73e-03

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 38.73  E-value: 1.73e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 145359074 162 PGMRALDVGSGTGYLtGCFALMVGAEgRVVGVDHIPELVDMSIKNIEK 209
Cdd:COG2263   45 EGKTVLDLGCGTGML-AIGAALLGAK-KVVGVDIDPEALEIARENAER 90
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 159-267 1.89e-03

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 38.97  E-value: 1.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145359074 159 KLHPGMRALDVGSGTGYLtgcfALMVGA---EGRVVGVDHIPELVDMSIKNieksVAASFLkKGSLSLHVGDGRKGWQEF 235
Cdd:COG4123   34 PVKKGGRVLDLGTGTGVI----ALMLAQrspGARITGVEIQPEAAELARRN----VALNGL-EDRITVIHGDLKEFAAEL 104

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 145359074 236 AP--YDAI------------------HVGAAASEIPQPLLD-------QLKPGGR--MVIP 267
Cdd:COG4123  105 PPgsFDLVvsnppyfkagsgrkspdeARAIARHEDALTLEDliraaarLLKPGGRfaLIHP 165
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 161-266 3.14e-03

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 37.57  E-value: 3.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145359074  161 HPGMRALDVGSGTGYLtGCFALMVGAEGRVVGVDhipelVD-MSIKNIEKSVAASFLKKGslSLHVGDGRKGWQEfAPYD 239
Cdd:pfam05175  30 DLSGKVLDLGCGAGVL-GAALAKESPDAELTMVD-----INaRALESARENLAANGLENG--EVVASDVYSGVED-GKFD 100

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 145359074  240 AI------HVGAAAS-EIPQPLL----DQLKPGGRMVI 266
Cdd:pfam05175 101 LIisnppfHAGLATTyNVAQRFIadakRHLRPGGELWI 138
FtsJ pfam01728
FtsJ-like methyltransferase; This family consists of FtsJ from various bacterial and archaeal ...
 153-194 4.42e-03

FtsJ-like methyltransferase; This family consists of FtsJ from various bacterial and archaeal sources FtsJ is a methyltransferase, but actually has no effect on cell division. FtsJ's substrate is the 23S rRNA. The 1.5 A crystal structure of FtsJ in complex with its cofactor S-adenosylmethionine revealed that FtsJ has a methyltransferase fold. This family also includes the N terminus of flaviviral NS5 protein. It has been hypothesized that the N-terminal domain of NS5 is a methyltransferase involved in viral RNA capping.


Pssm-ID: 426399  Cd Length: 179  Bit Score: 37.57  E-value: 4.42e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 145359074  153 LQLLE--DKLHPGMRALDVGSGTGYLTGCfALMVGAeGRVVGVD 194
Cdd:pfam01728  10 LEIDEkfGLLKPGKTVLDLGAAPGGWSQV-ALQRGA-GKVVGVD 51
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 153-266 5.36e-03

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 37.02  E-value: 5.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145359074  153 LQLLEDKLHPGMRALDVGSGTGYltgcFALMVGAEG-RVVGVDHIPELVDMSIKNIEKSVAasflkkgslslhvgDGRKG 231
Cdd:pfam13489  13 LLRLLPKLPSPGRVLDFGCGTGI----FLRLLRAQGfSVTGVDPSPIAIERALLNVRFDQF--------------DEQEA 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 145359074  232 WQEFAPYDAIHvgaaASE----IPQP------LLDQLKPGGRMVI 266
Cdd:pfam13489  75 AVPAGKFDVIV----AREvlehVPDPpallrqIAALLKPGGLLLL 115
PRK07580 PRK07580
Mg-protoporphyrin IX methyl transferase; Validated
 141-227 5.39e-03

Mg-protoporphyrin IX methyl transferase; Validated


Pssm-ID: 236059 [Multi-domain]  Cd Length: 230  Bit Score: 37.51  E-value: 5.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145359074 141 ATISAPH--MHATCLQ-LLEDKLHPGMRALDVGSGtgylTGCFALMVGAEG-RVVGVDHIPELVdmsikNIEKSVAASFL 216
Cdd:PRK07580  39 ATVRAGHqrMRDTVLSwLPADGDLTGLRILDAGCG----VGSLSIPLARRGaKVVASDISPQMV-----EEARERAPEAG 109

                         90
                 ....*....|.
gi 145359074 217 KKGSLSLHVGD 227
Cdd:PRK07580 110 LAGNITFEVGD 120
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH