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    MLO5 Seven transmembrane MLO family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817932, updated on 18-Sep-2024

    Summary

    Official Symbol
    MLO5
    Official Full Name
    Seven transmembrane MLO family protein
    Primary source
    TAIR:AT2G33670
    Locus tag
    AT2G33670
    See related
    Araport:AT2G33670
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATMLO5; F4P9.44; F4P9_44; MILDEW RESISTANCE LOCUS O 5
    Summary
    A member of a large family of seven-transmembrane domain proteins specific to plants, homologs of the barley mildew resistance locus o (MLO) protein. The Arabidopsis genome contains 15 genes encoding MLO proteins, with localization in plasma membrane. Phylogenetic analysis revealed four clades of closely-related AtMLO genes. ATMLO5 belongs to the clade III, with AtMLO7, AtMLO8, AtMLO9, and AtMLO10. The gene is expressed during seedling growth, in cotyledon vascular system, and in stigma, anther and pollen grains; it was not expressed in rosette leaves, as shown by GUS activity patterns. The expression of several phylogenetically closely-related AtMLO genes showed similar or overlapping tissue specificity and analogous responsiveness to external stimuli, suggesting functional redundancy, co-function, or antagonistic function(s).
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    Genomic context

    See MLO5 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    15
    Sequence:
    Chromosome: 2; NC_003071.7 (14244951..14248155)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene F-box and associated interaction domains-containing protein Neighboring gene tRNA-Asp Neighboring gene tRNA-Asp Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene uncharacterized protein Neighboring gene Late embryogenesis abundant protein, group 6 Neighboring gene Protein phosphatase 2C family protein

    Interactions

    General gene information

    Gene Ontology Provided by TAIR

    Component Evidence Code Pubs
    located_in plasma membrane PubMed 

    General protein information

    Preferred Names
    Seven transmembrane MLO family protein
    NP_180923.1
    • MILDEW RESISTANCE LOCUS O 5 (MLO5); FUNCTIONS IN: calmodulin binding; INVOLVED IN: cell death, defense response; LOCATED IN: integral to membrane, plasma membrane; EXPRESSED IN: 11 plant structures; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage, 4 anthesis, petal differentiation and expansion stage; CONTAINS InterPro DOMAIN/s: Mlo-related protein (InterPro:IPR004326); BEST Arabidopsis thaliana protein match is: Seven transmembrane MLO family protein (TAIR:AT1G42560.1); Has 551 Blast hits to 537 proteins in 60 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 544; Viruses - 0; Other Eukaryotes - 7 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      14244951..14248155
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_128925.2 → NP_180923.1  Seven transmembrane MLO family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_180923.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O22815
      UniProtKB/TrEMBL
      A0A178VYQ1, A0A5S9X455, A0A654F3L6
      Conserved Domains (1) summary
      pfam03094
      Location:15 → 462
      Mlo; Mlo family
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