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    FTSZ2-1 Tubulin/FtsZ family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818197, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FTSZ2-1
    Official Full Name
    Tubulin/FtsZ family protein
    Primary source
    TAIR:AT2G36250
    Locus tag
    AT2G36250
    See related
    Araport:AT2G36250
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATFTSZ2-1; F2H17.14; F2H17_14; FTSZ
    Summary
    Encodes one of two FtsZ proteins, tubulin-like proteins, in Arabidopsis. It is involved in chloroplast division.
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    Genomic context

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    See FTSZ2-1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    7
    Sequence:
    Chromosome: 2; NC_003071.7 (15197369..15200603, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Aldolase-type TIM barrel family protein Neighboring gene pentatricopeptide (PPR) repeat-containing protein Neighboring gene Defensin-like (DEFL) family protein Neighboring gene Iron-sulfur cluster biosynthesis family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Differential impacts of FtsZ proteins on plastid division in the shoot apex of Arabidopsis. Swid N, et al. Dev Biol, 2018 Sep 1. PMID 29920253
    2. Chloroplast division in higher plants requires members of two functionally divergent gene families with homology to bacterial ftsZ. Osteryoung KW, et al. Plant Cell, 1998 Dec. PMID 9836740, Free PMC Article
    3. The chloroplast division protein ARC6 acts to inhibit disassembly of GDP-bound FtsZ2. Sung MW, et al. J Biol Chem, 2018 Jul 6. PMID 29769312, Free PMC Article
    4. Chloroplast division protein ARC3 acts on FtsZ2 by preventing filament bundling and enhancing GTPase activity. Shaik RS, et al. Biochem J, 2018 Jan 2. PMID 29138260
    5. Chloroplast targeting of chloroplast division FtsZ2 proteins in Arabidopsis. Fujiwara M, et al. Biochem Biophys Res Commun, 2001 Sep 21. PMID 11554751

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study shows that ARC6 is involved in mediating Z ring-like structure formation of prokaryote-descended chloroplast FtsZ in Escherichia coli.
      Title: ARC6-mediated Z ring-like structure formation of prokaryote-descended chloroplast FtsZ in Escherichia coli.
    2. Chloroplast division protein ARC3 acts on FtsZ2 by preventing filament bundling and enhancing GTPase activity.
      Title: Chloroplast division protein ARC3 acts on FtsZ2 by preventing filament bundling and enhancing GTPase activity.
    3. FtsZ2-2, generally resulted in stronger effects in the shoot apex than those observed in mature leaves. The implications of these findings, along with additional observations made in this work, to our understanding of the mechanisms and regulation of plastid proliferation in the shoot apex are discussed.
      Title: Differential impacts of FtsZ proteins on plastid division in the shoot apex of Arabidopsis.
    4. FtsZ1 and FtsZ2 can heteropolymerize into a contractible ring ex vivo. Fluorescently labelled FtsZ1 and/or FtsZ2 formed single rings in cells of the yeast Pichia pastoris. Photobleaching experiments indicated that co-assembly of FtsZ1 and FtsZ2 imparts polarity to polymerization.
      Title: Chloroplast FtsZ assembles into a contractible ring via tubulin-like heteropolymerization.
    5. The negative regulation of FtsZ assembly by PARC6
      Title: Roles of Arabidopsis PARC6 in Coordination of the Chloroplast Division Complex and Negative Regulation of FtsZ Assembly.
    6. In plants lacking ARC3, the key negative regulator of FtsZ assembly, FtsZ1/FtsZ2 turnover was threefold slower.
      Title: FtsZ1/FtsZ2 Turnover in Chloroplasts and the Role of ARC3.
    7. Results suggest that ARC3 directly inhibits Z-ring assembly through interaction with FtsZ2 in heteropolymers and that ARC3 activity is spatially regulated by MinD1 and MinE1 to permit Z-ring assembly at the mid-plastid.
      Title: Chloroplast division protein ARC3 regulates chloroplast FtsZ-ring assembly and positioning in arabidopsis through interaction with FtsZ2.
    8. FtsZ1 and FtsZ2-1 are capable of in vitro self-assembly into two distinct filament types, termed type-I and type-II. During assembly of the type-II filaments the most common intermediate between the dimer and filament state is a tetramer.
      Title: Oligomerization of plant FtsZ1 and FtsZ2 plastid division proteins.
    9. Data show that FtsZ2-1 is essential for chloroplast division and that FtsZ2-2 plays a specific role in chloroplast morphology and internal organisation in addition to participating in chloroplast partition.
      Title: Multiple FtsZ2 isoforms involved in chloroplast division and biogenesis are developmentally associated with thylakoid membranes in Arabidopsis.
    10. Specific GTPase activities were determined and found to be different for FtsZ1-1 vs. FtsZ2-1.
      Title: Plant FtsZ1 and FtsZ2 expressed in a eukaryotic host: GTPase activity and self-assembly.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001336588.1
    NM_129183.2
    NM_201883.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within chloroplast fission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chloroplast fission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to gibberellin IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast stroma HDA PubMed 
    located_in chloroplast stroma IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast thylakoid HDA PubMed 
    colocalizes_with chloroplast thylakoid membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in contractile ring IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 

    General protein information

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    Preferred Names
    Tubulin/FtsZ family protein
    NP_565839.1
    • FTSZ2-1; FUNCTIONS IN: protein binding, structural molecule activity; INVOLVED IN: chloroplast fission; LOCATED IN: chloroplast stroma, chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Cell division protein FtsZ, N-terminal (InterPro:IPR000158), Cell division protein FtsZ, conserved site (InterPro:IPR020805), Tubulin/FtsZ, GTPase domain (InterPro:IPR003008), Tubulin/FtsZ, N-terminal (InterPro:IPR019746), Tubulin/FtsZ, C-terminal (InterPro:IPR008280), Tubulin/FtsZ, 2-layer sandwich domain (InterPro:IPR018316); BEST Arabidopsis thaliana protein match is: Tubulin/FtsZ family protein (TAIR:AT3G52750.1); Has 10598 Blast hits to 10598 proteins in 3190 species: Archae - 463; Bacteria - 6301; Metazoa - 8; Fungi - 0; Plants - 154; Viruses - 0; Other Eukaryotes - 3672 (source: NCBI BLink).
    NP_973612.1
    • FTSZ2-1; FUNCTIONS IN: protein binding, structural molecule activity; INVOLVED IN: chloroplast fission; LOCATED IN: chloroplast stroma, chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Cell division protein FtsZ, N-terminal (InterPro:IPR000158), Cell division protein FtsZ, conserved site (InterPro:IPR020805), Tubulin/FtsZ, GTPase domain (InterPro:IPR003008), Tubulin/FtsZ, N-terminal (InterPro:IPR019746), Tubulin/FtsZ, C-terminal (InterPro:IPR008280), Tubulin/FtsZ, 2-layer sandwich domain (InterPro:IPR018316); BEST Arabidopsis thaliana protein match is: Tubulin/FtsZ family protein (TAIR:AT3G52750.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      15197369..15200603 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001336589.1 → NP_001323531.1  Tubulin/FtsZ family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AXD8, A0A7G2EBP2

    2. NM_129183.2 → NP_565839.1  Tubulin/FtsZ family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565839.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O82533, Q93VK3
      UniProtKB/TrEMBL
      A0A178VTX0, A0A5S9X4E7, A0A7G2EBP2
      Conserved Domains (1) summary
      PRK09330
      Location:105 → 470
      PRK09330; cell division protein FtsZ; Validated

    3. NM_001336588.1 → NP_001323530.1  Tubulin/FtsZ family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O82533, Q93VK3
      UniProtKB/TrEMBL
      A0A178VTX0, A0A5S9X4E7, A0A7G2EBP2
      Conserved Domains (1) summary
      PRK09330
      Location:105 → 470
      PRK09330; cell division protein FtsZ; Validated

    4. NM_201883.1 → NP_973612.1  Tubulin/FtsZ family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_973612.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O82533, Q93VK3
      UniProtKB/TrEMBL
      A0A178VTX0, A0A5S9X4E7, A0A7G2EBP2
      Conserved Domains (1) summary
      PRK09330
      Location:105 → 470
      PRK09330; cell division protein FtsZ; Validated
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O82533.2

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