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    YY1 YY1 transcription factor [ Homo sapiens (human) ]

    Gene ID: 7528, updated on 10-Dec-2024

    Summary

    Official Symbol
    YY1provided by HGNC
    Official Full Name
    YY1 transcription factorprovided by HGNC
    Primary source
    HGNC:HGNC:12856
    See related
    Ensembl:ENSG00000100811 MIM:600013; AllianceGenome:HGNC:12856
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DELTA; NF-E1; UCRBP; GADEVS; INO80S; YIN-YANG-1
    Summary
    YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may direct histone deacetylases and histone acetyltransferases to a promoter in order to activate or repress the promoter, thus implicating histone modification in the function of YY1. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in thyroid (RPKM 24.9), bone marrow (RPKM 20.9) and 25 other tissues See more
    Orthologs
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    Genomic context

    See YY1 in Genome Data Viewer
    Location:
    14q32.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (100239144..100282788)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (94472191..94515818)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (100705481..100749125)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903380 Neighboring gene delta 4-desaturase, sphingolipid 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:100632407-100632908 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:100632909-100633408 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6075 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6076 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6077 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:100680080-100680580 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9029 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:100684247-100684748 Neighboring gene YY1 divergent transcript Neighboring gene Sharpr-MPRA regulatory region 8458 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:100698662-100699162 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:100699163-100699663 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:100704543-100705395 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6081 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6082 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9030 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6083 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:100711928-100712136 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:100744670-100745650 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6084 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6085 Neighboring gene solute carrier family 25 member 29 Neighboring gene microRNA 6764 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6086 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9031 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9032 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:100771717-100772283 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9033 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6087 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6088 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6089 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9034 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9035 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:100779917-100780815 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:100784285-100784831 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9037 Neighboring gene microRNA 345 Neighboring gene RNA, 7SL, cytoplasmic 523, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat YY1 and LSF transcription factors cooperatively recruit histone deacetylase 1 (HDAC1) to the HIV-1 LTR promoter, thereby inhibiting transcription and Tat activation of the promoter PubMed
    tat Inhibition of NF-kappaB and YY1 reverses HIV-1 Tat-mediated downregulation of CX3CR1 in microglia PubMed
    integrase gag-pol HIV-1 IN catalytic core (amino acids 50-212) and C-terminal (amino acids 213-288) domains bind weakly to YY1. YY1 enhances the integration activity of HIV-1 IN PubMed
    retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human YY1 transcription factor at amino acid residues 148-149 by the HIV-1 protease PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific PubMed 
    enables DNA-binding transcription factor binding PubMed 
    enables DNA-binding transcription repressor activity PubMed 
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific PubMed 
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific  
    enables RNA binding PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding PubMed 
    enables SMAD binding PubMed 
    enables chromatin binding  
    enables cis-regulatory region sequence-specific DNA binding PubMed 
    enables cis-regulatory region sequence-specific DNA binding PubMed 
    enables four-way junction DNA binding PubMed 
    enables metal ion binding  
    enables protein binding PubMed 
    enables sequence-specific double-stranded DNA binding PubMed 
    enables transcription cis-regulatory region binding PubMed 
    Items 1 - 25 of 33
    Process Evidence Code Pubs
    involved_in B cell differentiation  
    involved_in DNA damage response PubMed 
    involved_in RNA localization  
    involved_in anterior/posterior pattern specification  
    involved_in camera-type eye morphogenesis  
    involved_in cellular response to UV PubMed 
    involved_in cellular response to interleukin-1  
    involved_in chromatin remodeling PubMed 
    involved_in double-strand break repair via homologous recombination PubMed 
    involved_in immunoglobulin heavy chain V-D-J recombination  
    involved_in negative regulation of cell growth involved in cardiac muscle cell development  
    involved_in negative regulation of gene expression PubMed 
    involved_in negative regulation of interferon-beta production PubMed 
    involved_in negative regulation of miRNA transcription  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II PubMed 
    involved_in negative regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of DNA repair  
    involved_in positive regulation of DNA-templated transcription PubMed 
    involved_in positive regulation of gene expression  
    involved_in positive regulation of telomere maintenance in response to DNA damage  
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in regulation of DNA repair  
    involved_in regulation of DNA replication PubMed 
    involved_in regulation of DNA strand elongation PubMed 
    involved_in regulation of cell cycle PubMed 
    involved_in regulation of chromosome organization PubMed 
    involved_in regulation of embryonic development  
    involved_in regulation of transcription by RNA polymerase II  
    involved_in regulation of transcription by RNA polymerase II PubMed 
    involved_in response to UV-C PubMed 
    involved_in response to prostaglandin F  
    involved_in spermatogenesis  
    involved_in telomere maintenance  
    Items 1 - 25 of 33
    Component Evidence Code Pubs
    part_of Ino80 complex PubMed 
    part_of PcG protein complex  
    located_in chromatin  
    part_of chromatin silencing complex  
    located_in nuclear matrix  
    located_in nucleoplasm  
    located_in nucleus PubMed 
    located_in nucleus PubMed 
    part_of transcription regulator complex  

    General protein information

    Preferred Names
    transcriptional repressor protein YY1
    Names
    INO80 complex subunit S
    YY-1
    Yin and Yang 1 protein
    delta transcription factor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_046908.1 RefSeqGene

      Range
      5001..45270
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_003403.5 → NP_003394.1  transcriptional repressor protein YY1

      See identical proteins and their annotated locations for NP_003394.1

      Status: REVIEWED

      Source sequence(s)
      AL157871, BC037308, DA234524
      Consensus CDS
      CCDS9957.1
      UniProtKB/Swiss-Prot
      P25490, Q14935
      Related
      ENSP00000262238.4, ENST00000262238.10
      Conserved Domains (2) summary
      COG5048
      Location:268 → 407
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:327 → 347
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      100239144..100282788
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      94472191..94515818
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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