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ATF7 activating transcription factor 7 [ Homo sapiens (human) ]

Gene ID: 11016, updated on 27-Nov-2024

Summary

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Official Symbol
ATF7provided by HGNC
Official Full Name
activating transcription factor 7provided by HGNC
Primary source
HGNC:HGNC:792
See related
Ensembl:ENSG00000170653 MIM:606371; AllianceGenome:HGNC:792
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ATFA
Summary
Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; mitogen-activated protein kinase binding activity; and transcription coactivator binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. Part of RNA polymerase II transcription regulator complex. Biomarker of colorectal cancer. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in lung (RPKM 9.8), fat (RPKM 9.2) and 25 other tissues See more
Orthologs
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Genomic context

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See ATF7 in Genome Data Viewer
Location:
12q13.13
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (53507856..53626382, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (53473861..53592424, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (53901640..54020166, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase kinase 12 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6423 Neighboring gene Sharpr-MPRA regulatory region 3466 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:53902821-53903053 Neighboring gene ATF7-NPFF readthrough Neighboring gene uncharacterized LOC100652999 Neighboring gene TARBP2 subunit of RISC loading complex Neighboring gene ReSE screen-validated silencer GRCh37_chr12:53909665-53909906 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:53910873-53911372 Neighboring gene neuropeptide FF-amide peptide precursor Neighboring gene uncharacterized LOC124902937 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:53962840-53963409 Neighboring gene zinc finger protein 337 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4516 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6424 Neighboring gene MPRA-validated peak1736 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6425 Neighboring gene uncharacterized LOC124902938 Neighboring gene ribosomal protein L31 pseudogene 51

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Isolation and characterization of two novel, closely related ATF cDNA clones from HeLa cells. Gaire M, et al. Nucleic Acids Res, 1990 Jun 25. PMID 1694576, Free PMC Article
  2. Structure and expression of the ATFa gene. Goetz J, et al. J Biol Chem, 1996 Nov 22. PMID 8939888
  3. Cofactor competition between the ligand-bound oestrogen receptor and an intron 1 enhancer leads to oestrogen repression of ERBB2 expression in breast cancer. Newman SP, et al. Oncogene, 2000 Jan 27. PMID 10698518
  4. miRNA-103a-3p Promotes Human Gastric Cancer Cell Proliferation by Targeting and Suppressing ATF7 in vitro. Hu X, et al. Mol Cells, 2018 May 31. PMID 29754469, Free PMC Article
  5. Cdk1-mediated phosphorylation of human ATF7 at Thr-51 and Thr-53 promotes cell-cycle progression into M phase. Hasegawa H, et al. PLoS One, 2014. PMID 25545367, Free PMC Article

See all (71) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. lncRNA prostate cancer-associated transcript 18 upregulates activating transcription factor 7 to prevent metastasis of triple-negative breast cancer via sponging miR-103a-3p.
    Title: lncRNA prostate cancer-associated transcript 18 upregulates activating transcription factor 7 to prevent metastasis of triple-negative breast cancer via sponging miR-103a-3p.
  2. Results found that ATF7 is upregulated in hepatocellular carcinoma (HCC) tissue. Its expression is regulated by miR-340 which directly binds to the mRNA encoding ATF7. Under HBV infection, miR-340 is downregulated resulting in increasing ATF7 expression, leading to enhanced cell proliferation and inhibition of apoptosis.
    Title: Hepatitis B virus-regulated growth of liver cancer cells occurs through the microRNA-340-5p-activating transcription factor 7-heat shock protein A member 1B axis.
  3. ATF7 is a direct target of miR-103a-3p. In a stomach cancer cohort,miR-103a-3p expression was inversely correlated with ATF7 expression. Silencing ATF7 showed similar cellular and molecular effects as miR-103a-3p overexpression, namely, increased GC cell proliferation, improved CDK2 expression and decreased P27 expression.
    Title: miRNA-103a-3p Promotes Human Gastric Cancer Cell Proliferation by Targeting and Suppressing ATF7 in vitro.
  4. knockdown of the mammalian homologs of PDK1 and ATF7 in HEK293 cells resulted in changes in metallothionein expression, suggesting that this pathway was evolutionarily conserved
    Title: Identification of ATF-7 and the insulin signaling pathway in the regulation of metallothionein in C. elegans suggests roles in aging and reactive oxygen species.
  5. CARMA1- and MyD88-dependent activation of Jun/ATF-type AP-1 complexes is a hallmark of ABC diffuse large B-cell lymphomas.
    Title: CARMA1- and MyD88-dependent activation of Jun/ATF-type AP-1 complexes is a hallmark of ABC diffuse large B-cell lymphomas.
  6. mitotic stabilized ATF7 protein re-localizes onto chromatin at the end of telophase and contributes to induce the cyclin D1 gene expression.
    Title: ATF7 is stabilized during mitosis in a CDK1-dependent manner and contributes to cyclin D1 expression.
  7. It is negatively related between ATF7 expression and pathological stage and positive correlation with OS and PFS in CRC. ATF7 expression is a favorable factor for survival of patients with CRC.
    Title: Expression of activating transcription factor 7 is correlated with prognosis of colorectal cancer.
  8. These results suggest that the Cdk1-mediated phosphorylation of ATF7 facilitates G2/M progression, at least in part, by enabling Aurora signaling.
    Title: Cdk1-mediated phosphorylation of human ATF7 at Thr-51 and Thr-53 promotes cell-cycle progression into M phase.
  9. ATF7 interacts with TAF12 and contributes to the hypersensitivity of OCL precursors to 1,25-(OH)D in PD.
    Title: Role of ATF7-TAF12 interactions in the vitamin D response hypersensitivity of osteoclast precursors in Paget's disease.
  10. Data show that ATF7-4 is an important cytoplasmic negative regulator of ATF7 and ATF2 transcription factors.
    Title: A cytoplasmic negative regulator isoform of ATF7 impairs ATF7 and ATF2 phosphorylation and transcriptional activity.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci.
EBI GWAS Catalog
Genome-wide meta-analysis identifies new susceptibility loci for migraine.
EBI GWAS Catalog
Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry.
EBI GWAS Catalog
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Readthrough ATF7-NPFF

Readthrough gene: ATF7-NPFF, Included gene: NPFF

Homology

Clone Names

  • MGC57182

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables cAMP response element binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables mitogen-activated protein kinase binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coactivator binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in chromatin ISA
Inferred from Sequence Alignment
more info
  
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
cyclic AMP-dependent transcription factor ATF-7
Names
transcription factor ATF-A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130060.2 → NP_001123532.1  cyclic AMP-dependent transcription factor ATF-7 isoform 3

    See identical proteins and their annotated locations for NP_001123532.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in an internal exon, compared to variant 2, resulting in a shorter isoform (3, also known as ATFa1 or ATF-a delta), compared to isoform 2. There are no publicly available transcripts representing this variant; it is supported by data in PMIDs 1694576 and 8939888, and by alternative splicing annotation on accessions X52943.1 and X57197.1.
    Source sequence(s)
    AC023509, BP279417, BP312300, BQ184780, DB047160, X52943
    UniProtKB/TrEMBL
    B2R8U0
    Conserved Domains (3) summary
    cd12192
    Location:47 → 84
    GCN4_cent; GCN4 central activation domain-like acidic activation domain
    cd14687
    Location:313 → 373
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
    sd00019
    Location:9 → 31
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001206682.2 → NP_001193611.1  cyclic AMP-dependent transcription factor ATF-7 isoform 4

    See identical proteins and their annotated locations for NP_001193611.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 3' coding region and 3' UTR, compared to variant 2, resulting in an isoform (4) with a distinct and shorter C-terminus, compared to isoform 2. Variants 4, 5, and 13 all encode the same isoform (4).
    Source sequence(s)
    AA679547, BC140006, DB047160
    Consensus CDS
    CCDS58238.1
    UniProtKB/Swiss-Prot
    P17544
    Related
    ENSP00000465192.1, ENST00000591397.1
    Conserved Domains (1) summary
    cd12192
    Location:47 → 84
    GCN4_cent; GCN4 central activation domain-like acidic activation domain

  3. NM_001206683.1 → NP_001193612.1  cyclic AMP-dependent transcription factor ATF-7 isoform 4

    See identical proteins and their annotated locations for NP_001193612.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, 3' coding region and 3' UTR, compared to variant 2, resulting in an isoform (4) with a distinct and shorter C-terminus, compared to isoform 2. Variants 4, 5, and 13 all encode the same isoform (4).
    Source sequence(s)
    AA679547, AC023509, BC042363, DB490927
    Consensus CDS
    CCDS58238.1
    UniProtKB/Swiss-Prot
    P17544
    Related
    ENSP00000456858.1, ENST00000548118.6
    Conserved Domains (1) summary
    cd12192
    Location:47 → 84
    GCN4_cent; GCN4 central activation domain-like acidic activation domain

  4. NM_001366555.2 → NP_001353484.1  cyclic AMP-dependent transcription factor ATF-7 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) encodes the longest isoform (5).
    Source sequence(s)
    AC023509, AC073594
    Consensus CDS
    CCDS44905.1
    UniProtKB/TrEMBL
    B2R8U0
    Related
    ENSP00000449938.1, ENST00000548446.6
    Conserved Domains (3) summary
    cd12192
    Location:47 → 84
    GCN4_cent; GCN4 central activation domain-like acidic activation domain
    cd14687
    Location:345 → 405
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
    sd00019
    Location:9 → 31
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. NM_001366556.2 → NP_001353485.1  cyclic AMP-dependent transcription factor ATF-7 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8), as well as variants 2 and 9, encodes isoform 2.
    Source sequence(s)
    AC023509, AC073594
    Consensus CDS
    CCDS44906.1
    UniProtKB/Swiss-Prot
    A5D6Y4, B2RMP1, B4DQL4, P17544, Q13814, Q8IVR8, Q9UD83
    UniProtKB/TrEMBL
    B2R8U0
    Related
    ENSP00000387406.3, ENST00000456903.8
    Conserved Domains (3) summary
    cd12192
    Location:47 → 84
    GCN4_cent; GCN4 central activation domain-like acidic activation domain
    cd14687
    Location:334 → 394
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
    sd00019
    Location:9 → 31
    ZF_C2H2; C2H2 Zn finger [structural motif]

  6. NM_001366558.2 → NP_001353487.1  cyclic AMP-dependent transcription factor ATF-7 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9), as well as variants 2 and 8, encodes isoform 2.
    Source sequence(s)
    AC023509, AC073594
    Consensus CDS
    CCDS44906.1
    UniProtKB/Swiss-Prot
    A5D6Y4, B2RMP1, B4DQL4, P17544, Q13814, Q8IVR8, Q9UD83
    UniProtKB/TrEMBL
    B2R8U0
    Conserved Domains (3) summary
    cd12192
    Location:47 → 84
    GCN4_cent; GCN4 central activation domain-like acidic activation domain
    cd14687
    Location:334 → 394
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
    sd00019
    Location:9 → 31
    ZF_C2H2; C2H2 Zn finger [structural motif]

  7. NM_001366561.2 → NP_001353490.1  cyclic AMP-dependent transcription factor ATF-7 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC023509, AC073594
    UniProtKB/TrEMBL
    B2R8U0
    Conserved Domains (1) summary
    cd14687
    Location:279 → 339
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

  8. NM_001366562.2 → NP_001353491.1  cyclic AMP-dependent transcription factor ATF-7 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13), as well as variants 4 and 5, encodes isoform 4.
    Source sequence(s)
    AC023509, AC073594
    Consensus CDS
    CCDS58238.1
    Conserved Domains (1) summary
    cd12192
    Location:47 → 84
    GCN4_cent; GCN4 central activation domain-like acidic activation domain

  9. NM_001366563.2 → NP_001353492.1  cyclic AMP-dependent transcription factor ATF-7 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC023509, AC073594
    Conserved Domains (1) summary
    cd12192
    Location:18 → 54
    GCN4_cent; GCN4 central activation domain-like acidic activation domain

  10. NM_006856.3 → NP_006847.1  cyclic AMP-dependent transcription factor ATF-7 isoform 2

    See identical proteins and their annotated locations for NP_006847.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2), as well as variants 8 and 9, encodes isoform 2 (also known as ATFa2).
    Source sequence(s)
    AC023509, BP279417, BP312300, BQ184780, DB047160, X52943
    Consensus CDS
    CCDS44906.1
    UniProtKB/Swiss-Prot
    A5D6Y4, B2RMP1, B4DQL4, P17544, Q13814, Q8IVR8, Q9UD83
    UniProtKB/TrEMBL
    B2R8U0
    Related
    ENSP00000399465.1, ENST00000420353.7
    Conserved Domains (3) summary
    cd12192
    Location:47 → 84
    GCN4_cent; GCN4 central activation domain-like acidic activation domain
    cd14687
    Location:334 → 394
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
    sd00019
    Location:9 → 31
    ZF_C2H2; C2H2 Zn finger [structural motif]

RNA

  1. NR_073163.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) use an alternate splice site in an internal exon and has an alternate 3' structure, compared to variant 2. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC073594, AK298853

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    53507856..53626382 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    53473861..53592424 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001130059.1: Suppressed sequence

    Description
    NM_001130059.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P17544.3 GenPept UniProtKB/Swiss-Prot:P17544

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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