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    Mybl2 myeloblastosis oncogene-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 17865, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Mybl2provided by MGI
    Official Full Name
    myeloblastosis oncogene-like 2provided by MGI
    Primary source
    MGI:MGI:101785
    See related
    Ensembl:ENSMUSG00000017861 AllianceGenome:MGI:101785
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bmyb; B-Myb
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within cellular response to leukemia inhibitory factor and mitotic spindle assembly. Located in nucleus. Part of Myb complex. Is expressed in several structures, including brain; early conceptus; genitourinary system; hemolymphoid system; and skin. Used to study acute myeloid leukemia and myelodysplastic syndrome. Orthologous to human MYBL2 (MYB proto-oncogene like 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in liver E14.5 (RPKM 17.0), liver E14 (RPKM 15.7) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mybl2 in Genome Data Viewer
    Location:
    2 H2; 2 84.0 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (162896246..162926608)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (163054327..163084688)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene serum/glucocorticoid regulated kinase 2 Neighboring gene STARR-seq mESC enhancer starr_06293 Neighboring gene intraflagellar transport 52 Neighboring gene STARR-seq mESC enhancer starr_06295 Neighboring gene STARR-positive B cell enhancer ABC_E6013 Neighboring gene STARR-seq mESC enhancer starr_06298 Neighboring gene microRNA 7003 Neighboring gene gametocyte specific factor 1-like Neighboring gene predicted gene 11454

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A B-myb promoter corepressor site facilitates in vivo occupation of the adjacent E2F site by p107 x E2F and p130 x E2F complexes. Catchpole S, et al. J Biol Chem, 2002 Oct 11. PMID 12147683
    2. B-myb is required for inner cell mass formation at an early stage of development. Tanaka Y, et al. J Biol Chem, 1999 Oct 1. PMID 10497154
    3. An E2F-binding site mediates cell-cycle regulated repression of mouse B-myb transcription. Lam EW, et al. EMBO J, 1993 Jul. PMID 8334989, Free PMC Article
    4. Generation of a conditional allele of the B-myb gene. García P, et al. Genesis, 2005 Dec. PMID 16283626
    5. Differential splicing of the mouse B-myb gene. Kamano H, et al. Oncogene, 1995 Dec 21. PMID 8545114

    See all (85) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A cochlear progenitor pool influences patterning of the mammalian sensory epithelium via MYBL2.
      Title: A cochlear progenitor pool influences patterning of the mammalian sensory epithelium via MYBL2.
    2. Notch3 regulates Mybl2 via HeyL to limit proliferation and tumor initiation in breast cancer.
      Title: Notch3 regulates Mybl2 via HeyL to limit proliferation and tumor initiation in breast cancer.
    3. Protein-protein interaction studies showed that YAP binds directly to B-MYB, a subunit of MMB, in a manner dependent on the YAP WW domains and a PPXY motif in B-MYB. Disruption of the interaction by overexpression of the YAP binding domain of B-MYB strongly inhibits the proliferation of cardiomyocytes.
      Title: Interaction of YAP with the Myb-MuvB (MMB) complex defines a transcriptional program to promote the proliferation of cardiomyocytes.
    4. Downregulation of B-myb induced senescence by upregulation of p22(phox) and activation of the ROS/p53/p21 pathway
      Title: Downregulation of B-myb promotes senescence via the ROS-mediated p53/p21 pathway, in vascular endothelial cells.
    5. B-myb is an essential regulator of hematopoietic stem cell and myeloid progenitor cell development.
      Title: B-myb is an essential regulator of hematopoietic stem cell and myeloid progenitor cell development.
    6. MYBL2 haploinsufficiency increases susceptibility to age-related haematopoietic neoplasia.
      Title: MYBL2 haploinsufficiency increases susceptibility to age-related haematopoietic neoplasia.
    7. Results coupled with functional studies demonstrate that B-MYB not only controls and accelerates cell cycle progression in ESCs it contributes to fate decisions and maintenance of pluripotent stem cell identity.
      Title: The B-MYB transcriptional network guides cell cycle progression and fate decisions to sustain self-renewal and the identity of pluripotent stem cells.
    8. Our data suggest that B-Myb is required as a pioneer factor to enable FoxM1 binding to G2/M gene promoters and explains how these transcription factors may collaborate to induce mitosis.
      Title: Binding of FoxM1 to G2/M gene promoters is dependent upon B-Myb.
    9. Mybl2 upregulation induces fast growth and progression of premalignant and malignant liver, through cell cycle deregulation and activation of genes and pathways related to tumor progression.
      Title: Mybl2 expression is under genetic control and contributes to determine a hepatocellular carcinoma susceptible phenotype.
    10. Lin-9 and B-Myb were both required for transcription of G(2)/M genes such as Cyclin B1 and Survivin.
      Title: A Lin-9 complex is recruited by B-Myb to activate transcription of G2/M genes in undifferentiated embryonal carcinoma cells.
    Submit: New GeneRIF Correction See all GeneRIFs (18)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (8)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within mitotic spindle assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Myb complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    myb-related protein B
    Names
    myb-like protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008652.2 → NP_032678.1  myb-related protein B

      Status: PROVISIONAL

      Source sequence(s)
      AK028497
      Consensus CDS
      CCDS17006.1
      UniProtKB/Swiss-Prot
      P48972
      Related
      ENSMUSP00000018005.4, ENSMUST00000018005.10
      Conserved Domains (4) summary
      smart00717
      Location:83 → 131
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam00249
      Location:83 → 129
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam09316
      Location:454 → 599
      Cmyb_C; C-myb, C-terminal
      pfam13921
      Location:34 → 94
      Myb_DNA-bind_6; Myb-like DNA-binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      162896246..162926608
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498875.5 → XP_006498938.1  myb-related protein B isoform X2

      Conserved Domains (3) summary
      PLN03091
      Location:81 → 219
      PLN03091; hypothetical protein; Provisional
      pfam09316
      Location:317 → 497
      Cmyb_C; C-myb, C-terminal
      pfam13921
      Location:34 → 94
      Myb_DNA-bind_6; Myb-like DNA-binding domain

    2. XM_006498876.5 → XP_006498939.1  myb-related protein B isoform X3

      Conserved Domains (2) summary
      PLN03091
      Location:2 → 57
      PLN03091; hypothetical protein; Provisional
      pfam09316
      Location:292 → 476
      Cmyb_C; C-myb, C-terminal

    3. XM_006498873.5 → XP_006498936.1  myb-related protein B isoform X1

      Conserved Domains (3) summary
      PLN03091
      Location:81 → 219
      PLN03091; hypothetical protein; Provisional
      pfam09316
      Location:454 → 638
      Cmyb_C; C-myb, C-terminal
      pfam13921
      Location:34 → 94
      Myb_DNA-bind_6; Myb-like DNA-binding domain

    4. XM_006498878.5 → XP_006498941.1  myb-related protein B isoform X4

      Conserved Domains (3) summary
      PLN03091
      Location:81 → 219
      PLN03091; hypothetical protein; Provisional
      pfam09316
      Location:317 → 458
      Cmyb_C; C-myb, C-terminal
      pfam13921
      Location:34 → 94
      Myb_DNA-bind_6; Myb-like DNA-binding domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48972.1 GenPept UniProtKB/Swiss-Prot:P48972

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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