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Conserved domains on  [gi|568915698|ref|XP_006498938|]
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myb-related protein B isoform X2 [Mus musculus]

Protein Classification

SANT and Cmyb_C domain-containing protein( domain architecture ID 13851025)

SANT and Cmyb_C domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cmyb_C super family cl07814
C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb ...
 314-497 5.15e-47

C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb and the viral transforming protein myb. Truncation of the domain results in 'activation' of c-myb and subsequent tumourigenesis.


The actual alignment was detected with superfamily member pfam09316:

Pssm-ID: 462753  Cd Length: 157  Bit Score: 162.14  E-value: 5.15e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915698  314 LIESFLNFWNKQDTLELESPSLTSTPVCSQKVVVTTPLHRDKTPLHQKypssvsqklqsaravvahafnpstweaEAGGF 393
Cdd:pfam09316   2 SPSQFLNESSGQENLPLENPTLTSTPVCGQKVFLTTPLHKDQTPKYQK---------------------------ENTGF 54

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915698  394 lsSRPAWSKesevlpdqkYSMDNTPHTPTPFKNALE----KYGPLKPLPQTP-HLEEDLKEVLRSEAGMELIIEDDMRPE 468
Cdd:pfam09316  55 --RTPNIRR---------SILETTPRTPTPFKNALAaqekKYGPLKPLPQTPaHLEEDLQEVLKSEIGSDIEIGEDEKPW 123

                         170       180
                  ....*....|....*....|....*....
gi 568915698  469 KQKRKPGlRRSPIKKVRKSLALDIMDEDG 497
Cdd:pfam09316 124 KQKIKQE-HRSPNKKVRKSLWLDDWDKEH 151
PLN03091 super family cl33633
hypothetical protein; Provisional
 81-219 1.02e-29

hypothetical protein; Provisional


The actual alignment was detected with superfamily member PLN03091:

Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 122.39  E-value: 1.02e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915698  81 LVKGPWTKEEDQKVIELVKKYGTKQWTLIAKhLKG--RLGKQCRERWHNHLNPEVKKSCWTEEEDRIICEAHKVLGNRWA 158
Cdd:PLN03091  12 LRKGLWSPEEDEKLLRHITKYGHGCWSSVPK-QAGlqRCGKSCRLRWINYLRPDLKRGTFSQQEENLIIELHAVLGNRWS 90

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568915698 159 EIAKMLPGRTDNAVKNHWNSTIKRKVDTGGFPAESRdcKPvylLLELEDKEQHQgvQPVDG 219
Cdd:PLN03091  91 QIAAQLPGRTDNEIKNLWNSCLKKKLRQRGIDPNTH--KP---LSEVENGEDKN--PPTDD 144
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 34-94 5.90e-19

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


:

Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 80.82  E-value: 5.90e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568915698   34 WTHEEDEQLRALVRQFGQqDWKFLASHFPNRTDQQCQYRWLRVLNPDLVKGPWTKEEDQKV 94
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYGN-DWKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSKEEDQRL 60
 
Name Accession Description Interval E-value
Cmyb_C pfam09316
C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb ...
 314-497 5.15e-47

C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb and the viral transforming protein myb. Truncation of the domain results in 'activation' of c-myb and subsequent tumourigenesis.


Pssm-ID: 462753  Cd Length: 157  Bit Score: 162.14  E-value: 5.15e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915698  314 LIESFLNFWNKQDTLELESPSLTSTPVCSQKVVVTTPLHRDKTPLHQKypssvsqklqsaravvahafnpstweaEAGGF 393
Cdd:pfam09316   2 SPSQFLNESSGQENLPLENPTLTSTPVCGQKVFLTTPLHKDQTPKYQK---------------------------ENTGF 54

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915698  394 lsSRPAWSKesevlpdqkYSMDNTPHTPTPFKNALE----KYGPLKPLPQTP-HLEEDLKEVLRSEAGMELIIEDDMRPE 468
Cdd:pfam09316  55 --RTPNIRR---------SILETTPRTPTPFKNALAaqekKYGPLKPLPQTPaHLEEDLQEVLKSEIGSDIEIGEDEKPW 123

                         170       180
                  ....*....|....*....|....*....
gi 568915698  469 KQKRKPGlRRSPIKKVRKSLALDIMDEDG 497
Cdd:pfam09316 124 KQKIKQE-HRSPNKKVRKSLWLDDWDKEH 151
PLN03091 PLN03091
hypothetical protein; Provisional
 81-219 1.02e-29

hypothetical protein; Provisional


Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 122.39  E-value: 1.02e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915698  81 LVKGPWTKEEDQKVIELVKKYGTKQWTLIAKhLKG--RLGKQCRERWHNHLNPEVKKSCWTEEEDRIICEAHKVLGNRWA 158
Cdd:PLN03091  12 LRKGLWSPEEDEKLLRHITKYGHGCWSSVPK-QAGlqRCGKSCRLRWINYLRPDLKRGTFSQQEENLIIELHAVLGNRWS 90

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568915698 159 EIAKMLPGRTDNAVKNHWNSTIKRKVDTGGFPAESRdcKPvylLLELEDKEQHQgvQPVDG 219
Cdd:PLN03091  91 QIAAQLPGRTDNEIKNLWNSCLKKKLRQRGIDPNTH--KP---LSEVENGEDKN--PPTDD 144
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 80-195 2.82e-27

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 115.66  E-value: 2.82e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915698  80 DLVKGPWTKEEDQKVIELVKKYGTKQWTLIAKHLKGRLGKQCRERWHNHLNPEVKKSCWTEEEDRIICEAHKVLGNRWAE 159
Cdd:COG5147   17 KRKGGSWKRTEDEDLKALVKKLGPNNWSKVASLLISSTGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELGTQWST 96

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 568915698 160 IAKMLPGRTDNAVKNHWNSTIKRKVDTGGFPAESRD 195
Cdd:COG5147   97 IADYKDRRTAQQCVERYVNTLEDLSSTHDSKLQRRN 132
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 34-94 5.90e-19

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 80.82  E-value: 5.90e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568915698   34 WTHEEDEQLRALVRQFGQqDWKFLASHFPNRTDQQCQYRWLRVLNPDLVKGPWTKEEDQKV 94
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYGN-DWKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSKEEDQRL 60
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 86-144 7.97e-18

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 77.74  E-value: 7.97e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 568915698   86 WTKEEDQKVIELVKKYGtKQWTLIAKHLKGRLGKQCRERWHNHLNPEVKKSCWTEEEDR 144
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYG-NDWKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSKEEDQ 58
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
83-131 1.70e-16

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 73.41  E-value: 1.70e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 568915698    83 KGPWTKEEDQKVIELVKKYGTKQWTLIAKHLKGRLGKQCRERWHNHLNP 131
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 85-129 5.23e-16

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 71.84  E-value: 5.23e-16
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 568915698  85 PWTKEEDQKVIELVKKYGTKQWTLIAKHLKGRLGKQCRERWHNHL 129
Cdd:cd00167    1 PWTEEEDELLLEAVKKYGKNNWEKIAKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
31-79 1.43e-13

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 65.32  E-value: 1.43e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 568915698    31 KVKWTHEEDEQLRALVRQFGQQDWKFLASHFPNRTDQQCQYRWLRVLNP 79
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 33-77 5.55e-13

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 63.36  E-value: 5.55e-13
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 568915698  33 KWTHEEDEQLRALVRQFGQQDWKFLASHFPNRTDQQCQYRWLRVL 77
Cdd:cd00167    1 PWTEEEDELLLEAVKKYGKNNWEKIAKELPGRTPKQCRERWRNLL 45
 
Name Accession Description Interval E-value
Cmyb_C pfam09316
C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb ...
 314-497 5.15e-47

C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb and the viral transforming protein myb. Truncation of the domain results in 'activation' of c-myb and subsequent tumourigenesis.


Pssm-ID: 462753  Cd Length: 157  Bit Score: 162.14  E-value: 5.15e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915698  314 LIESFLNFWNKQDTLELESPSLTSTPVCSQKVVVTTPLHRDKTPLHQKypssvsqklqsaravvahafnpstweaEAGGF 393
Cdd:pfam09316   2 SPSQFLNESSGQENLPLENPTLTSTPVCGQKVFLTTPLHKDQTPKYQK---------------------------ENTGF 54

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915698  394 lsSRPAWSKesevlpdqkYSMDNTPHTPTPFKNALE----KYGPLKPLPQTP-HLEEDLKEVLRSEAGMELIIEDDMRPE 468
Cdd:pfam09316  55 --RTPNIRR---------SILETTPRTPTPFKNALAaqekKYGPLKPLPQTPaHLEEDLQEVLKSEIGSDIEIGEDEKPW 123

                         170       180
                  ....*....|....*....|....*....
gi 568915698  469 KQKRKPGlRRSPIKKVRKSLALDIMDEDG 497
Cdd:pfam09316 124 KQKIKQE-HRSPNKKVRKSLWLDDWDKEH 151
PLN03091 PLN03091
hypothetical protein; Provisional
 81-219 1.02e-29

hypothetical protein; Provisional


Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 122.39  E-value: 1.02e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915698  81 LVKGPWTKEEDQKVIELVKKYGTKQWTLIAKhLKG--RLGKQCRERWHNHLNPEVKKSCWTEEEDRIICEAHKVLGNRWA 158
Cdd:PLN03091  12 LRKGLWSPEEDEKLLRHITKYGHGCWSSVPK-QAGlqRCGKSCRLRWINYLRPDLKRGTFSQQEENLIIELHAVLGNRWS 90

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568915698 159 EIAKMLPGRTDNAVKNHWNSTIKRKVDTGGFPAESRdcKPvylLLELEDKEQHQgvQPVDG 219
Cdd:PLN03091  91 QIAAQLPGRTDNEIKNLWNSCLKKKLRQRGIDPNTH--KP---LSEVENGEDKN--PPTDD 144
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 80-195 2.82e-27

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 115.66  E-value: 2.82e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915698  80 DLVKGPWTKEEDQKVIELVKKYGTKQWTLIAKHLKGRLGKQCRERWHNHLNPEVKKSCWTEEEDRIICEAHKVLGNRWAE 159
Cdd:COG5147   17 KRKGGSWKRTEDEDLKALVKKLGPNNWSKVASLLISSTGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELGTQWST 96

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 568915698 160 IAKMLPGRTDNAVKNHWNSTIKRKVDTGGFPAESRD 195
Cdd:COG5147   97 IADYKDRRTAQQCVERYVNTLEDLSSTHDSKLQRRN 132
PLN03212 PLN03212
Transcription repressor MYB5; Provisional
 83-199 3.64e-26

Transcription repressor MYB5; Provisional


Pssm-ID: 178751 [Multi-domain]  Cd Length: 249  Bit Score: 107.47  E-value: 3.64e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915698  83 KGPWTKEEDQKVIELVKKYGTKQWTLIAKHLKG-RLGKQCRERWHNHLNPEVKKSCWTEEEDRIICEAHKVLGNRWAEIA 161
Cdd:PLN03212  25 RGPWTVEEDEILVSFIKKEGEGRWRSLPKRAGLlRCGKSCRLRWMNYLRPSVKRGGITSDEEDLILRLHRLLGNRWSLIA 104

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 568915698 162 KMLPGRTDNAVKNHWNSTIKRKVDTGGFPAESRdcKPV 199
Cdd:PLN03212 105 GRIPGRTDNEIKNYWNTHLRKKLLRQGIDPQTH--KPL 140
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 34-94 5.90e-19

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 80.82  E-value: 5.90e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568915698   34 WTHEEDEQLRALVRQFGQqDWKFLASHFPNRTDQQCQYRWLRVLNPDLVKGPWTKEEDQKV 94
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYGN-DWKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSKEEDQRL 60
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 86-144 7.97e-18

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 77.74  E-value: 7.97e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 568915698   86 WTKEEDQKVIELVKKYGtKQWTLIAKHLKGRLGKQCRERWHNHLNPEVKKSCWTEEEDR 144
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYG-NDWKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSKEEDQ 58
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
83-131 1.70e-16

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 73.41  E-value: 1.70e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 568915698    83 KGPWTKEEDQKVIELVKKYGTKQWTLIAKHLKGRLGKQCRERWHNHLNP 131
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERWRNLLKP 49
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 83-129 3.55e-16

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 72.54  E-value: 3.55e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 568915698   83 KGPWTKEEDQKVIELVKKYGtKQWTLIAKHLKGRLGKQCRERWHNHL 129
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLG-NRWKKIAKLLPGRTDNQCKNRWQNYL 46
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 85-129 5.23e-16

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 71.84  E-value: 5.23e-16
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 568915698  85 PWTKEEDQKVIELVKKYGTKQWTLIAKHLKGRLGKQCRERWHNHL 129
Cdd:cd00167    1 PWTEEEDELLLEAVKKYGKNNWEKIAKELPGRTPKQCRERWRNLL 45
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 135-178 3.28e-15

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 69.84  E-value: 3.28e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 568915698  135 KSCWTEEEDRIICEAHKVLGNRWAEIAKMLPGRTDNAVKNHWNS 178
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQN 44
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
31-79 1.43e-13

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 65.32  E-value: 1.43e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 568915698    31 KVKWTHEEDEQLRALVRQFGQQDWKFLASHFPNRTDQQCQYRWLRVLNP 79
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 33-77 5.55e-13

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 63.36  E-value: 5.55e-13
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 568915698  33 KWTHEEDEQLRALVRQFGQQDWKFLASHFPNRTDQQCQYRWLRVL 77
Cdd:cd00167    1 PWTEEEDELLLEAVKKYGKNNWEKIAKELPGRTPKQCRERWRNLL 45
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 138-177 3.87e-12

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 61.05  E-value: 3.87e-12
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 568915698 138 WTEEEDRIICEAHKVLG-NRWAEIAKMLPGRTDNAVKNHWN 177
Cdd:cd00167    2 WTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWR 42
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
135-182 5.05e-12

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 60.70  E-value: 5.05e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 568915698   135 KSCWTEEEDRIICEAHKVLG-NRWAEIAKMLPGRTDNAVKNHWNSTIKR 182
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLKP 49
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 31-77 6.59e-12

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 60.21  E-value: 6.59e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 568915698   31 KVKWTHEEDEQLRALVRQFGQqDWKFLASHFPNRTDQQCQYRWLRVL 77
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLGN-RWKKIAKLLPGRTDNQCKNRWQNYL 46
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 138-192 9.15e-10

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 54.62  E-value: 9.15e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 568915698  138 WTEEEDRIICEAHKVLGNRWAEIAKMLPGRTDNAVKNHWNSTIKRKVDTGGFPAE 192
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYGNDWKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSKE 55
SANT_CDC5_II cd11659
SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, ...
 79-125 5.43e-08

SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, cell division cycle 5-like protein (CDC5) functions in pre-mRNA splicing in cell cycle control. The DNA-binding, myb-like domain of CDC5 is a member of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 212557 [Multi-domain]  Cd Length: 53  Bit Score: 49.62  E-value: 5.43e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 568915698  79 PDLVKGPWTKEEDQKVIELVKKYGTkQWTLIAKhLKGRLGKQCRERW 125
Cdd:cd11659    1 PSIKKTEWTREEDEKLLHLAKLLPT-QWRTIAP-IVGRTAQQCLERY 45
SANT_TRF cd11660
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human ...
 85-127 8.33e-07

Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human telomere repeat binding factors, TRF1 and TRF2, function as part of the 6 component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminal (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA binding proteins (TRF2, TRF1, and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Schizosaccharomyces pombe TAZ1 is an orthlog and binds RAP1. Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM), the TIN2 binding motif (TBM) and a myb-like DNA binding domain, SANT, named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. Tandem copies of the domain bind telomeric DNA tandem repeats as part of the capping complex. The single myb-like domain of TRF-type proteins is similar to the tandem myb_like domains found in yeast RAP1.


Pssm-ID: 212558 [Multi-domain]  Cd Length: 50  Bit Score: 46.02  E-value: 8.33e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 568915698  85 PWTKEEDQKVIELVKKYGTKQWTLIAKH---LKGRLGKQCRERWHN 127
Cdd:cd11660    2 KWTDEEDEALVEGVEKYGVGNWAKILKDyffVNNRTSVDLKDKWRN 47
SANT_CDC5_II cd11659
SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, ...
 131-170 9.06e-05

SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, cell division cycle 5-like protein (CDC5) functions in pre-mRNA splicing in cell cycle control. The DNA-binding, myb-like domain of CDC5 is a member of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 212557 [Multi-domain]  Cd Length: 53  Bit Score: 40.37  E-value: 9.06e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 568915698 131 PEVKKSCWTEEEDRIICEAHKVLGNRWAEIAKMLpGRTDN 170
Cdd:cd11659    1 PSIKKTEWTREEDEKLLHLAKLLPTQWRTIAPIV-GRTAQ 39
SANT_TRF cd11660
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human ...
 32-79 9.29e-05

Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human telomere repeat binding factors, TRF1 and TRF2, function as part of the 6 component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminal (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA binding proteins (TRF2, TRF1, and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Schizosaccharomyces pombe TAZ1 is an orthlog and binds RAP1. Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM), the TIN2 binding motif (TBM) and a myb-like DNA binding domain, SANT, named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. Tandem copies of the domain bind telomeric DNA tandem repeats as part of the capping complex. The single myb-like domain of TRF-type proteins is similar to the tandem myb_like domains found in yeast RAP1.


Pssm-ID: 212558 [Multi-domain]  Cd Length: 50  Bit Score: 40.24  E-value: 9.29e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 568915698  32 VKWTHEEDEQLRALVRQFGQQDWKFLASHFP---NRTDQQCQYRWlRVLNP 79
Cdd:cd11660    1 RKWTDEEDEALVEGVEKYGVGNWAKILKDYFfvnNRTSVDLKDKW-RNLKK 50
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 31-181 2.67e-04

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 44.01  E-value: 2.67e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915698  31 KVKWTHEEDEQLRALVRQFGQQDWKFLASHFPNRTDQQCQYRWL-----------------RVLNPDLVKGPWTKEEDQK 93
Cdd:COG5147  222 KKGETLALEQEINEYKEKKGLSRKQFCERIWSTDRDEDKFWPNIykklpyrdkksiykhlrRKYNIFEQRGKWTKEEEQE 301

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568915698  94 VIELVKKYGtKQWTLIAKhLKGRLGKQCRERWHNHLNP--EVKKSCWT-EEEDRIIC-------EAHKVLGNRWAEIAKM 163
Cdd:COG5147  302 LAKLVVEHG-GSWTEIGK-LLGRMPNDCRDRWRDYVKCgdTLKRNRWSiEEEELLDKvvnemrlEAQQSSRILWLLIAQN 379

                        170
                 ....*....|....*...
gi 568915698 164 LPGRTDNAVKNHWNSTIK 181
Cdd:COG5147  380 IRNRLQHHCRDKYGVLIS 397
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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