U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Root Rootletin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42860, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Rootprovided by FlyBase
    Official Full Name
    Rootletinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039152
    Locus tag
    Dmel_CG6129
    See related
    AllianceGenome:FB:FBgn0039152
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6129; Dmel\CG6129; Q8IMX3_DROME
    Summary
    Involved in auditory behavior; ciliary basal body organization; and sensory perception of mechanical stimulus. Colocalizes with ciliary rootlet. Is expressed in antenna; chordotonal organ precursor cell; sense organ; sensory neurons; and spermatozoon. Orthologous to several human genes including CROCC (ciliary rootlet coiled-coil, rootletin). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Root in Genome Data Viewer
    Location:
    95E1-95E1; 3-83 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24113286..24128193)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19939008..19953915)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Leucine-TAA 2-1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Glutamyl-tRNA amidotransferase, subunit B Neighboring gene Tsc1 Neighboring gene Secretory 10

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The Drosophila homologue of Rootletin is required for mechanosensory function and ciliary rootlet formation in chordotonal sensory neurons. Styczynska-Soczka K, et al. Cilia, 2015. PMID 26140210, Free PMC Article
    2. Sas-4 Colocalizes with the Ciliary Rootlets of the Drosophila Sensory Organs. Persico V, et al. J Dev Biol, 2021 Jan 5. PMID 33466292, Free PMC Article
    3. Tissue specific requirement of Drosophila Rcd4 for centriole duplication and ciliogenesis. Panda P, et al. J Cell Biol, 2020 Sep 7. PMID 32543652, Free PMC Article
    4. Rootletin organizes the ciliary rootlet to achieve neuron sensory function in Drosophila. Chen JV, et al. J Cell Biol, 2015 Oct 26. PMID 26483560, Free PMC Article
    5. Gene regulation by the lysine demethylase KDM4A in Drosophila. Crona F, et al. Dev Biol, 2013 Jan 15. PMID 23195220

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in auditory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ciliary basal body organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mechanosensory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory perception of touch IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    colocalizes_with ciliary rootlet IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ciliary rootlet IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    rootletin
    Names
    CG6129-PD
    CG6129-PE
    CG6129-PF
    Root-PD
    Root-PE
    Root-PF

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      24113286..24128193
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300568.1 → NP_001287497.1  rootletin, isoform E [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VCD1
      Conserved Domains (3) summary
      COG1196
      Location:555 → 1384
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:991 → 1779
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15035
      Location:110 → 332
      Rootletin; Ciliary rootlet component, centrosome cohesion

    2. NM_142959.4 → NP_651216.2  rootletin, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VCD1
      Related
      FBpp0293091
      Conserved Domains (3) summary
      COG1196
      Location:555 → 1384
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:991 → 1779
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15035
      Location:110 → 332
      Rootletin; Ciliary rootlet component, centrosome cohesion

    3. NM_176553.2 → NP_788730.2  rootletin, isoform F [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VCD1
      Conserved Domains (3) summary
      COG1196
      Location:555 → 1384
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:991 → 1779
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15035
      Location:110 → 332
      Rootletin; Ciliary rootlet component, centrosome cohesion
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MSN3 Q8MSN3
    Q9VCD1 Q9VCD1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools