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    bin3 bicoid-interacting protein 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35552, updated on 17-Dec-2024

    Summary

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    Official Symbol
    bin3provided by FlyBase
    Official Full Name
    bicoid-interacting protein 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0263144
    Locus tag
    Dmel_CG8276
    See related
    AllianceGenome:FB:FBgn0263144
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Bin3; CG8276; Dmel\CG8276; l(2)SH1014; l(2)SH2 1014
    Summary
    Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and snRNA binding activity. Involved in developmental process and negative regulation of translation. Located in nucleus. Is expressed in several structures, including Malpighian tubule primordium; amnioserosa; ganglia; mesoderm; and nephrocyte. Orthologous to human MEPCE (methylphosphate capping enzyme). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See bin3 in Genome Data Viewer
    Location:
    42A13-42A14; 2-55 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (6214568..6240602)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2102073..2128107)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44161 Neighboring gene uncharacterized protein Neighboring gene tomboy40 Neighboring gene Tetratricopeptide repeat domain 7 Neighboring gene Phospholipase D Neighboring gene long non-coding RNA:CR46075

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of drosophila bicoid-interacting proteins using a custom two-hybrid selection. Zhu W, et al. Gene, 2000 Mar 21. PMID 10717484
    2. Drosophila Amus and Bin3 methylases functionally replace mammalian MePCE for capping and the stabilization of U6 and 7SK snRNAs. Peng Q, et al. Sci Adv, 2023 Dec 15. PMID 38100593, Free PMC Article
    3. TTC7 and Hyccin Regulate Neuronal Aβ42 Accumulation and its Associated Neural Deficits in Aβ42-Expressing Drosophila. Sun M, et al. J Alzheimers Dis, 2018. PMID 30103315
    4. Catalytic activity of the Bin3/MePCE methyltransferase domain is dispensable for 7SK snRNP function in Drosophila melanogaster. Palumbo RJ, et al. Genetics, 2024 Jan 3. PMID 37982586, Free PMC Article
    5. Distinguishing direct from indirect roles for bicoid mRNA localization factors. Weil TT, et al. Development, 2010 Jan. PMID 20023172, Free PMC Article

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Catalytic activity of the Bin3/MePCE methyltransferase domain is dispensable for 7SK snRNP function in Drosophila melanogaster.
      Title: Catalytic activity of the Bin3/MePCE methyltransferase domain is dispensable for 7SK snRNP function in Drosophila melanogaster.
    2. Drosophila Amus and Bin3 methylases functionally replace mammalian MePCE for capping and the stabilization of U6 and 7SK snRNAs.
      Title: Drosophila Amus and Bin3 methylases functionally replace mammalian MePCE for capping and the stabilization of U6 and 7SK snRNAs.
    3. Bicoid recruits Bin3 to the caudal 3' UTR.
      Title: The Bin3 RNA methyltransferase is required for repression of caudal translation in the Drosophila embryo.
    4. Data propose bicoid mRNA localization was done by Swallow indirectly organizing the cytoskeleton, whereas Staufen plays a direct role in dynein-dependent bicoid mRNA transport.
      Title: Distinguishing direct from indirect roles for bicoid mRNA localization factors.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 6234498-6234554 mobile_element_type = transposon:INE-1{}1746

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables O-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables snRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables snRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in developmental process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in methylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in negative regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in snRNA modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    bicoid-interacting protein 3
    Names
    Bicoid-interacting protein 3
    CG8276-PA
    CG8276-PB
    CG8276-PC
    CG8276-PD
    bicoid interacting protein 3
    bin3-PA
    bin3-PB
    bin3-PC
    bin3-PD
    lethal (2) SH1014
    NP_001260724.1
    NP_001303336.1
    NP_523626.2
    NP_724468.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      6214568..6240602
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078902.3 → NP_523626.2  bicoid-interacting protein 3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523626.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7K480, Q86LF5, Q9NJV6
      UniProtKB/TrEMBL
      E2QC61
      Related
      FBpp0085336
      Conserved Domains (2) summary
      pfam06859
      Location:1004 → 1112
      Bin3; Bicoid-interacting protein 3 (Bin3)
      pfam12847
      Location:820 → 867
      Methyltransf_18; Methyltransferase domain

    2. NM_001316407.1 → NP_001303336.1  bicoid-interacting protein 3, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7K480, Q86LF5, Q9NJV6
      UniProtKB/TrEMBL
      E2QC61
      Conserved Domains (2) summary
      pfam06859
      Location:1004 → 1112
      Bin3; Bicoid-interacting protein 3 (Bin3)
      pfam12847
      Location:820 → 867
      Methyltransf_18; Methyltransferase domain

    3. NM_165468.2 → NP_724468.1  bicoid-interacting protein 3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724468.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7K480, Q86LF5, Q9NJV6
      UniProtKB/TrEMBL
      E2QC61
      Related
      FBpp0085337
      Conserved Domains (2) summary
      pfam06859
      Location:1004 → 1112
      Bin3; Bicoid-interacting protein 3 (Bin3)
      pfam12847
      Location:820 → 867
      Methyltransf_18; Methyltransferase domain

    4. NM_001273795.1 → NP_001260724.1  bicoid-interacting protein 3, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260724.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7K480, Q86LF5, Q9NJV6
      UniProtKB/TrEMBL
      E2QC61
      Conserved Domains (2) summary
      pfam06859
      Location:1004 → 1112
      Bin3; Bicoid-interacting protein 3 (Bin3)
      pfam12847
      Location:820 → 867
      Methyltransf_18; Methyltransferase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E2QC61 E2QC61
    Q7K480.1 Q7K480

    Gene LinkOut

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