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Conserved domains on  [gi|24585988|ref|NP_724468|]
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bicoid-interacting protein 3, isoform A [Drosophila melanogaster]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 13391478)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0008168|GO:1904047
PubMed:  12504684|12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Bin3 pfam06859
Bicoid-interacting protein 3 (Bin3); This family represents a conserved region of ...
 1004-1112 4.63e-56

Bicoid-interacting protein 3 (Bin3); This family represents a conserved region of approximately 120 residues within eukaryotic Bicoid-interacting protein 3 (Bin3). Bin3, which shows similarity to a number of protein methyltransferases that modify RNA-binding proteins, interacts with Bicoid, which itself directs pattern formation in the early Drosophila embryo. The interaction might allow Bicoid to switch between its dual roles in transcription and translation. Note that family members contain a conserved HLN motif.


:

Pssm-ID: 462022  Cd Length: 109  Bit Score: 189.67  E-value: 4.63e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585988   1004 YDLILCLSVTKWIHLNFGDNGLKMAFKRMFNQLRPGGKLILEAQNWASYKKKKNLTPEIYNNYKQIEFFPNKFHEYLLsS 1083
Cdd:pfam06859    1 YDVILCLSVTKWIHLNWGDEGLKRFFKRIYSLLRPGGVLILEPQPWKSYKKAKRLSETIKANYKTIQLRPEDFEEYLL-S 79

                           90       100       110
                   ....*....|....*....|....*....|
gi 24585988   1084 EVGFSHSYTLG-VPRHMNKGFCRPIQLYAK 1112
Cdd:pfam06859   80 EVGFESVEELGsTPEGKSKGFDRPIYLFRK 109
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
824-864 1.03e-06

Trans-aconitate methyltransferase [Energy production and conversion];


:

Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 48.28  E-value: 1.03e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 24585988  824 ILDIGCNVGHMTITVARHLAPKTIVGIDIDRELVARARRNL 864
Cdd:COG4106    5 VLDLGCGTGRLTALLAERFPGARVTGVDLSPEMLARARARL 45
PRK07764 super family cl35613
DNA polymerase III subunits gamma and tau; Validated
 426-559 3.03e-05

DNA polymerase III subunits gamma and tau; Validated


The actual alignment was detected with superfamily member PRK07764:

Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 48.44  E-value: 3.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585988   426 EGGVGSELTDEPPLPAATSSLAASPVAAPLNVGgslllseSAAPAPGETAEMGQQQEQAhvhSPQSASTTTTAAEMPTPT 505
Cdd:PRK07764  382 ERRLGVAGGAGAPAAAAPSAAAAAPAAAPAPAA-------AAPAAAAAPAPAAAPQPAP---APAPAPAPPSPAGNAPAG 451

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 24585988   506 PTSAAAATATAEHKEQSAPAPTATSSPQRQQQHVAAAAEElPTPETSAAAETPA 559
Cdd:PRK07764  452 GAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPA-AAPAAPAAPAAPA 504
Cfa super family cl34437
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 783-862 1.77e-04

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


The actual alignment was detected with superfamily member COG2230:

Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 43.38  E-value: 1.77e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585988  783 DGLKYRYGNFDRYVDFrqMNEFRDVRLQVFQRHVELFENKDILDIGCNVGHMTITVARHLApKTIVGIDIDRELVARARR 862
Cdd:COG2230   16 PTMTYSCAYFEDPDDT--LEEAQEAKLDLILRKLGLKPGMRVLDIGCGWGGLALYLARRYG-VRVTGVTLSPEQLEYARE 92
 
Name Accession Description Interval E-value
Bin3 pfam06859
Bicoid-interacting protein 3 (Bin3); This family represents a conserved region of ...
 1004-1112 4.63e-56

Bicoid-interacting protein 3 (Bin3); This family represents a conserved region of approximately 120 residues within eukaryotic Bicoid-interacting protein 3 (Bin3). Bin3, which shows similarity to a number of protein methyltransferases that modify RNA-binding proteins, interacts with Bicoid, which itself directs pattern formation in the early Drosophila embryo. The interaction might allow Bicoid to switch between its dual roles in transcription and translation. Note that family members contain a conserved HLN motif.


Pssm-ID: 462022  Cd Length: 109  Bit Score: 189.67  E-value: 4.63e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585988   1004 YDLILCLSVTKWIHLNFGDNGLKMAFKRMFNQLRPGGKLILEAQNWASYKKKKNLTPEIYNNYKQIEFFPNKFHEYLLsS 1083
Cdd:pfam06859    1 YDVILCLSVTKWIHLNWGDEGLKRFFKRIYSLLRPGGVLILEPQPWKSYKKAKRLSETIKANYKTIQLRPEDFEEYLL-S 79

                           90       100       110
                   ....*....|....*....|....*....|
gi 24585988   1084 EVGFSHSYTLG-VPRHMNKGFCRPIQLYAK 1112
Cdd:pfam06859   80 EVGFESVEELGsTPEGKSKGFDRPIYLFRK 109
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
824-864 1.03e-06

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 48.28  E-value: 1.03e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 24585988  824 ILDIGCNVGHMTITVARHLAPKTIVGIDIDRELVARARRNL 864
Cdd:COG4106    5 VLDLGCGTGRLTALLAERFPGARVTGVDLSPEMLARARARL 45
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 824-865 3.49e-06

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 46.79  E-value: 3.49e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 24585988    824 ILDIGCNVGHMTITVARHLApKTIVGIDIDRELVARARRNLS 865
Cdd:pfam13649    1 VLDLGCGTGRLTLALARRGG-ARVTGVDLSPEMLERARERAA 41
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 426-559 3.03e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 48.44  E-value: 3.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585988   426 EGGVGSELTDEPPLPAATSSLAASPVAAPLNVGgslllseSAAPAPGETAEMGQQQEQAhvhSPQSASTTTTAAEMPTPT 505
Cdd:PRK07764  382 ERRLGVAGGAGAPAAAAPSAAAAAPAAAPAPAA-------AAPAAAAAPAPAAAPQPAP---APAPAPAPPSPAGNAPAG 451

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 24585988   506 PTSAAAATATAEHKEQSAPAPTATSSPQRQQQHVAAAAEElPTPETSAAAETPA 559
Cdd:PRK07764  452 GAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPA-AAPAAPAAPAAPA 504
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 783-862 1.77e-04

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 43.38  E-value: 1.77e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585988  783 DGLKYRYGNFDRYVDFrqMNEFRDVRLQVFQRHVELFENKDILDIGCNVGHMTITVARHLApKTIVGIDIDRELVARARR 862
Cdd:COG2230   16 PTMTYSCAYFEDPDDT--LEEAQEAKLDLILRKLGLKPGMRVLDIGCGWGGLALYLARRYG-VRVTGVTLSPEQLEYARE 92
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 823-863 4.62e-04

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 40.88  E-value: 4.62e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 24585988  823 DILDIGCNVGHMTITVARHLApKTIVGIDIDRELVARARRN 863
Cdd:cd02440    1 RVLDLGCGTGALALALASGPG-ARVTGVDISPVALELARKA 40
 
Name Accession Description Interval E-value
Bin3 pfam06859
Bicoid-interacting protein 3 (Bin3); This family represents a conserved region of ...
 1004-1112 4.63e-56

Bicoid-interacting protein 3 (Bin3); This family represents a conserved region of approximately 120 residues within eukaryotic Bicoid-interacting protein 3 (Bin3). Bin3, which shows similarity to a number of protein methyltransferases that modify RNA-binding proteins, interacts with Bicoid, which itself directs pattern formation in the early Drosophila embryo. The interaction might allow Bicoid to switch between its dual roles in transcription and translation. Note that family members contain a conserved HLN motif.


Pssm-ID: 462022  Cd Length: 109  Bit Score: 189.67  E-value: 4.63e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585988   1004 YDLILCLSVTKWIHLNFGDNGLKMAFKRMFNQLRPGGKLILEAQNWASYKKKKNLTPEIYNNYKQIEFFPNKFHEYLLsS 1083
Cdd:pfam06859    1 YDVILCLSVTKWIHLNWGDEGLKRFFKRIYSLLRPGGVLILEPQPWKSYKKAKRLSETIKANYKTIQLRPEDFEEYLL-S 79

                           90       100       110
                   ....*....|....*....|....*....|
gi 24585988   1084 EVGFSHSYTLG-VPRHMNKGFCRPIQLYAK 1112
Cdd:pfam06859   80 EVGFESVEELGsTPEGKSKGFDRPIYLFRK 109
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
824-864 1.03e-06

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 48.28  E-value: 1.03e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 24585988  824 ILDIGCNVGHMTITVARHLAPKTIVGIDIDRELVARARRNL 864
Cdd:COG4106    5 VLDLGCGTGRLTALLAERFPGARVTGVDLSPEMLARARARL 45
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 799-865 1.44e-06

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 48.86  E-value: 1.44e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24585988  799 RQMNEFRDVRLQVFQRHVeLFENKDILDIGCNVGHMTITVARHLApkTIVGIDIDRELVARARRNLS 865
Cdd:COG2227    4 PDARDFWDRRLAALLARL-LPAGGRVLDVGCGTGRLALALARRGA--DVTGVDISPEALEIARERAA 67
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 824-865 3.49e-06

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 46.79  E-value: 3.49e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 24585988    824 ILDIGCNVGHMTITVARHLApKTIVGIDIDRELVARARRNLS 865
Cdd:pfam13649    1 VLDLGCGTGRLTLALARRGG-ARVTGVDLSPEMLERARERAA 41
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 825-864 5.09e-06

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 46.21  E-value: 5.09e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 24585988    825 LDIGCNVGHMTITVARHLAPKTIVGIDIDRELVARARRNL 864
Cdd:pfam08242    1 LEIGCGTGTLLRALLEALPGLEYTGLDISPAALEAARERL 40
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 798-864 1.78e-05

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 46.14  E-value: 1.78e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24585988  798 FRQMNEFRDVRLQVFQRhVELFENKDILDIGCNVGHMTITVARHLApkTIVGIDIDRELVARARRNL 864
Cdd:COG2226    1 FDRVAARYDGREALLAA-LGLRPGARVLDLGCGTGRLALALAERGA--RVTGVDISPEMLELARERA 64
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 426-559 3.03e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 48.44  E-value: 3.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585988   426 EGGVGSELTDEPPLPAATSSLAASPVAAPLNVGgslllseSAAPAPGETAEMGQQQEQAhvhSPQSASTTTTAAEMPTPT 505
Cdd:PRK07764  382 ERRLGVAGGAGAPAAAAPSAAAAAPAAAPAPAA-------AAPAAAAAPAPAAAPQPAP---APAPAPAPPSPAGNAPAG 451

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 24585988   506 PTSAAAATATAEHKEQSAPAPTATSSPQRQQQHVAAAAEElPTPETSAAAETPA 559
Cdd:PRK07764  452 GAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPA-AAPAAPAAPAAPA 504
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
805-862 3.82e-05

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 45.76  E-value: 3.82e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585988  805 RDVRLQVFQRHvELFENKDILDIGCNVGHMtitvARHLAPK--TIVGIDIDRELVARARR 862
Cdd:COG4976   32 ALLAEELLARL-PPGPFGRVLDLGCGTGLL----GEALRPRgyRLTGVDLSEEMLAKARE 86
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 824-864 8.15e-05

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 45.52  E-value: 8.15e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 24585988  824 ILDIGCNVGHMTITVARHLAPKTIVGIDIDRELVARARRNL 864
Cdd:COG4123   41 VLDLGTGTGVIALMLAQRSPGARITGVEIQPEAAELARRNV 81
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 809-865 1.50e-04

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 44.52  E-value: 1.50e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 24585988  809 LQVFQRHVELFENKDILDIGCNVGHMTITVARHLApKTIVGIDIDRELVARARRNLS 865
Cdd:COG0500   15 AALLALLERLPKGGRVLDLGCGTGRNLLALAARFG-GRVIGIDLSPEAIALARARAA 70
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 818-863 1.50e-04

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 43.56  E-value: 1.50e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 24585988    818 LFENKDILDIGCNVGHMTITVARHLAPK-TIVGIDIDRELVARARRN 863
Cdd:pfam13847    1 IDKGMRVLDLGCGTGHLSFELAEELGPNaEVVGIDISEEAIEKAREN 47
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 783-862 1.77e-04

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 43.38  E-value: 1.77e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585988  783 DGLKYRYGNFDRYVDFrqMNEFRDVRLQVFQRHVELFENKDILDIGCNVGHMTITVARHLApKTIVGIDIDRELVARARR 862
Cdd:COG2230   16 PTMTYSCAYFEDPDDT--LEEAQEAKLDLILRKLGLKPGMRVLDIGCGWGGLALYLARRYG-VRVTGVTLSPEQLEYARE 92
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 823-863 4.62e-04

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 40.88  E-value: 4.62e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 24585988  823 DILDIGCNVGHMTITVARHLApKTIVGIDIDRELVARARRN 863
Cdd:cd02440    1 RVLDLGCGTGALALALASGPG-ARVTGVDISPVALELARKA 40
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
437-585 1.20e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 43.30  E-value: 1.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585988   437 PPLPAATSSLAASPVAAPlnVGGSLLLSESAAPAPGETAEMGQQQEQAHVHSPQSASTTTTAAEMPTPTPTSAAAATATA 516
Cdd:PRK07003  400 TAVTGAAGAALAPKAAAA--AAATRAEAPPAAPAPPATADRGDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSA 477

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24585988   517 EHKEQSAPAPTATSSPQRQQQHVAAAAEELPTPETSAAAETPAEEMLLSCSATSASlVASTLAERRASR 585
Cdd:PRK07003  478 SAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPAAAAPPAPEAR-PPTPAAAAPAAR 545
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 825-864 1.68e-03

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 39.19  E-value: 1.68e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 24585988    825 LDIGCNVGHMTITVARHLApkTIVGIDIDRELVARARRNL 864
Cdd:pfam08241    1 LDVGCGTGLLTELLARLGA--RVTGVDISPEMLELAREKA 38
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 814-864 2.66e-03

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 41.70  E-value: 2.66e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 24585988  814 RHVELFENKDILDIGCNVGhmTITVarHLAPKT--IVGIDIDRELVARARRNL 864
Cdd:COG2265  227 EWLDLTGGERVLDLYCGVG--TFAL--PLARRAkkVIGVEIVPEAVEDARENA 275
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 820-867 4.04e-03

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 39.55  E-value: 4.04e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 24585988  820 ENKDILDIGCNVGhmTITVARHLAPKTIVGIDIDRELVARARRNLSIF 867
Cdd:COG1041   26 EGDTVLDPFCGTG--TILIEAGLLGRRVIGSDIDPKMVEGARENLEHY 71
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 810-864 5.99e-03

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 39.40  E-value: 5.99e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 24585988  810 QVFQRHVELFENKDILDIGCNVGHMTITVARHLAPKTIVGIDIDRELVARARRNL 864
Cdd:COG2813   39 RLLLEHLPEPLGGRVLDLGCGYGVIGLALAKRNPEARVTLVDVNARAVELARANA 93
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 436-581 6.73e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.74  E-value: 6.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24585988   436 EPPLPAATSSLAASPVAAPlnvggslllSESAAPAPGET-----AEMGQQQEQAHVHSPQSASTTTTAAEMPTPTPTSAA 510
Cdd:PRK07764  382 ERRLGVAGGAGAPAAAAPS---------AAAAAPAAAPApaaaaPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGG 452

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24585988   511 AATATAEHKEQSAPAPTATSSPQRQQqhvAAAAEELPTPETSAAAETPAEEmllscSATSASLVASTLAER 581
Cdd:PRK07764  453 APSPPPAAAPSAQPAPAPAAAPEPTA---APAPAPPAAPAPAAAPAAPAAP-----AAPAGADDAATLRER 515
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 805-863 7.82e-03

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 38.56  E-value: 7.82e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24585988    805 RDVRLQVFQRHVELF----ENKDILDIGCNVGHMtitvARHLAPK--TIVGIDIDRELVARARRN 863
Cdd:pfam13489    3 HQRERLLADLLLRLLpklpSPGRVLDFGCGTGIF----LRLLRAQgfSVTGVDPSPIAIERALLN 63
PCMT pfam01135
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
816-864 8.05e-03

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 39.27  E-value: 8.05e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 24585988    816 VELFENKDILDIGCNVGHMTITVARHLAPK-TIVGIDIDRELVARARRNL 864
Cdd:pfam01135   69 LELKPGMRVLEIGSGSGYLTACFARMVGEVgRVVSIEHIPELVEIARRNL 118
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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