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    Tmem108 transmembrane protein 108 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300967, updated on 3-Dec-2024

    Summary

    Official Symbol
    Tmem108provided by RGD
    Official Full Name
    transmembrane protein 108provided by RGD
    Primary source
    RGD:1311530
    See related
    EnsemblRapid:ENSRNOG00000010911 AllianceGenome:RGD:1311530
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311530
    Summary
    Predicted to be involved in several processes, including cellular response to brain-derived neurotrophic factor stimulus; nervous system development; and regulation of signal transduction. Predicted to be located in several cellular components, including axon; endosome; and postsynaptic density. Predicted to be active in glutamatergic synapse and postsynaptic density membrane. Orthologous to human TMEM108 (transmembrane protein 108). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 13.2), Adrenal (RPKM 9.2) and 4 other tissues See more
    Orthologs
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    Genomic context

    See Tmem108 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (112944925..113238996, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (104066081..104360172, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (111968568..112265623, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102550226 Neighboring gene beaded filament structural protein 2 Neighboring gene uncharacterized LOC134480226 Neighboring gene uncharacterized LOC134480225 Neighboring gene uncharacterized LOC134480227 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1, pseudogene 7 Neighboring gene uncharacterized LOC102550471 Neighboring gene uncharacterized LOC134479986

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic density IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic density membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in somatodendritic compartment ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399273.1NP_001386202.1  transmembrane protein 108 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6I2K3, F1M8M1
      Conserved Domains (1) summary
      pfam15759
      Location:63575
      TMEM108; TMEM108 family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      112944925..113238996 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039082601.2XP_038938529.1  transmembrane protein 108 isoform X2

      UniProtKB/TrEMBL
      A6I2K3, F1M8M1
      Conserved Domains (1) summary
      pfam15759
      Location:63575
      TMEM108; TMEM108 family
    2. XM_039082589.2XP_038938517.1  transmembrane protein 108 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ALT4, A6I2K3
      Conserved Domains (1) summary
      pfam15759
      Location:95607
      TMEM108; TMEM108 family
    3. XM_008766590.4XP_008764812.2  transmembrane protein 108 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ALT4, A6I2K3
      Conserved Domains (1) summary
      pfam15759
      Location:95607
      TMEM108; TMEM108 family
    4. XM_063265234.1XP_063121304.1  transmembrane protein 108 isoform X5

    5. XM_063265233.1XP_063121303.1  transmembrane protein 108 isoform X5

    6. XM_039082607.2XP_038938535.1  transmembrane protein 108 isoform X2

      UniProtKB/TrEMBL
      A6I2K3, F1M8M1
      Conserved Domains (1) summary
      pfam15759
      Location:63575
      TMEM108; TMEM108 family
    7. XM_039082604.2XP_038938532.1  transmembrane protein 108 isoform X2

      UniProtKB/TrEMBL
      A6I2K3, F1M8M1
      Related
      ENSRNOP00000014520.9, ENSRNOT00000014519.9
      Conserved Domains (1) summary
      pfam15759
      Location:63575
      TMEM108; TMEM108 family
    8. XM_039082592.2XP_038938520.1  transmembrane protein 108 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ALT4, A6I2K3
      Conserved Domains (1) summary
      pfam15759
      Location:95607
      TMEM108; TMEM108 family
    9. XM_063265236.1XP_063121306.1  transmembrane protein 108 isoform X5

    10. XM_039082593.2XP_038938521.1  transmembrane protein 108 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ALT4, A6I2K3
      Conserved Domains (1) summary
      pfam15759
      Location:95607
      TMEM108; TMEM108 family
    11. XM_039082605.2XP_038938533.1  transmembrane protein 108 isoform X2

      UniProtKB/TrEMBL
      A6I2K3, F1M8M1
      Conserved Domains (1) summary
      pfam15759
      Location:63575
      TMEM108; TMEM108 family
    12. XM_039082594.2XP_038938522.1  transmembrane protein 108 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ALT4, A6I2K3
      Conserved Domains (1) summary
      pfam15759
      Location:95607
      TMEM108; TMEM108 family
    13. XM_039082590.2XP_038938518.1  transmembrane protein 108 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ALT4, A6I2K3
      Conserved Domains (1) summary
      pfam15759
      Location:95607
      TMEM108; TMEM108 family
    14. XM_039082606.2XP_038938534.1  transmembrane protein 108 isoform X2

      UniProtKB/TrEMBL
      A6I2K3, F1M8M1
      Conserved Domains (1) summary
      pfam15759
      Location:63575
      TMEM108; TMEM108 family
    15. XM_039082603.2XP_038938531.1  transmembrane protein 108 isoform X2

      UniProtKB/TrEMBL
      A6I2K3, F1M8M1
      Conserved Domains (1) summary
      pfam15759
      Location:63575
      TMEM108; TMEM108 family
    16. XM_063265235.1XP_063121305.1  transmembrane protein 108 isoform X5

    17. XM_063265232.1XP_063121302.1  transmembrane protein 108 isoform X4

      UniProtKB/TrEMBL
      A0A8I6GI14, A6I2K3
      Related
      ENSRNOP00000094794.2, ENSRNOT00000104880.2
    18. XM_063265231.1XP_063121301.1  transmembrane protein 108 isoform X3

      UniProtKB/TrEMBL
      A6I2K3