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    Mhcl Myosin heavy chain-like [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41955, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mhclprovided by FlyBase
    Official Full Name
    Myosin heavy chain-likeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0026059
    Locus tag
    Dmel_CG31045
    See related
    AllianceGenome:FB:FBgn0026059
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10218; CG10224; CG31045; Dmel\CG31045; DmPDZ; MHCL(PDZ); Myo7A
    Summary
    Enables actin filament binding activity. Predicted to be involved in actomyosin structure organization. Located in sarcomere. Is expressed in several structures, including adult head; epithelium; gut section; mesoderm; and muscle cell. Human ortholog(s) of this gene implicated in Klippel-Feil syndrome 4. Orthologous to several human genes including MYO18A (myosin XVIIIA). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Mhcl in Genome Data Viewer
    Location:
    89B2-89B3; 3-58 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (16068523..16098761, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11894245..11924483, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene mini spindles Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene sex-specific enzyme 2 Neighboring gene Akt kinase Neighboring gene Stubble Neighboring gene MICOS subunit 26/27

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila melanogaster myosin-18 represents a highly divergent motor with actin tethering properties. Guzik-Lendrum S, et al. J Biol Chem, 2011 Jun 17. PMID 21498886, Free PMC Article
    2. Mind bomb 2 promotes cell migration and epithelial structure by regulating adhesion complexes and the actin cytoskeleton. Trivedi S, et al. Dev Biol, 2022 Nov. PMID 36067835
    3. Myosin heavy chain-like localizes at cell contact sites during Drosophila myoblast fusion and interacts in vitro with Rolling pebbles 7. Bonn BR, et al. Exp Cell Res, 2013 Feb 15. PMID 23246571
    4. A millennial myosin census. Berg JS, et al. Mol Biol Cell, 2001 Apr. PMID 11294886, Free PMC Article
    5. Identification and phylogenetic analysis of Drosophila melanogaster myosins. Tzolovsky G, et al. Mol Biol Evol, 2002 Jul. PMID 12082124

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mhcl deficient embryos develop a wild-type musculature.
      Title: Myosin heavy chain-like localizes at cell contact sites during Drosophila myoblast fusion and interacts in vitro with Rolling pebbles 7.
    2. Drosophila melanogaster myosin-18 represents a highly divergent motor with actin tethering properties
      Title: Drosophila melanogaster myosin-18 represents a highly divergent motor with actin tethering properties.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables cytoskeletal motor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actomyosin structure organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of myosin II complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in myosin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sarcomere IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    myosin heavy chain-like
    Names
    CG31045-PA
    CG31045-PB
    CG31045-PC
    CG31045-PD
    CG31045-PF
    CG31045-PG
    CG31045-PH
    CG31045-PI
    Mhcl-PA
    Mhcl-PB
    Mhcl-PC
    Mhcl-PD
    Mhcl-PF
    Mhcl-PG
    Mhcl-PH
    Mhcl-PI
    Myosin-heavy-chain-like
    PDZ-myosin
    myosin 18
    myosin XVIII
    myosin XVIII (PDZ)
    myosin heavy chain

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      16068523..16098761 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169700.3 → NP_732108.2  myosin heavy chain-like, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732108.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K523, Q961M7, Q9VEZ0
      Conserved Domains (6) summary
      smart00242
      Location:556 → 1317
      MYSc; Myosin. Large ATPases
      COG1340
      Location:1565 → 1833
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd00992
      Location:339 → 426
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01386
      Location:575 → 1305
      MYSc_Myo18; class XVIII myosin, motor domain
      cd16269
      Location:1723 → 1734
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:1540 → 1750
      GBP_C; Guanylate-binding protein, C-terminal domain

    2. NM_169701.3 → NP_732109.2  myosin heavy chain-like, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732109.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K523, Q8INC3
      Conserved Domains (6) summary
      smart00242
      Location:556 → 1317
      MYSc; Myosin. Large ATPases
      COG1340
      Location:1565 → 1833
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd00992
      Location:339 → 426
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01386
      Location:575 → 1305
      MYSc_Myo18; class XVIII myosin, motor domain
      cd16269
      Location:1723 → 1734
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:1540 → 1750
      GBP_C; Guanylate-binding protein, C-terminal domain

    3. NM_001275694.1 → NP_001262623.1  myosin heavy chain-like, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262623.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGR6, Q8SZW3
      Conserved Domains (2) summary
      pfam01576
      Location:406 → 1032
      Myosin_tail_1; Myosin tail
      cl19219
      Location:925 → 1033
      DUF342; Protein of unknown function (DUF342)

    4. NM_169703.1 → NP_732111.1  myosin heavy chain-like, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732111.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8INC1, Q8SZW3
      Related
      FBpp0082687, FBtr0083233
      Conserved Domains (2) summary
      pfam01576
      Location:427 → 1053
      Myosin_tail_1; Myosin tail
      cl19219
      Location:946 → 1054
      DUF342; Protein of unknown function (DUF342)

    5. NM_001043250.2 → NP_001036715.1  myosin heavy chain-like, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036715.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0KI67, Q7K523
      Conserved Domains (6) summary
      smart00242
      Location:556 → 1317
      MYSc; Myosin. Large ATPases
      COG1340
      Location:1565 → 1833
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd00992
      Location:339 → 426
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01386
      Location:575 → 1305
      MYSc_Myo18; class XVIII myosin, motor domain
      cd16269
      Location:1723 → 1734
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:1540 → 1750
      GBP_C; Guanylate-binding protein, C-terminal domain

    6. NM_001043251.2 → NP_001036716.1  myosin heavy chain-like, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036716.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0KI66, Q7K523
      Conserved Domains (5) summary
      smart00242
      Location:319 → 1080
      MYSc; Myosin. Large ATPases
      COG1340
      Location:1328 → 1596
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd01386
      Location:338 → 1068
      MYSc_Myo18; class XVIII myosin, motor domain
      cd16269
      Location:1486 → 1497
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:1303 → 1513
      GBP_C; Guanylate-binding protein, C-terminal domain

    7. NM_170650.4 → NP_732110.2  myosin heavy chain-like, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732110.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IH49, Q8INC2
      Conserved Domains (1) summary
      pfam01576
      Location:153 → 827
      Myosin_tail_1; Myosin tail

    8. NM_001202304.1 → NP_001189233.1  myosin heavy chain-like, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189233.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4JCY5
      Conserved Domains (2) summary
      TIGR02168
      Location:7 → 232
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:134 → 446
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4JCY5 A0A0B4JCY5
    A0A0B4KGR6 A0A0B4KGR6
    O96816 O96816
    Q0KI66 Q0KI66
    Q0KI67 Q0KI67
    Q7K523 Q7K523
    Q8IH49 Q8IH49
    Q8INC1 Q8INC1
    Q8INC3 Q8INC3
    Q8T6M0 Q8T6M0
    Q9VEZ0 Q9VEZ0

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