nord nord [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: nordprovided by FlyBase
Official Full Name: nordprovided by FlyBase
Primary source: FLYBASE:FBgn0050418
Locus tag: Dmel_CG30418
See related: AllianceGenome:FB:FBgn0050418
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG13574; CG30418; CG3372; Dmel\CG30418; E3272
Summary: Enables BMP binding activity and glycosylation-dependent protein binding activity. Involved in imaginal disc-derived wing vein morphogenesis and regulation of signal transduction. Acts upstream of with a positive effect on cell proliferation involved in imaginal disc-derived wing morphogenesis. Is active in extracellular space. Is expressed in embryonic brain and gonad. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism. Orthologous to human NDNF (neuron derived neurotrophic factor). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (24243255..24255094)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (20130778..20142617)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

The NDNF-like factor Nord is a Hedgehog-induced extracellular BMP modulator that regulates Drosophila wing patterning and growth.
Title: The NDNF-like factor Nord is a Hedgehog-induced extracellular BMP modulator that regulates Drosophila wing patterning and growth.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables BMP binding	IDA Inferred from Direct Assay more info	PubMed
enables carbohydrate derivative binding	ISS Inferred from Sequence or Structural Similarity more info
enables glycosylation-dependent protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_positive_effect cell proliferation involved in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in extracellular matrix organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in extracellular regulation of signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in imaginal disc-derived wing vein morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular matrix	ISS Inferred from Sequence or Structural Similarity more info
is_active_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

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