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Conserved domains on  [gi|24762592|ref|NP_611900|]
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nord [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NDNF pfam10179
Neuron-derived neurotrophic factor, first Fn(III) domain; This domain is found towards the ...
 208-333 4.47e-34

Neuron-derived neurotrophic factor, first Fn(III) domain; This domain is found towards the N-terminal of Neuron-derived neurotrophic factor (NDNF) which contains the first fibronectin type III domain and one of the predicted N-linked glycosylation sites. NDNF is a glycosylated and disulfide-bonded secreted protein expressed in brain and spinal cord that promotes migration and neurite growth. It also promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization.


:

Pssm-ID: 462981  Cd Length: 127  Bit Score: 125.63  E-value: 4.47e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762592   208 MIVKWERSK--FDFHVMHYCLVIQRlsmdtpRMIFTNFCQAVSAYTDQQPM--TPSCAAGGPLEGIWGAPPQRERRLNPR 283
Cdd:pfam10179   1 VTLKWKPSPsvLDRHPMHYCLVVNR------KHNYKSLCAAVEAIRKEQPPgkTSKSFDPASFEFLKERWPQKERKLNPR 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 24762592   284 Q---NVHIVCTGKRRQQLLRRLLPRSSYHLDLFGIHQGRQNLTLRLASSQVNF 333
Cdd:pfam10179  75 VssgDLQIVCVGTKTVQTVSGLKPDTQYYFDVFVVDQLTNTSSAYLGTFAVTF 127
NDNF_C super family cl44851
Neuron-derived Neurotrophic Factor C-terminal; This is the C-terminal domain of Neuron-derived ...
 418-568 3.70e-06

Neuron-derived Neurotrophic Factor C-terminal; This is the C-terminal domain of Neuron-derived Neurotrophic Factor (NDNF). NDNF is a glycosylated and disulfide-bonded secreted protein expressed in brain and spinal cord that promotes migration and neurite growth of hippocampal neurons. It also promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization. This domain contains the second fibronectin type III domain (FnIII) present in NDNF and one of the two potential consensus sites for N-linked glycosylation.


The actual alignment was detected with superfamily member pfam19433:

Pssm-ID: 466079  Cd Length: 174  Bit Score: 47.35  E-value: 3.70e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762592   418 PGERYLMRFEPSnddeALRAQKVMVALSSEALFRDLPELPQNTT--VFNVRTRCSRATIAWNGSpdeRELS-YCiiVFNL 494
Cdd:pfam19433  20 PKAEYLVRLKSG----RKGNSSLKVFATTNPHKQPFPSLPEDTKikVFDKLRTCNSVTVAWLGT---QERSkYC--LYKK 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762592   495 PQRNRSVVDFT---NYCMDfvPK-RvmqyRYFEWMTCRE-RQQSPD-NIETETILNLMPGSSYL--VYVTAnlSMGKPLP 566
Cdd:pfam19433  91 EVEEDQVERESrkqNRCLG--PEsR----KKSEKVLCKYfHGANLQrAVTTETIEGLEPGTLYLldVYVIG--QGGHSVK 162


                  ..
gi 24762592   567 YQ 568
Cdd:pfam19433 163 YQ 164
 
Name Accession Description Interval E-value
NDNF pfam10179
Neuron-derived neurotrophic factor, first Fn(III) domain; This domain is found towards the ...
 208-333 4.47e-34

Neuron-derived neurotrophic factor, first Fn(III) domain; This domain is found towards the N-terminal of Neuron-derived neurotrophic factor (NDNF) which contains the first fibronectin type III domain and one of the predicted N-linked glycosylation sites. NDNF is a glycosylated and disulfide-bonded secreted protein expressed in brain and spinal cord that promotes migration and neurite growth. It also promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization.


Pssm-ID: 462981  Cd Length: 127  Bit Score: 125.63  E-value: 4.47e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762592   208 MIVKWERSK--FDFHVMHYCLVIQRlsmdtpRMIFTNFCQAVSAYTDQQPM--TPSCAAGGPLEGIWGAPPQRERRLNPR 283
Cdd:pfam10179   1 VTLKWKPSPsvLDRHPMHYCLVVNR------KHNYKSLCAAVEAIRKEQPPgkTSKSFDPASFEFLKERWPQKERKLNPR 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 24762592   284 Q---NVHIVCTGKRRQQLLRRLLPRSSYHLDLFGIHQGRQNLTLRLASSQVNF 333
Cdd:pfam10179  75 VssgDLQIVCVGTKTVQTVSGLKPDTQYYFDVFVVDQLTNTSSAYLGTFAVTF 127
NDNF_C pfam19433
Neuron-derived Neurotrophic Factor C-terminal; This is the C-terminal domain of Neuron-derived ...
 418-568 3.70e-06

Neuron-derived Neurotrophic Factor C-terminal; This is the C-terminal domain of Neuron-derived Neurotrophic Factor (NDNF). NDNF is a glycosylated and disulfide-bonded secreted protein expressed in brain and spinal cord that promotes migration and neurite growth of hippocampal neurons. It also promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization. This domain contains the second fibronectin type III domain (FnIII) present in NDNF and one of the two potential consensus sites for N-linked glycosylation.


Pssm-ID: 466079  Cd Length: 174  Bit Score: 47.35  E-value: 3.70e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762592   418 PGERYLMRFEPSnddeALRAQKVMVALSSEALFRDLPELPQNTT--VFNVRTRCSRATIAWNGSpdeRELS-YCiiVFNL 494
Cdd:pfam19433  20 PKAEYLVRLKSG----RKGNSSLKVFATTNPHKQPFPSLPEDTKikVFDKLRTCNSVTVAWLGT---QERSkYC--LYKK 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762592   495 PQRNRSVVDFT---NYCMDfvPK-RvmqyRYFEWMTCRE-RQQSPD-NIETETILNLMPGSSYL--VYVTAnlSMGKPLP 566
Cdd:pfam19433  91 EVEEDQVERESrkqNRCLG--PEsR----KKSEKVLCKYfHGANLQrAVTTETIEGLEPGTLYLldVYVIG--QGGHSVK 162


                  ..
gi 24762592   567 YQ 568
Cdd:pfam19433 163 YQ 164
 
Name Accession Description Interval E-value
NDNF pfam10179
Neuron-derived neurotrophic factor, first Fn(III) domain; This domain is found towards the ...
 208-333 4.47e-34

Neuron-derived neurotrophic factor, first Fn(III) domain; This domain is found towards the N-terminal of Neuron-derived neurotrophic factor (NDNF) which contains the first fibronectin type III domain and one of the predicted N-linked glycosylation sites. NDNF is a glycosylated and disulfide-bonded secreted protein expressed in brain and spinal cord that promotes migration and neurite growth. It also promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization.


Pssm-ID: 462981  Cd Length: 127  Bit Score: 125.63  E-value: 4.47e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762592   208 MIVKWERSK--FDFHVMHYCLVIQRlsmdtpRMIFTNFCQAVSAYTDQQPM--TPSCAAGGPLEGIWGAPPQRERRLNPR 283
Cdd:pfam10179   1 VTLKWKPSPsvLDRHPMHYCLVVNR------KHNYKSLCAAVEAIRKEQPPgkTSKSFDPASFEFLKERWPQKERKLNPR 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 24762592   284 Q---NVHIVCTGKRRQQLLRRLLPRSSYHLDLFGIHQGRQNLTLRLASSQVNF 333
Cdd:pfam10179  75 VssgDLQIVCVGTKTVQTVSGLKPDTQYYFDVFVVDQLTNTSSAYLGTFAVTF 127
NDNF_C pfam19433
Neuron-derived Neurotrophic Factor C-terminal; This is the C-terminal domain of Neuron-derived ...
 418-568 3.70e-06

Neuron-derived Neurotrophic Factor C-terminal; This is the C-terminal domain of Neuron-derived Neurotrophic Factor (NDNF). NDNF is a glycosylated and disulfide-bonded secreted protein expressed in brain and spinal cord that promotes migration and neurite growth of hippocampal neurons. It also promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization. This domain contains the second fibronectin type III domain (FnIII) present in NDNF and one of the two potential consensus sites for N-linked glycosylation.


Pssm-ID: 466079  Cd Length: 174  Bit Score: 47.35  E-value: 3.70e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762592   418 PGERYLMRFEPSnddeALRAQKVMVALSSEALFRDLPELPQNTT--VFNVRTRCSRATIAWNGSpdeRELS-YCiiVFNL 494
Cdd:pfam19433  20 PKAEYLVRLKSG----RKGNSSLKVFATTNPHKQPFPSLPEDTKikVFDKLRTCNSVTVAWLGT---QERSkYC--LYKK 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762592   495 PQRNRSVVDFT---NYCMDfvPK-RvmqyRYFEWMTCRE-RQQSPD-NIETETILNLMPGSSYL--VYVTAnlSMGKPLP 566
Cdd:pfam19433  91 EVEEDQVERESrkqNRCLG--PEsR----KKSEKVLCKYfHGANLQrAVTTETIEGLEPGTLYLldVYVIG--QGGHSVK 162


                  ..
gi 24762592   567 YQ 568
Cdd:pfam19433 163 YQ 164
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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