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    Fign Fidgetin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33544, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fignprovided by FlyBase
    Official Full Name
    Fidgetinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031519
    Locus tag
    Dmel_CG3326
    See related
    AllianceGenome:FB:FBgn0031519
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3326; DmCG3326; Dmel\CG3326; fign
    Summary
    Enables microtubule severing ATPase activity. Involved in several processes, including microtubule severing; mitotic sister chromatid segregation; and regulation of microtubule depolymerization. Located in centrosome and chromosome. Human ortholog(s) of this gene implicated in nicotine dependence. Orthologous to several human genes including FIGNL1 (fidgetin like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Fign in Genome Data Viewer
    Location:
    23E3-23E3; 2-9 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (3316794..3319872, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (3316794..3319872, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of the Drosophila melanogaster homolog of the human spastin gene. Kammermeier L, et al. Dev Genes Evol, 2003 Aug. PMID 12908108
    2. Three microtubule severing enzymes contribute to the "Pacman-flux" machinery that moves chromosomes. Zhang D, et al. J Cell Biol, 2007 Apr 23. PMID 17452528, Free PMC Article
    3. A systematic analysis of microtubule-destabilizing factors during dendrite pruning in Drosophila. Bu S, et al. EMBO Rep, 2021 Oct 5. PMID 34338441, Free PMC Article
    4. The microtubule-severing protein fidgetin acts after dendrite injury to promote their degeneration. Tao J, et al. J Cell Sci, 2016 Sep 1. PMID 27411367, Free PMC Article
    5. Unpredictable Effects of the Genetic Background of Transgenic Lines in Physiological Quantitative Traits. Evangelou A, et al. G3 (Bethesda), 2019 Nov 5. PMID 31540975, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. fidgetin acts after injury to promote disassembly of microtubules in dendrites severed from the cell body.
      Title: The microtubule-severing protein fidgetin acts after dendrite injury to promote their degeneration.
    2. Spastin and Fidgetin are utilized to stimulate microtubule minus-end depolymerization and flux; they concentrate at centrosomes, where they catalyze the turnover of gamma-tubulin.
      Title: Three microtubule severing enzymes contribute to the "Pacman-flux" machinery that moves chromosomes.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables magnesium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables microtubule severing ATPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule severing ATPase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ATP metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in microtubule severing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic sister chromatid segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of microtubule depolymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to wounding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    fidgetin
    Names
    CG3326-PA
    CG3326-PB
    Dm-fidgetin
    Fign-PA
    Fign-PB
    fidgetin_DROME
    NP_001259995.1
    NP_608763.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      3316794..3319872 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273066.1 → NP_001259995.1  fidgetin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259995.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95TF9, Q9VQN8
      UniProtKB/TrEMBL
      M9PC18
      Conserved Domains (3) summary
      smart00382
      Location:282 → 418
      AAA; ATPases associated with a variety of cellular activities
      pfam00004
      Location:286 → 416
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam09336
      Location:480 → 520
      Vps4_C; Vps4 C terminal oligomerization domain

    2. NM_134919.3 → NP_608763.2  fidgetin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608763.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95TF9, Q9VQN8
      UniProtKB/TrEMBL
      M9PC18
      Related
      FBpp0077290
      Conserved Domains (3) summary
      smart00382
      Location:282 → 418
      AAA; ATPases associated with a variety of cellular activities
      pfam00004
      Location:286 → 416
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam09336
      Location:480 → 520
      Vps4_C; Vps4 C terminal oligomerization domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PC18 M9PC18
    Q9VQN8.2 Q9VQN8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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