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Conserved domains on  [gi|24581396|ref|NP_608763|]
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fidgetin, isoform A [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
P-loop_NTPase super family cl38936
P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain ...
 229-414 3.23e-91

P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a hydrophobic residue). The Walker A and B motifs bind the beta-gamma phosphate moiety of the bound nucleotide (typically ATP or GTP) and the Mg2+ cation, respectively. The P-loop NTPases are involved in diverse cellular functions, and they can be divided into two major structural classes: the KG (kinase-GTPase) class which includes Ras-like GTPases and its circularly permutated YlqF-like; and the ASCE (additional strand catalytic E) class which includes ATPase Binding Cassette (ABC), DExD/H-like helicases, 4Fe-4S iron sulfur cluster binding proteins of NifH family, RecA-like F1-ATPases, and ATPases Associated with a wide variety of Activities (AAA). Also included are a diverse set of nucleotide/nucleoside kinase families.


The actual alignment was detected with superfamily member cd19525:

Pssm-ID: 476819 [Multi-domain]  Cd Length: 186  Bit Score: 276.87  E-value: 3.23e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 229 DSKMVDHILGESMHDFKPVAWEDIAGLESAKSTFLEAIIMPLRRPDLFTGVRCPPRGVLLFGPPGTGKTLIAKSIASQAK 308
Cdd:cd19525   1 EPKMIELIMSEIMDHGPPINWADIAGLEFAKKTIKEIVVWPMLRPDIFTGLRGPPKGILLFGPPGTGKTLIGKCIASQSG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 309 AKFFSINPSSLTSKWVGDAEKLVKTLFAVAAAHQPAIIFIDEVDSLLSKRSANENESTLRLKNEFLIHLDGAASNEEIRV 388
Cdd:cd19525  81 ATFFSISASSLTSKWVGEGEKMVRALFSVARCKQPAVIFIDEIDSLLSQRGEGEHESSRRIKTEFLVQLDGATTSSEDRI 160

                       170       180
                ....*....|....*....|....*.
gi 24581396 389 LVIGATNRPQELDEAVRRRFVRRLYV 414
Cdd:cd19525 161 LVVGATNRPQEIDEAARRRLVKRLYI 186
AAA_lid_3 pfam17862
AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the ...
 444-495 2.12e-07

AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.


:

Pssm-ID: 465537 [Multi-domain]  Cd Length: 45  Bit Score: 47.53  E-value: 2.12e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 24581396   444 ELAELTDGYSGADVDTLCRYASMAPLRsltpdqmevietHQLPAVTMDDFKQ 495
Cdd:pfam17862   6 ELAERTEGFSGADLEALCREAALAALR------------RGLEAVTQEDLEE 45
Vps4_C super family cl07827
Vps4 C terminal oligomerization domain; This domain is found at the C terminal of ATPase ...
 480-520 7.12e-05

Vps4 C terminal oligomerization domain; This domain is found at the C terminal of ATPase proteins involved in vacuolar sorting. It forms an alpha helix structure and is required for oligomerization.


The actual alignment was detected with superfamily member pfam09336:

Pssm-ID: 462762 [Multi-domain]  Cd Length: 61  Bit Score: 40.56  E-value: 7.12e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 24581396   480 IETHQL--PAVTMDDFKQALRVISKSVSSEDCKQFEAWNEIYG 520
Cdd:pfam09336  19 IPSDKLlePPVTMKDFLKALKSSRPTVSKEDLEKYEEFTKEFG 61
PH-like super family cl17171
Pleckstrin homology-like domain; The PH-like family includes the PH domain, both the Shc-like ...
 4-50 8.87e-03

Pleckstrin homology-like domain; The PH-like family includes the PH domain, both the Shc-like and IRS-like PTB domains, the ran-binding domain, the EVH1 domain, a domain in neurobeachin and the third domain of FERM. All of these domains have a PH fold, but lack significant sequence similarity. They are generally involved in targeting to protein to the appropriate cellular location or interacting with a binding partner. This domain family possesses multiple functions including the ability to bind inositol phosphates and to other proteins.


The actual alignment was detected with superfamily member pfam08416:

Pssm-ID: 473070  Cd Length: 131  Bit Score: 36.56  E-value: 8.87e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 24581396     4 EQSSWRSKLLLICQQTRSSSESIHFAALKDHHARLQAcESMEKAMKE 50
Cdd:pfam08416  78 NDGRYNSILALVCQEPGQSKPDVHLFQCDELGAELIA-EDIESALSD 123
 
Name Accession Description Interval E-value
RecA-like_Figl-1 cd19525
ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; ...
 229-414 3.23e-91

ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; it may be involved in DNA double-strand break repair via homologous recombination. Caenorhabditis elegans FIGL-1 is a nuclear protein and controls the mitotic progression in the germ line and mouse FIGL-1 may be involved in the control of male meiosis. human FIGL-1 has been shown to be a centrosome protein involved in ciliogenesis perhaps as a microtubule-severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410933 [Multi-domain]  Cd Length: 186  Bit Score: 276.87  E-value: 3.23e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 229 DSKMVDHILGESMHDFKPVAWEDIAGLESAKSTFLEAIIMPLRRPDLFTGVRCPPRGVLLFGPPGTGKTLIAKSIASQAK 308
Cdd:cd19525   1 EPKMIELIMSEIMDHGPPINWADIAGLEFAKKTIKEIVVWPMLRPDIFTGLRGPPKGILLFGPPGTGKTLIGKCIASQSG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 309 AKFFSINPSSLTSKWVGDAEKLVKTLFAVAAAHQPAIIFIDEVDSLLSKRSANENESTLRLKNEFLIHLDGAASNEEIRV 388
Cdd:cd19525  81 ATFFSISASSLTSKWVGEGEKMVRALFSVARCKQPAVIFIDEIDSLLSQRGEGEHESSRRIKTEFLVQLDGATTSSEDRI 160

                       170       180
                ....*....|....*....|....*.
gi 24581396 389 LVIGATNRPQELDEAVRRRFVRRLYV 414
Cdd:cd19525 161 LVVGATNRPQEIDEAARRRLVKRLYI 186
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 247-507 2.48e-81

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 256.47  E-value: 2.48e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 247 VAWEDIAGLESAKSTFLEAIIMPLRRPDLFT--GVRcPPRGVLLFGPPGTGKTLIAKSIASQAKAKFFSINPSSLTSKWV 324
Cdd:COG1222  75 VTFDDIGGLDEQIEEIREAVELPLKNPELFRkyGIE-PPKGVLLYGPPGTGKTLLAKAVAGELGAPFIRVRGSELVSKYI 153

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 325 GDAEKLVKTLFAVAAAHQPAIIFIDEVDSLLSKRSANENESTL-RLKNEFLIHLDGAASNEEirVLVIGATNRPQELDEA 403
Cdd:COG1222 154 GEGARNVREVFELAREKAPSIIFIDEIDAIAARRTDDGTSGEVqRTVNQLLAELDGFESRGD--VLIIAATNRPDLLDPA 231

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 404 VRR--RFVRRLYVPLPTREARQKIIEklIH----QVKHNLDVRqviELAELTDGYSGADVDTLCRYASMAPLRSltpdqm 477
Cdd:COG1222 232 LLRpgRFDRVIEVPLPDEEAREEILK--IHlrdmPLADDVDLD---KLAKLTEGFSGADLKAIVTEAGMFAIRE------ 300

                       250       260       270
                ....*....|....*....|....*....|
gi 24581396 478 eviethQLPAVTMDDFKQALRVISKSVSSE 507
Cdd:COG1222 301 ------GRDTVTMEDLEKAIEKVKKKTETA 324
cell_div_CdvC NF041006
cell division protein CdvC;
221-517 4.28e-74

cell division protein CdvC;


Pssm-ID: 468935 [Multi-domain]  Cd Length: 371  Bit Score: 239.25  E-value: 4.28e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396  221 IPPALAHLDSKMVDHILGEsmhdfKP-VAWEDIAGLESAKSTFLEAIIMPLRRPDLFtgvrcP---PRGVLLFGPPGTGK 296
Cdd:NF041006  78 EPAGPDVEKESDEELVVKE-----KPkVTFSDIVGLEDVKEALKEAIVYPSKRPDLF-----PlgwPRGILLYGPPGCGK 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396  297 TLIAKSIASQAKAKFFSINPSSLTSKWVGDAEKLVKTLFAVA-----AAHQPAIIFIDEVDSLLSKRSaNENESTLRLKN 371
Cdd:NF041006 148 TMLAAAVANEIDSEFIHVDAASIMSKWLGEAEKNVAKIFKKArekskEEGKPAIIFIDEIDALLGVYS-SEVGGEVRVRN 226

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396  372 EFLIHLDGAA-SNEEIRVLVIGATNRPQELDEAVRRRFVRRLYVPLPTREARQKIIEKLIHQVKHNLDVrQVIELAELTD 450
Cdd:NF041006 227 QFLKEMDGLQdKSENYHVYVIGATNKPWRLDEPFLRRFQKRIYIPLPDREQRLELLKYYTSKIKLENDV-DLDELAEMTE 305

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24581396  451 GYSGADVDTLCRYASMAPLRSLTPDQMEviethQLPAVTMDDFKQALRVISKSVSSEDCKQFEAWNE 517
Cdd:NF041006 306 GYTASDIRDIVQAAHMRVVKEMFEKGLG-----EPRPITMEDFKEVLKIRKPSVNQEMLKAYEAWHE 367
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 247-520 4.62e-67

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 229.79  E-value: 4.62e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396   247 VAWEDIAGLESAKSTFLEAIIMPLRRPDLFT--GVRcPPRGVLLFGPPGTGKTLIAKSIASQAKAKFFSINPSSLTSKWV 324
Cdd:TIGR01243 450 VRWSDIGGLEEVKQELREAVEWPLKHPEIFEkmGIR-PPKGVLLFGPPGTGKTLLAKAVATESGANFIAVRGPEILSKWV 528

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396   325 GDAEKLVKTLFAVAAAHQPAIIFIDEVDSLLSKRSANENES-TLRLKNEFLIHLDGAASNEEirVLVIGATNRPQELDEA 403
Cdd:TIGR01243 529 GESEKAIREIFRKARQAAPAIIFFDEIDAIAPARGARFDTSvTDRIVNQLLTEMDGIQELSN--VVVIAATNRPDILDPA 606

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396   404 VRR--RFVRRLYVPLPTREARQKIIEklIHQVKHNL--DVrQVIELAELTDGYSGADVDTLCRYASMAPLR----SLTPD 475
Cdd:TIGR01243 607 LLRpgRFDRLILVPPPDEEARKEIFK--IHTRSMPLaeDV-DLEELAEMTEGYTGADIEAVCREAAMAALResigSPAKE 683

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 24581396   476 QMEVIETHQLP--AVTMDDFKQALRVISKSVSSEDCKQFEAWNEIYG 520
Cdd:TIGR01243 684 KLEVGEEEFLKdlKVEMRHFLEALKKVKPSVSKEDMLRYERLAKELK 730
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 247-502 2.05e-58

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 198.52  E-value: 2.05e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396  247 VAWEDIAGLESAKSTFLEAIIMPLRRPDLFT--GVRcPPRGVLLFGPPGTGKTLIAKSIASQAKAKFFSINPSSLTSKWV 324
Cdd:PRK03992 128 VTYEDIGGLEEQIREVREAVELPLKKPELFEevGIE-PPKGVLLYGPPGTGKTLLAKAVAHETNATFIRVVGSELVQKFI 206

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396  325 GDAEKLVKTLFAVAAAHQPAIIFIDEVDSLLSKR-------SANENESTLRLknefLIHLDGAASNEEIRvlVIGATNRP 397
Cdd:PRK03992 207 GEGARLVRELFELAREKAPSIIFIDEIDAIAAKRtdsgtsgDREVQRTLMQL----LAEMDGFDPRGNVK--IIAATNRI 280

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396  398 QELDEAVRR--RFVRRLYVPLPTREARQKIIEklIHQVKHNL--DVRqVIELAELTDGYSGADVDTLCRYASMAPLRSlt 473
Cdd:PRK03992 281 DILDPAILRpgRFDRIIEVPLPDEEGRLEILK--IHTRKMNLadDVD-LEELAELTEGASGADLKAICTEAGMFAIRD-- 355

                        250       260
                 ....*....|....*....|....*....
gi 24581396  474 pdqmeviethQLPAVTMDDFKQALRVISK 502
Cdd:PRK03992 356 ----------DRTEVTMEDFLKAIEKVMG 374
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 286-416 1.05e-51

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 172.39  E-value: 1.05e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396   286 VLLFGPPGTGKTLIAKSIASQAKAKFFSINPSSLTSKWVGDAEKLVKTLFAVAAAHQPAIIFIDEVDSLLSKRSANENES 365
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGESEKRLRELFEAAKKLAPCVIFIDEIDALAGSRGSGGDSE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 24581396   366 TLRLKNEFLIHLDGAASNEEiRVLVIGATNRPQELDEAVRRRFVRRLYVPL 416
Cdd:pfam00004  81 SRRVVNQLLTELDGFTSSNS-KVIVIAATNRPDKLDPALLGRFDRIIEFPL 130
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 282-418 1.39e-19

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 85.50  E-value: 1.39e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396    282 PPRGVLLFGPPGTGKTLIAKSIASQAK---AKFFSINPSSLTS--------------KWVGDAEKLVKTLFAVAAAHQPA 344
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARALARELGppgGGVIYIDGEDILEevldqllliivggkKASGSGELRLRLALALARKLKPD 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24581396    345 IIFIDEVDSLLSKRSANENESTLRLKNEFLIHLDGaasneeiRVLVIGATNRPQELDEA-VRRRFVRRLYVPLPT 418
Cdd:smart00382  81 VLILDEITSLLDAEQEALLLLLEELRLLLLLKSEK-------NLTVILTTNDEKDLGPAlLRRRFDRRIVLLLIL 148
AAA_lid_3 pfam17862
AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the ...
 444-495 2.12e-07

AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.


Pssm-ID: 465537 [Multi-domain]  Cd Length: 45  Bit Score: 47.53  E-value: 2.12e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 24581396   444 ELAELTDGYSGADVDTLCRYASMAPLRsltpdqmevietHQLPAVTMDDFKQ 495
Cdd:pfam17862   6 ELAERTEGFSGADLEALCREAALAALR------------RGLEAVTQEDLEE 45
Vps4_C pfam09336
Vps4 C terminal oligomerization domain; This domain is found at the C terminal of ATPase ...
 480-520 7.12e-05

Vps4 C terminal oligomerization domain; This domain is found at the C terminal of ATPase proteins involved in vacuolar sorting. It forms an alpha helix structure and is required for oligomerization.


Pssm-ID: 462762 [Multi-domain]  Cd Length: 61  Bit Score: 40.56  E-value: 7.12e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 24581396   480 IETHQL--PAVTMDDFKQALRVISKSVSSEDCKQFEAWNEIYG 520
Cdd:pfam09336  19 IPSDKLlePPVTMKDFLKALKSSRPTVSKEDLEKYEEFTKEFG 61
IS21_help_AAA NF038214
IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was ...
 286-313 2.13e-03

IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was built to hit full-length AAA+ ATPases of IS21 family IS (insertion sequence) elements.


Pssm-ID: 439516  Cd Length: 232  Bit Score: 39.76  E-value: 2.13e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 24581396  286 VLLFGPPGTGKTLIAKSIASQA-----KAKFFS 313
Cdd:NF038214  93 VLLLGPPGTGKTHLAIALGYAAcrqgyRVRFTT 125
PTB pfam08416
Phosphotyrosine-binding domain; The phosphotyrosine-binding domain (PTB, also ...
 4-50 8.87e-03

Phosphotyrosine-binding domain; The phosphotyrosine-binding domain (PTB, also phosphotyrosine-interaction or PI domain) in the protein tensin tends to be found at the C-terminus. Tensin is a multi-domain protein that binds to actin filaments and functions as a focal-adhesion molecule (focal adhesions are regions of plasma membrane through which cells attach to the extracellular matrix). Human tensin has actin-binding sites, an SH2 (pfam00017) domain and a region similar to the tumour suppressor PTEN. The PTB domain interacts with the cytoplasmic tails of beta integrin by binding to an NPXY motif.


Pssm-ID: 429984  Cd Length: 131  Bit Score: 36.56  E-value: 8.87e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 24581396     4 EQSSWRSKLLLICQQTRSSSESIHFAALKDHHARLQAcESMEKAMKE 50
Cdd:pfam08416  78 NDGRYNSILALVCQEPGQSKPDVHLFQCDELGAELIA-EDIESALSD 123
 
Name Accession Description Interval E-value
RecA-like_Figl-1 cd19525
ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; ...
 229-414 3.23e-91

ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; it may be involved in DNA double-strand break repair via homologous recombination. Caenorhabditis elegans FIGL-1 is a nuclear protein and controls the mitotic progression in the germ line and mouse FIGL-1 may be involved in the control of male meiosis. human FIGL-1 has been shown to be a centrosome protein involved in ciliogenesis perhaps as a microtubule-severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410933 [Multi-domain]  Cd Length: 186  Bit Score: 276.87  E-value: 3.23e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 229 DSKMVDHILGESMHDFKPVAWEDIAGLESAKSTFLEAIIMPLRRPDLFTGVRCPPRGVLLFGPPGTGKTLIAKSIASQAK 308
Cdd:cd19525   1 EPKMIELIMSEIMDHGPPINWADIAGLEFAKKTIKEIVVWPMLRPDIFTGLRGPPKGILLFGPPGTGKTLIGKCIASQSG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 309 AKFFSINPSSLTSKWVGDAEKLVKTLFAVAAAHQPAIIFIDEVDSLLSKRSANENESTLRLKNEFLIHLDGAASNEEIRV 388
Cdd:cd19525  81 ATFFSISASSLTSKWVGEGEKMVRALFSVARCKQPAVIFIDEIDSLLSQRGEGEHESSRRIKTEFLVQLDGATTSSEDRI 160

                       170       180
                ....*....|....*....|....*.
gi 24581396 389 LVIGATNRPQELDEAVRRRFVRRLYV 414
Cdd:cd19525 161 LVVGATNRPQEIDEAARRRLVKRLYI 186
RecA-like_VPS4-like cd19509
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...
 252-414 1.62e-83

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410917 [Multi-domain]  Cd Length: 163  Bit Score: 256.13  E-value: 1.62e-83
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 252 IAGLESAKSTFLEAIIMPLRRPDLFTGVRCPPRGVLLFGPPGTGKTLIAKSIASQAKAKFFSINPSSLTSKWVGDAEKLV 331
Cdd:cd19509   1 IAGLDDAKEALKEAVILPSLRPDLFPGLRGPPRGILLYGPPGTGKTLLARAVASESGSTFFSISASSLVSKWVGESEKIV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 332 KTLFAVAAAHQPAIIFIDEVDSLLSKRSANENESTLRLKNEFLIHLDGAASNEEIRVLVIGATNRPQELDEAVRRRFVRR 411
Cdd:cd19509  81 RALFALARELQPSIIFIDEIDSLLSERGSGEHEASRRVKTEFLVQMDGVLNKPEDRVLVLGATNRPWELDEAFLRRFEKR 160


                ...
gi 24581396 412 LYV 414
Cdd:cd19509 161 IYI 163
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 247-507 2.48e-81

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 256.47  E-value: 2.48e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 247 VAWEDIAGLESAKSTFLEAIIMPLRRPDLFT--GVRcPPRGVLLFGPPGTGKTLIAKSIASQAKAKFFSINPSSLTSKWV 324
Cdd:COG1222  75 VTFDDIGGLDEQIEEIREAVELPLKNPELFRkyGIE-PPKGVLLYGPPGTGKTLLAKAVAGELGAPFIRVRGSELVSKYI 153

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 325 GDAEKLVKTLFAVAAAHQPAIIFIDEVDSLLSKRSANENESTL-RLKNEFLIHLDGAASNEEirVLVIGATNRPQELDEA 403
Cdd:COG1222 154 GEGARNVREVFELAREKAPSIIFIDEIDAIAARRTDDGTSGEVqRTVNQLLAELDGFESRGD--VLIIAATNRPDLLDPA 231

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 404 VRR--RFVRRLYVPLPTREARQKIIEklIH----QVKHNLDVRqviELAELTDGYSGADVDTLCRYASMAPLRSltpdqm 477
Cdd:COG1222 232 LLRpgRFDRVIEVPLPDEEAREEILK--IHlrdmPLADDVDLD---KLAKLTEGFSGADLKAIVTEAGMFAIRE------ 300

                       250       260       270
                ....*....|....*....|....*....|
gi 24581396 478 eviethQLPAVTMDDFKQALRVISKSVSSE 507
Cdd:COG1222 301 ------GRDTVTMEDLEKAIEKVKKKTETA 324
RecA-like_spastin cd19524
ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in ...
 251-414 8.97e-80

ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in microtubule dynamics; it specifically recognizes and cuts microtubules that are polyglutamylated. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410932 [Multi-domain]  Cd Length: 164  Bit Score: 246.69  E-value: 8.97e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 251 DIAGLESAKSTFLEAIIMPLRRPDLFTGVRCPPRGVLLFGPPGTGKTLIAKSIASQAKAKFFSINPSSLTSKWVGDAEKL 330
Cdd:cd19524   1 DIAGQDLAKQALQEMVILPSLRPELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 331 VKTLFAVAAAHQPAIIFIDEVDSLLSKRSANENESTLRLKNEFLIHLDGAASNEEIRVLVIGATNRPQELDEAVRRRFVR 410
Cdd:cd19524  81 VRALFAVARELQPSIIFIDEVDSLLSERSEGEHEASRRLKTEFLIEFDGVQSNGDDRVLVMGATNRPQELDDAVLRRFTK 160


                ....
gi 24581396 411 RLYV 414
Cdd:cd19524 161 RVYV 164
cell_div_CdvC NF041006
cell division protein CdvC;
221-517 4.28e-74

cell division protein CdvC;


Pssm-ID: 468935 [Multi-domain]  Cd Length: 371  Bit Score: 239.25  E-value: 4.28e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396  221 IPPALAHLDSKMVDHILGEsmhdfKP-VAWEDIAGLESAKSTFLEAIIMPLRRPDLFtgvrcP---PRGVLLFGPPGTGK 296
Cdd:NF041006  78 EPAGPDVEKESDEELVVKE-----KPkVTFSDIVGLEDVKEALKEAIVYPSKRPDLF-----PlgwPRGILLYGPPGCGK 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396  297 TLIAKSIASQAKAKFFSINPSSLTSKWVGDAEKLVKTLFAVA-----AAHQPAIIFIDEVDSLLSKRSaNENESTLRLKN 371
Cdd:NF041006 148 TMLAAAVANEIDSEFIHVDAASIMSKWLGEAEKNVAKIFKKArekskEEGKPAIIFIDEIDALLGVYS-SEVGGEVRVRN 226

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396  372 EFLIHLDGAA-SNEEIRVLVIGATNRPQELDEAVRRRFVRRLYVPLPTREARQKIIEKLIHQVKHNLDVrQVIELAELTD 450
Cdd:NF041006 227 QFLKEMDGLQdKSENYHVYVIGATNKPWRLDEPFLRRFQKRIYIPLPDREQRLELLKYYTSKIKLENDV-DLDELAEMTE 305

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24581396  451 GYSGADVDTLCRYASMAPLRSLTPDQMEviethQLPAVTMDDFKQALRVISKSVSSEDCKQFEAWNE 517
Cdd:NF041006 306 GYTASDIRDIVQAAHMRVVKEMFEKGLG-----EPRPITMEDFKEVLKIRKPSVNQEMLKAYEAWHE 367
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 237-498 3.24e-73

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 237.89  E-value: 3.24e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 237 LGESMHDFKPVAWEDIAGLESAKSTFLEAIIMPLRRPDLFT--GVRcPPRGVLLFGPPGTGKTLIAKSIASQAKAKFFSI 314
Cdd:COG0464 144 LEEELLELREAILDDLGGLEEVKEELRELVALPLKRPELREeyGLP-PPRGLLLYGPPGTGKTLLARALAGELGLPLIEV 222

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 315 NPSSLTSKWVGDAEKLVKTLFAVAAAHQPAIIFIDEVDSLLSKRSANENESTLRLKNEFLIHLDGAASneeiRVLVIGAT 394
Cdd:COG0464 223 DLSDLVSKYVGETEKNLREVFDKARGLAPCVLFIDEADALAGKRGEVGDGVGRRVVNTLLTEMEELRS----DVVVIAAT 298

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 395 NRPQELDEAVRRRFVRRLYVPLPTREARQKIIEKLIHQVKHNLDVrQVIELAELTDGYSGADVDTLCRYASMAPLRSLTP 474
Cdd:COG0464 299 NRPDLLDPALLRRFDEIIFFPLPDAEERLEIFRIHLRKRPLDEDV-DLEELAEATEGLSGADIRNVVRRAALQALRLGRE 377

                       250       260
                ....*....|....*....|....
gi 24581396 475 DqmeviethqlpaVTMDDFKQALR 498
Cdd:COG0464 378 P------------VTTEDLLEALE 389
RecA-like_VPS4 cd19521
ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein ...
 245-414 1.12e-70

ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein sorting-associated protein 4 (Vps4) is believed to be involved in intracellular protein transport out of a prevacuolar endosomal compartment. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410929 [Multi-domain]  Cd Length: 170  Bit Score: 223.20  E-value: 1.12e-70
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 245 KP-VAWEDIAGLESAKSTFLEAIIMPLRRPDLFTGVRCPPRGVLLFGPPGTGKTLIAKSIASQAKAKFFSINPSSLTSKW 323
Cdd:cd19521   1 KPnVKWEDVAGLEGAKEALKEAVILPVKFPHLFTGNRKPWSGILLYGPPGTGKSYLAKAVATEANSTFFSVSSSDLVSKW 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 324 VGDAEKLVKTLFAVAAAHQPAIIFIDEVDSLLSKRSANENESTLRLKNEFLIHLDGAASNEEiRVLVIGATNRPQELDEA 403
Cdd:cd19521  81 MGESEKLVKQLFAMARENKPSIIFIDEVDSLCGTRGEGESEASRRIKTELLVQMNGVGNDSQ-GVLVLGATNIPWQLDSA 159

                       170
                ....*....|.
gi 24581396 404 VRRRFVRRLYV 414
Cdd:cd19521 160 IRRRFEKRIYI 170
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 247-520 4.62e-67

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 229.79  E-value: 4.62e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396   247 VAWEDIAGLESAKSTFLEAIIMPLRRPDLFT--GVRcPPRGVLLFGPPGTGKTLIAKSIASQAKAKFFSINPSSLTSKWV 324
Cdd:TIGR01243 450 VRWSDIGGLEEVKQELREAVEWPLKHPEIFEkmGIR-PPKGVLLFGPPGTGKTLLAKAVATESGANFIAVRGPEILSKWV 528

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396   325 GDAEKLVKTLFAVAAAHQPAIIFIDEVDSLLSKRSANENES-TLRLKNEFLIHLDGAASNEEirVLVIGATNRPQELDEA 403
Cdd:TIGR01243 529 GESEKAIREIFRKARQAAPAIIFFDEIDAIAPARGARFDTSvTDRIVNQLLTEMDGIQELSN--VVVIAATNRPDILDPA 606

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396   404 VRR--RFVRRLYVPLPTREARQKIIEklIHQVKHNL--DVrQVIELAELTDGYSGADVDTLCRYASMAPLR----SLTPD 475
Cdd:TIGR01243 607 LLRpgRFDRLILVPPPDEEARKEIFK--IHTRSMPLaeDV-DLEELAEMTEGYTGADIEAVCREAAMAALResigSPAKE 683

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 24581396   476 QMEVIETHQLP--AVTMDDFKQALRVISKSVSSEDCKQFEAWNEIYG 520
Cdd:TIGR01243 684 KLEVGEEEFLKdlKVEMRHFLEALKKVKPSVSKEDMLRYERLAKELK 730
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
 251-414 1.17e-66

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 212.67  E-value: 1.17e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 251 DIAGLESAKSTFLEAIIMPLRRPDLFTGVRC--PPRGVLLFGPPGTGKTLIAKSIASQAKAKFFSINPSSLTSKWVGDAE 328
Cdd:cd19520   1 DIGGLDEVITELKELVILPLQRPELFDNSRLlqPPKGVLLYGPPGCGKTMLAKATAKEAGARFINLQVSSLTDKWYGESQ 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 329 KLVKTLFAVAAAHQPAIIFIDEVDSLLSKRSANENESTLRLKNEFLIHLDGAASNEEIRVLVIGATNRPQELDEAVRRRF 408
Cdd:cd19520  81 KLVAAVFSLASKLQPSIIFIDEIDSFLRQRSSTDHEATAMMKAEFMSLWDGLSTDGNCRVIVMGATNRPQDLDEAILRRM 160


                ....*.
gi 24581396 409 VRRLYV 414
Cdd:cd19520 161 PKRFHI 166
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 247-507 2.73e-60

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 211.69  E-value: 2.73e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396   247 VAWEDIAGLESAKSTFLEAIIMPLRRPDLFT--GVRcPPRGVLLFGPPGTGKTLIAKSIASQAKAKFFSINPSSLTSKWV 324
Cdd:TIGR01243 175 VTYEDIGGLKEAKEKIREMVELPMKHPELFEhlGIE-PPKGVLLYGPPGTGKTLLAKAVANEAGAYFISINGPEIMSKYY 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396   325 GDAEKLVKTLFAVAAAHQPAIIFIDEVDSLLSKRSANENESTLRLKNEFLIHLDGAasNEEIRVLVIGATNRPQELDEAV 404
Cdd:TIGR01243 254 GESEERLREIFKEAEENAPSIIFIDEIDAIAPKREEVTGEVEKRVVAQLLTLMDGL--KGRGRVIVIGATNRPDALDPAL 331

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396   405 RR--RFVRRLYVPLPTREARQKIIEKLIHQVKHNLDVrQVIELAELTDGYSGADVDTLCRYASMAPLRSLTPDQMEVIET 482
Cdd:TIGR01243 332 RRpgRFDREIVIRVPDKRARKEILKVHTRNMPLAEDV-DLDKLAEVTHGFVGADLAALAKEAAMAALRRFIREGKINFEA 410

                         250       260       270
                  ....*....|....*....|....*....|..
gi 24581396   483 HQLPA-------VTMDDFKQALRVISKSVSSE 507
Cdd:TIGR01243 411 EEIPAevlkelkVTMKDFMEALKMVEPSAIRE 442
RecA-like_KTNA1 cd19522
Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is ...
 251-414 1.92e-59

Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is the catalytic subunit of the Katanin complex which is severs microtubules in an ATP-dependent manner, and is implicated in multiple aspects of microtubule dynamics. In addition to the p60 catalytic ATPase subunit, Katanin contains an accessory subunit (p80 or p80-like). The microtubule-severing activity of the ATPase is essential for female meiotic spindle assembly, and male gamete production; and the katanin complex severing microtubules is under tight regulation during the transition from the meiotic to mitotic stage to allow proper embryogenesis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410930 [Multi-domain]  Cd Length: 170  Bit Score: 194.05  E-value: 1.92e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 251 DIAGLESAKSTFLEAIIMPLRRPDLFTGVRCPPRGVLLFGPPGTGKTLIAKSIASQAKAKFFSINPSSLTSKWVGDAEKL 330
Cdd:cd19522   1 DIADLEEAKKLLEEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECGTTFFNVSSSTLTSKYRGESEKL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 331 VKTLFAVAAAHQPAIIFIDEVDSLLSKR-SANENESTLRLKNEFLIHLDG---AASNEEIR--VLVIGATNRPQELDEAV 404
Cdd:cd19522  81 VRLLFEMARFYAPTTIFIDEIDSICSRRgTSEEHEASRRVKSELLVQMDGvggASENDDPSkmVMVLAATNFPWDIDEAL 160

                       170
                ....*....|
gi 24581396 405 RRRFVRRLYV 414
Cdd:cd19522 161 RRRLEKRIYI 170
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 247-502 2.05e-58

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 198.52  E-value: 2.05e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396  247 VAWEDIAGLESAKSTFLEAIIMPLRRPDLFT--GVRcPPRGVLLFGPPGTGKTLIAKSIASQAKAKFFSINPSSLTSKWV 324
Cdd:PRK03992 128 VTYEDIGGLEEQIREVREAVELPLKKPELFEevGIE-PPKGVLLYGPPGTGKTLLAKAVAHETNATFIRVVGSELVQKFI 206

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396  325 GDAEKLVKTLFAVAAAHQPAIIFIDEVDSLLSKR-------SANENESTLRLknefLIHLDGAASNEEIRvlVIGATNRP 397
Cdd:PRK03992 207 GEGARLVRELFELAREKAPSIIFIDEIDAIAAKRtdsgtsgDREVQRTLMQL----LAEMDGFDPRGNVK--IIAATNRI 280

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396  398 QELDEAVRR--RFVRRLYVPLPTREARQKIIEklIHQVKHNL--DVRqVIELAELTDGYSGADVDTLCRYASMAPLRSlt 473
Cdd:PRK03992 281 DILDPAILRpgRFDRIIEVPLPDEEGRLEILK--IHTRKMNLadDVD-LEELAELTEGASGADLKAICTEAGMFAIRD-- 355

                        250       260
                 ....*....|....*....|....*....
gi 24581396  474 pdqmeviethQLPAVTMDDFKQALRVISK 502
Cdd:PRK03992 356 ----------DRTEVTMEDFLKAIEKVMG 374
RecA-like_fidgetin cd19523
ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. ...
 251-414 2.61e-54

ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410931 [Multi-domain]  Cd Length: 163  Bit Score: 180.47  E-value: 2.61e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 251 DIAGLESAKSTFLEAIIMPLRRPDLFTGVRCPPRGVLLFGPPGTGKTLIAKSIASQAKAKFFSINPSSLTSKWVGDAEKL 330
Cdd:cd19523   1 DIAGLGALKAAIKEEVLWPLLRPDAFSGLLRLPRSILLFGPRGTGKTLLGRCLASQLGATFLRLRGSTLVAKWAGEGEKI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 331 VKTLFAVAAAHQPAIIFIDEVDSLLSKRsANENESTLRLKNEFLIHLDGAASNEEIRVLVIGATNRPQELDEAVRRRFVR 410
Cdd:cd19523  81 LQASFLAARCRQPSVLFISDLDALLSSQ-DDEASPVGRLQVELLAQLDGVLGSGEDGVLVVCTTSKPEEIDESLRRYFSK 159


                ....
gi 24581396 411 RLYV 414
Cdd:cd19523 160 RLLV 163
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
 251-414 1.57e-53

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 178.25  E-value: 1.57e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 251 DIAGLESAKSTFLEAIIMPLRRPDLFT--GVRcPPRGVLLFGPPGTGKTLIAKSIASQAKAKFFSINPSSLTSKWVGDAE 328
Cdd:cd19503   1 DIGGLDEQIASLKELIELPLKYPELFRalGLK-PPRGVLLHGPPGTGKTLLARAVANEAGANFLSISGPSIVSKYLGESE 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 329 KLVKTLFAVAAAHQPAIIFIDEVDSLLSKRSANENESTLRLKNEFLIHLDGAASNEeiRVLVIGATNRPQELDEAVRR-- 406
Cdd:cd19503  80 KNLREIFEEARSHAPSIIFIDEIDALAPKREEDQREVERRVVAQLLTLMDGMSSRG--KVVVIAATNRPDAIDPALRRpg 157


                ....*...
gi 24581396 407 RFVRRLYV 414
Cdd:cd19503 158 RFDREVEI 165
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 286-416 1.05e-51

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 172.39  E-value: 1.05e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396   286 VLLFGPPGTGKTLIAKSIASQAKAKFFSINPSSLTSKWVGDAEKLVKTLFAVAAAHQPAIIFIDEVDSLLSKRSANENES 365
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGESEKRLRELFEAAKKLAPCVIFIDEIDALAGSRGSGGDSE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 24581396   366 TLRLKNEFLIHLDGAASNEEiRVLVIGATNRPQELDEAVRRRFVRRLYVPL 416
Cdd:pfam00004  81 SRRVVNQLLTELDGFTSSNS-KVIVIAATNRPDKLDPALLGRFDRIIEFPL 130
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
249-508 8.24e-51

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 173.92  E-value: 8.24e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 249 WEDIAGLESAKSTfLEAIIMPLRRPDLFTG-VRCPPRGVLLFGPPGTGKTLIAKSIASQAKAKFFSINPSSLTSKWVGDA 327
Cdd:COG1223   1 LDDVVGQEEAKKK-LKLIIKELRRRENLRKfGLWPPRKILFYGPPGTGKTMLAEALAGELKLPLLTVRLDSLIGSYLGET 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 328 EKLVKTLFAvAAAHQPAIIFIDEVDSLLSKRSANENESTL-RLKNEFLIHLDGAASNeeirVLVIGATNRPQELDEAVRR 406
Cdd:COG1223  80 ARNLRKLFD-FARRAPCVIFFDEFDAIAKDRGDQNDVGEVkRVVNALLQELDGLPSG----SVVIAATNHPELLDSALWR 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 407 RFVRRLYVPLPTREARQKIIEKLIHQVKHNLDvRQVIELAELTDGYSGADVDTLCR-YASMAplrsltpdqmeVIEthQL 485
Cdd:COG1223 155 RFDEVIEFPLPDKEERKEILELNLKKFPLPFE-LDLKKLAKKLEGLSGADIEKVLKtALKKA-----------ILE--DR 220

                       250       260
                ....*....|....*....|...
gi 24581396 486 PAVTMDDFKQALRVISKSVSSED 508
Cdd:COG1223 221 EKVTKEDLEEALKQRKERKKEPK 243
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
 258-414 1.29e-48

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 165.15  E-value: 1.29e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 258 AKSTFLEAIIMPLRRPDLFT--GVRcPPRGVLLFGPPGTGKTLIAKSIASQAKAKFFSINPSSLTSKWVGDAEKLVKTLF 335
Cdd:cd19511   1 VKRELKEAVEWPLKHPDAFKrlGIR-PPKGVLLYGPPGCGKTLLAKALASEAGLNFISVKGPELFSKYVGESERAVREIF 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 336 AVAAAHQPAIIFIDEVDSLLSKRSANENES-TLRLKNEFLIHLDGAasnEEIR-VLVIGATNRPQELDEAVRR--RFVRR 411
Cdd:cd19511  80 QKARQAAPCIIFFDEIDSLAPRRGQSDSSGvTDRVVSQLLTELDGI---ESLKgVVVIAATNRPDMIDPALLRpgRLDKL 156


                ...
gi 24581396 412 LYV 414
Cdd:cd19511 157 IYV 159
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 258-414 2.82e-48

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 164.38  E-value: 2.82e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 258 AKSTFLEAIIMPLRRPDLFTGVRCPPRGVLLFGPPGTGKTLIAKSIASQAKAKFFSINPSSLTSKWVGDAEKLVKTLFAV 337
Cdd:cd19481   1 LKASLREAVEAPRRGSRLRRYGLGLPKGILLYGPPGTGKTLLAKALAGELGLPLIVVKLSSLLSKYVGESEKNLRKIFER 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 338 AAAHQPAIIFIDEVDSLLSKRSAN-ENESTLRLKNEFLIHLDGAASNEeiRVLVIGATNRPQELDEAVRR--RFVRRLYV 414
Cdd:cd19481  81 ARRLAPCILFIDEIDAIGRKRDSSgESGELRRVLNQLLTELDGVNSRS--KVLVIAATNRPDLLDPALLRpgRFDEVIEF 158
FtsH_fam TIGR01241
ATP-dependent metalloprotease FtsH; HflB(FtsH) is a pleiotropic protein required for correct ...
 247-500 3.29e-48

ATP-dependent metalloprotease FtsH; HflB(FtsH) is a pleiotropic protein required for correct cell division in bacteria. It has ATP-dependent zinc metalloprotease activity. It was formerly designated cell division protein FtsH. [Cellular processes, Cell division, Protein fate, Degradation of proteins, peptides, and glycopeptides]


Pssm-ID: 273520 [Multi-domain]  Cd Length: 495  Bit Score: 174.01  E-value: 3.29e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396   247 VAWEDIAGLESAKSTFLEaIIMPLRRPDLFT--GVRcPPRGVLLFGPPGTGKTLIAKSIASQAKAKFFSINPSSLTSKWV 324
Cdd:TIGR01241  52 VTFKDVAGIDEAKEELME-IVDFLKNPSKFTklGAK-IPKGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEMFV 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396   325 GDAEKLVKTLFAVAAAHQPAIIFIDEVDSLLSKRSA------NENESTLrlkNEFLIHLDGAASNEEirVLVIGATNRPQ 398
Cdd:TIGR01241 130 GVGASRVRDLFEQAKKNAPCIIFIDEIDAVGRQRGAglgggnDEREQTL---NQLLVEMDGFGTNTG--VIVIAATNRPD 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396   399 ELDEAVRR--RFVRRLYVPLPTREARQKIIEKLIHQVKHNLDVrQVIELAELTDGYSGADVDTLCRYASMAPLRsltpdq 476
Cdd:TIGR01241 205 VLDPALLRpgRFDRQVVVDLPDIKGREEILKVHAKNKKLAPDV-DLKAVARRTPGFSGADLANLLNEAALLAAR------ 277

                         250       260
                  ....*....|....*....|....*
gi 24581396   477 mevietHQLPAVTMDDFKQAL-RVI 500
Cdd:TIGR01241 278 ------KNKTEITMNDIEEAIdRVI 296
RecA-like_FtsH cd19501
ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc ...
 247-414 1.30e-46

ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. It is anchored to the cytoplasmic membrane such that the amino- and carboxy-termini are exposed to the cytoplasm. It presents a membrane-bound hexameric structure that is able to unfold and degrade protein substrates. It is comprised of an N-terminal transmembrane region and the larger C-terminal cytoplasmic region, which consists of an ATPase domain and a protease domain. This RecA-Like FTsH subfamily represents the ATPase domain, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410909 [Multi-domain]  Cd Length: 171  Bit Score: 160.09  E-value: 1.30e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 247 VAWEDIAGLESAKSTFLEaIIMPLRRPDLFT--GVRcPPRGVLLFGPPGTGKTLIAKSIASQAKAKFFSINPSSLTSKWV 324
Cdd:cd19501   1 VTFKDVAGCEEAKEELKE-VVEFLKNPEKFTklGAK-IPKGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEMFV 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 325 GDAEKLVKTLFAVAAAHQPAIIFIDEVDSLLSKRSA------NENESTLrlkNEFLIHLDGAASNEEirVLVIGATNRPQ 398
Cdd:cd19501  79 GVGASRVRDLFEQAKKNAPCIVFIDEIDAVGRKRGAglggghDEREQTL---NQLLVEMDGFESNTG--VIVIAATNRPD 153

                       170
                ....*....|....*...
gi 24581396 399 ELDEAVRR--RFVRRLYV 414
Cdd:cd19501 154 VLDPALLRpgRFDRQVYV 171
RecA-like_VCP_r2 cd19529
second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ...
 258-414 3.38e-45

second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ATPase domains; The Valosin-containing protein-like ATPase of Thermoplasma acidophilum (VAT), is an archaeal homolog of the ubiquitous Cdc48/p97. It is a protein unfoldase that functions in concert with the 20S proteasome by unfolding proteasome substrates and passing them on for degradation. VAT forms a homohexamer, each monomer contains two tandem ATPase domains, referred to as D1 and D2, and an N-terminal domain. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410937 [Multi-domain]  Cd Length: 159  Bit Score: 156.12  E-value: 3.38e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 258 AKSTFLEAIIMPLRRPDLFT--GVRcPPRGVLLFGPPGTGKTLIAKSIASQAKAKFFSINPSSLTSKWVGDAEKLVKTLF 335
Cdd:cd19529   1 VKQELKEAVEWPLLKPEVFKrlGIR-PPKGILLYGPPGTGKTLLAKAVATESNANFISVKGPELLSKWVGESEKAIREIF 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 336 AVAAAHQPAIIFIDEVDSLLSKR-SANENESTLRLKNEFLIHLDGAASNEEirVLVIGATNRPQELDEAVRR--RFVRRL 412
Cdd:cd19529  80 RKARQVAPCVIFFDEIDSIAPRRgTTGDSGVTERVVNQLLTELDGLEEMNG--VVVIAATNRPDIIDPALLRagRFDRLI 157


                ..
gi 24581396 413 YV 414
Cdd:cd19529 158 YI 159
ftsH CHL00176
cell division protein; Validated
 245-500 1.36e-43

cell division protein; Validated


Pssm-ID: 214386 [Multi-domain]  Cd Length: 638  Bit Score: 163.68  E-value: 1.36e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396  245 KPVAWEDIAGLESAKSTFlEAIIMPLRRPDLFTGVRC-PPRGVLLFGPPGTGKTLIAKSIASQAKAKFFSINPSSLTSKW 323
Cdd:CHL00176 178 TGITFRDIAGIEEAKEEF-EEVVSFLKKPERFTAVGAkIPKGVLLVGPPGTGKTLLAKAIAGEAEVPFFSISGSEFVEMF 256

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396  324 VGDAEKLVKTLFAVAAAHQPAIIFIDEVDSLLSKRSAN------ENESTLrlkNEFLIHLDGAASNEEirVLVIGATNRP 397
Cdd:CHL00176 257 VGVGAARVRDLFKKAKENSPCIVFIDEIDAVGRQRGAGigggndEREQTL---NQLLTEMDGFKGNKG--VIVIAATNRV 331

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396  398 QELDEAVRR--RFVRRLYVPLPTREARQKIIEKLIHQVKHNLDVRQVIeLAELTDGYSGADVDTLCRYASMAPLRsltpd 475
Cdd:CHL00176 332 DILDAALLRpgRFDRQITVSLPDREGRLDILKVHARNKKLSPDVSLEL-IARRTPGFSGADLANLLNEAAILTAR----- 405

                        250       260
                 ....*....|....*....|....*.
gi 24581396  476 qmevietHQLPAVTMDDFKQAL-RVI 500
Cdd:CHL00176 406 -------RKKATITMKEIDTAIdRVI 424
RecA-like_NVL_r2-like cd19530
second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 255-414 1.55e-43

second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410938 [Multi-domain]  Cd Length: 161  Bit Score: 151.87  E-value: 1.55e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 255 LESAKSTFLEAIIMPLRRPDLFT--GVRCPpRGVLLFGPPGTGKTLIAKSIASQAKAKFFSINPSSLTSKWVGDAEKLVK 332
Cdd:cd19530   1 LDHVREELTMSILRPIKRPDIYKalGIDLP-TGVLLYGPPGCGKTLLAKAVANESGANFISVKGPELLNKYVGESERAVR 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 333 TLFAVAAAHQPAIIFIDEVDSLLSKRSANENESTLRLKNEFLIHLDGAASNEEirVLVIGATNRPQELDEAVRR--RFVR 410
Cdd:cd19530  80 QVFQRARASAPCVIFFDEVDALVPKRGDGGSWASERVVNQLLTEMDGLEERSN--VFVIAATNRPDIIDPAMLRpgRLDK 157


                ....
gi 24581396 411 RLYV 414
Cdd:cd19530 158 TLYV 161
PTZ00361 PTZ00361
26 proteosome regulatory subunit 4-like protein; Provisional
 248-470 4.44e-43

26 proteosome regulatory subunit 4-like protein; Provisional


Pssm-ID: 185575 [Multi-domain]  Cd Length: 438  Bit Score: 158.78  E-value: 4.44e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396  248 AWEDIAGLESAKSTFLEAIIMPLRRPDLF--TGVRcPPRGVLLFGPPGTGKTLIAKSIASQAKAKFFSINPSSLTSKWVG 325
Cdd:PTZ00361 181 SYADIGGLEQQIQEIKEAVELPLTHPELYddIGIK-PPKGVILYGPPGTGKTLLAKAVANETSATFLRVVGSELIQKYLG 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396  326 DAEKLVKTLFAVAAAHQPAIIFIDEVDSLLSKR----SANENEsTLRLKNEFLIHLDGAASNEEIRvlVIGATNRPQELD 401
Cdd:PTZ00361 260 DGPKLVRELFRVAEENAPSIVFIDEIDAIGTKRydatSGGEKE-IQRTMLELLNQLDGFDSRGDVK--VIMATNRIESLD 336

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24581396  402 EAVRR--RFVRRLYVPLPTREARQKIIEklIHQVKHNL--DVrQVIELAELTDGYSGADVDTLCRYASMAPLR 470
Cdd:PTZ00361 337 PALIRpgRIDRKIEFPNPDEKTKRRIFE--IHTSKMTLaeDV-DLEEFIMAKDELSGADIKAICTEAGLLALR 406
RecA-like_CDC48_r1-like cd19519
first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP ...
 251-415 5.61e-43

first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r1-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410927 [Multi-domain]  Cd Length: 166  Bit Score: 150.28  E-value: 5.61e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 251 DIAGLESAKSTFLEAIIMPLRRPDLFT--GVRcPPRGVLLFGPPGTGKTLIAKSIASQAKAKFFSINPSSLTSKWVGDAE 328
Cdd:cd19519   1 DIGGCRKQLAQIREMVELPLRHPELFKaiGIK-PPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESE 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 329 KLVKTLFAVAAAHQPAIIFIDEVDSLLSKRSANENESTLRLKNEFLIHLDGAASNEeiRVLVIGATNRPQELDEAVRR-- 406
Cdd:cd19519  80 SNLRKAFEEAEKNAPAIIFIDEIDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRA--HVIVMAATNRPNSIDPALRRfg 157


                ....*....
gi 24581396 407 RFVRRLYVP 415
Cdd:cd19519 158 RFDREIDIG 166
RecA-like_PAN_like cd19502
proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily ...
 249-414 8.40e-42

proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily contains ATPase subunits of the eukaryotic 26S proteasome, and of the archaeal proteasome which carry out ATP-dependent degradation of substrates of the ubiquitin-proteasome pathway. The eukaryotic 26S proteasome consists of a proteolytic 20S core particle (CP), and a 19S regulatory particle (RP) which provides the ATP-dependence and the specificity for ubiquitinated proteins. In the archaea the RP is a homohexameric complex of proteasome-activating nucleotidase (PAN). This subfamily also includes various eukaryotic 26S subunits including, proteasome 26S subunit, ATPase 2 (PSMC2, also known as S7 and MSS1) which is a member of the 19S RP and has a chaperone like activity; and proteasome 20S subunit alpha 6 (PSMA6, also known as IOTA, p27K, and PROS27) which is a member of the 20S CP. This RecA-like_PAN subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410910 [Multi-domain]  Cd Length: 171  Bit Score: 147.48  E-value: 8.40e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 249 WEDIAGLESAKSTFLEAIIMPLRRPDLFTGVRC-PPRGVLLFGPPGTGKTLIAKSIASQAKAKFFSINPSSLTSKWVGDA 327
Cdd:cd19502   2 YEDIGGLDEQIREIREVVELPLKHPELFEELGIePPKGVLLYGPPGTGKTLLAKAVANHTDATFIRVVGSELVQKYIGEG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 328 EKLVKTLFAVAAAHQPAIIFIDEVDSLLSKR----SANENEsTLRLKNEFLIHLDGAASNEEIRvlVIGATNRPQELDEA 403
Cdd:cd19502  82 ARLVRELFEMAREKAPSIIFIDEIDAIGAKRfdsgTGGDRE-VQRTMLELLNQLDGFDPRGNIK--VIMATNRPDILDPA 158

                       170
                ....*....|...
gi 24581396 404 VRR--RFVRRLYV 414
Cdd:cd19502 159 LLRpgRFDRKIEF 171
HflB COG0465
ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];
250-500 8.45e-40

ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440233 [Multi-domain]  Cd Length: 583  Bit Score: 152.11  E-value: 8.45e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 250 EDIAGLESAKSTfLEAIIMPLRRPDLFT--GVRCPpRGVLLFGPPGTGKTLIAKSIASQAKAKFFSINPSSLTSKWVG-D 326
Cdd:COG0465 142 DDVAGVDEAKEE-LQEIVDFLKDPEKFTrlGAKIP-KGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEMFVGvG 219

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 327 AEKlVKTLFAVAAAHQPAIIFIDEVDSLLSKRSAN------ENESTLrlkNEFLIHLDGAASNEeiRVLVIGATNRPQEL 400
Cdd:COG0465 220 ASR-VRDLFEQAKKNAPCIIFIDEIDAVGRQRGAGlggghdEREQTL---NQLLVEMDGFEGNE--GVIVIAATNRPDVL 293

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 401 DEAVRR--RFVRRLYVPLPTREARQKIIEklIH--QVKHNLDVRqVIELAELTDGYSGADVDTLC-RYASMAPLRSLTpd 475
Cdd:COG0465 294 DPALLRpgRFDRQVVVDLPDVKGREAILK--VHarKKPLAPDVD-LEVIARRTPGFSGADLANLVnEAALLAARRNKK-- 368

                       250       260
                ....*....|....*....|....*.
gi 24581396 476 qmeviethqlpAVTMDDFKQAL-RVI 500
Cdd:COG0465 369 -----------AVTMEDFEEAIdRVI 383
PTZ00454 PTZ00454
26S protease regulatory subunit 6B-like protein; Provisional
 245-470 4.42e-38

26S protease regulatory subunit 6B-like protein; Provisional


Pssm-ID: 240423 [Multi-domain]  Cd Length: 398  Bit Score: 144.14  E-value: 4.42e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396  245 KP-VAWEDIAGLESAKSTFLEAIIMPLRRPDLFTGVRC-PPRGVLLFGPPGTGKTLIAKSIASQAKAKFFSINPSSLTSK 322
Cdd:PTZ00454 139 KPdVTYSDIGGLDIQKQEIREAVELPLTCPELYEQIGIdPPRGVLLYGPPGTGKTMLAKAVAHHTTATFIRVVGSEFVQK 218

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396  323 WVGDAEKLVKTLFAVAAAHQPAIIFIDEVDSLLSKR---SANENESTLRLKNEFLIHLDGAasNEEIRVLVIGATNRPQE 399
Cdd:PTZ00454 219 YLGEGPRMVRDVFRLARENAPSIIFIDEVDSIATKRfdaQTGADREVQRILLELLNQMDGF--DQTTNVKVIMATNRADT 296

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24581396  400 LDEAVRR--RFVRRLYVPLPTReaRQKiieKLIHQV---KHNLDVRQVIE-LAELTDGYSGADVDTLCRYASMAPLR 470
Cdd:PTZ00454 297 LDPALLRpgRLDRKIEFPLPDR--RQK---RLIFQTitsKMNLSEEVDLEdFVSRPEKISAADIAAICQEAGMQAVR 368
RecA-like_NVL_r1-like cd19518
first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 251-410 6.08e-38

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410926 [Multi-domain]  Cd Length: 169  Bit Score: 137.15  E-value: 6.08e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 251 DIAGLESAKSTFLEAIIMPLRRPDLF--TGVRcPPRGVLLFGPPGTGKTLIAKSIASQAKAKFFSINPSSLTSKWVGDAE 328
Cdd:cd19518   1 DIGGMDSTLKELCELLIHPILPPEYFqhLGVE-PPRGVLLHGPPGCGKTMLANAIAGELKVPFLKISATEIVSGVSGESE 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 329 KLVKTLFAVAAAHQPAIIFIDEVDSLLSKRSANENESTLRLKNEFLIHLDGAASNEEI--RVLVIGATNRPQELDEAVRR 406
Cdd:cd19518  80 EKIRELFDQAISNAPCIVFIDEIDAITPKRESAQREMERRIVSQLLTCMDELNNEKTAggPVLVIGATNRPDSLDPALRR 159


                ....*.
gi 24581396 407 --RFVR 410
Cdd:cd19518 160 agRFDR 165
hflB PRK10733
ATP-dependent zinc metalloprotease FtsH;
248-470 7.14e-38

ATP-dependent zinc metalloprotease FtsH;


Pssm-ID: 182683 [Multi-domain]  Cd Length: 644  Bit Score: 147.49  E-value: 7.14e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396  248 AWEDIAGLESAKSTFLEaIIMPLRRPDLFTGVRCP-PRGVLLFGPPGTGKTLIAKSIASQAKAKFFSINPSSLTSKWVGD 326
Cdd:PRK10733 150 TFADVAGCDEAKEEVAE-LVEYLREPSRFQKLGGKiPKGVLMVGPPGTGKTLLAKAIAGEAKVPFFTISGSDFVEMFVGV 228

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396  327 AEKLVKTLFAVAAAHQPAIIFIDEVDSLLSKRSA------NENESTLrlkNEFLIHLDGAASNEEIrvLVIGATNRPQEL 400
Cdd:PRK10733 229 GASRVRDMFEQAKKAAPCIIFIDEIDAVGRQRGAglggghDEREQTL---NQMLVEMDGFEGNEGI--IVIAATNRPDVL 303

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24581396  401 DEAVRR--RFVRRLYVPLPTREARQKIIEKLIHQVKHNLDVRQVIeLAELTDGYSGADVDTLCRYASMAPLR 470
Cdd:PRK10733 304 DPALLRpgRFDRQVVVGLPDVRGREQILKVHMRRVPLAPDIDAAI-IARGTPGFSGADLANLVNEAALFAAR 374
RecA-like_CDC48_r2-like cd19528
second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or ...
 259-414 7.54e-37

second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP in metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the second of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r2-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410936 [Multi-domain]  Cd Length: 161  Bit Score: 133.79  E-value: 7.54e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 259 KSTFLEAIIMPLRRPDLFT--GVRcPPRGVLLFGPPGTGKTLIAKSIASQAKAKFFSINPSSLTSKWVGDAEKLVKTLFA 336
Cdd:cd19528   2 KRELQELVQYPVEHPDKFLkfGMT-PSKGVLFYGPPGCGKTLLAKAIANECQANFISVKGPELLTMWFGESEANVRDIFD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 337 VAAAHQPAIIFIDEVDSLLSKRSAN---ENESTLRLKNEFLIHLDGAasNEEIRVLVIGATNRPQELDEAVRR--RFVRR 411
Cdd:cd19528  81 KARAAAPCVLFFDELDSIAKARGGNigdAGGAADRVINQILTEMDGM--NTKKNVFIIGATNRPDIIDPAILRpgRLDQL 158


                ...
gi 24581396 412 LYV 414
Cdd:cd19528 159 IYI 161
RecA-like_Yta7-like cd19517
ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces ...
 251-413 8.35e-37

ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces cerevisiae Yta7 is a chromatin-associated AAA-ATPase involved in regulation of chromatin dynamics. Its human ortholog ANCCA/ATAD2 transcriptionally activates pathways of malignancy in a broad range of cancers. The RecA-like_Yta7 subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410925 [Multi-domain]  Cd Length: 170  Bit Score: 133.79  E-value: 8.35e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 251 DIAGLESAKSTFLEAIIMPLRRPDLFTGVRC-PPRGVLLFGPPGTGKTLIAKSIASQA-----KAKFFSINPSSLTSKWV 324
Cdd:cd19517   1 DIGGLSHYINQLKEMVFFPLLYPEVFAKFKItPPRGVLFHGPPGTGKTLMARALAAECskggqKVSFFMRKGADCLSKWV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 325 GDAEKLVKTLFAVAAAHQPAIIFIDEVDSLLSKRSANENESTLRLKNEFLIHLDGAASNEEirVLVIGATNRPQELDEAV 404
Cdd:cd19517  81 GEAERQLRLLFEEAYRMQPSIIFFDEIDGLAPVRSSKQEQIHASIVSTLLALMDGLDNRGQ--VVVIGATNRPDALDPAL 158

                       170
                ....*....|.
gi 24581396 405 RR--RFVRRLY 413
Cdd:cd19517 159 RRpgRFDREFY 169
RecA-like_PEX6_r2 cd19527
second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as ...
 259-414 1.78e-34

second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as Peroxin61)/PEX1 is a protein unfoldase; PEX6 and PEX1 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. This subfamily represents the second ATPase domain of PEX6. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410935 [Multi-domain]  Cd Length: 160  Bit Score: 127.24  E-value: 1.78e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 259 KSTFLEAIIMPLRRPDLFT-GVRcPPRGVLLFGPPGTGKTLIAKSIASQAKAKFFSINPSSLTSKWVGDAEKLVKTLFAV 337
Cdd:cd19527   2 KKEILDTIQLPLEHPELFSsGLR-KRSGILLYGPPGTGKTLLAKAIATECSLNFLSVKGPELINMYIGESEANVREVFQK 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 338 AAAHQPAIIFIDEVDSLLSKRSANENESTL--RLKNEFLIHLDGAASNEEiRVLVIGATNRPQELDEAVRR--RFVRRLY 413
Cdd:cd19527  81 ARDAKPCVIFFDELDSLAPSRGNSGDSGGVmdRVVSQLLAELDGMSSSGQ-DVFVIGATNRPDLLDPALLRpgRFDKLLY 159


                .
gi 24581396 414 V 414
Cdd:cd19527 160 L 160
RecA-like_PEX1_r2 cd19526
second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as ...
 258-413 1.82e-32

second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as Peroxin-1)/PEX6 is a protein unfoldase; PEX1 and PEX6 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. PEX-1 is required for stability of PEX5. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410934 [Multi-domain]  Cd Length: 158  Bit Score: 121.77  E-value: 1.82e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 258 AKSTFLEAIIMPLRRPDLFTGVRCP-PRGVLLFGPPGTGKTLIAKSIASQAKAKFFSINPSSLTSKWVGDAEKLVKTLFA 336
Cdd:cd19526   1 VKKALEETIEWPSKYPKIFASSPLRlRSGILLYGPPGCGKTLLASAIASECGLNFISVKGPELLNKYIGASEQNVRDLFS 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24581396 337 VAAAHQPAIIFIDEVDSLLSKRSANENESTLRLKNEFLIHLDGAASNEEirVLVIGATNRPQELDEAVRR--RFVRRLY 413
Cdd:cd19526  81 RAQSAKPCILFFDEFDSIAPKRGHDSTGVTDRVVNQLLTQLDGVEGLDG--VYVLAATSRPDLIDPALLRpgRLDKLVY 157
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 282-416 3.88e-25

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 101.07  E-value: 3.88e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 282 PPRGVLLFGPPGTGKTLIAKSIA---SQAKAKFFSINPSSLTSKWVGDAEK---LVKTLFAVAAAHQPAIIFIDEVDSlL 355
Cdd:cd00009  18 PPKNLLLYGPPGTGKTTLARAIAnelFRPGAPFLYLNASDLLEGLVVAELFghfLVRLLFELAEKAKPGVLFIDEIDS-L 96

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24581396 356 SKRSANENESTLRLKNEFLIHLDgaasneeiRVLVIGATNRP--QELDEAVRRRFVRRLYVPL 416
Cdd:cd00009  97 SRGAQNALLRVLETLNDLRIDRE--------NVRVIGATNRPllGDLDRALYDRLDIRIVIPL 151
RecA-like_NSF-SEC18_r1-like cd19504
first of two ATPase domains of NSF and SEC18, and similar ATPase domains; ...
 284-406 3.33e-21

first of two ATPase domains of NSF and SEC18, and similar ATPase domains; N-ethylmaleimide-sensitive factor (NSF) and Saccharomyces cerevisiae Vesicular-fusion protein Sec18, key factors for eukaryotic trafficking, are ATPases and SNARE disassembly chaperones. NSF/Sec18 activate or prime SNAREs, the terminal catalysts of membrane fusion. Sec18/NSF associates with SNARE complexes through binding Sec17/alpha-SNAP. Sec18 has an N-terminal cap domain and two nucleotide-binding domains (D1 and D2) which form the two rings of the hexameric complex. The hydrolysis of ATP by D1 generates most of the energy necessary to disassemble inactive SNARE bundles, while the D2 ring binds ATP to stabilize the homohexamer. This subfamily includes the first (D1) ATPase domain of NSF/Sec18, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410912 [Multi-domain]  Cd Length: 177  Bit Score: 91.01  E-value: 3.33e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 284 RGVLLFGPPGTGKTLIAKSIASQAKAKFFSI-NPSSLTSKWVGDAEKLVKTLFAVAAAHQPA--------IIFIDEVDSL 354
Cdd:cd19504  36 KGILLYGPPGTGKTLMARQIGKMLNAREPKIvNGPEILNKYVGESEANIRKLFADAEEEQRRlgansglhIIIFDEIDAI 115

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 24581396 355 LSKRSANENESTL--RLKNEFLIHLDGAASNEEIrvLVIGATNRPQELDEAVRR 406
Cdd:cd19504 116 CKQRGSMAGSTGVhdTVVNQLLSKIDGVEQLNNI--LVIGMTNRKDLIDEALLR 167
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 282-418 1.39e-19

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 85.50  E-value: 1.39e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396    282 PPRGVLLFGPPGTGKTLIAKSIASQAK---AKFFSINPSSLTS--------------KWVGDAEKLVKTLFAVAAAHQPA 344
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARALARELGppgGGVIYIDGEDILEevldqllliivggkKASGSGELRLRLALALARKLKPD 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24581396    345 IIFIDEVDSLLSKRSANENESTLRLKNEFLIHLDGaasneeiRVLVIGATNRPQELDEA-VRRRFVRRLYVPLPT 418
Cdd:smart00382  81 VLILDEITSLLDAEQEALLLLLEELRLLLLLKSEK-------NLTVILTTNDEKDLGPAlLRRRFDRRIVLLLIL 148
ycf46 CHL00195
Ycf46; Provisional
 283-457 6.63e-16

Ycf46; Provisional


Pssm-ID: 177094 [Multi-domain]  Cd Length: 489  Bit Score: 80.06  E-value: 6.63e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396  283 PRGVLLFGPPGTGKTLIAKSIASQAKAKFFSINPSSLTSKWVGDAEKLVKTLFAVAAAHQPAIIFIDEVDSLLSK-RSAN 361
Cdd:CHL00195 259 PRGLLLVGIQGTGKSLTAKAIANDWQLPLLRLDVGKLFGGIVGESESRMRQMIRIAEALSPCILWIDEIDKAFSNsESKG 338

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396  362 ENESTLRLKNEFLIHLdgaaSNEEIRVLVIGATNRPQELD-EAVRR-RFVRRLYVPLPTREARQKIIEKLIHQVK----H 435
Cdd:CHL00195 339 DSGTTNRVLATFITWL----SEKKSPVFVVATANNIDLLPlEILRKgRFDEIFFLDLPSLEEREKIFKIHLQKFRpkswK 414

                        170       180
                 ....*....|....*....|..
gi 24581396  436 NLDVRQvieLAELTDGYSGADV 457
Cdd:CHL00195 415 KYDIKK---LSKLSNKFSGAEI 433
RecA-like_Pch2-like cd19508
ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as ...
 284-414 5.79e-14

ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as Thyroid hormone receptor interactor 13 (TRIP13) and 16E1BP) is a key regulator of specific chromosomal events, like the control of G2/prophase processes such as DNA break formation and recombination, checkpoint signaling, and chromosome synapsis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion


Pssm-ID: 410916 [Multi-domain]  Cd Length: 199  Bit Score: 70.55  E-value: 5.79e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 284 RGVLLFGPPGTGKTLIAKSIASQ---------AKAKFFSINPSSLTSKWVGDAEKLVKTLF---AVAAAHQPAIIF--ID 349
Cdd:cd19508  53 RLVLLHGPPGTGKTSLCKALAQKlsirlssryRYGQLIEINSHSLFSKWFSESGKLVTKMFqkiQELIDDKDALVFvlID 132

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24581396 350 EVDSLLSKRSA----NENESTLRLKNEFLIHLDGAASNEEirVLVIGATNRPQELDEAVRRRFVRRLYV 414
Cdd:cd19508 133 EVESLAAARSAsssgTEPSDAIRVVNAVLTQIDRIKRYHN--NVILLTSNLLEKIDVAFVDRADIKQYI 199
RecA-like_ATAD3-like cd19512
ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase ...
 280-408 5.85e-14

ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase domains; ATPase AAA-domain protein 3 (ATAD3) is a ubiquitously expressed mitochondrial protein involved in mitochondrial dynamics, DNA-nucleoid structural organization, cholesterol transport and steroidogenesis. The ATAD3 gene family in human comprises three paralog genes: ATAD3A, ATAD3B and ATAD3C. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410920 [Multi-domain]  Cd Length: 150  Bit Score: 69.48  E-value: 5.85e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 280 RCPPRGVLLFGPPGTGKTLIAKSIASQAKAKFfsinpSSLTSkwvGDAEKLVKTlfAVAAAHQ----------PAIIFID 349
Cdd:cd19512  19 KGLYRNILFYGPPGTGKTLFAKKLALHSGMDY-----AIMTG---GDVAPMGRE--GVTAIHKvfdwantsrrGLLLFVD 88

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 350 EVDSLLSKRSANENESTLRLK-NEFLIHLdGAASNEEIRVLvigATNRPQELDEAVRRRF 408
Cdd:cd19512  89 EADAFLRKRSTEKISEDLRAAlNAFLYRT-GEQSNKFMLVL---ASNQPEQFDWAINDRI 144
RecA-like_Ycf46-like cd19507
ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of ...
 282-414 2.35e-13

ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of photosynthesis in cyanobacteria, especially in CO2 uptake and utilization. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410915 [Multi-domain]  Cd Length: 161  Bit Score: 67.78  E-value: 2.35e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 282 PPRGVLLFGPPGTGKTLIAKSIASQAKAKFFSINPSSLTSKWVGDAEKLVKTLFAVAAAHQPAIIFIDEVDSLLSKR-SA 360
Cdd:cd19507  30 TPKGLLLVGIQGTGKSLTAKAIAGVWQLPLLRLDMGRLFGGLVGESESRLRQMIQTAEAIAPCVLWIDEIEKGFSNAdSK 109

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 24581396 361 NENESTLRLKNEFLIHLdgaaSNEEIRVLVIGATNRPQEL-DEAVRR-RFVRRLYV 414
Cdd:cd19507 110 GDSGTSSRVLGTFLTWL----QEKKKPVFVVATANNVQSLpPELLRKgRFDEIFFV 161
RecA-like_IQCA1 cd19506
ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein ...
 284-401 2.14e-11

ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein regulatory complex subunit 11, DRC11 and IQCA) is an ATPase subunit of the nexin-dynein regulatory complex (N-DRC). The 9 + 2 axoneme of most motile cilia and flagella consists of nine outer doublet microtubules arranged in a ring surrounding a central pair of two singlet microtubules. The N-DRC complex maintains alignment between outer doublet microtubules and limits microtubule sliding in motile axonemes. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410914 [Multi-domain]  Cd Length: 160  Bit Score: 62.16  E-value: 2.14e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 284 RGVLLFGPPGTGKTLIAKSIASQAKAKFFSINPSSLTSKWVGDA--EKLVKTLFAVAAAHQPAIIFIDEVDSLLSKRSAN 361
Cdd:cd19506  27 KSLLLAGPSGVGKKMLVHAICTETGANLFNLSPSNIAGKYPGKNglQMMLHLVLKVARQLQPSVIWIGDAEKTFYKKVPK 106

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 24581396 362 ENEST--LRLKNEFLIHLDGAASneEIRVLVIGATNRPQELD 401
Cdd:cd19506 107 TEKQLdpKRLKKDLPKILKSLKP--EDRVLIVGTTSRPFEAD 146
T7SS_EccA TIGR03922
type VII secretion AAA-ATPase EccA; This model represents the AAA family ATPase, EccA, of the ...
 254-447 2.98e-10

type VII secretion AAA-ATPase EccA; This model represents the AAA family ATPase, EccA, of the actinobacterial flavor of type VII secretion systems. Species such as Mycobacterium tuberculosis have several instances of this system per genome, designated EccA1, EccA2, etc. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 188437 [Multi-domain]  Cd Length: 557  Bit Score: 62.55  E-value: 2.98e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396   254 GLESAK---STFLEAIIMPLRRPDLFTGVRCPPRGVLLFGPPGTGKTLIAKSIASQ-------AKAKFFSINPSSLTSKW 323
Cdd:TIGR03922 280 GLERVKrqvAALKSSTAMALARAERGLPVAQTSNHMLFAGPPGTGKTTIARVVAKIycglgvlRKPLVREVSRADLIGQY 359

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396   324 VGDAEKLVKTLFAVAAAhqpAIIFIDEVDSLLSKRSANENESTLRLKNEFLIHLDgaasNEEIRVLVIGATNRPQ----- 398
Cdd:TIGR03922 360 IGESEAKTNEIIDSALG---GVLFLDEAYTLVETGYGQKDPFGLEAIDTLLARME----NDRDRLVVIGAGYRKDldkfl 432

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396   399 ELDEAVRRRFVRRL----YVP-----LPTR--EARQKIIEKLIHQ--------------------VKHNLD-------VR 440
Cdd:TIGR03922 433 EVNEGLRSRFTRVIefpsYSPdelveIARRmaTERDSVLDDAAADalleaattlaqdttpdangdLRRGLDiagngrfVR 512


                  ....*..
gi 24581396   441 QVIELAE 447
Cdd:TIGR03922 513 NVVERAE 519
RecA-like_BCS1 cd19510
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ...
 284-407 3.74e-10

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410918 [Multi-domain]  Cd Length: 153  Bit Score: 58.52  E-value: 3.74e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 284 RGVLLFGPPGTGKTLIaksIASQAKAKFFSINPSSLTSkwVGDAEKLVKTLFAVAAahQPAIIFIDEVDSLLSKRSAN-- 361
Cdd:cd19510  24 RGYLLYGPPGTGKSSF---IAALAGELDYDICDLNLSE--VVLTDDRLNHLLNTAP--KQSIILLEDIDAAFESREHNkk 96

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 24581396 362 -----ENESTLRLkNEFLIHLDGAASNEEiRVLVIgATNRPQELDEAVRRR 407
Cdd:cd19510  97 npsayGGLSRVTF-SGLLNALDGVASSEE-RIVFM-TTNHIERLDPALIRP 144
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
 286-355 9.16e-10

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 60.48  E-value: 9.16e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24581396  286 VLLFGPPGTGKTLIAKSIASQAKAKFFSINpsSLTSKwVGDAEKLVKTLFAVAAAHQPAIIFIDEV--------DSLL 355
Cdd:PRK13342  39 MILWGPPGTGKTTLARIIAGATDAPFEALS--AVTSG-VKDLREVIEEARQRRSAGRRTILFIDEIhrfnkaqqDALL 113
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 285-408 1.32e-09

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 56.53  E-value: 1.32e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396   285 GVLLFGPPGTGKTLIAKSIAS----------QAKAK------FFSINPSSLTSKWVgDAEklvktlfAVAAAHQPAIIFI 348
Cdd:pfam07728   1 GVLLVGPPGTGKTELAERLAAalsnrpvfyvQLTRDtteedlFGRRNIDPGGASWV-DGP-------LVRAAREGEIAVL 72

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24581396   349 DEVDsllsKRSANENESTLRLKNEflIHLDGAASNEEIRV-----LVIGATNRP----QELDEAVRRRF 408
Cdd:pfam07728  73 DEIN----RANPDVLNSLLSLLDE--RRLLLPDGGELVKAapdgfRLIATMNPLdrglNELSPALRSRF 135
RarA COG2256
Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, ...
 269-355 5.85e-09

Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, recombination and repair];


Pssm-ID: 441857 [Multi-domain]  Cd Length: 439  Bit Score: 58.14  E-value: 5.85e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 269 PLRRpdLFTGVRCPPrgVLLFGPPGTGKTLIAKSIASQAKAKFFSINPSslTSKwVGDAEKLVKTLFAVAAAHQPAIIFI 348
Cdd:COG2256  39 PLRR--AIEAGRLSS--MILWGPPGTGKTTLARLIANATDAEFVALSAV--TSG-VKDIREVIEEARERRAYGRRTILFV 111

                        90
                ....*....|....*
gi 24581396 349 DEV--------DSLL 355
Cdd:COG2256 112 DEIhrfnkaqqDALL 126
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
 286-448 1.76e-08

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 55.94  E-value: 1.76e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 286 VLLFGPPGTGKTLIAKSIASQAKAKFFSIN------PSSLTSKWVGDAEK----LVK-TLFAVaaahqpaIIFIDEVD-- 352
Cdd:COG0714  34 LLLEGVPGVGKTTLAKALARALGLPFIRIQftpdllPSDILGTYIYDQQTgefeFRPgPLFAN-------VLLADEINra 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 353 ------SLL---SKRS---ANEnesTLRLKNEFlihldgaasneeirvLVIgATNRPQE------LDEAVRRRFVRRLYV 414
Cdd:COG0714 107 ppktqsALLeamEERQvtiPGG---TYKLPEPF---------------LVI-ATQNPIEqegtypLPEAQLDRFLLKLYI 167

                       170       180       190
                ....*....|....*....|....*....|....
gi 24581396 415 PLPTREARQKIIEKliHQVKHNLDVRQVIELAEL 448
Cdd:COG0714 168 GYPDAEEEREILRR--HTGRHLAEVEPVLSPEEL 199
RecA-like_Ycf2 cd19505
ATPase domain of plant YCF2; Ycf2 is a chloroplast ATPase which has an essential function; ...
 282-403 3.13e-08

ATPase domain of plant YCF2; Ycf2 is a chloroplast ATPase which has an essential function; however, its function remains unclear. The gene encoding YCF2 is the largest known plastid gene in angiosperms and has been used to predict phylogenetic relationships. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410913 [Multi-domain]  Cd Length: 161  Bit Score: 53.15  E-value: 3.13e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 282 PPRGVLLFGPPGTGKTLIAKSIASQA---------------KAKFFSINPSSLTSKWVGDAEKLVKTlFAVAAAHQPAII 346
Cdd:cd19505  11 PSKGILLIGSIETGRSYLIKSLAANSyvplirislnkllynKPDFGNDDWIDGMLILKESLHRLNLQ-FELAKAMSPCII 89

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 24581396 347 FIDEVDSLLSKRSANE-NESTLRLKNEFLIHLDGAASNEEIR-VLVIGATNRPQELDEA 403
Cdd:cd19505  90 WIPNIHELNVNRSTQNlEEDPKLLLGLLLNYLSRDFEKSSTRnILVIASTHIPQKVDPA 148
RecA-like_HslU cd19498
ATP-dependent protease ATPase subunit HslU; HslU is a component of the ATP-dependent protease ...
 252-364 7.11e-08

ATP-dependent protease ATPase subunit HslU; HslU is a component of the ATP-dependent protease HslVU. In HslVU, HslU ATPase serves to unfold and translocate protein substrate, and the HslV protease degrades the unfolded proteins. This RecA-like_HslU subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410906 [Multi-domain]  Cd Length: 183  Bit Score: 52.38  E-value: 7.11e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 252 IAGLESAKSTFLEAIIMPLRRPDLFTGVR--CPPRGVLLFGPPGTGKTLIAKSIASQAKAKFFSINPSSLTS-KWVG-DA 327
Cdd:cd19498  13 IIGQDEAKRAVAIALRNRWRRMQLPEELRdeVTPKNILMIGPTGVGKTEIARRLAKLAGAPFIKVEATKFTEvGYVGrDV 92

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 24581396 328 EKLVKTLFAvaaahqpAIIFIDEVDSLLSKRSANENE 364
Cdd:cd19498  93 ESIIRDLVE-------GIVFIDEIDKIAKRGGSSGPD 122
RecA-like_superfamily cd01120
RecA-like_NTPases; RecA-like NTPases. This superfamily includes the NTP binding domain of F1 ...
 286-401 1.93e-07

RecA-like_NTPases; RecA-like NTPases. This superfamily includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410865 [Multi-domain]  Cd Length: 119  Bit Score: 49.81  E-value: 1.93e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 286 VLLFGPPGTGKTLIAKSIASQAKAK-----FFSInpssltskwvgdAEKLVKTLFAVAAAHQPAIIFIDEVDSLLSKRSA 360
Cdd:cd01120   1 ILITGPPGSGKTTLLLQFAEQALLSdepviFISF------------LDTILEAIEDLIEEKKLDIIIIDSLSSLARASQG 68

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 24581396 361 NENESTLrlknEFLIHLDGAASNEEIRVLVIgaTNRPQELD 401
Cdd:cd01120  69 DRSSELL----EDLAKLLRAARNTGITVIAT--IHSDKFDI 103
clpX PRK05342
ATP-dependent Clp protease ATP-binding subunit ClpX;
286-361 1.94e-07

ATP-dependent Clp protease ATP-binding subunit ClpX;


Pssm-ID: 235422 [Multi-domain]  Cd Length: 412  Bit Score: 53.24  E-value: 1.94e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396  286 VLLFGPPGTGKTLIAKSIasqakAKF----FSI-NPSSLT-SKWVG-DAEK-LVKTLFA----VAAAhQPAIIFIDEVDS 353
Cdd:PRK05342 111 ILLIGPTGSGKTLLAQTL-----ARIldvpFAIaDATTLTeAGYVGeDVENiLLKLLQAadydVEKA-QRGIVYIDEIDK 184


                 ....*...
gi 24581396  354 lLSKRSAN 361
Cdd:PRK05342 185 -IARKSEN 191
AAA_lid_3 pfam17862
AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the ...
 444-495 2.12e-07

AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.


Pssm-ID: 465537 [Multi-domain]  Cd Length: 45  Bit Score: 47.53  E-value: 2.12e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 24581396   444 ELAELTDGYSGADVDTLCRYASMAPLRsltpdqmevietHQLPAVTMDDFKQ 495
Cdd:pfam17862   6 ELAERTEGFSGADLEALCREAALAALR------------RGLEAVTQEDLEE 45
RecA-like_ClpX cd19497
ATP-dependent Clp protease ATP-binding subunit ClpX; ClpX is a component of the ATP-dependent ...
 286-368 2.83e-07

ATP-dependent Clp protease ATP-binding subunit ClpX; ClpX is a component of the ATP-dependent protease ClpXP. In ClpXP, ClpX ATPase serves to specifically recognize, unfold, and translocate protein substrates into the chamber of ClpP protease for degradation. This RecA-like_ClpX domain subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410905 [Multi-domain]  Cd Length: 251  Bit Score: 51.83  E-value: 2.83e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 286 VLLFGPPGTGKTLIAKSIASQAKAKFFSINPSSLT-SKWVG-DAEKLVKTL-----FAVAAAhQPAIIFIDEVDSLLSKr 358
Cdd:cd19497  53 ILLIGPTGSGKTLLAQTLAKILDVPFAIADATTLTeAGYVGeDVENILLKLlqaadYDVERA-QRGIVYIDEIDKIARK- 130

                        90
                ....*....|
gi 24581396 359 saNENESTLR 368
Cdd:cd19497 131 --SENPSITR 138
McrB COG1401
5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB ...
 255-456 7.01e-06

5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB [Defense mechanisms];


Pssm-ID: 441011 [Multi-domain]  Cd Length: 477  Bit Score: 48.61  E-value: 7.01e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 255 LESAKSTFLEAIIMPLRRPDLftgvrcpprgVLLFGPPGTGKT----LIAKSIASQAKAKFFSI--NPSsltskW----- 323
Cdd:COG1401 203 LREKFEETLEAFLAALKTKKN----------VILAGPPGTGKTylarRLAEALGGEDNGRIEFVqfHPS-----Wsyedf 267

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 324 ------VGDAEKLVKTL-----FAVAAAHQPA---IIFIDE-----VD-------SLLSKRSANENEStlrlkneflIHL 377
Cdd:COG1401 268 llgyrpSLDEGKYEPTPgiflrFCLKAEKNPDkpyVLIIDEinranVEkyfgellSLLESDKRGEELS---------IEL 338

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 378 DGAASNEEIRV----LVIGATN---RPQEL-DEAVRRRFVRRLYVPLPTREARQKIIEKLIhqvkhnlDVRQVIELAELT 449
Cdd:COG1401 339 PYSGEGEEFSIppnlYIIGTMNtddRSLALsDKALRRRFTFEFLDPDLDKLSNEEVVDLLE-------ELNEILEKRDFQ 411


                ....*..
gi 24581396 450 DGYSGAD 456
Cdd:COG1401 412 IGHRALL 418
CDC6 COG1474
Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];
282-408 1.71e-05

Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];


Pssm-ID: 441083 [Multi-domain]  Cd Length: 389  Bit Score: 47.15  E-value: 1.71e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 282 PPRGVLLFGPPGTGKTLIAKSIASQAKA---------KFFSINPSSLTSKW---------VGDAEKLVKT------LF-- 335
Cdd:COG1474  50 RPSNVLIYGPTGTGKTAVAKYVLEELEEeaeergvdvRVVYVNCRQASTRYrvlsrileeLGSGEDIPSTglstdeLFdr 129

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 336 ---AVAAAHQPAIIFIDEVDSLLSKrsanENESTL----RLkNEFLihldgaasnEEIRVLVIGATNRPQ---ELDEAVR 405
Cdd:COG1474 130 lyeALDERDGVLVVVLDEIDYLVDD----EGDDLLyqllRA-NEEL---------EGARVGVIGISNDLEfleNLDPRVK 195


                ...
gi 24581396 406 RRF 408
Cdd:COG1474 196 SSL 198
RecA-like_Lon cd19500
lon protease homolog 2 peroxisomal; Lon protease (also known as Lon peptidase) is an ...
 250-314 2.39e-05

lon protease homolog 2 peroxisomal; Lon protease (also known as Lon peptidase) is an evolutionarily conserved ATP-dependent serine protease, present in bacteria and eukaryotic mitochondria and peroxisomes, which mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Lon protease is both an ATP-dependent peptidase and a protein-activated ATPase. This RecA-like Lon domain subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410908 [Multi-domain]  Cd Length: 182  Bit Score: 44.86  E-value: 2.39e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24581396 250 EDIAGLESAKSTFLEAIIMPLRRPDLFTGVRCpprgvlLFGPPGTGKTLIAKSIASQAKAKFFSI 314
Cdd:cd19500  10 ADHYGLEDVKERILEYLAVRKLKGSMKGPILC------LVGPPGVGKTSLGKSIARALGRKFVRI 68
ClpX COG1219
ATP-dependent protease Clp, ATPase subunit ClpX [Posttranslational modification, protein ...
 286-361 2.44e-05

ATP-dependent protease Clp, ATPase subunit ClpX [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440832 [Multi-domain]  Cd Length: 409  Bit Score: 46.58  E-value: 2.44e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 286 VLLFGPPGTGKTLIAKSIAsqakaKF----FSI-NPSSLT-SKWVG-DAEK-LVKTLFA----VAAAhQPAIIFIDEVDS 353
Cdd:COG1219 112 ILLIGPTGSGKTLLAQTLA-----RIldvpFAIaDATTLTeAGYVGeDVENiLLKLLQAadydVEKA-ERGIIYIDEIDK 185


                ....*...
gi 24581396 354 lLSKRSAN 361
Cdd:COG1219 186 -IARKSEN 192
Vps4_C pfam09336
Vps4 C terminal oligomerization domain; This domain is found at the C terminal of ATPase ...
 480-520 7.12e-05

Vps4 C terminal oligomerization domain; This domain is found at the C terminal of ATPase proteins involved in vacuolar sorting. It forms an alpha helix structure and is required for oligomerization.


Pssm-ID: 462762 [Multi-domain]  Cd Length: 61  Bit Score: 40.56  E-value: 7.12e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 24581396   480 IETHQL--PAVTMDDFKQALRVISKSVSSEDCKQFEAWNEIYG 520
Cdd:pfam09336  19 IPSDKLlePPVTMKDFLKALKSSRPTVSKEDLEKYEEFTKEFG 61
AAA_16 pfam13191
AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the ...
 283-412 7.19e-05

AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.


Pssm-ID: 433025 [Multi-domain]  Cd Length: 167  Bit Score: 43.26  E-value: 7.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396   283 PRGVLLFGPPGTGKTLIAKSIASQAK--------AKFFSINPSSLTSKwVGDAEKLVKTLFAVAAAHQPAiIFIDEVDSL 354
Cdd:pfam13191  24 PPSVLLTGEAGTGKTTLLRELLRALErdggyflrGKCDENLPYSPLLE-ALTREGLLRQLLDELESSLLE-AWRAALLEA 101

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 24581396   355 LSKRSANENESTLRLKNEFLIHLDGAASNEEIRVLVIGATNRPQELDEAVRRRFVRRL 412
Cdd:pfam13191 102 LAPVPELPGDLAERLLDLLLRLLDLLARGERPLVLVLDDLQWADEASLQLLAALLRLL 159
clpA PRK11034
ATP-dependent Clp protease ATP-binding subunit; Provisional
 287-446 1.57e-04

ATP-dependent Clp protease ATP-binding subunit; Provisional


Pssm-ID: 236828 [Multi-domain]  Cd Length: 758  Bit Score: 44.44  E-value: 1.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396  287 LLFGPPGTGKTLIAKSIASQ----------AKAKFFSINPSSLT--SKWVGDAEKLVKTLFAVAAAHQPAIIFIDEVDSL 354
Cdd:PRK11034 211 LLVGESGVGKTAIAEGLAWRivqgdvpevmADCTIYSLDIGSLLagTKYRGDFEKRFKALLKQLEQDTNSILFIDEIHTI 290

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396  355 LSKRSANENEstlrlkneflihLDGA------ASNEEIRvlVIGATNRPQ-----ELDEAVRRRFvRRLYVPLPTREARQ 423
Cdd:PRK11034 291 IGAGAASGGQ------------VDAAnlikplLSSGKIR--VIGSTTYQEfsnifEKDRALARRF-QKIDITEPSIEETV 355

                        170       180       190
                 ....*....|....*....|....*....|
gi 24581396  424 KIIEKLI------HQVKH-NLDVRQVIELA 446
Cdd:PRK11034 356 QIINGLKpkyeahHDVRYtAKAVRAAVELA 385
clpC CHL00095
Clp protease ATP binding subunit
 288-437 2.47e-04

Clp protease ATP binding subunit


Pssm-ID: 214361 [Multi-domain]  Cd Length: 821  Bit Score: 43.89  E-value: 2.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396  288 LFGPPGTGKTLIAKSIA---SQAKAKFFSINPSSLT---------SKWVGDAEKLVKTLFAVAAAHQPAIIFIDEVDSLL 355
Cdd:CHL00095 205 LIGEPGVGKTAIAEGLAqriVNRDVPDILEDKLVITldiglllagTKYRGEFEERLKRIFDEIQENNNIILVIDEVHTLI 284

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396  356 SKRSAnenESTLRLKN---EFL----IHLDGAASNEEIRVLVigatnrpqELDEAVRRRFvRRLYVPLPTREARQKIIEK 428
Cdd:CHL00095 285 GAGAA---EGAIDAANilkPALargeLQCIGATTLDEYRKHI--------EKDPALERRF-QPVYVGEPSVEETIEILFG 352

                        170
                 ....*....|.
gi 24581396  429 L--IHQVKHNL 437
Cdd:CHL00095 353 LrsRYEKHHNL 363
RAD55 COG0467
RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms];
283-391 2.98e-04

RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms];


Pssm-ID: 440235 [Multi-domain]  Cd Length: 221  Bit Score: 42.21  E-value: 2.98e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 283 PRG--VLLFGPPGTGKTLIAKSIASQA---------------------KAKFFSINPSSL------------TSKWVGDA 327
Cdd:COG0467  18 PRGssTLLSGPPGTGKTTLALQFLAEGlrrgekglyvsfeespeqllrRAESLGLDLEEYiesgllriidlsPEELGLDL 97

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24581396 328 EKLVKTLFAVAAAHQPAIIFIDEVDSLLskrSANENESTLRlknEFLIHLDGAASNEEIRVLVI 391
Cdd:COG0467  98 EELLARLREAVEEFGAKRVVIDSLSGLL---LALPDPERLR---EFLHRLLRYLKKRGVTTLLT 155
TIP49 COG1224
DNA helicase TIP49, TBP-interacting protein [Transcription];
284-334 8.50e-04

DNA helicase TIP49, TBP-interacting protein [Transcription];


Pssm-ID: 440837 [Multi-domain]  Cd Length: 452  Bit Score: 41.88  E-value: 8.50e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 24581396 284 RGVLLFGPPGTGKTLIAKSIASQ--AKAKFFSINPSSLTSKWVGDAEKLVKTL 334
Cdd:COG1224  65 KGILIVGPPGTGKTALAVAIARElgEDTPFVAISGSEIYSAELKKTEFLMQAL 117
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 286-427 1.13e-03

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 41.49  E-value: 1.13e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 286 VLLFGPPGTGKTLIAKSIASQ---AKAKFFSINPSSLTskwvgdAEKLVKTLF-----AVAAAHQPAI----------IF 347
Cdd:COG2204 157 VLITGESGTGKELVARAIHRLsprADGPFVAVNCAAIP------EELLESELFghekgAFTGAVARRIgkfeladggtLF 230

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 348 IDEVDSLlskrSANENESTLRLKNEFLIHLDGAASNEEIRVLVIGATNRPqeLDEAVRR-RFVRRLY-----VPL---PT 418
Cdd:COG2204 231 LDEIGEM----PLALQAKLLRVLQEREFERVGGNKPIPVDVRVIAATNRD--LEELVEEgRFREDLYyrlnvFPIelpPL 304


                ....*....
gi 24581396 419 REARQKIIE 427
Cdd:COG2204 305 RERREDIPL 313
AAA_2 pfam07724
AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected ...
 283-352 1.24e-03

AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400187 [Multi-domain]  Cd Length: 168  Bit Score: 39.87  E-value: 1.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396   283 PRGVLLF-GPPGTGKTLIAKSIASQ---AKAKFFSINPSSLT-----SKWVGDAEKLVK-----TLFAVAAAHQPAIIFI 348
Cdd:pfam07724   2 PIGSFLFlGPTGVGKTELAKALAELlfgDERALIRIDMSEYMeehsvSRLIGAPPGYVGyeeggQLTEAVRRKPYSIVLI 81


                  ....
gi 24581396   349 DEVD 352
Cdd:pfam07724  82 DEIE 85
TIP49 pfam06068
TIP49 P-loop domain; This family consists of the C-terminal region of several eukaryotic and ...
 284-330 1.40e-03

TIP49 P-loop domain; This family consists of the C-terminal region of several eukaryotic and archaeal RuvB-like 1 (Pontin or TIP49a) and RuvB-like 2 (Reptin or TIP49b) proteins. The N-terminal domain contains the pfam00004 domain. In zebrafish, the liebeskummer (lik) mutation, causes development of hyperplastic embryonic hearts. lik encodes Reptin, a component of a DNA-stimulated ATPase complex. Beta-catenin and Pontin, a DNA-stimulated ATPase that is often part of complexes with Reptin, are in the same genetic pathways. The Reptin/Pontin ratio serves to regulate heart growth during development, at least in part via the beta-catenin pathway. TBP-interacting protein 49 (TIP49) was originally identified as a TBP-binding protein, and two related proteins are encoded by individual genes, tip49a and b. Although the function of this gene family has not been elucidated, they are supposed to play a critical role in nuclear events because they interact with various kinds of nuclear factors and have DNA helicase activities.TIP49a has been suggested to act as an autoantigen in some patients with autoimmune diseases.


Pssm-ID: 399217 [Multi-domain]  Cd Length: 347  Bit Score: 41.14  E-value: 1.40e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 24581396   284 RGVLLFGPPGTGKTLIAKSIASQ--AKAKFFSINPSSLTSKWVGDAEKL 330
Cdd:pfam06068  51 RAVLIAGPPGTGKTALAIAISKElgEDTPFTSISGSEVYSLEMKKTEAL 99
IS21_help_AAA NF038214
IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was ...
 286-313 2.13e-03

IS21-like element helper ATPase IstB; This protein family model resembles PF01695, but was built to hit full-length AAA+ ATPases of IS21 family IS (insertion sequence) elements.


Pssm-ID: 439516  Cd Length: 232  Bit Score: 39.76  E-value: 2.13e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 24581396  286 VLLFGPPGTGKTLIAKSIASQA-----KAKFFS 313
Cdd:NF038214  93 VLLLGPPGTGKTHLAIALGYAAcrqgyRVRFTT 125
PRK04195 PRK04195
replication factor C large subunit; Provisional
 246-354 2.16e-03

replication factor C large subunit; Provisional


Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 40.67  E-value: 2.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396  246 PVAWEDIAGLESAKSTFLEAIIMPLRrpdlftGVrcPPRGVLLFGPPGTGKTLIAKSIASQAKAKFFSINPSSLTSKwvG 325
Cdd:PRK04195  10 PKTLSDVVGNEKAKEQLREWIESWLK------GK--PKKALLLYGPPGVGKTSLAHALANDYGWEVIELNASDQRTA--D 79

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 24581396  326 DAEKLV------KTLFavaaAHQPAIIFIDEVDSL 354
Cdd:PRK04195  80 VIERVAgeaatsGSLF----GARRKLILLDEVDGI 110
PHA02244 PHA02244
ATPase-like protein
 286-409 2.40e-03

ATPase-like protein


Pssm-ID: 107157 [Multi-domain]  Cd Length: 383  Bit Score: 40.49  E-value: 2.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396  286 VLLFGPPGTGKTLIAKSIASQAKAKFFSINPSSLTSKWVG--DAE-KLVKTLFaVAAAHQPAIIFIDEVDSLLSKRSANE 362
Cdd:PHA02244 122 VFLKGGAGSGKNHIAEQIAEALDLDFYFMNAIMDEFELKGfiDANgKFHETPF-YEAFKKGGLFFIDEIDASIPEALIII 200

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 24581396  363 NEStlrLKNEFLIHLDGAA-SNEEIRVLVIGAT---------NRPQELDEAVRRRFV 409
Cdd:PHA02244 201 NSA---IANKFFDFADERVtAHEDFRVISAGNTlgkgadhiyVARNKIDGATLDRFA 254
PRK13341 PRK13341
AAA family ATPase;
287-351 2.55e-03

AAA family ATPase;


Pssm-ID: 237354 [Multi-domain]  Cd Length: 725  Bit Score: 40.42  E-value: 2.55e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24581396  287 LLFGPPGTGKTLIAKSIASQAKAKFFSINpSSLTSkwvgdaeklVKTLFA-VAAAHQP-------AIIFIDEV 351
Cdd:PRK13341  56 ILYGPPGVGKTTLARIIANHTRAHFSSLN-AVLAG---------VKDLRAeVDRAKERlerhgkrTILFIDEV 118
KaiC-like cd01124
Circadian Clock Protein KaiC; KaiC is a circadian clock protein, most studied in cyanobacteria. ...
 283-377 2.56e-03

Circadian Clock Protein KaiC; KaiC is a circadian clock protein, most studied in cyanobacteria. KaiC, an autokinase, autophosphatase, and ATPase, is part of the core oscillator, composed of three proteins: KaiA, KaiB, and KaiC. The circadian oscillation is regulated via KaiC phosphorylation.


Pssm-ID: 410869 [Multi-domain]  Cd Length: 222  Bit Score: 39.55  E-value: 2.56e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 283 PRG--VLLFGPPGTGKTLIA-----------------------KSIASQAKAKFFSINPS-----------SLTSKWVGD 326
Cdd:cd01124  17 PKGsvTLLTGGPGTGKTLFGlqflyagakngepglfftfeespERLLRNAKSFGWDFDEMedegkliivdaPPTEAGRFS 96

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 24581396 327 AEKLVKTLFAVAAAHQPAIIFIDEVDSLlskRSANENESTLRlknEFLIHL 377
Cdd:cd01124  97 LDELLSRILSIIKSFKAKRVVIDSLSGL---RRAKEDQMRAR---RIVIAL 141
ruvB PRK00080
Holliday junction branch migration DNA helicase RuvB;
286-311 2.86e-03

Holliday junction branch migration DNA helicase RuvB;


Pssm-ID: 234619 [Multi-domain]  Cd Length: 328  Bit Score: 39.73  E-value: 2.86e-03
                         10        20
                 ....*....|....*....|....*.
gi 24581396  286 VLLFGPPGTGKTLIAKSIASQAKAKF 311
Cdd:PRK00080  54 VLLYGPPGLGKTTLANIIANEMGVNI 79
COG2842 COG2842
Bacteriophage DNA transposition protein, AAA+ family ATPase [Mobilome: prophages, transposons]; ...
 286-504 3.56e-03

Bacteriophage DNA transposition protein, AAA+ family ATPase [Mobilome: prophages, transposons];


Pssm-ID: 442090 [Multi-domain]  Cd Length: 254  Bit Score: 39.16  E-value: 3.56e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 286 VLLFGPPGTGKTLIAKSIASQAK-AKFFSINPSSlTSKWV--------------GDAEKLVKTLFAVAAAHQPAIIfIDE 350
Cdd:COG2842  53 GVVYGESGVGKTTAAREYANRNPnVIYVTASPSW-TSKELleelaeelgipappGTIADLRDRILERLAGTGRLLI-IDE 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 351 VDSLlsKRSANEnesTLRlknefLIHlDGAasneEIRVLVIGaTNRpqeLDEAVRR--RFVRRLYVPLPTREARQKIIEK 428
Cdd:COG2842 131 ADHL--KPKALE---ELR-----DIH-DET----GVGVVLIG-MER---LPAKLKRyeQLYSRIGFWVEFKPLSLEDVRA 191

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24581396 429 LIhQVKHNLDVRQVIE-LAELTDGYSGAdVDTLCRYASMAplrsltpdqmevIETHQLPAVTMDDFKQALRVISKSV 504
Cdd:COG2842 192 LA-EAWGELTDPDLLElLHRITRGNLRR-LDRTLRLAARA------------AKRNGLTKITLDHVRAAALMLGEGP 254
DnaC COG1484
DNA replication protein DnaC [Replication, recombination and repair];
284-313 5.37e-03

DNA replication protein DnaC [Replication, recombination and repair];


Pssm-ID: 441093 [Multi-domain]  Cd Length: 242  Bit Score: 38.61  E-value: 5.37e-03
                        10        20        30
                ....*....|....*....|....*....|....*
gi 24581396 284 RGVLLFGPPGTGKTLIAKSIASQA-----KAKFFS 313
Cdd:COG1484 100 ENLILLGPPGTGKTHLAIALGHEAcragyRVRFTT 134
Lon COG0466
ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, ...
 286-304 7.67e-03

ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440234 [Multi-domain]  Cd Length: 785  Bit Score: 39.23  E-value: 7.67e-03
                        10        20
                ....*....|....*....|
gi 24581396 286 VLLF-GPPGTGKTLIAKSIA 304
Cdd:COG0466 354 ILCLvGPPGVGKTSLGKSIA 373
ABC_ATPase cd00267
ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large ...
 286-409 8.17e-03

ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide-binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.


Pssm-ID: 213179 [Multi-domain]  Cd Length: 157  Bit Score: 37.22  E-value: 8.17e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581396 286 VLLFGPPGTGKTLIAKSIA-----SQAKAKFFSINPSSLTSKWVGDAEKLV-------KTLFAVAAA--HQPAIIFIDEV 351
Cdd:cd00267  28 VALVGPNGSGKSTLLRAIAgllkpTSGEILIDGKDIAKLPLEELRRRIGYVpqlsggqRQRVALARAllLNPDLLLLDEP 107

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 24581396 352 DSLLSKRSANENESTLRlkneflihldgAASNEEIRVLVIgaTNRPQELDEAVRRRFV 409
Cdd:cd00267 108 TSGLDPASRERLLELLR-----------ELAEEGRTVIIV--THDPELAELAADRVIV 152
PTB pfam08416
Phosphotyrosine-binding domain; The phosphotyrosine-binding domain (PTB, also ...
 4-50 8.87e-03

Phosphotyrosine-binding domain; The phosphotyrosine-binding domain (PTB, also phosphotyrosine-interaction or PI domain) in the protein tensin tends to be found at the C-terminus. Tensin is a multi-domain protein that binds to actin filaments and functions as a focal-adhesion molecule (focal adhesions are regions of plasma membrane through which cells attach to the extracellular matrix). Human tensin has actin-binding sites, an SH2 (pfam00017) domain and a region similar to the tumour suppressor PTEN. The PTB domain interacts with the cytoplasmic tails of beta integrin by binding to an NPXY motif.


Pssm-ID: 429984  Cd Length: 131  Bit Score: 36.56  E-value: 8.87e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 24581396     4 EQSSWRSKLLLICQQTRSSSESIHFAALKDHHARLQAcESMEKAMKE 50
Cdd:pfam08416  78 NDGRYNSILALVCQEPGQSKPDVHLFQCDELGAELIA-EDIESALSD 123
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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