U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    POC5 POC5 centriolar protein [ Homo sapiens (human) ]

    Gene ID: 134359, updated on 27-Dec-2024

    Summary

    Official Symbol
    POC5provided by HGNC
    Official Full Name
    POC5 centriolar proteinprovided by HGNC
    Primary source
    HGNC:HGNC:26658
    See related
    Ensembl:ENSG00000152359 MIM:617880; AllianceGenome:HGNC:26658
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C5orf37
    Summary
    Predicted to be involved in eye photoreceptor cell development. Located in centrosome; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis (RPKM 10.4), lymph node (RPKM 4.7) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See POC5 in Genome Data Viewer
    Location:
    5q13.3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (75674124..75717437, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (76155204..76198513, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (74969949..75013262, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene DNA polymerase kappa Neighboring gene RNA, U7 small nuclear 175 pseudogene Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:74861405-74862604 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22682 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22683 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:74884456-74885040 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:74905964-74906771 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:74906772-74907578 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:74907579-74908385 Neighboring gene ankyrin repeat and death domain containing 1B Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:74959194-74960393 Neighboring gene NANOG hESC enhancer GRCh37_chr5:74962804-74963305 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:74991871-74992409 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22684 Neighboring gene RNA, U6 small nuclear 680, pseudogene Neighboring gene uncharacterized LOC441087 Neighboring gene solute carrier family 25 member 5 pseudogene 9 Neighboring gene karyopherin subunit alpha 7 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
    EBI GWAS Catalog
    Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ35779, MGC120442, MGC120443, MGC120444

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in eye photoreceptor cell development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in centriole IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in photoreceptor connecting cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    centrosomal protein POC5
    Names
    POC5 centriolar protein homolog
    hPOC5
    protein of centriole 5
    proteome of centriole 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099271.2NP_001092741.1  centrosomal protein POC5 isoform 1

      See identical proteins and their annotated locations for NP_001092741.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC010245, BC010695, BJ991592, CA441610
      Consensus CDS
      CCDS47236.1
      UniProtKB/Swiss-Prot
      B4DJG7, Q494X7, Q494X9, Q6P085, Q8NA72
      UniProtKB/TrEMBL
      D6RDG4
      Related
      ENSP00000410216.2, ENST00000428202.7
      Conserved Domains (1) summary
      PRK14951
      Location:403537
      PRK14951; DNA polymerase III subunits gamma and tau; Provisional
    2. NM_152408.3NP_689621.2  centrosomal protein POC5 isoform 2

      See identical proteins and their annotated locations for NP_689621.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences in the presence and absence of exons at its 5' end, compared to variant 1. These differences produce a unique 5' UTR and cause translation initiation at a unique start codon, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.
      Source sequence(s)
      AC010245, BC101327, CA441610, DB448626
      Consensus CDS
      CCDS47237.1
      UniProtKB/TrEMBL
      D6RDG4
      Related
      ENSP00000399481.2, ENST00000446329.6
      Conserved Domains (1) summary
      cl26386
      Location:378512
      DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      75674124..75717437 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011543160.2XP_011541462.1  centrosomal protein POC5 isoform X4

      See identical proteins and their annotated locations for XP_011541462.1

      UniProtKB/TrEMBL
      D6RDG4
      Conserved Domains (1) summary
      PRK14951
      Location:286420
      PRK14951; DNA polymerase III subunits gamma and tau; Provisional
    2. XM_047416725.1XP_047272681.1  centrosomal protein POC5 isoform X3

      UniProtKB/TrEMBL
      D6RDG4
    3. XM_005248436.2XP_005248493.1  centrosomal protein POC5 isoform X1

      UniProtKB/TrEMBL
      D6RDG4
      Conserved Domains (2) summary
      COG1196
      Location:192375
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      PRK14951
      Location:376509
      PRK14951; DNA polymerase III subunits gamma and tau; Provisional
    4. XM_011543158.3XP_011541460.1  centrosomal protein POC5 isoform X2

      UniProtKB/TrEMBL
      D6RDG4
      Conserved Domains (1) summary
      PHA03247
      Location:403496
      PHA03247; large tegument protein UL36; Provisional
    5. XM_047416726.1XP_047272682.1  centrosomal protein POC5 isoform X4

      UniProtKB/TrEMBL
      D6RDG4
    6. XM_047416727.1XP_047272683.1  centrosomal protein POC5 isoform X4

      UniProtKB/TrEMBL
      D6RDG4
      Related
      ENSP00000426796.1, ENST00000510798.5
    7. XM_024454363.2XP_024310131.1  centrosomal protein POC5 isoform X6

    8. XM_024454362.2XP_024310130.1  centrosomal protein POC5 isoform X5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      76155204..76198513 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054351629.1XP_054207604.1  centrosomal protein POC5 isoform X4

      UniProtKB/TrEMBL
      D6RDG4
    2. XM_054351628.1XP_054207603.1  centrosomal protein POC5 isoform X3

      UniProtKB/TrEMBL
      D6RDG4
    3. XM_054351626.1XP_054207601.1  centrosomal protein POC5 isoform X1

      UniProtKB/TrEMBL
      D6RDG4
    4. XM_054351627.1XP_054207602.1  centrosomal protein POC5 isoform X2

      UniProtKB/TrEMBL
      D6RDG4
    5. XM_054351630.1XP_054207605.1  centrosomal protein POC5 isoform X4

      UniProtKB/TrEMBL
      D6RDG4
    6. XM_054351631.1XP_054207606.1  centrosomal protein POC5 isoform X4

      UniProtKB/TrEMBL
      D6RDG4
    7. XM_054351633.1XP_054207608.1  centrosomal protein POC5 isoform X6

    8. XM_054351632.1XP_054207607.1  centrosomal protein POC5 isoform X5