U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CG11975 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41074, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CG11975provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037648
    Locus tag
    Dmel_CG11975
    See related
    AllianceGenome:FB:FBgn0037648
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG11975
    Summary
    Predicted to enable phosphatidylinositol-3,5-bisphosphate binding activity and phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in autophagy of mitochondrion and macroautophagy. Predicted to be active in cytosol and phagophore assembly site membrane. Orthologous to human WDR45B (WD repeat domain 45B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CG11975 in Genome Data Viewer
    Location:
    85C1-85C1; 3-48 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (8993253..8995212)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (4818975..4820934)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Carbonic anhydrase beta Neighboring gene Ras-related GTP binding A/B Neighboring gene uncharacterized protein Neighboring gene Enhancer of variegation 3-9 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Proteasome beta3 subunit

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Phosphatidylinositol 3,5-bisphosphate: metabolism and cellular functions. Michell RH, et al. Trends Biochem Sci, 2006 Jan. PMID 16364647
    2. Svp1p defines a family of phosphatidylinositol 3,5-bisphosphate effectors. Dove SK, et al. EMBO J, 2004 May 5. PMID 15103325, Free PMC Article
    3. The SAC1 domain in synaptojanin is required for autophagosome maturation at presynaptic terminals. Vanhauwaert R, et al. EMBO J, 2017 May 15. PMID 28331029, Free PMC Article
    4. E(var)3-9 of Drosophila melanogaster encodes a zinc finger protein. Weiler KS. Genetics, 2007 Sep. PMID 17660546, Free PMC Article
    5. Copper homeostasis gene discovery in Drosophila melanogaster. Norgate M, et al. Biometals, 2007 Jun. PMID 17216353

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables phosphatidylinositol-3,5-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagy of mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in autophagy of peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein lipidation involved in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to phagophore assembly site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in phagophore assembly site membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    uncharacterized protein
    Names
    CG11975-PA
    CG11975-PB
    PROPPIN-3

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      8993253..8995212
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275465.1 → NP_001262394.1  uncharacterized protein Dmel_CG11975, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262394.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VHJ2
      Conserved Domains (2) summary
      sd00039
      Location:102 → 136
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:141 → 265
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_141596.2 → NP_649853.1  uncharacterized protein Dmel_CG11975, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649853.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VHJ2
      Related
      FBpp0081440
      Conserved Domains (2) summary
      sd00039
      Location:102 → 136
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:141 → 265
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VHJ2 Q9VHJ2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous