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Conserved domains on  [gi|24645218|ref|NP_649853|]
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uncharacterized protein Dmel_CG11975, isoform A [Drosophila melanogaster]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
70-265 2.52e-12

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 67.24  E-value: 2.52e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24645218  70 GGGIRPLYPPNKVIVWD-DLKKSPAISLDFNQPVRAVRLRRD--RIVVVLE-GVIKVFTfTQQPQQLHVFETSSNP-NGL 144
Cdd:COG2319  90 GRLLASASADGTVRLWDlATGLLLRTLTGHTGAVRSVAFSPDgkTLASGSAdGTVRLWD-LATGKLLRTLTGHSGAvTSV 168

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24645218 145 CVlcpHSNKSLLAfPGRRTGHVQIVDLAnTERAPLEVIAHEAGISCIALNLQGTRLATAGEKGTlIRIFDTESGKKVSEL 224
Cdd:COG2319 169 AF---SPDGKLLA-SGSDDGTVRLWDLA-TGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGT-VRLWDLATGKLLRTL 242

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 24645218 225 RRGSNhaNIFCINFNHQSTMVVVASDHGTIHVFNLEDNKPR 265
Cdd:COG2319 243 TGHSG--SVRSVAFSPDGRLLASGSADGTVRLWDLATGELL 281
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
70-265 2.52e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 67.24  E-value: 2.52e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24645218  70 GGGIRPLYPPNKVIVWD-DLKKSPAISLDFNQPVRAVRLRRD--RIVVVLE-GVIKVFTfTQQPQQLHVFETSSNP-NGL 144
Cdd:COG2319  90 GRLLASASADGTVRLWDlATGLLLRTLTGHTGAVRSVAFSPDgkTLASGSAdGTVRLWD-LATGKLLRTLTGHSGAvTSV 168

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24645218 145 CVlcpHSNKSLLAfPGRRTGHVQIVDLAnTERAPLEVIAHEAGISCIALNLQGTRLATAGEKGTlIRIFDTESGKKVSEL 224
Cdd:COG2319 169 AF---SPDGKLLA-SGSDDGTVRLWDLA-TGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGT-VRLWDLATGKLLRTL 242

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 24645218 225 RRGSNhaNIFCINFNHQSTMVVVASDHGTIHVFNLEDNKPR 265
Cdd:COG2319 243 TGHSG--SVRSVAFSPDGRLLASGSADGTVRLWDLATGELL 281
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 141-265 2.46e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 63.51  E-value: 2.46e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24645218 141 PNGLCVLCPHSNKSLLAFpGRRTGHVQIVDLaNTERAPLEVIAHEAGISCIALNLQGTRLATAGEKGTlIRIFDTESGKK 220
Cdd:cd00200   9 TGGVTCVAFSPDGKLLAT-GSGDGTIKVWDL-ETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKT-IRLWDLETGEC 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 24645218 221 VSELRrgsNHAN-IFCINFNHQSTMVVVASDHGTIHVFNLEDNKPR 265
Cdd:cd00200  86 VRTLT---GHTSyVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCL 128
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 183-214 7.59e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 33.83  E-value: 7.59e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 24645218    183 AHEAGISCIALNLQGTRLATAGEKGTlIRIFD 214
Cdd:smart00320  10 GHTGPVTSVAFSPDGKYLASGSDDGT-IKLWD 40
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
70-265 2.52e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 67.24  E-value: 2.52e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24645218  70 GGGIRPLYPPNKVIVWD-DLKKSPAISLDFNQPVRAVRLRRD--RIVVVLE-GVIKVFTfTQQPQQLHVFETSSNP-NGL 144
Cdd:COG2319  90 GRLLASASADGTVRLWDlATGLLLRTLTGHTGAVRSVAFSPDgkTLASGSAdGTVRLWD-LATGKLLRTLTGHSGAvTSV 168

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24645218 145 CVlcpHSNKSLLAfPGRRTGHVQIVDLAnTERAPLEVIAHEAGISCIALNLQGTRLATAGEKGTlIRIFDTESGKKVSEL 224
Cdd:COG2319 169 AF---SPDGKLLA-SGSDDGTVRLWDLA-TGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGT-VRLWDLATGKLLRTL 242

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 24645218 225 RRGSNhaNIFCINFNHQSTMVVVASDHGTIHVFNLEDNKPR 265
Cdd:COG2319 243 TGHSG--SVRSVAFSPDGRLLASGSADGTVRLWDLATGELL 281
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 141-265 2.46e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 63.51  E-value: 2.46e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24645218 141 PNGLCVLCPHSNKSLLAFpGRRTGHVQIVDLaNTERAPLEVIAHEAGISCIALNLQGTRLATAGEKGTlIRIFDTESGKK 220
Cdd:cd00200   9 TGGVTCVAFSPDGKLLAT-GSGDGTIKVWDL-ETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKT-IRLWDLETGEC 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 24645218 221 VSELRrgsNHAN-IFCINFNHQSTMVVVASDHGTIHVFNLEDNKPR 265
Cdd:cd00200  86 VRTLT---GHTSyVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCL 128
WD40 COG2319
WD40 repeat [General function prediction only];
80-264 4.09e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.39  E-value: 4.09e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24645218  80 NKVIVWDDLKKSPAISLD-FNQPVRAVRLRRD-RIVVV--LEGVIKVFTfTQQPQQLHVFETSSN--------PNGlcvl 147
Cdd:COG2319 184 GTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDgKLLASgsADGTVRLWD-LATGKLLRTLTGHSGsvrsvafsPDG---- 258

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24645218 148 cphsnkSLLAFpGRRTGHVQIVDLAnTERAPLEVIAHEAGISCIALNLQGTRLATAGEKGTlIRIFDTESGKKVSELRrg 227
Cdd:COG2319 259 ------RLLAS-GSADGTVRLWDLA-TGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGT-VRLWDLATGKLLRTLT-- 327

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 24645218 228 SNHANIFCINFNHQSTMVVVASDHGTIHVFNLEDNKP 264
Cdd:COG2319 328 GHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGEL 364
WD40 COG2319
WD40 repeat [General function prediction only];
80-264 2.17e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.47  E-value: 2.17e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24645218  80 NKVIVWDDLKKSPAISL-DFNQPVRAVRLRRD--RIVVVLE-GVIKVFTfTQQPQQLHVFETSSNP-NGLCVlcpHSNKS 154
Cdd:COG2319 142 GTVRLWDLATGKLLRTLtGHSGAVTSVAFSPDgkLLASGSDdGTVRLWD-LATGKLLRTLTGHTGAvRSVAF---SPDGK 217

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24645218 155 LLAFpGRRTGHVQIVDLAnTERAPLEVIAHEAGISCIALNLQGTRLATAGEKGTlIRIFDTESGKKVSELRRGSNHanIF 234
Cdd:COG2319 218 LLAS-GSADGTVRLWDLA-TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGT-VRLWDLATGELLRTLTGHSGG--VN 292

                       170       180       190
                ....*....|....*....|....*....|
gi 24645218 235 CINFNHQSTMVVVASDHGTIHVFNLEDNKP 264
Cdd:COG2319 293 SVAFSPDGKLLASGSDDGTVRLWDLATGKL 322
WD40 COG2319
WD40 repeat [General function prediction only];
82-265 2.95e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.08  E-value: 2.95e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24645218  82 VIVWDDLKKSPAISLDFNQPVRAVRLRRDRIVVVL---EGVIKVFTFTQQPQQLHVFETSSNPNGLCVlcpHSNKSLLAF 158
Cdd:COG2319  61 LLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASasaDGTVRLWDLATGLLLRTLTGHTGAVRSVAF---SPDGKTLAS 137

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24645218 159 pGRRTGHVQIVDLAN-TERAPLEviAHEAGISCIALNLQGTRLATAGEKGTlIRIFDTESGKKVSELRRGSNhaNIFCIN 237
Cdd:COG2319 138 -GSADGTVRLWDLATgKLLRTLT--GHSGAVTSVAFSPDGKLLASGSDDGT-VRLWDLATGKLLRTLTGHTG--AVRSVA 211

                       170       180
                ....*....|....*....|....*...
gi 24645218 238 FNHQSTMVVVASDHGTIHVFNLEDNKPR 265
Cdd:COG2319 212 FSPDGKLLASGSADGTVRLWDLATGKLL 239
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 118-312 1.62e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 58.12  E-value: 1.62e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24645218 118 GVIKVFTFTQQpQQLHVFETSSNPNGLCVLCPHSNKSLLAFPGRRtghVQIVDLaNTERAPLEVIAHEAGISCIALNLQG 197
Cdd:cd00200  31 GTIKVWDLETG-ELLRTLKGHTGPVRDVAASADGTYLASGSSDKT---IRLWDL-ETGECVRTLTGHTSYVSSVAFSPDG 105

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24645218 198 TRLATAGEKGTlIRIFDTESGKKVSELRrgsNHAN-IFCINFNHQSTMVVVASDHGTIHVFNLEDNKPRE---------S 267
Cdd:cd00200 106 RILSSSSRDKT-IKVWDVETGKCLTTLR---GHTDwVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVAtltghtgevN 181

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 24645218 268 SLPIIPK----YFSSQWSFVKFSIPQGPRCVCAFGADPNSVVAICADGH 312
Cdd:cd00200 182 SVAFSPDgeklLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPD 230
WD40 COG2319
WD40 repeat [General function prediction only];
80-261 2.32e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.00  E-value: 2.32e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24645218  80 NKVIVWD-DLKKSPAISLDFNQPVRAVRLRRD-RIVVV--LEGVIKVFTfTQQPQQLHVFETSSNP-NGLCVlcpHSNKS 154
Cdd:COG2319 226 GTVRLWDlATGKLLRTLTGHSGSVRSVAFSPDgRLLASgsADGTVRLWD-LATGELLRTLTGHSGGvNSVAF---SPDGK 301

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24645218 155 LLAFpGRRTGHVQIVDLAnTERAPLEVIAHEAGISCIALNLQGTRLATAGEKGTlIRIFDTESGKKVSELRRGSNhaNIF 234
Cdd:COG2319 302 LLAS-GSDDGTVRLWDLA-TGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGT-VRLWDLATGELLRTLTGHTG--AVT 376

                       170       180
                ....*....|....*....|....*..
gi 24645218 235 CINFNHQSTMVVVASDHGTIHVFNLED 261
Cdd:COG2319 377 SVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 184-264 1.20e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 52.34  E-value: 1.20e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24645218 184 HEAGISCIALNLQGTRLATAGEKGTlIRIFDTESGKKvseLRRGSNHA-NIFCINFNHQSTMVVVASDHGTIHVFNLEDN 262
Cdd:cd00200   8 HTGGVTCVAFSPDGKLLATGSGDGT-IKVWDLETGEL---LRTLKGHTgPVRDVAASADGTYLASGSSDKTIRLWDLETG 83


                ..
gi 24645218 263 KP 264
Cdd:cd00200  84 EC 85
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 80-258 3.05e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 51.18  E-value: 3.05e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24645218  80 NKVIVWDDLKKSPAISLDF-NQPVRAVRLRRDRIVVV---LEGVIKVFTF-TQQPQQLHVFETSsnpNGLCVlCPHSNKS 154
Cdd:cd00200 115 KTIKVWDVETGKCLTTLRGhTDWVNSVAFSPDGTFVAsssQDGTIKLWDLrTGKCVATLTGHTG---EVNSV-AFSPDGE 190

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24645218 155 LLAFpGRRTGHVQIVDLaNTERAPLEVIAHEAGISCIALNlQGTRLATAGEKGTLIRIFDTESGKKVSELrrgSNHAN-I 233
Cdd:cd00200 191 KLLS-SSSDGTIKLWDL-STGKCLGTLRGHENGVNSVAFS-PDGYLLASGSEDGTIRVWDLRTGECVQTL---SGHTNsV 264

                       170       180
                ....*....|....*....|....*
gi 24645218 234 FCINFNHQSTMVVVASDHGTIHVFN 258
Cdd:cd00200 265 TSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
104-265 1.15e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 49.91  E-value: 1.15e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24645218 104 AVRLRRDRIVVVLEGVIKVFTFTQQPQQLHVFETSSNPNGLCVLCPHSNKSLLAFPGRRTghvqIVDLANTERAPLEVIA 183
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTL----LLLDAAAGALLATLLG 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24645218 184 HEAGISCIALNLQGTRLATAGEKGTlIRIFDTESGKKVSELRRGSNhaNIFCINFNHQSTMVVVASDHGTIHVFNLEDNK 263
Cdd:COG2319  77 HTAAVLSVAFSPDGRLLASASADGT-VRLWDLATGLLLRTLTGHTG--AVRSVAFSPDGKTLASGSADGTVRLWDLATGK 153


                ..
gi 24645218 264 PR 265
Cdd:COG2319 154 LL 155
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
130-262 2.49e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 41.99  E-value: 2.49e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24645218 130 QQLHVFETSSNPNGLCVlcpHSNKSLLAFPGRRTGHVQIVDLANteRAPLEVIAHEAGISCIALNLQGTRLATAGEKG-- 207
Cdd:COG3391 101 KVVATIPVGGGPRGLAV---DPDGGRLYVADSGNGRVSVIDTAT--GKVVATIPVGAGPHGIAVDPDGKRLYVANSGSnt 175

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24645218 208 --TLIRIFDTESGKKVSELRRGSnhaNIFCINFNHQSTMVVVASDH--------GTIHVFNLEDN 262
Cdd:COG3391 176 vsVIVSVIDTATGKVVATIPVGG---GPVGVAVSPDGRRLYVANRGsntsnggsNTVSVIDLATL 237
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
160-263 1.78e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 39.29  E-value: 1.78e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24645218 160 GRRTGHVQIVDLANteRAPLEVIAHEAGISCIALNLQGTRLATAGEKGTLIRIFDTESGKKVSELRRGSNHANIFcinFN 239
Cdd:COG3391  86 NSGSGRVSVIDLAT--GKVVATIPVGGGPRGLAVDPDGGRLYVADSGNGRVSVIDTATGKVVATIPVGAGPHGIA---VD 160

                        90       100
                ....*....|....*....|....*....
gi 24645218 240 HQSTMVVVAS-DHGTIH----VFNLEDNK 263
Cdd:COG3391 161 PDGKRLYVANsGSNTVSvivsVIDTATGK 189
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 183-214 7.59e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 33.83  E-value: 7.59e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 24645218    183 AHEAGISCIALNLQGTRLATAGEKGTlIRIFD 214
Cdd:smart00320  10 GHTGPVTSVAFSPDGKYLASGSDDGT-IKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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