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    Nprl3 Nitrogen permease regulator-like 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39550, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nprl3provided by FlyBase
    Official Full Name
    Nitrogen permease regulator-like 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0036397
    Locus tag
    Dmel_CG8783
    See related
    AllianceGenome:FB:FBgn0036397
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8783; Dmel\CG8783; GATOR1; Nplr3; NPR3; nprl3
    Summary
    Involved in several processes, including cellular response to amino acid starvation; negative regulation of TORC1 signaling; and negative regulation of cell size. Located in autolysosome and nucleus. Part of GATOR2 complex. Is expressed in organism. Used to study familial focal epilepsy with variable foci 3. Human ortholog(s) of this gene implicated in familial focal epilepsy with variable foci 3. Orthologous to human NPRL3 (NPR3 like, GATOR1 complex subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Nprl3 in Genome Data Viewer
    Location:
    70C11-70C11; 3-41 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (13999380..14001880, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (13992480..13994980, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Cathepsin K1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene upSET Neighboring gene PAX transcription activation domain interacting protein

    Genomic regions, transcripts, and products

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in TORC1 signaling  
    involved_in cellular response to amino acid starvation  
    involved_in cellular response to amino acid starvation PubMed 
    involved_in cellular response to starvation PubMed 
    involved_in germarium-derived egg chamber formation PubMed 
    involved_in negative regulation of TOR signaling  
    involved_in negative regulation of TOR signaling PubMed 
    involved_in negative regulation of TORC1 signaling  
    involved_in negative regulation of TORC1 signaling PubMed 
    involved_in negative regulation of TORC1 signaling PubMed 
    involved_in negative regulation of cell size PubMed 
    involved_in oogenesis PubMed 
    involved_in positive regulation of autophagy  
    involved_in positive regulation of macroautophagy PubMed 
    acts_upstream_of positive regulation of triglyceride catabolic process PubMed 
    Component Evidence Code Pubs
    part_of GATOR1 complex  
    part_of GATOR1 complex PubMed 
    part_of GATOR2 complex PubMed 
    part_of Seh1-associated complex PubMed 
    part_of Seh1-associated complex PubMed 
    located_in autolysosome PubMed 
    located_in cytoplasm PubMed 
    located_in lysosome PubMed 
    located_in nucleus PubMed 

    General protein information

    Preferred Names
    nitrogen permease regulator-like 3
    Names
    CG8783-PA
    CG8783-PB
    CG8783-PC
    Nprl3-PA
    Nprl3-PB
    Nprl3-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      13999380..14001880 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168570.1 → NP_729945.1  nitrogen permease regulator-like 3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729945.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V1X9, Q95RI3, Q9VUB4
      UniProtKB/TrEMBL
      B6IDY8
      Related
      FBpp0075527, FBtr0075785
      Conserved Domains (1) summary
      cl24021
      Location:76 → 413
      NPR3; Nitrogen Permease regulator of amino acid transport activity 3
    2. NM_140423.3 → NP_648680.2  nitrogen permease regulator-like 3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648680.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V1X9, Q95RI3, Q9VUB4
      UniProtKB/TrEMBL
      B6IDY8
      Related
      FBpp0075528
      Conserved Domains (1) summary
      cl24021
      Location:76 → 413
      NPR3; Nitrogen Permease regulator of amino acid transport activity 3
    3. NM_001274889.1 → NP_001261818.1  nitrogen permease regulator-like 3, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261818.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V1X9, Q95RI3, Q9VUB4
      UniProtKB/TrEMBL
      B6IDY8
      Conserved Domains (1) summary
      cl24021
      Location:76 → 413
      NPR3; Nitrogen Permease regulator of amino acid transport activity 3
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