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l(3)73Ah lethal (3) 73Ah [ Drosophila melanogaster (fruit fly) ]

Gene ID: 48903, updated on 4-Jan-2025

Summary

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Official Symbol
l(3)73Ahprovided by FlyBase
Official Full Name
lethal (3) 73Ahprovided by FlyBase
Primary source
FLYBASE:FBgn0002283
Locus tag
Dmel_CG4195
See related
AllianceGenome:FB:FBgn0002283
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4195; Dmel\CG4195; I(3)73Ah; l(3)02540; l(3)133.18; L(3)73Ah
Summary
Predicted to enable zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of PRC1 complex. Is expressed in fat body; organism; and ovary. Orthologous to human PCGF3 (polycomb group ring finger 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See l(3)73Ah in Genome Data Viewer
Location:
73A10-73A10; 3-44 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16588475..16590132)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16581575..16583232)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Ubiquinol-cytochrome c reductase core protein 2 Neighboring gene antisense RNA:CR45895 Neighboring gene Syntaxin 8 Neighboring gene uncharacterized protein Neighboring gene transformer Neighboring gene spindle defective 2 Neighboring gene Apollo Neighboring gene pseudo

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular genetics of transformer, a genetic switch controlling sexual differentiation in Drosophila. Belote JM, et al. Dev Genet, 1989. PMID 2472240
  2. Molecular genetic analysis of Suppressor 2 of zeste identifies key functional domains. Emmons RB, et al. Genetics, 2009 Aug. PMID 19528329, Free PMC Article
  3. The Drosophila melanogaster gene lethal(3)73Ah encodes a ring finger protein homologous to the oncoproteins MEL-18 and BMI-1. Irminger-Finger I, et al. Gene, 1995 Oct 3. PMID 7590267
  4. Interspecific comparison of the transformer gene of Drosophila reveals an unusually high degree of evolutionary divergence. O'Neil MT, et al. Genetics, 1992 May. PMID 1592233, Free PMC Article
  5. Drosophila abl tyrosine kinase in embryonic CNS axons: a role in axonogenesis is revealed through dosage-sensitive interactions with disabled. Gertler FB, et al. Cell, 1989 Jul 14. PMID 2502313

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables zinc ion binding ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of PRC1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
lethal (3) 73Ah
Names
CG4195-PA
CG4195-PB
l(3)73Ah-PA
l(3)73Ah-PB
lethal(3)73Ah

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    16588475..16590132
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080194.4 → NP_524933.1  lethal (3) 73Ah, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524933.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VV77
    Related
    FBpp0075071
    Conserved Domains (2) summary
    cd16735
    Location:13 → 59
    RING-HC_PCGF3; RING finger found in polycomb group RING finger protein 3 (PCGF3) and similar proteins
    cd17083
    Location:133 → 217
    RAWUL_PCGF3; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 3 (PCGF3) and similar proteins

  2. NM_001259868.2 → NP_001246797.1  lethal (3) 73Ah, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246797.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VV77
    Conserved Domains (2) summary
    cd16735
    Location:13 → 59
    RING-HC_PCGF3; RING finger found in polycomb group RING finger protein 3 (PCGF3) and similar proteins
    cd17083
    Location:133 → 217
    RAWUL_PCGF3; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 3 (PCGF3) and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VV77 Q9VV77

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