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    Eif4g1 eukaryotic translation initiation factor 4, gamma 1 [ Mus musculus (house mouse) ]

    Gene ID: 208643, updated on 4-Jan-2025

    Summary

    Official Symbol
    Eif4g1provided by MGI
    Official Full Name
    eukaryotic translation initiation factor 4, gamma 1provided by MGI
    Primary source
    MGI:MGI:2384784
    See related
    Ensembl:ENSMUSG00000045983 AllianceGenome:MGI:2384784
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    eIF4GI; eIF-4G1; eIF-4G 1; E030015G23Rik; eIF-4-gamma 1
    Summary
    This gene encodes a member of the eukaryotic translation initiation factors (eIF) that play important roles in translation initiation by mediating recruitment of additional initiation factors and providing a scaffold for ribosome/mRNA-bridging. Along with eIF4A and eIF4E, the encoded protein forms the eIF4F complex that bridges the 5' UTR with the polyadenylated 3' UTR resulting in mRNA circularization, enhanced translation initiation and mRNA stability. Through its association with eIF3, the encoded protein mediates recruitment of the 43S pre-initiation complex to mRNA. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes for this gene have been identified on chromosomes 2 and 13. [provided by RefSeq, Jan 2015]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 72.7), limb E14.5 (RPKM 65.1) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Eif4g1 in Genome Data Viewer
    Location:
    16 A3; 16 12.49 cM
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (20491457..20511633)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (20672720..20692883)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 Neighboring gene eukaryotic translation elongation factor 1 gamma pseudogene Neighboring gene small nucleolar RNA, C/D box 66 Neighboring gene family with sequence similarity 131, member A Neighboring gene STARR-seq mESC enhancer starr_40329 Neighboring gene chloride channel, voltage-sensitive 2 Neighboring gene STARR-positive B cell enhancer ABC_E1489 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide H

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3)  1 citation
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC37551, MGC90776

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP binding  
    enables eukaryotic initiation factor 4E binding  
    enables eukaryotic initiation factor 4E binding  
    enables mRNA binding  
    enables mRNA binding  
    enables mRNA binding  
    enables protein binding PubMed 
    enables translation factor activity, RNA binding  
    enables translation initiation factor activity  
    enables translation initiation factor activity  
    enables translation initiation factor activity  
    Items 1 - 25 of 36
    Process Evidence Code Pubs
    acts_upstream_of_or_within behavioral fear response PubMed 
    involved_in cellular response to nutrient levels  
    involved_in cellular response to nutrient levels  
    involved_in energy homeostasis  
    involved_in energy homeostasis  
    involved_in lung development  
    involved_in macromolecule biosynthetic process  
    involved_in miRNA-mediated gene silencing by inhibition of translation  
    involved_in miRNA-mediated gene silencing by inhibition of translation  
    involved_in negative regulation of autophagy  
    involved_in negative regulation of autophagy  
    involved_in negative regulation of peptidyl-threonine phosphorylation  
    acts_upstream_of neuron differentiation PubMed 
    involved_in positive regulation of G1/S transition of mitotic cell cycle  
    involved_in positive regulation of G1/S transition of mitotic cell cycle  
    involved_in positive regulation of cell growth  
    involved_in positive regulation of cell growth  
    involved_in positive regulation of eukaryotic translation initiation factor 4F complex assembly  
    involved_in positive regulation of eukaryotic translation initiation factor 4F complex assembly  
    involved_in positive regulation of mRNA cap binding  
    acts_upstream_of_or_within positive regulation of neuron differentiation PubMed 
    involved_in positive regulation of peptidyl-serine phosphorylation  
    involved_in positive regulation of protein localization to cell periphery  
    involved_in positive regulation of protein localization to cell periphery  
    involved_in positive regulation of protein metabolic process  
    involved_in positive regulation of translation in response to endoplasmic reticulum stress  
    involved_in positive regulation of translation in response to endoplasmic reticulum stress  
    involved_in regulation of presynapse assembly  
    involved_in regulation of presynapse assembly  
    involved_in regulation of translational initiation  
    involved_in regulation of translational initiation  
    involved_in response to ethanol  
    involved_in translation  
    involved_in translational initiation  
    involved_in translational initiation  
    involved_in translational initiation PubMed 
    Items 1 - 25 of 36
    Component Evidence Code Pubs
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in cytoplasmic stress granule  
    located_in cytoplasmic stress granule  
    located_in cytosol  
    located_in cytosol  
    part_of eukaryotic translation initiation factor 4F complex  
    part_of eukaryotic translation initiation factor 4F complex  
    part_of eukaryotic translation initiation factor 4F complex PubMed 
    located_in nucleus  
    located_in nucleus  
    located_in postsynapse  
    is_active_in postsynapse  
    located_in ribosome  
    located_in ribosome  

    General protein information

    Preferred Names
    eukaryotic translation initiation factor 4 gamma 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001304432.2NP_001291361.1  eukaryotic translation initiation factor 4 gamma 1 isoform c

      See identical proteins and their annotated locations for NP_001291361.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform c), compared to isoform a.
      Source sequence(s)
      AC087898
      Consensus CDS
      CCDS84213.1
      UniProtKB/TrEMBL
      A0A0J9YUS5
      Related
      ENSMUSP00000111123.2, ENSMUST00000115463.8
      Conserved Domains (3) summary
      cd11559
      Location:14271556
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      pfam02847
      Location:12281340
      MA3; MA3 domain
      pfam02854
      Location:758986
      MIF4G; MIF4G domain
    2. NM_001403460.1NP_001390389.1  eukaryotic translation initiation factor 4 gamma 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC087898
      UniProtKB/TrEMBL
      A0A0J9YUS5, E9PVC5
      Related
      ENSMUSP00000111121.2, ENSMUST00000115461.8
    3. NM_001403461.1NP_001390390.1  eukaryotic translation initiation factor 4 gamma 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC087898
      UniProtKB/TrEMBL
      A0A0J9YUS5, E9PVC5
    4. NM_001403462.1NP_001390391.1  eukaryotic translation initiation factor 4 gamma 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC087898
      UniProtKB/TrEMBL
      A0A0J9YUS5, E9Q9E1
      Related
      ENSMUSP00000073506.6, ENSMUST00000073840.12
    5. NM_001403463.1NP_001390392.1  eukaryotic translation initiation factor 4 gamma 1 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC087898
      UniProtKB/TrEMBL
      A0A0J9YUS5
    6. NM_001403464.1NP_001390393.1  eukaryotic translation initiation factor 4 gamma 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC087898
      UniProtKB/TrEMBL
      A0A0J9YUS5
    7. NM_001403465.1NP_001390394.1  eukaryotic translation initiation factor 4 gamma 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC087898
      UniProtKB/TrEMBL
      A0A0J9YUS5
    8. NM_001403466.1NP_001390395.1  eukaryotic translation initiation factor 4 gamma 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC087898
      UniProtKB/TrEMBL
      A0A0J9YUS5, E9PVC6
    9. NM_001403467.1NP_001390396.1  eukaryotic translation initiation factor 4 gamma 1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC087898
      UniProtKB/TrEMBL
      A0A0J9YUS5
    10. NM_001403468.1NP_001390397.1  eukaryotic translation initiation factor 4 gamma 1 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC087898
      UniProtKB/TrEMBL
      A0A0J9YUS5
      Related
      ENSMUST00000132320.8
    11. NM_145941.4NP_666053.2  eukaryotic translation initiation factor 4 gamma 1 isoform a

      See identical proteins and their annotated locations for NP_666053.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC087898
      Consensus CDS
      CCDS28055.1
      UniProtKB/Swiss-Prot
      Q6NZJ6, Q6NZN8, Q8BW99
      UniProtKB/TrEMBL
      A0A0J9YUS5
      Related
      ENSMUSP00000047678.8, ENSMUST00000044783.14
      Conserved Domains (5) summary
      cd11559
      Location:14411570
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      PHA03247
      Location:4463
      PHA03247; large tegument protein UL36; Provisional
      TIGR00600
      Location:373612
      rad2; DNA excision repair protein (rad2)
      pfam02847
      Location:12421354
      MA3; MA3 domain
      pfam02854
      Location:765993
      MIF4G; MIF4G domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      20491457..20511633
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521935.2XP_006521998.1  eukaryotic translation initiation factor 4 gamma 1 isoform X1

      See identical proteins and their annotated locations for XP_006521998.1

      UniProtKB/TrEMBL
      A0A0J9YUS5
      Conserved Domains (5) summary
      cd11559
      Location:14421571
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      PHA03247
      Location:4463
      PHA03247; large tegument protein UL36; Provisional
      TIGR00600
      Location:373612
      rad2; DNA excision repair protein (rad2)
      pfam02847
      Location:12431355
      MA3; MA3 domain
      pfam02854
      Location:766994
      MIF4G; MIF4G domain
    2. XM_006521937.2XP_006522000.1  eukaryotic translation initiation factor 4 gamma 1 isoform X2

      See identical proteins and their annotated locations for XP_006522000.1

      UniProtKB/Swiss-Prot
      Q6NZJ6, Q6NZN8, Q8BW99
      UniProtKB/TrEMBL
      A0A0J9YUS5
      Conserved Domains (5) summary
      cd11559
      Location:14411570
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      PHA03247
      Location:4463
      PHA03247; large tegument protein UL36; Provisional
      TIGR00600
      Location:373612
      rad2; DNA excision repair protein (rad2)
      pfam02847
      Location:12421354
      MA3; MA3 domain
      pfam02854
      Location:765993
      MIF4G; MIF4G domain
    3. XM_011245861.2XP_011244163.1  eukaryotic translation initiation factor 4 gamma 1 isoform X5

      UniProtKB/TrEMBL
      A0A0J9YUS5
      Conserved Domains (4) summary
      cd11559
      Location:14321561
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      PHA03247
      Location:7560
      PHA03247; large tegument protein UL36; Provisional
      pfam02847
      Location:12331345
      MA3; MA3 domain
      pfam02854
      Location:756984
      MIF4G; MIF4G domain
    4. XM_030249023.2XP_030104883.1  eukaryotic translation initiation factor 4 gamma 1 isoform X6

      UniProtKB/TrEMBL
      A0A0J9YUS5
      Conserved Domains (4) summary
      cd11559
      Location:14311560
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      PHA03247
      Location:7560
      PHA03247; large tegument protein UL36; Provisional
      pfam02847
      Location:12321344
      MA3; MA3 domain
      pfam02854
      Location:755983
      MIF4G; MIF4G domain
    5. XM_006521940.5XP_006522003.1  eukaryotic translation initiation factor 4 gamma 1 isoform X4

      UniProtKB/TrEMBL
      A0A0J9YUS5, E9Q9E1
      Conserved Domains (5) summary
      cd11559
      Location:14341563
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      PHA03247
      Location:4456
      PHA03247; large tegument protein UL36; Provisional
      TIGR00600
      Location:366605
      rad2; DNA excision repair protein (rad2)
      pfam02847
      Location:12351347
      MA3; MA3 domain
      pfam02854
      Location:758986
      MIF4G; MIF4G domain
    6. XM_006521944.4XP_006522007.1  eukaryotic translation initiation factor 4 gamma 1 isoform X10

      UniProtKB/TrEMBL
      A0A0J9YUS5
      Conserved Domains (5) summary
      cd11559
      Location:13951524
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      PHA03247
      Location:2523
      PHA03247; large tegument protein UL36; Provisional
      pfam05109
      Location:156415
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam02847
      Location:11961308
      MA3; MA3 domain
      pfam02854
      Location:719947
      MIF4G; MIF4G domain
    7. XM_006521943.2XP_006522006.1  eukaryotic translation initiation factor 4 gamma 1 isoform X9

      UniProtKB/TrEMBL
      A0A0J9YUS5
      Conserved Domains (4) summary
      cd11559
      Location:14021531
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      PHA03247
      Location:20530
      PHA03247; large tegument protein UL36; Provisional
      pfam02847
      Location:12031315
      MA3; MA3 domain
      pfam02854
      Location:726954
      MIF4G; MIF4G domain
    8. XM_036159852.1XP_036015745.1  eukaryotic translation initiation factor 4 gamma 1 isoform X11

      UniProtKB/TrEMBL
      A0A0J9YUS5, E9PVC6
      Related
      ENSMUSP00000111117.2, ENSMUST00000115457.8
      Conserved Domains (5) summary
      cd11559
      Location:13941523
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      PHA03247
      Location:2523
      PHA03247; large tegument protein UL36; Provisional
      pfam05109
      Location:156415
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam02847
      Location:11951307
      MA3; MA3 domain
      pfam02854
      Location:718946
      MIF4G; MIF4G domain
    9. XM_036159855.1XP_036015748.1  eukaryotic translation initiation factor 4 gamma 1 isoform X14

      UniProtKB/TrEMBL
      A0A0J9YUS5
      Conserved Domains (5) summary
      cd11559
      Location:13841513
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      TIGR00600
      Location:316555
      rad2; DNA excision repair protein (rad2)
      pfam05109
      Location:146405
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam02847
      Location:11851297
      MA3; MA3 domain
      pfam02854
      Location:708936
      MIF4G; MIF4G domain
    10. XM_006521936.3XP_006521999.1  eukaryotic translation initiation factor 4 gamma 1 isoform X1

      See identical proteins and their annotated locations for XP_006521999.1

      UniProtKB/TrEMBL
      A0A0J9YUS5
      Conserved Domains (5) summary
      cd11559
      Location:14421571
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      PHA03247
      Location:4463
      PHA03247; large tegument protein UL36; Provisional
      TIGR00600
      Location:373612
      rad2; DNA excision repair protein (rad2)
      pfam02847
      Location:12431355
      MA3; MA3 domain
      pfam02854
      Location:766994
      MIF4G; MIF4G domain
    11. XM_030249025.2XP_030104885.1  eukaryotic translation initiation factor 4 gamma 1 isoform X9

      UniProtKB/TrEMBL
      A0A0J9YUS5
      Conserved Domains (4) summary
      cd11559
      Location:14021531
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      PHA03247
      Location:20530
      PHA03247; large tegument protein UL36; Provisional
      pfam02847
      Location:12031315
      MA3; MA3 domain
      pfam02854
      Location:726954
      MIF4G; MIF4G domain
    12. XM_006521945.2XP_006522008.1  eukaryotic translation initiation factor 4 gamma 1 isoform X12

      UniProtKB/TrEMBL
      A0A0J9YUS5
      Conserved Domains (4) summary
      cd11559
      Location:13921521
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      PHA03247
      Location:73520
      PHA03247; large tegument protein UL36; Provisional
      pfam02847
      Location:11931305
      MA3; MA3 domain
      pfam02854
      Location:716944
      MIF4G; MIF4G domain
    13. XM_030249026.2XP_030104886.1  eukaryotic translation initiation factor 4 gamma 1 isoform X10

      UniProtKB/TrEMBL
      A0A0J9YUS5
      Conserved Domains (5) summary
      cd11559
      Location:13951524
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      PHA03247
      Location:2523
      PHA03247; large tegument protein UL36; Provisional
      pfam05109
      Location:156415
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam02847
      Location:11961308
      MA3; MA3 domain
      pfam02854
      Location:719947
      MIF4G; MIF4G domain
    14. XM_036159856.1XP_036015749.1  eukaryotic translation initiation factor 4 gamma 1 isoform X16

      UniProtKB/TrEMBL
      A0A0J9YUS5
      Related
      ENSMUSP00000144320.2, ENSMUST00000143939.8
      Conserved Domains (4) summary
      cd11559
      Location:13471476
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      PHA03247
      Location:19476
      PHA03247; large tegument protein UL36; Provisional
      pfam02847
      Location:11481260
      MA3; MA3 domain
      pfam02854
      Location:671899
      MIF4G; MIF4G domain
    15. XM_030249027.2XP_030104887.1  eukaryotic translation initiation factor 4 gamma 1 isoform X17

      UniProtKB/TrEMBL
      A0A0J9YUS5
      Conserved Domains (4) summary
      cd11559
      Location:13381467
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      PHA03247
      Location:19466
      PHA03247; large tegument protein UL36; Provisional
      pfam02847
      Location:11391251
      MA3; MA3 domain
      pfam02854
      Location:662890
      MIF4G; MIF4G domain

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