|
Name |
Accession |
Description |
Interval |
E-value |
| MIF4G |
pfam02854 |
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ... |
726-954 |
2.52e-63 |
|
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.
:
Pssm-ID: 397130 Cd Length: 203 Bit Score: 214.15 E-value: 2.52e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 726 FRRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMAlkvpttekpTVTVNFR 805
Cdd:pfam02854 1 LKKVKGILNKLSPENFEKLIKELLKLIMSDPELLKYLIELIFEKAVEEPNFIPAYARLCSGLNL---------RNPTDFG 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 806 KLLLNRCQKEFEKdkdddevfekkqkemdeaataeergrlKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCV 885
Cdd:pfam02854 72 IHLLNRLQEEFEK---------------------------RFELEENEQGNRRRRLGLVRFLGELYKFGLLTEKILFECL 124
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720386707 886 VKLLKNH-------DEESLECLCRLLTTIGKDLDFAKAKPRMDQYFNQMEKII---KEKKTSSRIRFMLQDVLDLRQSN 954
Cdd:pfam02854 125 KELLSSLtkedlkrDLFNLECLLTLLTTIGKLLENEKLPKLMDQFLDEIQKYVlskDDPKLSSRLRFMLQDLIELRKNK 203
|
|
| W2_eIF4G1_like |
cd11559 |
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar ... |
1402-1531 |
1.09e-54 |
|
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins; eIF4G1 is a component of the multi-subunit eukaryotic translation initiation factor 4F, which facilitates recruitment of the mRNA to the ribosome, a rate-limiting step during translation initiation. This C-terminal domain, whose structure resembles that of a set of concatenated HEAT repeats, has been associated with binding to/recruiting the kinase Mnk1, which phosphorylates eIF4E.
:
Pssm-ID: 211397 Cd Length: 134 Bit Score: 186.72 E-value: 1.09e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 1402 EELRRQLEKLLKDGGSNQRVFDWIDANLNEQQIASNTLVRALMTTVCYSAIIFETPLRVDVQVLKVRARLLQKYLC-DEQ 1480
Cdd:cd11559 4 LRVQAELLKLLQEDPNPDELYKWIKENVSPELYASPGFVRALMTAVLKYAIEEKSLPEKEKALLEKYAPLLQKYLDdDEQ 83
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1720386707 1481 KELQALYALQALVVTLEQPANLLRMFFDALYDEDVVKEDAFYSWESSKDPA 1531
Cdd:cd11559 84 LQLQALYALQALVHTLEFPKGLLLRFFDALYDEDVIEEEAFLKWKEDVDPA 134
|
|
| MA3 |
pfam02847 |
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain ... |
1203-1315 |
4.91e-35 |
|
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains.
:
Pssm-ID: 397128 Cd Length: 113 Bit Score: 129.70 E-value: 4.91e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 1203 VEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRLGIESTLERSTIAREHMGRLLHQLLCAGHLSTAQYYQGLYE 1282
Cdd:pfam02847 1 LKRKIFLILEEYLSSGDYDEAARCLLKLGLPSQHHEVVKVLIECALEESKTYREFYGLLLERLCEFNLISTKQFEKGFWR 80
|
90 100 110
....*....|....*....|....*....|...
gi 1720386707 1283 TLELAEDMEIDIPHVWLYLAELITPILQEDGVP 1315
Cdd:pfam02847 81 VLEDLEDLELDIPNAWRNLAEFVARLISDDGLP 113
|
|
| PHA03247 super family |
cl33720 |
large tegument protein UL36; Provisional |
20-530 |
9.42e-07 |
|
large tegument protein UL36; Provisional
The actual alignment was detected with superfamily member PHA03247:
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 54.17 E-value: 9.42e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 20 PSRAQPPSSAASRvqsaaparpgpaphvyPAGSQVMMIPSQISYSASQGAYYIPGQGRSTYVVPTQQYPVQPGAPGFYPG 99
Cdd:PHA03247 2564 PDRSVPPPRPAPR----------------PSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPP 2627
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 100 A-SPTEFGTYAGAYYPAQGVQQFPASVAPAPVLMNQPPQIapKRERKTIRIRDPNQGGKDITEEIMSGARTASTPTPPQt 178
Cdd:PHA03247 2628 PpSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRA--RRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPP- 2704
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 179 GGSLEPQPNGESPqvAVIIRPDDRSQGAAIGGRPGLPGPEHSPGTESQPSSPSPTPSPPPILEPGSESNLGVLSIPGDTM 258
Cdd:PHA03247 2705 PPTPEPAPHALVS--ATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRR 2782
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 259 TTGMIPMSVEESTPISCETGEPyclSPEPTLAEPILEVEVTLSKPIPESEFSSSPLQVSTALVPHKVETHEPNG--VIPS 336
Cdd:PHA03247 2783 LTRPAVASLSESRESLPSPWDP---ADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGgsVAPG 2859
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 337 EDL-------------------------EPEVESSTE--------PAPPPLSPCASESLVPIAPTAQPEEL-------LN 376
Cdd:PHA03247 2860 GDVrrrppsrspaakpaaparppvrrlaRPAVSRSTEsfalppdqPERPPQPQAPPPPQPQPQPPPPPQPQpppppppRP 2939
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 377 GAPSPPAVDLSPVSEPEEQAKKVSSAALASILSPA-----PPVAPSDTSPAQEEEMEEDDDDEEGGEAESEKGgedVPLD 451
Cdd:PHA03247 2940 QPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVprfrvPQPAPSREAPASSTPPLTGHSLSRVSSWASSLA---LHEE 3016
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720386707 452 STPVPAQLSQNLEVAAATQVAvSVPKRRRKIKELNKKEAVgDLLDAFKEVDPAVPEVENQPPTGSNPSPESEGSMVPTQ 530
Cdd:PHA03247 3017 TDPPPVSLKQTLWPPDDTEDS-DADSLFDSDSERSDLEAL-DPLPPEPHDPFAHEPDPATPEAGARESPSSQFGPPPLS 3093
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MIF4G |
pfam02854 |
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ... |
726-954 |
2.52e-63 |
|
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.
Pssm-ID: 397130 Cd Length: 203 Bit Score: 214.15 E-value: 2.52e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 726 FRRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMAlkvpttekpTVTVNFR 805
Cdd:pfam02854 1 LKKVKGILNKLSPENFEKLIKELLKLIMSDPELLKYLIELIFEKAVEEPNFIPAYARLCSGLNL---------RNPTDFG 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 806 KLLLNRCQKEFEKdkdddevfekkqkemdeaataeergrlKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCV 885
Cdd:pfam02854 72 IHLLNRLQEEFEK---------------------------RFELEENEQGNRRRRLGLVRFLGELYKFGLLTEKILFECL 124
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720386707 886 VKLLKNH-------DEESLECLCRLLTTIGKDLDFAKAKPRMDQYFNQMEKII---KEKKTSSRIRFMLQDVLDLRQSN 954
Cdd:pfam02854 125 KELLSSLtkedlkrDLFNLECLLTLLTTIGKLLENEKLPKLMDQFLDEIQKYVlskDDPKLSSRLRFMLQDLIELRKNK 203
|
|
| W2_eIF4G1_like |
cd11559 |
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar ... |
1402-1531 |
1.09e-54 |
|
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins; eIF4G1 is a component of the multi-subunit eukaryotic translation initiation factor 4F, which facilitates recruitment of the mRNA to the ribosome, a rate-limiting step during translation initiation. This C-terminal domain, whose structure resembles that of a set of concatenated HEAT repeats, has been associated with binding to/recruiting the kinase Mnk1, which phosphorylates eIF4E.
Pssm-ID: 211397 Cd Length: 134 Bit Score: 186.72 E-value: 1.09e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 1402 EELRRQLEKLLKDGGSNQRVFDWIDANLNEQQIASNTLVRALMTTVCYSAIIFETPLRVDVQVLKVRARLLQKYLC-DEQ 1480
Cdd:cd11559 4 LRVQAELLKLLQEDPNPDELYKWIKENVSPELYASPGFVRALMTAVLKYAIEEKSLPEKEKALLEKYAPLLQKYLDdDEQ 83
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1720386707 1481 KELQALYALQALVVTLEQPANLLRMFFDALYDEDVVKEDAFYSWESSKDPA 1531
Cdd:cd11559 84 LQLQALYALQALVHTLEFPKGLLLRFFDALYDEDVIEEEAFLKWKEDVDPA 134
|
|
| MIF4G |
smart00543 |
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The ... |
727-954 |
7.41e-53 |
|
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA. Ponting (TiBS) "Novel eIF4G domain homologues (in press)
Pssm-ID: 214713 Cd Length: 200 Bit Score: 184.10 E-value: 7.41e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 727 RRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMAlKVPttekptvtvNFRK 806
Cdd:smart00543 2 KKVKGLINKLSPSNFESIIKELLKLNNSDKNLRKYILELIFEKAVEEPNFIPAYARLCALLNA-KNP---------DFGS 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 807 LLLNRCQKEFEKDkdddevfekkqkemdeaataeergrlkeeLEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVV 886
Cdd:smart00543 72 LLLERLQEEFEKG-----------------------------LESEEESDKQRRLGLVRFLGELYNFQVLTSKIILELLK 122
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720386707 887 KLLKNH-------DEESLECLCRLLTTIGKDLDFAKAKPRMDQYFNQMEKIIKEKKT---SSRIRFMLQDVLDLRQSN 954
Cdd:smart00543 123 ELLNDLtkldpprSDFSVECLLSLLPTCGKDLEREKSPKLLDEILERLQDYLLKKDKtelSSRLRFMLELLIELRKNK 200
|
|
| MA3 |
pfam02847 |
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain ... |
1203-1315 |
4.91e-35 |
|
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains.
Pssm-ID: 397128 Cd Length: 113 Bit Score: 129.70 E-value: 4.91e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 1203 VEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRLGIESTLERSTIAREHMGRLLHQLLCAGHLSTAQYYQGLYE 1282
Cdd:pfam02847 1 LKRKIFLILEEYLSSGDYDEAARCLLKLGLPSQHHEVVKVLIECALEESKTYREFYGLLLERLCEFNLISTKQFEKGFWR 80
|
90 100 110
....*....|....*....|....*....|...
gi 1720386707 1283 TLELAEDMEIDIPHVWLYLAELITPILQEDGVP 1315
Cdd:pfam02847 81 VLEDLEDLELDIPNAWRNLAEFVARLISDDGLP 113
|
|
| MA3 |
smart00544 |
Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and ... |
1203-1315 |
2.59e-34 |
|
Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains Ponting (TIBS) "Novel eIF4G domain homologues" in press
Pssm-ID: 214714 Cd Length: 113 Bit Score: 127.75 E-value: 2.59e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 1203 VEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRLGIESTLERSTIAREHMGRLLHQLLCAGHLSTAQYYQGLYE 1282
Cdd:smart00544 1 LKKKIFLIIEEYLSSGDTDEAVHCLLELKLPEQHHEVVKVLLTCALEEKRTYREMYSVLLSRLCQANVISTKQFEKGFWR 80
|
90 100 110
....*....|....*....|....*....|...
gi 1720386707 1283 TLELAEDMEIDIPHVWLYLAELITPILQEDGVP 1315
Cdd:smart00544 81 LLEDIEDLELDIPNAWRNLAEFVARLISDGILP 113
|
|
| eIF5C |
smart00515 |
Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5; |
1471-1553 |
2.01e-27 |
|
Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;
Pssm-ID: 214705 Cd Length: 83 Bit Score: 106.99 E-value: 2.01e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 1471 LLQKYLCDEQKELQALYALQALVVTLEQPANLLRMFFDALYDEDVVKEDAFYSWESSKDPAEqqGKGVALKSVTAFFNWL 1550
Cdd:smart00515 3 LLKFLAKDEEEQLELLYAIEEFCVELEKLGKLLPKILKSLYDADILEEEAILKWYEKAVSAE--GKKKVRKNAKPFVTWL 80
|
...
gi 1720386707 1551 REA 1553
Cdd:smart00515 81 QEA 83
|
|
| W2 |
pfam02020 |
eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of ... |
1482-1558 |
6.55e-23 |
|
eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of several translation initiation factors.
Pssm-ID: 460415 Cd Length: 76 Bit Score: 93.75 E-value: 6.55e-23
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720386707 1482 ELQALYALQALVVTLEQPANLLRMFFDALYDEDVVKEDAFYSWESSKDPAEqQGKGVALKSVTAFFNWLREAEDEES 1558
Cdd:pfam02020 1 QVDLLLALQEFCAKLEELLKLLLKILKALYDLDIVEEEAILKWWEDVSSAE-KGMKKVRKQAKPFVEWLEEAEEESD 76
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
20-530 |
9.42e-07 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 54.17 E-value: 9.42e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 20 PSRAQPPSSAASRvqsaaparpgpaphvyPAGSQVMMIPSQISYSASQGAYYIPGQGRSTYVVPTQQYPVQPGAPGFYPG 99
Cdd:PHA03247 2564 PDRSVPPPRPAPR----------------PSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPP 2627
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 100 A-SPTEFGTYAGAYYPAQGVQQFPASVAPAPVLMNQPPQIapKRERKTIRIRDPNQGGKDITEEIMSGARTASTPTPPQt 178
Cdd:PHA03247 2628 PpSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRA--RRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPP- 2704
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 179 GGSLEPQPNGESPqvAVIIRPDDRSQGAAIGGRPGLPGPEHSPGTESQPSSPSPTPSPPPILEPGSESNLGVLSIPGDTM 258
Cdd:PHA03247 2705 PPTPEPAPHALVS--ATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRR 2782
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 259 TTGMIPMSVEESTPISCETGEPyclSPEPTLAEPILEVEVTLSKPIPESEFSSSPLQVSTALVPHKVETHEPNG--VIPS 336
Cdd:PHA03247 2783 LTRPAVASLSESRESLPSPWDP---ADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGgsVAPG 2859
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 337 EDL-------------------------EPEVESSTE--------PAPPPLSPCASESLVPIAPTAQPEEL-------LN 376
Cdd:PHA03247 2860 GDVrrrppsrspaakpaaparppvrrlaRPAVSRSTEsfalppdqPERPPQPQAPPPPQPQPQPPPPPQPQpppppppRP 2939
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 377 GAPSPPAVDLSPVSEPEEQAKKVSSAALASILSPA-----PPVAPSDTSPAQEEEMEEDDDDEEGGEAESEKGgedVPLD 451
Cdd:PHA03247 2940 QPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVprfrvPQPAPSREAPASSTPPLTGHSLSRVSSWASSLA---LHEE 3016
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720386707 452 STPVPAQLSQNLEVAAATQVAvSVPKRRRKIKELNKKEAVgDLLDAFKEVDPAVPEVENQPPTGSNPSPESEGSMVPTQ 530
Cdd:PHA03247 3017 TDPPPVSLKQTLWPPDDTEDS-DADSLFDSDSERSDLEAL-DPLPPEPHDPFAHEPDPATPEAGARESPSSQFGPPPLS 3093
|
|
| Herpes_BLLF1 |
pfam05109 |
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
163-422 |
8.03e-05 |
|
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.
Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 47.60 E-value: 8.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 163 IMSGARTASTPTPPQTGGSLEPQPNGESPQVaviirpdDRSQGAAIGGRPGLPGPEHSPGTESQPSSPSPTPSPPPILEP 242
Cdd:pfam05109 404 IITRTATNATTTTHKVIFSKAPESTTTSPTL-------NTTGFAAPNTTTGLPSSTHVPTNLTAPASTGPTVSTADVTSP 476
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 243 ---GSESNLGVLS---IPGDTMTTGMIPMSVEESTPISCETgePYCLSPEPTLAEPILE-VEVTLSKPIPESEFsSSPLQ 315
Cdd:pfam05109 477 tpaGTTSGASPVTpspSPRDNGTESKAPDMTSPTSAVTTPT--PNATSPTPAVTTPTPNaTSPTLGKTSPTSAV-TTPTP 553
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 316 VSTALVPhKVETHEPNGVIPSEDLEPEVESSTEPAPPPLSPCASESlVPIAPTAQpeELLNGAPSPPAVDLSP---VSEP 392
Cdd:pfam05109 554 NATSPTP-AVTTPTPNATIPTLGKTSPTSAVTTPTPNATSPTVGET-SPQANTTN--HTLGGTSSTPVVTSPPknaTSAV 629
|
250 260 270
....*....|....*....|....*....|
gi 1720386707 393 EEQAKKVSSAALASiLSPAPPVAPSDTSPA 422
Cdd:pfam05109 630 TTGQHNITSSSTSS-MSLRPSSISETLSPS 658
|
|
| rad2 |
TIGR00600 |
DNA excision repair protein (rad2); All proteins in this family for which functions are known ... |
333-572 |
1.46e-03 |
|
DNA excision repair protein (rad2); All proteins in this family for which functions are known are flap endonucleases that generate the 3' incision next to DNA damage as part of nucleotide excision repair. This family is related to many other flap endonuclease families including the fen1 family. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273166 [Multi-domain] Cd Length: 1034 Bit Score: 43.35 E-value: 1.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 333 VIPSEDlEPEVESSTEPAPPPLSpCASESLVPIAPTAQPEELLNG-APSPPAVDLSPVSepeeqakkvSSAALASILSPA 411
Cdd:TIGR00600 520 VKPVSS-EFGLPSQREDKLAIPT-EGTQNLQGISDHPEQFEFQNElSPLETKNNESNLS---------SDAETEGSPNPE 588
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 412 PPVAPSDTSPAQEEEMEEDDDDEeggeaesekGGEDV--PLDSTPVpaqlSQNLEVAAAtQVAVSVPKRRRKIkELNKKE 489
Cdd:TIGR00600 589 MPSWSSVTVPSEALDNYETTNPS---------NAKEVrnFAETGIQ----TTNVGESAD-LLLISNPMEVEPM-ESEKEE 653
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 490 AVGDllDAFKEVDPAVPEVENQPPTGSNPSPESE-------GSMVPTQPEETEEtWDSKEDKIHNAENIQPGEQKYEYKS 562
Cdd:TIGR00600 654 SESD--GSFIEVDSVSSTLELQVPSKSQPTDESEenaenkvASIEGEHRKEIED-LLFDESEEDNIVGMIEEEKDADDFK 730
|
250
....*....|
gi 1720386707 563 DQWKPLNLEE 572
Cdd:TIGR00600 731 NEWQDISLEE 740
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MIF4G |
pfam02854 |
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ... |
726-954 |
2.52e-63 |
|
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.
Pssm-ID: 397130 Cd Length: 203 Bit Score: 214.15 E-value: 2.52e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 726 FRRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMAlkvpttekpTVTVNFR 805
Cdd:pfam02854 1 LKKVKGILNKLSPENFEKLIKELLKLIMSDPELLKYLIELIFEKAVEEPNFIPAYARLCSGLNL---------RNPTDFG 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 806 KLLLNRCQKEFEKdkdddevfekkqkemdeaataeergrlKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCV 885
Cdd:pfam02854 72 IHLLNRLQEEFEK---------------------------RFELEENEQGNRRRRLGLVRFLGELYKFGLLTEKILFECL 124
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720386707 886 VKLLKNH-------DEESLECLCRLLTTIGKDLDFAKAKPRMDQYFNQMEKII---KEKKTSSRIRFMLQDVLDLRQSN 954
Cdd:pfam02854 125 KELLSSLtkedlkrDLFNLECLLTLLTTIGKLLENEKLPKLMDQFLDEIQKYVlskDDPKLSSRLRFMLQDLIELRKNK 203
|
|
| W2_eIF4G1_like |
cd11559 |
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar ... |
1402-1531 |
1.09e-54 |
|
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins; eIF4G1 is a component of the multi-subunit eukaryotic translation initiation factor 4F, which facilitates recruitment of the mRNA to the ribosome, a rate-limiting step during translation initiation. This C-terminal domain, whose structure resembles that of a set of concatenated HEAT repeats, has been associated with binding to/recruiting the kinase Mnk1, which phosphorylates eIF4E.
Pssm-ID: 211397 Cd Length: 134 Bit Score: 186.72 E-value: 1.09e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 1402 EELRRQLEKLLKDGGSNQRVFDWIDANLNEQQIASNTLVRALMTTVCYSAIIFETPLRVDVQVLKVRARLLQKYLC-DEQ 1480
Cdd:cd11559 4 LRVQAELLKLLQEDPNPDELYKWIKENVSPELYASPGFVRALMTAVLKYAIEEKSLPEKEKALLEKYAPLLQKYLDdDEQ 83
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1720386707 1481 KELQALYALQALVVTLEQPANLLRMFFDALYDEDVVKEDAFYSWESSKDPA 1531
Cdd:cd11559 84 LQLQALYALQALVHTLEFPKGLLLRFFDALYDEDVIEEEAFLKWKEDVDPA 134
|
|
| MIF4G |
smart00543 |
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The ... |
727-954 |
7.41e-53 |
|
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA. Ponting (TiBS) "Novel eIF4G domain homologues (in press)
Pssm-ID: 214713 Cd Length: 200 Bit Score: 184.10 E-value: 7.41e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 727 RRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMAlKVPttekptvtvNFRK 806
Cdd:smart00543 2 KKVKGLINKLSPSNFESIIKELLKLNNSDKNLRKYILELIFEKAVEEPNFIPAYARLCALLNA-KNP---------DFGS 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 807 LLLNRCQKEFEKDkdddevfekkqkemdeaataeergrlkeeLEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVV 886
Cdd:smart00543 72 LLLERLQEEFEKG-----------------------------LESEEESDKQRRLGLVRFLGELYNFQVLTSKIILELLK 122
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720386707 887 KLLKNH-------DEESLECLCRLLTTIGKDLDFAKAKPRMDQYFNQMEKIIKEKKT---SSRIRFMLQDVLDLRQSN 954
Cdd:smart00543 123 ELLNDLtkldpprSDFSVECLLSLLPTCGKDLEREKSPKLLDEILERLQDYLLKKDKtelSSRLRFMLELLIELRKNK 200
|
|
| MA3 |
pfam02847 |
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain ... |
1203-1315 |
4.91e-35 |
|
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains.
Pssm-ID: 397128 Cd Length: 113 Bit Score: 129.70 E-value: 4.91e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 1203 VEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRLGIESTLERSTIAREHMGRLLHQLLCAGHLSTAQYYQGLYE 1282
Cdd:pfam02847 1 LKRKIFLILEEYLSSGDYDEAARCLLKLGLPSQHHEVVKVLIECALEESKTYREFYGLLLERLCEFNLISTKQFEKGFWR 80
|
90 100 110
....*....|....*....|....*....|...
gi 1720386707 1283 TLELAEDMEIDIPHVWLYLAELITPILQEDGVP 1315
Cdd:pfam02847 81 VLEDLEDLELDIPNAWRNLAEFVARLISDDGLP 113
|
|
| MA3 |
smart00544 |
Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and ... |
1203-1315 |
2.59e-34 |
|
Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains Ponting (TIBS) "Novel eIF4G domain homologues" in press
Pssm-ID: 214714 Cd Length: 113 Bit Score: 127.75 E-value: 2.59e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 1203 VEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRLGIESTLERSTIAREHMGRLLHQLLCAGHLSTAQYYQGLYE 1282
Cdd:smart00544 1 LKKKIFLIIEEYLSSGDTDEAVHCLLELKLPEQHHEVVKVLLTCALEEKRTYREMYSVLLSRLCQANVISTKQFEKGFWR 80
|
90 100 110
....*....|....*....|....*....|...
gi 1720386707 1283 TLELAEDMEIDIPHVWLYLAELITPILQEDGVP 1315
Cdd:smart00544 81 LLEDIEDLELDIPNAWRNLAEFVARLISDGILP 113
|
|
| eIF5C |
smart00515 |
Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5; |
1471-1553 |
2.01e-27 |
|
Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;
Pssm-ID: 214705 Cd Length: 83 Bit Score: 106.99 E-value: 2.01e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 1471 LLQKYLCDEQKELQALYALQALVVTLEQPANLLRMFFDALYDEDVVKEDAFYSWESSKDPAEqqGKGVALKSVTAFFNWL 1550
Cdd:smart00515 3 LLKFLAKDEEEQLELLYAIEEFCVELEKLGKLLPKILKSLYDADILEEEAILKWYEKAVSAE--GKKKVRKNAKPFVTWL 80
|
...
gi 1720386707 1551 REA 1553
Cdd:smart00515 81 QEA 83
|
|
| W2 |
pfam02020 |
eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of ... |
1482-1558 |
6.55e-23 |
|
eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of several translation initiation factors.
Pssm-ID: 460415 Cd Length: 76 Bit Score: 93.75 E-value: 6.55e-23
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720386707 1482 ELQALYALQALVVTLEQPANLLRMFFDALYDEDVVKEDAFYSWESSKDPAEqQGKGVALKSVTAFFNWLREAEDEES 1558
Cdd:pfam02020 1 QVDLLLALQEFCAKLEELLKLLLKILKALYDLDIVEEEAILKWWEDVSSAE-KGMKKVRKQAKPFVEWLEEAEEESD 76
|
|
| W2 |
cd11473 |
C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon; This domain is found at the C-terminus of ... |
1402-1525 |
2.36e-19 |
|
C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon; This domain is found at the C-terminus of several translation initiation factors, including the epsilon chain of eIF2b, where it has been found to catalyze the conversion of eIF2.GDP to its active eIF2.GTP form. The structure of the domain resembles that of a set of concatenated HEAT repeats.
Pssm-ID: 211395 Cd Length: 135 Bit Score: 85.61 E-value: 2.36e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 1402 EELRRQLEKLLK-DGGSNQRVFDWIDANLNEQQIASNTLVRALMTTVCYSAIIFE----TPLRVDVQVLKVRARLLQKYL 1476
Cdd:cd11473 4 KKLRDSLLKELEeDKSSDVESVKAAKSKLDLDPISLEEVVKVLLTAVVNAVESADsislTQKEQLVLVLKKYGPVLRELL 83
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 1720386707 1477 CD-EQKELQALYALQALVVT--LEQPANLLRMFFDALYDEDVVKEDAFYSWE 1525
Cdd:cd11473 84 KLiKKDQLYLLLKIEKLCLQlkLSELISLLEKILDLLYDADVLSEEAILSWF 135
|
|
| W2_eIF2B_epsilon |
cd11558 |
C-terminal W2 domain of eukaryotic translation initiation factor 2B epsilon; eIF2B is a ... |
1471-1558 |
1.68e-13 |
|
C-terminal W2 domain of eukaryotic translation initiation factor 2B epsilon; eIF2B is a heteropentameric complex which functions as a guanine nucleotide exchange factor in the recycling of eIF-2 during the initiation of translation in eukaryotes. The epsilon and gamma subunits are sequence similar and both are essential in yeast. Epsilon appears to be the catalytically active subunit, with gamma enhancing its activity. The C-terminal domain of the eIF2B epsilon subunit contains bipartite motifs rich in acidic and aromatic residues, which are responsible for the interaction with eIF2. The structure of the domain resembles that of a set of concatenated HEAT repeats.
Pssm-ID: 211396 Cd Length: 169 Bit Score: 69.98 E-value: 1.68e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 1471 LLQKYLCDEQKELQALYALQALVVTLEQPANLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFNWL 1550
Cdd:cd11558 82 LLENYVKSQDDQVELLLALEEFCLESEEGGPLFAKLLHALYDLDILEEEAILEWWEEPDAGADEEMKKVRELVKKFIEWL 161
|
....*...
gi 1720386707 1551 REAEDEES 1558
Cdd:cd11558 162 EEAEEESD 169
|
|
| W2_eIF5 |
cd11561 |
C-terminal W2 domain of eukaryotic translation initiation factor 5; eIF5 functions as a GTPase ... |
1462-1558 |
4.24e-07 |
|
C-terminal W2 domain of eukaryotic translation initiation factor 5; eIF5 functions as a GTPase acceleration protein (GAP), as well as a GDP dissociation inhibitor (GDI) during translational initiation in eukaryotes. The structure of this C-terminal domain resembles that of a set of concatenated HEAT repeats.
Pssm-ID: 211399 Cd Length: 157 Bit Score: 51.08 E-value: 4.24e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 1462 VQVLKVRARLLQKYLCDEQKELQALYALQALVVtlEQPANLLRMF---FDALYDEDVVKEDAFYSW---ESSKDPAEQQG 1535
Cdd:cd11561 58 VKEIKKRKALLLKLVTDEKAQKALLGGIERFCG--KHSPELLKKVpliLKALYDNDILEEEVILKWyekVSKKYVSKEKS 135
|
90 100
....*....|....*....|...
gi 1720386707 1536 KGVaLKSVTAFFNWLREAEDEES 1558
Cdd:cd11561 136 KKV-RKAAEPFVEWLEEAEEEEE 157
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
20-530 |
9.42e-07 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 54.17 E-value: 9.42e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 20 PSRAQPPSSAASRvqsaaparpgpaphvyPAGSQVMMIPSQISYSASQGAYYIPGQGRSTYVVPTQQYPVQPGAPGFYPG 99
Cdd:PHA03247 2564 PDRSVPPPRPAPR----------------PSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPP 2627
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 100 A-SPTEFGTYAGAYYPAQGVQQFPASVAPAPVLMNQPPQIapKRERKTIRIRDPNQGGKDITEEIMSGARTASTPTPPQt 178
Cdd:PHA03247 2628 PpSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRA--RRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPP- 2704
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 179 GGSLEPQPNGESPqvAVIIRPDDRSQGAAIGGRPGLPGPEHSPGTESQPSSPSPTPSPPPILEPGSESNLGVLSIPGDTM 258
Cdd:PHA03247 2705 PPTPEPAPHALVS--ATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRR 2782
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 259 TTGMIPMSVEESTPISCETGEPyclSPEPTLAEPILEVEVTLSKPIPESEFSSSPLQVSTALVPHKVETHEPNG--VIPS 336
Cdd:PHA03247 2783 LTRPAVASLSESRESLPSPWDP---ADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGgsVAPG 2859
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 337 EDL-------------------------EPEVESSTE--------PAPPPLSPCASESLVPIAPTAQPEEL-------LN 376
Cdd:PHA03247 2860 GDVrrrppsrspaakpaaparppvrrlaRPAVSRSTEsfalppdqPERPPQPQAPPPPQPQPQPPPPPQPQpppppppRP 2939
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 377 GAPSPPAVDLSPVSEPEEQAKKVSSAALASILSPA-----PPVAPSDTSPAQEEEMEEDDDDEEGGEAESEKGgedVPLD 451
Cdd:PHA03247 2940 QPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVprfrvPQPAPSREAPASSTPPLTGHSLSRVSSWASSLA---LHEE 3016
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720386707 452 STPVPAQLSQNLEVAAATQVAvSVPKRRRKIKELNKKEAVgDLLDAFKEVDPAVPEVENQPPTGSNPSPESEGSMVPTQ 530
Cdd:PHA03247 3017 TDPPPVSLKQTLWPPDDTEDS-DADSLFDSDSERSDLEAL-DPLPPEPHDPFAHEPDPATPEAGARESPSSQFGPPPLS 3093
|
|
| W2_eIF5C_like |
cd11560 |
C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins; ... |
1396-1556 |
2.79e-06 |
|
C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins; eIF5C appears to be essential for the initiation of protein translation; its actual function, and specifically that of the C-terminal W2 domain, are not well understood. The Drosophila ortholog, kra (krasavietz) or exba (extra bases), may be involved in translational inhibition in neural development. The structure of this C-terminal domain resembles that of a set of concatenated HEAT repeats.
Pssm-ID: 211398 [Multi-domain] Cd Length: 194 Bit Score: 49.52 E-value: 2.79e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 1396 QRTLAFEELRRQLEKLLKDGGSNQRVFDWIDANLNEQQIASN--------TLVRALMTTVCYSA---IIFETPLRVdvqv 1464
Cdd:cd11560 29 YRKQASQEIKKELQQELKEMIAEEEPVKEIIAAVKEQMKKSSlpehevvgLLWTALMDAVEWSKkedQIAEQALRH---- 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 1465 LKVRARLLQKYLCDEQKELQALYALQalVVTLEQpANLLRMFFD---ALYDEDVVKEDAFYSWesSKDPAEQQGKGVALK 1541
Cdd:cd11560 105 LKKYAPLLAAFCTTARAELALLNKIQ--EYCYEN-MKFMKVFQKivkLLYKADVLSEDAILKW--YKKGHSPKGKQVFLK 179
|
170
....*....|....*
gi 1720386707 1542 SVTAFFNWLREAEDE 1556
Cdd:cd11560 180 QMEPFVEWLQEAEEE 194
|
|
| Herpes_BLLF1 |
pfam05109 |
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
163-422 |
8.03e-05 |
|
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.
Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 47.60 E-value: 8.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 163 IMSGARTASTPTPPQTGGSLEPQPNGESPQVaviirpdDRSQGAAIGGRPGLPGPEHSPGTESQPSSPSPTPSPPPILEP 242
Cdd:pfam05109 404 IITRTATNATTTTHKVIFSKAPESTTTSPTL-------NTTGFAAPNTTTGLPSSTHVPTNLTAPASTGPTVSTADVTSP 476
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 243 ---GSESNLGVLS---IPGDTMTTGMIPMSVEESTPISCETgePYCLSPEPTLAEPILE-VEVTLSKPIPESEFsSSPLQ 315
Cdd:pfam05109 477 tpaGTTSGASPVTpspSPRDNGTESKAPDMTSPTSAVTTPT--PNATSPTPAVTTPTPNaTSPTLGKTSPTSAV-TTPTP 553
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 316 VSTALVPhKVETHEPNGVIPSEDLEPEVESSTEPAPPPLSPCASESlVPIAPTAQpeELLNGAPSPPAVDLSP---VSEP 392
Cdd:pfam05109 554 NATSPTP-AVTTPTPNATIPTLGKTSPTSAVTTPTPNATSPTVGET-SPQANTTN--HTLGGTSSTPVVTSPPknaTSAV 629
|
250 260 270
....*....|....*....|....*....|
gi 1720386707 393 EEQAKKVSSAALASiLSPAPPVAPSDTSPA 422
Cdd:pfam05109 630 TTGQHNITSSSTSS-MSLRPSSISETLSPS 658
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
122-535 |
3.42e-04 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 45.70 E-value: 3.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 122 PASVAPAPVLMNQPPQIAPK--------RERKTIRIRDPNQGGKDITEEIMSGARTASTPTPPQTGgSLEPQPNGESPqv 193
Cdd:PHA03247 2557 PAAPPAAPDRSVPPPRPAPRpsepavtsRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTH-APDPPPPSPSP-- 2633
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 194 aviirpddRSQGAAIGGRPGLPGPEHSPGTESQPSSPSPTPSPPPILEPGSESNLGVLSIPGDTMTTGMIPMSVEESTPi 273
Cdd:PHA03247 2634 --------AANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPP- 2704
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 274 scetgEPyclSPEPTlaePILEVEVTLSKPIPESEFSSSPLQVSTALVPHKVETHEPNGVIPSEDLEPEVESSTEPAPPP 353
Cdd:PHA03247 2705 -----PP---TPEPA---PHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPA 2773
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 354 LSPCASESLVPIAPTAQPEELLNGAPSPPAVDLSPVSEPEeqakkvSSAALASILSPAPPVAPSDTS-PAQEEEMEEDDD 432
Cdd:PHA03247 2774 APAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLA------PAAALPPAASPAGPLPPPTSAqPTAPPPPPGPPP 2847
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 433 DEEGGEAESEKGGedvPLDSTPVPAQlsqnlevAAATQVAVSVPKRRRKikelnKKEAVGDLLDAFKE-VDPAVPEVENQ 511
Cdd:PHA03247 2848 PSLPLGGSVAPGG---DVRRRPPSRS-------PAAKPAAPARPPVRRL-----ARPAVSRSTESFALpPDQPERPPQPQ 2912
|
410 420
....*....|....*....|....
gi 1720386707 512 PPTGSNPSPESEGSMVPTQPEETE 535
Cdd:PHA03247 2913 APPPPQPQPQPPPPPQPQPPPPPP 2936
|
|
| rad2 |
TIGR00600 |
DNA excision repair protein (rad2); All proteins in this family for which functions are known ... |
333-572 |
1.46e-03 |
|
DNA excision repair protein (rad2); All proteins in this family for which functions are known are flap endonucleases that generate the 3' incision next to DNA damage as part of nucleotide excision repair. This family is related to many other flap endonuclease families including the fen1 family. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273166 [Multi-domain] Cd Length: 1034 Bit Score: 43.35 E-value: 1.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 333 VIPSEDlEPEVESSTEPAPPPLSpCASESLVPIAPTAQPEELLNG-APSPPAVDLSPVSepeeqakkvSSAALASILSPA 411
Cdd:TIGR00600 520 VKPVSS-EFGLPSQREDKLAIPT-EGTQNLQGISDHPEQFEFQNElSPLETKNNESNLS---------SDAETEGSPNPE 588
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 412 PPVAPSDTSPAQEEEMEEDDDDEeggeaesekGGEDV--PLDSTPVpaqlSQNLEVAAAtQVAVSVPKRRRKIkELNKKE 489
Cdd:TIGR00600 589 MPSWSSVTVPSEALDNYETTNPS---------NAKEVrnFAETGIQ----TTNVGESAD-LLLISNPMEVEPM-ESEKEE 653
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 490 AVGDllDAFKEVDPAVPEVENQPPTGSNPSPESE-------GSMVPTQPEETEEtWDSKEDKIHNAENIQPGEQKYEYKS 562
Cdd:TIGR00600 654 SESD--GSFIEVDSVSSTLELQVPSKSQPTDESEenaenkvASIEGEHRKEIED-LLFDESEEDNIVGMIEEEKDADDFK 730
|
250
....*....|
gi 1720386707 563 DQWKPLNLEE 572
Cdd:TIGR00600 731 NEWQDISLEE 740
|
|
| PRK08691 |
PRK08691 |
DNA polymerase III subunits gamma and tau; Validated |
287-447 |
3.15e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236333 [Multi-domain] Cd Length: 709 Bit Score: 42.00 E-value: 3.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 287 PTLAEPILEVEVTLSKPIPESEFSSSPLQV-STALVPHKVETHEPNGVIPSEDLEP---EVESSTEPAPPPLSPCASESL 362
Cdd:PRK08691 380 PSAQTAEKETAAKKPQPRPEAETAQTPVQTaSAAAMPSEGKTAGPVSNQENNDVPPwedAPDEAQTAAGTAQTSAKSIQT 459
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 363 VPIAPTAQPEEL-------------LNGAPSPPAVDLSPVSEPEEQAKKVSSAalasilsPAPPVA----PSDTSPAQEE 425
Cdd:PRK08691 460 ASEAETPPENQVsknkaadnetdapLSEVPSENPIQATPNDEAVETETFAHEA-------PAEPFYgygfPDNDCPPEDG 532
|
170 180
....*....|....*....|..
gi 1720386707 426 EMEEDDDDEEGGEAESEKGGED 447
Cdd:PRK08691 533 AEIPPPDWEHAAPADTAGGGAD 554
|
|
| Rib_recp_KP_reg |
pfam05104 |
Ribosome receptor lysine/proline rich region; This highly conserved region is found towards ... |
328-422 |
3.29e-03 |
|
Ribosome receptor lysine/proline rich region; This highly conserved region is found towards the C-terminus of the transmembrane domain. The function is unclear.
Pssm-ID: 461548 [Multi-domain] Cd Length: 140 Bit Score: 39.72 E-value: 3.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 328 HEPNGVIPseDLEPEVESSTEPAPPPLSPCASESLVPIAPTAQPEELLNGAPSPPAVDlSPVSEPEEQAKKVSSAALAsi 407
Cdd:pfam05104 44 EKPNGKLP--ESEQADESEEEPREFKTPDEAPSAALEPEPVPTPVPAPVEPEPAPPSE-SPAPSPKEKKKKEKKSAKV-- 118
|
90
....*....|....*
gi 1720386707 408 lSPAPPVAPSDTSPA 422
Cdd:pfam05104 119 -EPAETPEAVQPKPA 132
|
|
| PRK11633 |
PRK11633 |
cell division protein DedD; Provisional |
306-422 |
4.41e-03 |
|
cell division protein DedD; Provisional
Pssm-ID: 236940 [Multi-domain] Cd Length: 226 Bit Score: 40.37 E-value: 4.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 306 ESEFSSSPLqvstalVPHKVETHEPNGV---------IPSEDLEPEVESSTEPAPPPLSPCASESLVPIAPTAQPEElln 376
Cdd:PRK11633 35 QDEFAAIPL------VPKPGDRDEPDMMpaatqalptQPPEGAAEAVRAGDAAAPSLDPATVAPPNTPVEPEPAPVE--- 105
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 1720386707 377 gAPSPPavdlsPVSEPEEQAKKVSSAALASILSPAP-PVAPSDTSPA 422
Cdd:PRK11633 106 -PPKPK-----PVEKPKPKPKPQQKVEAPPAPKPEPkPVVEEKAAPT 146
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
20-320 |
5.80e-03 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 41.46 E-value: 5.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 20 PSRAQPPSSAASRVQSAAPARPGPAPHVYPAGSQVMMIPSQISYSASQGAYYIPGQGRSTYVVPTQQYP----VQPGAPG 95
Cdd:PHA03247 2761 PTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPpptsAQPTAPP 2840
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 96 FYPGASPTEFgTYAGAYYPAQGVQQFPASVAPAPVL----------MNQP-------PQIAPKRERKTIRIRDPNQGGKD 158
Cdd:PHA03247 2841 PPPGPPPPSL-PLGGSVAPGGDVRRRPPSRSPAAKPaaparppvrrLARPavsrsteSFALPPDQPERPPQPQAPPPPQP 2919
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 159 ITEEIMSGARTASTPTPPQTGGSLEPQPNGESPQVAVIIRPDDRSqGAAIGGR------------PGLPGPEHSPGTESQ 226
Cdd:PHA03247 2920 QPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWL-GALVPGRvavprfrvpqpaPSREAPASSTPPLTG 2998
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 227 PSSPSPTPSPPPIL-----EPGSESNLGVLSIPGDtmTTGMIPMSVEESTPISCETGEPYCLSPEPTLA---EPILEVEV 298
Cdd:PHA03247 2999 HSLSRVSSWASSLAlheetDPPPVSLKQTLWPPDD--TEDSDADSLFDSDSERSDLEALDPLPPEPHDPfahEPDPATPE 3076
|
330 340
....*....|....*....|..
gi 1720386707 299 TLSKPIPESEFSSSPLQVSTAL 320
Cdd:PHA03247 3077 AGARESPSSQFGPPPLSANAAL 3098
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
98-521 |
6.12e-03 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 41.29 E-value: 6.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 98 PGASPTEFGTYAGAYYPAQGVQQFPaSVAPAPVLMNQPPQIAPKRERKTIRIRDPNQGGKDITEEIMSGARTASTPTPPQ 177
Cdd:pfam03154 171 PPVLQAQSGAASPPSPPPPGTTQAA-TAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPHPPL 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 178 TGGSLEPQPNGESPQVavIIRPDDRSQGAAiGGRPGLPGPEHSPGTESQPSSPSPTPSPPPILEPGSESNLgvlsiPGDT 257
Cdd:pfam03154 250 QPMTQPPPPSQVSPQP--LPQPSLHGQMPP-MPHSLQTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAA-----PGQS 321
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 258 MTTGMIPMSVEESTPISCETGEPYCLSP------EPTLAEPILEVEVTLSKPIPESEFSSSPLQVSTALVPhkvethePN 331
Cdd:pfam03154 322 QQRIHTPPSQSQLQSQQPPREQPLPPAPlsmphiKPPPTTPIPQLPNPQSHKHPPHLSGPSPFQMNSNLPP-------PP 394
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 332 GVIPSEDLEPEVESSTEPAPPPLSPcASESLVPiaPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKKVSSAALAS-ILSP 410
Cdd:pfam03154 395 ALKPLSSLSTHHPPSAHPPPLQLMP-QSQQLPP--PPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPfVPGG 471
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386707 411 APPVAPSDTSPAQEEEMEEDDDDEEGGEAESekggedvpldSTPVPAqlsqnlevaaatQVAVSVPKRRRKIKELNKKEa 490
Cdd:pfam03154 472 PPPITPPSGPPTSTSSAMPGIQPPSSASVSS----------SGPVPA------------AVSCPLPPVQIKEEALDEAE- 528
|
410 420 430
....*....|....*....|....*....|.
gi 1720386707 491 vgdlldafkevdpavpEVENQPPTGSNPSPE 521
Cdd:pfam03154 529 ----------------EPESPPPPPRSPSPE 543
|
|
| |
