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    apoc1 apolipoprotein C-I [ Danio rerio (zebrafish) ]

    Gene ID: 570638, updated on 9-Dec-2024

    Summary

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    Official Symbol
    apoc1provided by ZNC
    Official Full Name
    apolipoprotein C-Iprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-1074
    See related
    Ensembl:ENSDARG00000092170 AllianceGenome:ZFIN:ZDB-GENE-030131-1074
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    apoc1l; fb58g10; wu:fb58g10
    Summary
    Predicted to enable fatty acid binding activity and phospholipase inhibitor activity. Acts upstream of or within cell migration involved in gastrulation. Predicted to be located in extracellular region. Predicted to be part of high-density lipoprotein particle and very-low-density lipoprotein particle. Is expressed in DEL; blastoderm; and liver. Human ortholog(s) of this gene implicated in Alzheimer's disease and obesity. Orthologous to human APOC1 (apolipoprotein C1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See apoc1 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (23972127..23973723)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (24057095..24058691)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene apolipoprotein A-IV b, tandem duplicate 2 Neighboring gene apolipoprotein Eb Neighboring gene apolipoprotein C-IV Neighboring gene apolipoprotein A-II

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and expression characterization of ApoC-I in the orange-spotted grouper. Wang Y, et al. Fish Physiol Biochem, 2008 Dec. PMID 18958591
    2. Apolipoprotein C1 regulates epiboly during gastrulation in zebrafish. Wang Y, et al. Sci China Life Sci, 2013 Nov. PMID 24203452
    3. Modulation of retinoid-X-receptors differentially regulates expression of apolipoprotein genes apoc1 and apoeb by zebrafish microglia. Thiel WA, et al. Biol Open, 2022 Jan 15. PMID 34878094, Free PMC Article
    4. BMP and RA signaling cooperate to regulate Apolipoprotein C1 expression during embryonic development. Wang Y, et al. Gene, 2015 Jan 10. PMID 25445289
    5. MicroRNA-146 function in the innate immune transcriptome response of zebrafish embryos to Salmonella typhimurium infection. Ordas A, et al. BMC Genomics, 2013 Oct 10. PMID 24112639, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results show that apoc1 expression is induced by bone morphogenetic proteins (BMPs) signaling during zebrafish embryonic development.
      Title: BMP and RA signaling cooperate to regulate Apolipoprotein C1 expression during embryonic development.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables fatty acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell migration involved in gastrulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipoprotein metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cholesterol transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of lipid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of very-low-density lipoprotein particle clearance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in triglyceride metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in very-low-density lipoprotein particle clearance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of high-density lipoprotein particle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of very-low-density lipoprotein particle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    apolipoprotein C-I
    Names
    apolipoprotein C-I like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291886.1 → NP_001278815.1  apolipoprotein C-I isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
      Source sequence(s)
      BC162528, CN321250, EH489275
      UniProtKB/TrEMBL
      A0A8M1P660, E9QDI1
      Related
      ENSDARP00000121190.1, ENSDART00000145330.2
      Conserved Domains (1) summary
      pfam04691
      Location:24 → 83
      ApoC-I; Apolipoprotein C-I (ApoC-1)

    2. NM_001291887.1 → NP_001278816.1  apolipoprotein C-I isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      CN321250, EH489275
      UniProtKB/TrEMBL
      A0A8M1P0R3, E9QFX0
      Related
      ENSDARP00000118222.1, ENSDART00000132742.3
      Conserved Domains (1) summary
      pfam04691
      Location:23 → 82
      ApoC-I; Apolipoprotein C-I (ApoC-1)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      23972127..23973723
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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