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    gjb3 gap junction protein beta 3 [ Danio rerio (zebrafish) ]

    Gene ID: 550380, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gjb3provided by ZNC
    Official Full Name
    gap junction protein beta 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050417-174
    See related
    Ensembl:ENSDARG00000042866 AllianceGenome:ZFIN:ZDB-GENE-050417-174
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cx35.4; wu:fb02c04; zgc:112004
    Summary
    Predicted to enable gap junction channel activity. Predicted to be involved in cell-cell signaling. Predicted to act upstream of or within cell communication. Predicted to be located in gap junction and plasma membrane. Predicted to be part of connexin complex. Is expressed in EVL; periderm; pharynx; and sensory system. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 2B; autosomal recessive nonsyndromic deafness 1A; colorectal adenocarcinoma; erythrokeratodermia variabilis; and erythrokeratodermia variabilis et progressiva 1. Orthologous to human GJB3 (gap junction protein beta 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See gjb3 in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (24848987..24853915)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (24830586..24835514)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137488100 Neighboring gene gap junction protein beta 10 Neighboring gene 3-hydroxy-3-methylglutaryl-CoA lyase Neighboring gene zinc finger and BTB domain containing 8A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The connexin 30.3 of zebrafish homologue of human connexin 26 may play similar role in the inner ear. Chang-Chien J, et al. Hear Res, 2014 Jul. PMID 24811980
    2. Cx23, a connexin with only four extracellular-loop cysteines, forms functional gap junction channels and hemichannels. Iovine MK, et al. FEBS Lett, 2008 Jan 23. PMID 18068130, Free PMC Article
    3. Phylogeny of teleost connexins reveals highly inconsistent intra- and interspecies use of nomenclature and misassemblies in recent teleost chromosome assemblies. Mikalsen SO, et al. BMC Genomics, 2020 Mar 11. PMID 32160866, Free PMC Article
    4. Wnt-PLC-IP(3)-Connexin-Ca(2+) axis maintains ependymal motile cilia in zebrafish spinal cord. Zhang J, et al. Nat Commun, 2020 Apr 20. PMID 32312952, Free PMC Article
    5. Evolutionary selection pressure and family relationships among connexin genes. Cruciani V, et al. Biol Chem, 2007 Mar. PMID 17338632

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables gap junction channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell communication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell-cell signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of connexin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of connexin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in gap junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    gap junction protein beta 3
    Names
    connexin 35.4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017685.1 → NP_001017685.1  gap junction protein beta 3

      See identical proteins and their annotated locations for NP_001017685.1

      Status: PROVISIONAL

      Source sequence(s)
      BC093154
      UniProtKB/TrEMBL
      Q567J2
      Related
      ENSDARP00000062916.5, ENSDART00000062917.6
      Conserved Domains (3) summary
      smart00037
      Location:42 → 75
      CNX; Connexin homologues
      smart01089
      Location:134 → 201
      Connexin_CCC; Gap junction channel protein cysteine-rich domain
      pfam00029
      Location:2 → 202
      Connexin; Connexin

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      24848987..24853915
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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