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    elp2 elongator acetyltransferase complex subunit 2 [ Danio rerio (zebrafish) ]

    Gene ID: 560338, updated on 9-Dec-2024

    Summary

    Official Symbol
    elp2provided by ZNC
    Official Full Name
    elongator acetyltransferase complex subunit 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060503-525
    See related
    Ensembl:ENSDARG00000017199 AllianceGenome:ZFIN:ZDB-GENE-060503-525
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:153559; si:dkey-190l1.1
    Summary
    Predicted to act upstream of or within tRNA wobble uridine modification. Predicted to be located in cytoplasm and nucleus. Predicted to be part of elongator holoenzyme complex. Is expressed in female organism. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 58. Orthologous to human ELP2 (elongator acetyltransferase complex subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See elp2 in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (34691639..34742446, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (35104524..35155326, complement)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103909261 Neighboring gene uncharacterized LOC137488535 Neighboring gene gamma-aminobutyric acid (GABA) B receptor, 2 Neighboring gene uncharacterized LOC137488536 Neighboring gene actin binding transcription modulator Neighboring gene catenin (cadherin-associated protein), alpha-like 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Markers

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within tRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within tRNA wobble uridine modification IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    part_of elongator holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of elongator holoenzyme complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    elongator complex protein 2
    Names
    elongation protein 2 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044925.1NP_001038390.1  elongator complex protein 2

      Status: PROVISIONAL

      Source sequence(s)
      BX927389
      UniProtKB/Swiss-Prot
      Q05AM5, Q1LUN8
      UniProtKB/TrEMBL
      A0A8M1N9L6, Z4YI78
      Related
      ENSDARP00000104754.2, ENSDART00000122625.3
      Conserved Domains (4) summary
      COG2319
      Location:51455
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:52403
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:61103
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:564832
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      34691639..34742446 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021468089.2XP_021323764.1  elongator complex protein 2 isoform X2

      UniProtKB/Swiss-Prot
      Q05AM5, Q1LUN8
      UniProtKB/TrEMBL
      A0A8M9PGH1
      Conserved Domains (3) summary
      cd00200
      Location:52403
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:61103
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:557789
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. XM_005159658.5XP_005159715.1  elongator complex protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q05AM5, Q1LUN8
      UniProtKB/TrEMBL
      A0A286Y893, A0A8M2B6Q7
      Related
      ENSDARP00000143361.1, ENSDART00000175621.2
      Conserved Domains (4) summary
      COG2319
      Location:51455
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:52403
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:61103
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:549817
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...