NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|113678559|ref|NP_001038390|]
View 

elongator complex protein 2 [Danio rerio]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11525814)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 52-403 1.69e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 142.09  E-value: 1.69e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559  52 LNKHTGRVNAVQWvhepdcSPENQLI-SGGSDNNVIVWEKLDGKFRACavCSGHSGPVcavDAVSLSSSHLLVASASSDS 130
Cdd:cd00200    5 LKGHTGGVTCVAF------SPDGKLLaTGSGDGTIKVWDLETGELLRT--LKGHTGPV---RDVAASADGTYLASGSSDK 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 131 TVKLWTYSSDaaECLQTVAfgsGFMMDV-SLALLPGSRVpvLACGGDDSRVHLYVQLSGQFQRvlTLTGHEDWVRGVEWa 209
Cdd:cd00200   74 TIRLWDLETG--ECVRTLT---GHTSYVsSVAFSPDGRI--LSSSSRDKTIKVWDVETGKCLT--TLRGHTDWVNSVAF- 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 210 NKDGELwLASCSQDCLIRVWrlfaktaaepDLQTDGIIKmkenifqvsgeefavtletVLAGHENWVYGIHWQPpsvkgd 289
Cdd:cd00200  144 SPDGTF-VASSSQDGTIKLW----------DLRTGKCVA-------------------TLTGHTGEVNSVAFSP------ 187

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 290 sveQSLKLLSASMDKTMILWGPeeDSGMWVemvrvGEVGGNTLGFYGCQMSPDGSMILAHAFHGALHLWHHDSnqeWRPS 369
Cdd:cd00200  188 ---DGEKLLSSSSDGTIKLWDL--STGKCL-----GTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRT---GECV 254

                        330       340       350
                 ....*....|....*....|....*....|....
gi 113678559 370 VVISGHFNAVQDMSWDPEGEFIITVGSDQTTRLF 403
Cdd:cd00200  255 QTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
593-832 2.23e-17

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 85.35  E-value: 2.23e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 593 ASKAEHASILLWSTASWKQLQSLSCHSLTITQMAFSPNGQLLLAVSRDRTWSLWrrgnpDLDT-EAMFSLyantskdtSV 671
Cdd:COG2319  136 ASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW-----DLATgKLLRTL--------TG 202

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 672 HTRIIWSCDWSADNKYFVTSSRDKKVIIWGHA-GSGVAVGEGEDARVTSCSsvldvgdsatavsicpFlcSDHSYLLAVG 750
Cdd:COG2319  203 HTGAVRSVAFSPDGKLLASGSADGTVRLWDLAtGKLLRTLTGHSGSVRSVA----------------F--SPDGRLLASG 264

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 751 LENGQILLYKWKPLEDLSSEsdwsrckdtdacQGHTMVVKRLRWRPrlgrgghggqDSKeeqawvQLASAGADHVVKIFD 830
Cdd:COG2319  265 SADGTVRLWDLATGELLRTL------------TGHSGGVNSVAFSP----------DGK------LLASGSDDGTVRLWD 316


                 ..
gi 113678559 831 IN 832
Cdd:COG2319  317 LA 318
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 52-403 1.69e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 142.09  E-value: 1.69e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559  52 LNKHTGRVNAVQWvhepdcSPENQLI-SGGSDNNVIVWEKLDGKFRACavCSGHSGPVcavDAVSLSSSHLLVASASSDS 130
Cdd:cd00200    5 LKGHTGGVTCVAF------SPDGKLLaTGSGDGTIKVWDLETGELLRT--LKGHTGPV---RDVAASADGTYLASGSSDK 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 131 TVKLWTYSSDaaECLQTVAfgsGFMMDV-SLALLPGSRVpvLACGGDDSRVHLYVQLSGQFQRvlTLTGHEDWVRGVEWa 209
Cdd:cd00200   74 TIRLWDLETG--ECVRTLT---GHTSYVsSVAFSPDGRI--LSSSSRDKTIKVWDVETGKCLT--TLRGHTDWVNSVAF- 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 210 NKDGELwLASCSQDCLIRVWrlfaktaaepDLQTDGIIKmkenifqvsgeefavtletVLAGHENWVYGIHWQPpsvkgd 289
Cdd:cd00200  144 SPDGTF-VASSSQDGTIKLW----------DLRTGKCVA-------------------TLTGHTGEVNSVAFSP------ 187

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 290 sveQSLKLLSASMDKTMILWGPeeDSGMWVemvrvGEVGGNTLGFYGCQMSPDGSMILAHAFHGALHLWHHDSnqeWRPS 369
Cdd:cd00200  188 ---DGEKLLSSSSDGTIKLWDL--STGKCL-----GTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRT---GECV 254

                        330       340       350
                 ....*....|....*....|....*....|....
gi 113678559 370 VVISGHFNAVQDMSWDPEGEFIITVGSDQTTRLF 403
Cdd:cd00200  255 QTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
21-402 2.47e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 141.97  E-value: 2.47e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559  21 VVSWGRGGLIAFGTCNSVAIYNPEEIRVVDLLNKHTGRVNAVQWvhepdcSPENQ-LISGGSDNNVIVWEKLDGKFRAca 99
Cdd:COG2319   85 AFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAF------SPDGKtLASGSADGTVRLWDLATGKLLR-- 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 100 VCSGHSGpvcAVDAVSLSSSHLLVASASSDSTVKLWtySSDAAECLQTVAFGSGFmmDVSLALLPGSRVpvLACGGDDSR 179
Cdd:COG2319  157 TLTGHSG---AVTSVAFSPDGKLLASGSDDGTVRLW--DLATGKLLRTLTGHTGA--VRSVAFSPDGKL--LASGSADGT 227

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 180 VHLYvQLSGQfQRVLTLTGHEDWVRGVEWANkDGElWLASCSQDCLIRVWrlfaktaaepDLQTDgiikmkenifqvsge 259
Cdd:COG2319  228 VRLW-DLATG-KLLRTLTGHSGSVRSVAFSP-DGR-LLASGSADGTVRLW----------DLATG--------------- 278

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 260 efavTLETVLAGHENWVYGIHWQPpsvkgdsveQSLKLLSASMDKTMILWGPEEDSgmwvemvRVGEVGGNTLGFYGCQM 339
Cdd:COG2319  279 ----ELLRTLTGHSGGVNSVAFSP---------DGKLLASGSDDGTVRLWDLATGK-------LLRTLTGHTGAVRSVAF 338

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 113678559 340 SPDGSMILAHAFHGALHLWHHDSNQEWRpsvVISGHFNAVQDMSWDPEGEFIITVGSDQTTRL 402
Cdd:COG2319  339 SPDGKTLASGSDDGTVRLWDLATGELLR---TLTGHTGAVTSVAFSPDGRTLASGSADGTVRL 398
WD40 COG2319
WD40 repeat [General function prediction only];
593-832 2.23e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 85.35  E-value: 2.23e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 593 ASKAEHASILLWSTASWKQLQSLSCHSLTITQMAFSPNGQLLLAVSRDRTWSLWrrgnpDLDT-EAMFSLyantskdtSV 671
Cdd:COG2319  136 ASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW-----DLATgKLLRTL--------TG 202

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 672 HTRIIWSCDWSADNKYFVTSSRDKKVIIWGHA-GSGVAVGEGEDARVTSCSsvldvgdsatavsicpFlcSDHSYLLAVG 750
Cdd:COG2319  203 HTGAVRSVAFSPDGKLLASGSADGTVRLWDLAtGKLLRTLTGHSGSVRSVA----------------F--SPDGRLLASG 264

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 751 LENGQILLYKWKPLEDLSSEsdwsrckdtdacQGHTMVVKRLRWRPrlgrgghggqDSKeeqawvQLASAGADHVVKIFD 830
Cdd:COG2319  265 SADGTVRLWDLATGELLRTL------------TGHSGGVNSVAFSP----------DGK------LLASGSDDGTVRLWD 316


                 ..
gi 113678559 831 IN 832
Cdd:COG2319  317 LA 318
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 564-832 1.30e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 81.23  E-value: 1.30e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 564 EVQKLYGHGFEMFCLASDCARTVVASACkaskaEHASILLWSTASWKQLQSLSCHSLTITQMAFSPNGQLLLAVSRDRTW 643
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGS-----GDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTI 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 644 SLWrrgnpDLDTEAMFSLYANtskdtsvHTRIIWSCDWSADNKYFVTSSRDKKVIIWghagsgvavgegeDARVTSCSSV 723
Cdd:cd00200   76 RLW-----DLETGECVRTLTG-------HTSYVSSVAFSPDGRILSSSSRDKTIKVW-------------DVETGKCLTT 130

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 724 L-DVGDSATAVSICPFlcsdhSYLLAVGLENGQILLYkwkpleDLSSEsdwsRCKDTdaCQGHTMVVKRLRWRPRLGRgg 802
Cdd:cd00200  131 LrGHTDWVNSVAFSPD-----GTFVASSSQDGTIKLW------DLRTG----KCVAT--LTGHTGEVNSVAFSPDGEK-- 191

                        250       260       270
                 ....*....|....*....|....*....|
gi 113678559 803 hggqdskeeqawvqLASAGADHVVKIFDIN 832
Cdd:cd00200  192 --------------LLSSSSDGTIKLWDLS 207
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 608-646 1.00e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 1.00e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 113678559   608 SWKQLQSLSCHSLTITQMAFSPNGQLLLAVSRDRTWSLW 646
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
609-646 5.15e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 5.15e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 113678559  609 WKQLQSLSCHSLTITQMAFSPNGQLLLAVSRDRTWSLW 646
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 189-229 1.47e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 1.47e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 113678559   189 QFQRVLTLTGHEDWVRGVEWaNKDGElWLASCSQDCLIRVW 229
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAF-SPDGK-YLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
190-229 1.56e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 1.56e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 113678559  190 FQRVLTLTGHEDWVRGVEWaNKDGElWLASCSQDCLIRVW 229
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAF-SPDGK-LLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 52-403 1.69e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 142.09  E-value: 1.69e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559  52 LNKHTGRVNAVQWvhepdcSPENQLI-SGGSDNNVIVWEKLDGKFRACavCSGHSGPVcavDAVSLSSSHLLVASASSDS 130
Cdd:cd00200    5 LKGHTGGVTCVAF------SPDGKLLaTGSGDGTIKVWDLETGELLRT--LKGHTGPV---RDVAASADGTYLASGSSDK 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 131 TVKLWTYSSDaaECLQTVAfgsGFMMDV-SLALLPGSRVpvLACGGDDSRVHLYVQLSGQFQRvlTLTGHEDWVRGVEWa 209
Cdd:cd00200   74 TIRLWDLETG--ECVRTLT---GHTSYVsSVAFSPDGRI--LSSSSRDKTIKVWDVETGKCLT--TLRGHTDWVNSVAF- 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 210 NKDGELwLASCSQDCLIRVWrlfaktaaepDLQTDGIIKmkenifqvsgeefavtletVLAGHENWVYGIHWQPpsvkgd 289
Cdd:cd00200  144 SPDGTF-VASSSQDGTIKLW----------DLRTGKCVA-------------------TLTGHTGEVNSVAFSP------ 187

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 290 sveQSLKLLSASMDKTMILWGPeeDSGMWVemvrvGEVGGNTLGFYGCQMSPDGSMILAHAFHGALHLWHHDSnqeWRPS 369
Cdd:cd00200  188 ---DGEKLLSSSSDGTIKLWDL--STGKCL-----GTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRT---GECV 254

                        330       340       350
                 ....*....|....*....|....*....|....
gi 113678559 370 VVISGHFNAVQDMSWDPEGEFIITVGSDQTTRLF 403
Cdd:cd00200  255 QTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
21-402 2.47e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 141.97  E-value: 2.47e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559  21 VVSWGRGGLIAFGTCNSVAIYNPEEIRVVDLLNKHTGRVNAVQWvhepdcSPENQ-LISGGSDNNVIVWEKLDGKFRAca 99
Cdd:COG2319   85 AFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAF------SPDGKtLASGSADGTVRLWDLATGKLLR-- 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 100 VCSGHSGpvcAVDAVSLSSSHLLVASASSDSTVKLWtySSDAAECLQTVAFGSGFmmDVSLALLPGSRVpvLACGGDDSR 179
Cdd:COG2319  157 TLTGHSG---AVTSVAFSPDGKLLASGSDDGTVRLW--DLATGKLLRTLTGHTGA--VRSVAFSPDGKL--LASGSADGT 227

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 180 VHLYvQLSGQfQRVLTLTGHEDWVRGVEWANkDGElWLASCSQDCLIRVWrlfaktaaepDLQTDgiikmkenifqvsge 259
Cdd:COG2319  228 VRLW-DLATG-KLLRTLTGHSGSVRSVAFSP-DGR-LLASGSADGTVRLW----------DLATG--------------- 278

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 260 efavTLETVLAGHENWVYGIHWQPpsvkgdsveQSLKLLSASMDKTMILWGPEEDSgmwvemvRVGEVGGNTLGFYGCQM 339
Cdd:COG2319  279 ----ELLRTLTGHSGGVNSVAFSP---------DGKLLASGSDDGTVRLWDLATGK-------LLRTLTGHTGAVRSVAF 338

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 113678559 340 SPDGSMILAHAFHGALHLWHHDSNQEWRpsvVISGHFNAVQDMSWDPEGEFIITVGSDQTTRL 402
Cdd:COG2319  339 SPDGKTLASGSDDGTVRLWDLATGELLR---TLTGHTGAVTSVAFSPDGRTLASGSADGTVRL 398
WD40 COG2319
WD40 repeat [General function prediction only];
18-418 1.34e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 133.88  E-value: 1.34e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559  18 APNVVSWGRGGLIAFGTCNSVAIYNPEEIRVVDLLNKHTGRVNAVQWVhepdcSPENQLISGGSDNNVIVWEKLDGKFRA 97
Cdd:COG2319   40 ASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFS-----PDGRLLASASADGTVRLWDLATGLLLR 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559  98 caVCSGHSGPVcavDAVSLSSSHLLVASASSDSTVKLWtySSDAAECLQTVAFGSGFMmdVSLALLPGSRVpvLACGGDD 177
Cdd:COG2319  115 --TLTGHTGAV---RSVAFSPDGKTLASGSADGTVRLW--DLATGKLLRTLTGHSGAV--TSVAFSPDGKL--LASGSDD 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 178 SRVHLYVQLSGQFQRvlTLTGHEDWVRGVEWAnKDGElWLASCSQDCLIRVWrlfaktaaepDLQTDGIIKmkenifqvs 257
Cdd:COG2319  184 GTVRLWDLATGKLLR--TLTGHTGAVRSVAFS-PDGK-LLASGSADGTVRLW----------DLATGKLLR--------- 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 258 geefavtletVLAGHENWVYGIHWQPpsvkgdsveQSLKLLSASMDKTMILWGPEEDSgmwvemvRVGEVGGNTLGFYGC 337
Cdd:COG2319  241 ----------TLTGHSGSVRSVAFSP---------DGRLLASGSADGTVRLWDLATGE-------LLRTLTGHSGGVNSV 294

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 338 QMSPDGSMILAHAFHGALHLWHHDSNQEWRpsvVISGHFNAVQDMSWDPEGEFIITVGSDQTTRLFTPWTRKGSSQITWH 417
Cdd:COG2319  295 AFSPDGKLLASGSDDGTVRLWDLATGKLLR---TLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGH 371


                 .
gi 113678559 418 E 418
Cdd:COG2319  372 T 372
WD40 COG2319
WD40 repeat [General function prediction only];
27-358 2.19e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 115.39  E-value: 2.19e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559  27 GGLIAFGTC-NSVAIYNPEEIRVVDLLNKHTGRVNAVQWvhepdcSPENQ-LISGGSDNNVIVWEKLDGKFRAcaVCSGH 104
Cdd:COG2319  132 GKTLASGSAdGTVRLWDLATGKLLRTLTGHSGAVTSVAF------SPDGKlLASGSDDGTVRLWDLATGKLLR--TLTGH 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 105 SGPVcavDAVSLSSSHLLVASASSDSTVKLWtySSDAAECLQTVAFGSGFMMdvSLALLPGSRVpvLACGGDDSRVHLYv 184
Cdd:COG2319  204 TGAV---RSVAFSPDGKLLASGSADGTVRLW--DLATGKLLRTLTGHSGSVR--SVAFSPDGRL--LASGSADGTVRLW- 273

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 185 QLSGQfQRVLTLTGHEDWVRGVEWAnKDGElWLASCSQDCLIRVWrlfaktaaepDLQTdgiikmkenifqvsGEEFAVt 264
Cdd:COG2319  274 DLATG-ELLRTLTGHSGGVNSVAFS-PDGK-LLASGSDDGTVRLW----------DLAT--------------GKLLRT- 325

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 265 letvLAGHENWVYGIHWQPpsvkgdsveQSLKLLSASMDKTMILWGPEEDSgmwvemvRVGEVGGNTLGFYGCQMSPDGS 344
Cdd:COG2319  326 ----LTGHTGAVRSVAFSP---------DGKTLASGSDDGTVRLWDLATGE-------LLRTLTGHTGAVTSVAFSPDGR 385

                        330
                 ....*....|....
gi 113678559 345 MILAHAFHGALHLW 358
Cdd:COG2319  386 TLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
27-231 7.78e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 98.83  E-value: 7.78e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559  27 GGLIAFGTC-NSVAIYNPEEIRVVDLLNKHTGRVNAVQWvhepdcSPENQ-LISGGSDNNVIVWEKLDGKFRAcaVCSGH 104
Cdd:COG2319  216 GKLLASGSAdGTVRLWDLATGKLLRTLTGHSGSVRSVAF------SPDGRlLASGSADGTVRLWDLATGELLR--TLTGH 287

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 105 SGPVCAVdAVSLSSSHLlvASASSDSTVKLWTYSSdaAECLQTVAFGSGfmMDVSLALLPGSRVpvLACGGDDSRVHLYv 184
Cdd:COG2319  288 SGGVNSV-AFSPDGKLL--ASGSDDGTVRLWDLAT--GKLLRTLTGHTG--AVRSVAFSPDGKT--LASGSDDGTVRLW- 357

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 113678559 185 QLSGQfQRVLTLTGHEDWVRGVEWANkDGElWLASCSQDCLIRVWRL 231
Cdd:COG2319  358 DLATG-ELLRTLTGHTGAVTSVAFSP-DGR-TLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-230 1.41e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 90.09  E-value: 1.41e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559   8 TCHVSCCA-NRAPNVVSWGRGGliafgtcNSVAIYNPEEIRVVDLLNKHTGRVNAVQWvhepdcSPENQLISGGS-DNNV 85
Cdd:cd00200   93 TSYVSSVAfSPDGRILSSSSRD-------KTIKVWDVETGKCLTTLRGHTDWVNSVAF------SPDGTFVASSSqDGTI 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559  86 IVWEKLDGKFraCAVCSGHSGPVCAVdAVSLSSSHLLvaSASSDSTVKLWTYSSDaaECLQT-VAFGSGFMmdvSLALLP 164
Cdd:cd00200  160 KLWDLRTGKC--VATLTGHTGEVNSV-AFSPDGEKLL--SSSSDGTIKLWDLSTG--KCLGTlRGHENGVN---SVAFSP 229

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 113678559 165 GSRVpvLACGGDDSRVHLYVQLSGQfqRVLTLTGHEDWVRGVEWANkDGeLWLASCSQDCLIRVWR 230
Cdd:cd00200  230 DGYL--LASGSEDGTIRVWDLRTGE--CVQTLSGHTNSVTSLAWSP-DG-KRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
110-700 1.93e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 91.51  E-value: 1.93e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 110 AVDAVSLSSSHLLVASASSDSTVKLWTysSDAAECLQTVAFGSGFmmDVSLALLPGSRVpvLACGGDDSRVHLYVQLSGQ 189
Cdd:COG2319   38 AVASLAASPDGARLAAGAGDLTLLLLD--AAAGALLATLLGHTAA--VLSVAFSPDGRL--LASASADGTVRLWDLATGL 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 190 fqRVLTLTGHEDWVRGVEWAnKDGElWLASCSQDCLIRVWrlfaktaaepDLQTDGIIKmkenifqvsgeefavtletVL 269
Cdd:COG2319  112 --LLRTLTGHTGAVRSVAFS-PDGK-TLASGSADGTVRLW----------DLATGKLLR-------------------TL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 270 AGHENWVYGIHWQPpsvkgdsveQSLKLLSASMDKTMILWGPEEDSgmwvemvRVGEVGGNTLGFYGCQMSPDGSMILAH 349
Cdd:COG2319  159 TGHSGAVTSVAFSP---------DGKLLASGSDDGTVRLWDLATGK-------LLRTLTGHTGAVRSVAFSPDGKLLASG 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 350 AFHGALHLWHHDSNQEWRpsvVISGHFNAVQDMSWDPEGEFIITVGSDQTTRLFTPWTRKgssqitwheisrpqihgydm 429
Cdd:COG2319  223 SADGTVRLWDLATGKLLR---TLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGE-------------------- 279

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 430 qcltmvgrfqfvsgadekVLRVFKAPRNFVenfahisgtslekllgcndiadlpegastpalglsNKAVFqgmnplkwst 509
Cdd:COG2319  280 ------------------LLRTLTGHSGGV-----------------------------------NSVAF---------- 296

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 510 tgeftlcdlaspSPqqDGgdfnslsdqykesyfqplklaeppteddllqntlwpevqklyghgfemfclasdcarTVVAS 589
Cdd:COG2319  297 ------------SP--DG---------------------------------------------------------KLLAS 305

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 590 ACkaskaEHASILLWSTASWKQLQSLSCHSLTITQMAFSPNGQLLLAVSRDRTWSLWrrgnpDLDTEAmfslyanTSKDT 669
Cdd:COG2319  306 GS-----DDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW-----DLATGE-------LLRTL 368

                        570       580       590
                 ....*....|....*....|....*....|.
gi 113678559 670 SVHTRIIWSCDWSADNKYFVTSSRDKKVIIW 700
Cdd:COG2319  369 TGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
593-832 2.23e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 85.35  E-value: 2.23e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 593 ASKAEHASILLWSTASWKQLQSLSCHSLTITQMAFSPNGQLLLAVSRDRTWSLWrrgnpDLDT-EAMFSLyantskdtSV 671
Cdd:COG2319  136 ASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW-----DLATgKLLRTL--------TG 202

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 672 HTRIIWSCDWSADNKYFVTSSRDKKVIIWGHA-GSGVAVGEGEDARVTSCSsvldvgdsatavsicpFlcSDHSYLLAVG 750
Cdd:COG2319  203 HTGAVRSVAFSPDGKLLASGSADGTVRLWDLAtGKLLRTLTGHSGSVRSVA----------------F--SPDGRLLASG 264

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 751 LENGQILLYKWKPLEDLSSEsdwsrckdtdacQGHTMVVKRLRWRPrlgrgghggqDSKeeqawvQLASAGADHVVKIFD 830
Cdd:COG2319  265 SADGTVRLWDLATGELLRTL------------TGHSGGVNSVAFSP----------DGK------LLASGSDDGTVRLWD 316


                 ..
gi 113678559 831 IN 832
Cdd:COG2319  317 LA 318
WD40 COG2319
WD40 repeat [General function prediction only];
561-832 4.39e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 84.19  E-value: 4.39e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 561 LW-----PEVQKLYGHGFEMFCLASDCARTVVASACKASkaehaSILLWSTASWKQLQSLSCHSLTITQMAFSPNGQLLL 635
Cdd:COG2319  146 LWdlatgKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDG-----TVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLA 220

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 636 AVSRDRTWSLWrrgnpDLDT-EAMFSLyantskdtSVHTRIIWSCDWSADNKYFVTSSRDKKVIIWG-HAGSGVAVGEGE 713
Cdd:COG2319  221 SGSADGTVRLW-----DLATgKLLRTL--------TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDlATGELLRTLTGH 287

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 714 DARVTSCSsvldvgdsatavsicpflCSDHSYLLAVGLENGQILLYkwkpledlssesDWSRCKDTDACQGHTMVVKRLR 793
Cdd:COG2319  288 SGGVNSVA------------------FSPDGKLLASGSDDGTVRLW------------DLATGKLLRTLTGHTGAVRSVA 337

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 113678559 794 WRPrlgrgghggqDSKeeqawvQLASAGADHVVKIFDIN 832
Cdd:COG2319  338 FSP----------DGK------TLASGSDDGTVRLWDLA 360
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 564-832 1.30e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 81.23  E-value: 1.30e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 564 EVQKLYGHGFEMFCLASDCARTVVASACkaskaEHASILLWSTASWKQLQSLSCHSLTITQMAFSPNGQLLLAVSRDRTW 643
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGS-----GDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTI 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 644 SLWrrgnpDLDTEAMFSLYANtskdtsvHTRIIWSCDWSADNKYFVTSSRDKKVIIWghagsgvavgegeDARVTSCSSV 723
Cdd:cd00200   76 RLW-----DLETGECVRTLTG-------HTSYVSSVAFSPDGRILSSSSRDKTIKVW-------------DVETGKCLTT 130

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 724 L-DVGDSATAVSICPFlcsdhSYLLAVGLENGQILLYkwkpleDLSSEsdwsRCKDTdaCQGHTMVVKRLRWRPRLGRgg 802
Cdd:cd00200  131 LrGHTDWVNSVAFSPD-----GTFVASSSQDGTIKLW------DLRTG----KCVAT--LTGHTGEVNSVAFSPDGEK-- 191

                        250       260       270
                 ....*....|....*....|....*....|
gi 113678559 803 hggqdskeeqawvqLASAGADHVVKIFDIN 832
Cdd:cd00200  192 --------------LLSSSSDGTIKLWDLS 207
WD40 COG2319
WD40 repeat [General function prediction only];
323-721 2.37e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 82.27  E-value: 2.37e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 323 RVGEVGGNTLGFYGCQMSPDGSMILAHAFHGALHLWHHDSNQEWRPsvvISGHFNAVQDMSWDPEGEFIITVGSDQTTRL 402
Cdd:COG2319   70 LLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRT---LTGHTGAVRSVAFSPDGKTLASGSADGTVRL 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 403 FTPWTRKgssqitwhEISRPQIHGYDMQCLTMV--GRFqFVSGADEKVLRVFkaprnfvenfahisgtslekllgcndia 480
Cdd:COG2319  147 WDLATGK--------LLRTLTGHSGAVTSVAFSpdGKL-LASGSDDGTVRLW---------------------------- 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 481 DLPEGASTPALGLSNKAVFQgmnpLKWSTTGEFtlcdLASPSpqQDGGdfnslsdqykesyfqpLKLAEPPTEddllqnt 560
Cdd:COG2319  190 DLATGKLLRTLTGHTGAVRS----VAFSPDGKL----LASGS--ADGT----------------VRLWDLATG------- 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 561 lwPEVQKLYGHGFEMFCLA-SDCARTVVASAckaskaEHASILLWSTASWKQLQSLSCHSLTITQMAFSPNGQLLLAVSR 639
Cdd:COG2319  237 --KLLRTLTGHSGSVRSVAfSPDGRLLASGS------ADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSD 308

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 640 DRTWSLWrrgnpDLDTEAMFSLYANtskdtsvHTRIIWSCDWSADNKYFVTSSRDKKVIIWG-HAGSGVAVGEGEDARVT 718
Cdd:COG2319  309 DGTVRLW-----DLATGKLLRTLTG-------HTGAVRSVAFSPDGKTLASGSDDGTVRLWDlATGELLRTLTGHTGAVT 376


                 ...
gi 113678559 719 SCS 721
Cdd:COG2319  377 SVA 379
WD40 COG2319
WD40 repeat [General function prediction only];
564-832 5.52e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 81.11  E-value: 5.52e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 564 EVQKLYGHGFEMFCLASDCARTVVASAckaskAEHASILLWSTASWKQLQSLSCHSLTITQMAFSPNGQLLLAVSRDRTW 643
Cdd:COG2319  196 LLRTLTGHTGAVRSVAFSPDGKLLASG-----SADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTV 270

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 644 SLWrrgnpDLDTEAMFSLYANtskdtsvHTRIIWSCDWSADNKYFVTSSRDKKVIIWgHAGSG--VAVGEGEDARVTSCS 721
Cdd:COG2319  271 RLW-----DLATGELLRTLTG-------HSGGVNSVAFSPDGKLLASGSDDGTVRLW-DLATGklLRTLTGHTGAVRSVA 337

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 722 svldvgdsatavsicpflCSDHSYLLAVGLENGQILLYkwkpledlssesDWSRCKDTDACQGHTMVVKRLRWRPrlgrg 801
Cdd:COG2319  338 ------------------FSPDGKTLASGSDDGTVRLW------------DLATGELLRTLTGHTGAVTSVAFSP----- 382

                        250       260       270
                 ....*....|....*....|....*....|.
gi 113678559 802 ghggqDSKeeqawvQLASAGADHVVKIFDIN 832
Cdd:COG2319  383 -----DGR------TLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
593-832 6.04e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 80.73  E-value: 6.04e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 593 ASKAEHASILLWSTASWKQLQSLSCHSLTITQMAFSPNGQLLLAVSRDRTWSLWrrgnpDLDT-EAMFSLyantskdtSV 671
Cdd:COG2319   94 ASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLW-----DLATgKLLRTL--------TG 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 672 HTRIIWSCDWSADNKYFVTSSRDKKVIIW-GHAGSGVAVGEGEDARVTScssvldvgdsataVSICPflcsDHSYlLAVG 750
Cdd:COG2319  161 HSGAVTSVAFSPDGKLLASGSDDGTVRLWdLATGKLLRTLTGHTGAVRS-------------VAFSP----DGKL-LASG 222

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 751 LENGQILLYkwkpledlssesDWSRCKDTDACQGHTMVVKRLRWRPrlgrgghggqDSKeeqawvQLASAGADHVVKIFD 830
Cdd:COG2319  223 SADGTVRLW------------DLATGKLLRTLTGHSGSVRSVAFSP----------DGR------LLASGSADGTVRLWD 274


                 ..
gi 113678559 831 IN 832
Cdd:COG2319  275 LA 276
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 564-830 5.60e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 76.22  E-value: 5.60e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 564 EVQKLYGHGFEMFCLASDCARTVVASAckaskAEHASILLWSTASWKQLQSLSCHSLTITQMAFSPNGQLLLAVSRDRTW 643
Cdd:cd00200   85 CVRTLTGHTSYVSSVAFSPDGRILSSS-----SRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTI 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 644 SLWrrgnpdlDTEAMFSLYANTSkdtsvHTRIIWSCDWSADNKYFVTSSRDKKVIIWGH-AGSGVAVGEGEDARVTSCSS 722
Cdd:cd00200  160 KLW-------DLRTGKCVATLTG-----HTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLsTGKCLGTLRGHENGVNSVAF 227

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 723 vldvgdsatavsicpflcSDHSYLLAVGLENGQILLYkwkpledlssesDWSRCKDTDACQGHTMVVKRLRWRPRLGRgg 802
Cdd:cd00200  228 ------------------SPDGYLLASGSEDGTIRVW------------DLRTGECVQTLSGHTNSVTSLAWSPDGKR-- 275

                        250       260
                 ....*....|....*....|....*...
gi 113678559 803 hggqdskeeqawvqLASAGADHVVKIFD 830
Cdd:cd00200  276 --------------LASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 195-700 6.93e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 76.22  E-value: 6.93e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 195 TLTGHEDWVRGVEWaNKDGElWLASCSQDCLIRVWrlfaktaaepDLQTDgiikmkenifqvsgeefavTLETVLAGHEN 274
Cdd:cd00200    4 TLKGHTGGVTCVAF-SPDGK-LLATGSGDGTIKVW----------DLETG-------------------ELLRTLKGHTG 52

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 275 WVYGIHWQPpsvkgdsveQSLKLLSASMDKTMILWGPEEDSgmwvemvRVGEVGGNTLGFYGCQMSPDGSMILAHAFHGA 354
Cdd:cd00200   53 PVRDVAASA---------DGTYLASGSSDKTIRLWDLETGE-------CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKT 116

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 355 LHLWHHDSNQewrPSVVISGHFNAVQDMSWDPEGEFIITVGSDQTTRLftpwtrkgssqitwheisrpqihgYDMqcltm 434
Cdd:cd00200  117 IKVWDVETGK---CLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKL------------------------WDL----- 164

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 435 vgrfqfvsgADEKVLRVFKAPRNFVeNFAHISGTSLEKLLGCNDiadlpegastpalglsnkavfqgmnplkwsttgeft 514
Cdd:cd00200  165 ---------RTGKCVATLTGHTGEV-NSVAFSPDGEKLLSSSSD------------------------------------ 198

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 515 lcdlaspspqqdggdfnslsdqykesyfqplklaeppteddllqntlwpevqklyghgfemfclasdcartvvasackas 594
Cdd:cd00200      --------------------------------------------------------------------------------

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 595 kaehASILLWSTASWKQLQSLSCHSLTITQMAFSPNGQLLLAVSRDRTWSLWRRGNPDLdteaMFSLYAntskdtsvHTR 674
Cdd:cd00200  199 ----GTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGEC----VQTLSG--------HTN 262

                        490       500
                 ....*....|....*....|....*.
gi 113678559 675 IIWSCDWSADNKYFVTSSRDKKVIIW 700
Cdd:cd00200  263 SVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
547-832 2.50e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 69.55  E-value: 2.50e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 547 LAEPPTEDDLLQNTLWPEVQKLYGHGFEMFCLASDCARTVVASACKASKAEHASILLWSTASWKQLQSLSCHSLTITQMA 626
Cdd:COG2319    6 GAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 627 FSPNGQLLLAVSRDRTWSLWrrgnpDLDTEAMFSLYANtskdtsvHTRIIWSCDWSADNKYFVTSSRDKKVIIWgHAGSG 706
Cdd:COG2319   86 FSPDGRLLASASADGTVRLW-----DLATGLLLRTLTG-------HTGAVRSVAFSPDGKTLASGSADGTVRLW-DLATG 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113678559 707 --VAVGEGEDARVTScssvldvgdsataVSIcpflcSDHSYLLAVGLENGQILLYkwkpledlssesDWSRCKDTDACQG 784
Cdd:COG2319  153 klLRTLTGHSGAVTS-------------VAF-----SPDGKLLASGSDDGTVRLW------------DLATGKLLRTLTG 202

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 113678559 785 HTMVVKRLRWRPrlgrgghggqDSKeeqawvQLASAGADHVVKIFDIN 832
Cdd:COG2319  203 HTGAVRSVAFSP----------DGK------LLASGSADGTVRLWDLA 234
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 608-646 1.00e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 1.00e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 113678559   608 SWKQLQSLSCHSLTITQMAFSPNGQLLLAVSRDRTWSLW 646
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
609-646 5.15e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 5.15e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 113678559  609 WKQLQSLSCHSLTITQMAFSPNGQLLLAVSRDRTWSLW 646
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 672-700 8.30e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 8.30e-05
                           10        20
                   ....*....|....*....|....*....
gi 113678559   672 HTRIIWSCDWSADNKYFVTSSRDKKVIIW 700
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 189-229 1.47e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 1.47e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 113678559   189 QFQRVLTLTGHEDWVRGVEWaNKDGElWLASCSQDCLIRVW 229
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAF-SPDGK-YLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
190-229 1.56e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 1.56e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 113678559  190 FQRVLTLTGHEDWVRGVEWaNKDGElWLASCSQDCLIRVW 229
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAF-SPDGK-LLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
672-700 2.08e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 2.08e-04
                          10        20
                  ....*....|....*....|....*....
gi 113678559  672 HTRIIWSCDWSADNKYFVTSSRDKKVIIW 700
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 94-135 1.19e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 1.19e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 113678559    94 KFRACAVCSGHSGPVCAVDavsLSSSHLLVASASSDSTVKLW 135
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVA---FSPDGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 366-403 6.07e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 6.07e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 113678559   366 WRPSVVISGHFNAVQDMSWDPEGEFIITVGSDQTTRLF 403
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
99-135 7.20e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 7.20e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 113678559   99 AVCSGHSGPVCAVDavsLSSSHLLVASASSDSTVKLW 135
Cdd:pfam00400   5 KTLEGHTGSVTSLA---FSPDGKLLASGSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH