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    glis3 GLIS family zinc finger 3 [ Danio rerio (zebrafish) ]

    Gene ID: 571000, updated on 9-Dec-2024

    Summary

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    Official Symbol
    glis3provided by ZNC
    Official Full Name
    GLIS family zinc finger 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070112-2232
    See related
    Ensembl:ENSDARG00000069726 AllianceGenome:ZFIN:ZDB-GENE-070112-2232
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fa55a05; zgc:158249
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in smoothened signaling pathway and thyroid gland development. Acts upstream of or within glucose homeostasis; pancreas regeneration; and type B pancreatic cell development. Predicted to be active in nucleus. Is expressed in several structures, including brain; endoderm; otic vesicle; pectoral fin bud; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in neonatal diabetes mellitus with congenital hypothyroidism. Orthologous to human GLIS3 (GLIS family zinc finger 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See glis3 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (643684..690223, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (628141..674274, complement)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene SMAD family member 4a Neighboring gene regulatory factor X, 3 (influences HLA class II expression) Neighboring gene uncharacterized LOC137496532 Neighboring gene unc-5 netrin receptor Cb Neighboring gene bone morphogenetic protein receptor, type IBb

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. GLIS3 and Thyroid: A Pleiotropic Candidate Gene for Congenital Hypothyroidism. Rurale G, et al. Front Endocrinol (Lausanne), 2018. PMID 30555422, Free PMC Article
    2. Identification and expression analysis of zebrafish polypeptide α-N-acetylgalactosaminyltransferase Y-subfamily genes during embryonic development. Nakayama Y, et al. Gene Expr Patterns, 2014 Sep. PMID 25026003
    3. Glis3 as a Critical Regulator of Thyroid Primordium Specification. Rurale G, et al. Thyroid, 2020 Feb. PMID 31797737
    4. Assignment of Functional Relevance to Genes at Type 2 Diabetes-Associated Loci Through Investigation of β-Cell Mass Deficits. O'Hare EA, et al. Mol Endocrinol, 2016 Apr. PMID 26963759, Free PMC Article
    5. Systematic discovery of novel ciliary genes through functional genomics in the zebrafish. Choksi SP, et al. Development, 2014 Sep. PMID 25139857, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Glis3 as a Critical Regulator of Thyroid Primordium Specification.
      Title: Glis3 as a Critical Regulator of Thyroid Primordium Specification.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pancreas regeneration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in thyroid gland development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within type B pancreatic cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein GLIS3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080607.2 → NP_001074076.2  zinc finger protein GLIS3

      Status: VALIDATED

      Source sequence(s)
      BC129173, CA470456, CD585814, CU468737, DV591821
      UniProtKB/TrEMBL
      A0A8M1NCX8, A1L1Q6, F1QB13
      Related
      ENSDARP00000118619.1, ENSDART00000142833.2
      Conserved Domains (2) summary
      sd00017
      Location:469 → 491
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:483 → 510
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      643684..690223 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009305042.4 → XP_009303317.1  zinc finger protein GLIS3 isoform X2

      UniProtKB/TrEMBL
      A0A8M3B5Y0, A1L1Q6
      Conserved Domains (2) summary
      sd00017
      Location:468 → 490
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:482 → 509
      zf-H2C2_2; Zinc-finger double domain

    2. XM_021479194.2 → XP_021334869.1  zinc finger protein GLIS3 isoform X3

      UniProtKB/TrEMBL
      A0A8M9Q669, A1L1Q6
      Conserved Domains (2) summary
      COG5189
      Location:458 → 552
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:469 → 491
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_017357981.3 → XP_017213470.1  zinc finger protein GLIS3 isoform X1

      UniProtKB/TrEMBL
      A0A8M6Z1B7, A1L1Q6

    4. XM_021479193.2 → XP_021334868.1  zinc finger protein GLIS3 isoform X3

      UniProtKB/TrEMBL
      A0A8M9Q669, A1L1Q6
      Conserved Domains (2) summary
      COG5189
      Location:458 → 552
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:469 → 491
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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