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Conserved domains on  [gi|347800689|ref|NP_001074076|]
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zinc finger protein GLIS3 [Danio rerio]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 458-552 3.46e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 50.10  E-value: 3.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347800689 458 MRVHSGEKPNKCSFEGCQKAFSRLENLKIHlRSHTGEKPYVCPHPgclkafsnssDRAKHQRTHVDTKPYACQIqgCGKR 537
Cdd:COG5189  341 MLKVKDGKPYKCPVEGCNKKYKNQNGLKYH-MLHGHQNQKLHENP----------SPEKMNIFSAKDKPYRCEV--CDKR 407

                         90
                 ....*....|....*
gi 347800689 538 YTDPSSLRKHVKsHS 552
Cdd:COG5189  408 YKNLNGLKYHRK-HS 421
KLF1_2_4_N super family cl41729
N-terminal domain of Kruppel-like factor (KLF) 1, KLF2, KLF4, and similar proteins; Kruppel ...
 619-696 3.39e-03

N-terminal domain of Kruppel-like factor (KLF) 1, KLF2, KLF4, and similar proteins; Kruppel/Krueppel-like transcription factors (KLFs) belong to a family of proteins called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specifity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the related N-terminal domains of KLF1, KLF2, KLF4, and similar proteins.


The actual alignment was detected with superfamily member cd22056:

Pssm-ID: 425360 [Multi-domain]  Cd Length: 339  Bit Score: 40.41  E-value: 3.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347800689 619 NSPMQIAGGPQTHQSPHQTHQAHQIHQTQTHLTHQTHQAHQTQTHHIQQIHQTHLTHQIQQIHQTHLSP------HGALP 692
Cdd:cd22056  198 AGGGGFMGQQKPKHQMHSVHPQAFTHHQAAGPGALQGRGGRGGPDCHLLHSSHHHHHHHHLQYQYMNAPypphyaHQGAP 277


                 ....
gi 347800689 693 PLQG 696
Cdd:cd22056  278 QFHG 281
 
Name Accession Description Interval E-value
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 458-552 3.46e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 50.10  E-value: 3.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347800689 458 MRVHSGEKPNKCSFEGCQKAFSRLENLKIHlRSHTGEKPYVCPHPgclkafsnssDRAKHQRTHVDTKPYACQIqgCGKR 537
Cdd:COG5189  341 MLKVKDGKPYKCPVEGCNKKYKNQNGLKYH-MLHGHQNQKLHENP----------SPEKMNIFSAKDKPYRCEV--CDKR 407

                         90
                 ....*....|....*
gi 347800689 538 YTDPSSLRKHVKsHS 552
Cdd:COG5189  408 YKNLNGLKYHRK-HS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
483-510 1.01e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.01e-03
                          10        20
                  ....*....|....*....|....*...
gi 347800689  483 NLKIHLRSHTGEKPYVCPHpgCLKAFSN 510
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
KLF1_2_4_N-like cd22056
N-terminal domain of Kruppel-like factors with similarity to the N-terminal domains of ...
 619-696 3.39e-03

N-terminal domain of Kruppel-like factors with similarity to the N-terminal domains of Kruppel-like factor (KLF)1, KLF2, and KLF4; Kruppel/Krueppel-like transcription factors (KLFs) belong to a family of proteins called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specifity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domains of an unknown subfamily of KLFs, predominantly found in fish, related to the N-terminal domains of KLF1, KLF2, and KLF4.


Pssm-ID: 409231 [Multi-domain]  Cd Length: 339  Bit Score: 40.41  E-value: 3.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347800689 619 NSPMQIAGGPQTHQSPHQTHQAHQIHQTQTHLTHQTHQAHQTQTHHIQQIHQTHLTHQIQQIHQTHLSP------HGALP 692
Cdd:cd22056  198 AGGGGFMGQQKPKHQMHSVHPQAFTHHQAAGPGALQGRGGRGGPDCHLLHSSHHHHHHHHLQYQYMNAPypphyaHQGAP 277


                 ....
gi 347800689 693 PLQG 696
Cdd:cd22056  278 QFHG 281
 
Name Accession Description Interval E-value
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 458-552 3.46e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 50.10  E-value: 3.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347800689 458 MRVHSGEKPNKCSFEGCQKAFSRLENLKIHlRSHTGEKPYVCPHPgclkafsnssDRAKHQRTHVDTKPYACQIqgCGKR 537
Cdd:COG5189  341 MLKVKDGKPYKCPVEGCNKKYKNQNGLKYH-MLHGHQNQKLHENP----------SPEKMNIFSAKDKPYRCEV--CDKR 407

                         90
                 ....*....|....*
gi 347800689 538 YTDPSSLRKHVKsHS 552
Cdd:COG5189  408 YKNLNGLKYHRK-HS 421
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
470-521 6.51e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.15  E-value: 6.51e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 347800689 470 SFEGCQKAFSRLENLKIHLRSHTGEKPYVCPHPGCLKAFSNSSDRAKHQRTH 521
Cdd:COG5048   35 SCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTH 86
zf-H2C2_2 pfam13465
Zinc-finger double domain;
483-510 1.01e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.01e-03
                          10        20
                  ....*....|....*....|....*...
gi 347800689  483 NLKIHLRSHTGEKPYVCPHpgCLKAFSN 510
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
KLF1_2_4_N-like cd22056
N-terminal domain of Kruppel-like factors with similarity to the N-terminal domains of ...
 619-696 3.39e-03

N-terminal domain of Kruppel-like factors with similarity to the N-terminal domains of Kruppel-like factor (KLF)1, KLF2, and KLF4; Kruppel/Krueppel-like transcription factors (KLFs) belong to a family of proteins called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specifity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domains of an unknown subfamily of KLFs, predominantly found in fish, related to the N-terminal domains of KLF1, KLF2, and KLF4.


Pssm-ID: 409231 [Multi-domain]  Cd Length: 339  Bit Score: 40.41  E-value: 3.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 347800689 619 NSPMQIAGGPQTHQSPHQTHQAHQIHQTQTHLTHQTHQAHQTQTHHIQQIHQTHLTHQIQQIHQTHLSP------HGALP 692
Cdd:cd22056  198 AGGGGFMGQQKPKHQMHSVHPQAFTHHQAAGPGALQGRGGRGGPDCHLLHSSHHHHHHHHLQYQYMNAPypphyaHQGAP 277


                 ....
gi 347800689 693 PLQG 696
Cdd:cd22056  278 QFHG 281
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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