st8sia1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: st8sia1provided by ZNC
Official Full Name: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-051005-1
See related: Ensembl:ENSDARG00000098221 AllianceGenome:ZFIN:ZDB-GENE-051005-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: siat 8A; zgc:158304
Summary: Predicted to enable alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity. Predicted to act upstream of or within protein glycosylation and sphingolipid metabolic process. Predicted to be located in Golgi membrane. Is expressed in several structures, including corpuscles of Stannius; forebrain neural plate; kidney; nervous system; and unfertilized egg. Orthologous to human ST8SIA1 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	4	NC_007115.7 (26303610..26322836, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	4	NC_007115.6 (26314412..26333638, complement)

Chromosome 4 - NC_007115.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity	IEA Inferred from Electronic Annotation more info
enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables sialyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in N-glycan processing	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in oligosaccharide metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein glycosylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein glycosylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sphingolipid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: alpha-N-acetylneuraminide alpha-2,8-sialyltransferase

Names: alpha-2,8-sialyltransferase ST8Sia I

NP_001075101.1

EC 2.4.3.8

NP_001314770.1

EC 2.4.3.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081632.1 → NP_001075101.1 alpha-N-acetylneuraminide alpha-2,8-sialyltransferase isoform 2

See identical proteins and their annotated locations for NP_001075101.1

Status: PROVISIONAL

Description

Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the C-terminus compared to isoform 1.

Source sequence(s)

BC128837

UniProtKB/TrEMBL

A0A8M1ND26, A1A5W4

Related

ENSDARP00000134208.1, ENSDART00000161687.2

Conserved Domains (1) summary

pfam00777
Location:72 → 145

Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
NM_001327841.1 → NP_001314770.1 alpha-N-acetylneuraminide alpha-2,8-sialyltransferase isoform 1

Status: PROVISIONAL

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

CT573128, CU137645

UniProtKB/TrEMBL

A3KQF4, Q6KC13

Related

ENSDARP00000136671.1, ENSDART00000170709.2

Conserved Domains (1) summary

pfam00777
Location:72 → 323

Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)