glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125995402  54 TAVELYRKLLTDCCNPKRMFAVTKENSPLGKVLWYDGEFYHYHTVTNETYPIFVQDTPLQLPLKRCSVVGNGGVLKHSGC 133
Cdd:cd23989    1 TAVEAFRKLLEDCCDPKRLFAVTKHNSPLGKNLWFDGEFLHSHTVDNETYSLFPQDTPLQLPLKKCSVVGNGGILKNSGC 80

                         90
                 ....*....|..
gi 125995402 134 GNEIDRADFIMR 145
Cdd:cd23989   81 GQQIDRADFVMR 92

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125995402  54 TAVELYRKLLTDCCNPKRMFAVTKENSPLGKVLWYDGEFYHYHTVTNETYPIFVQDTPLQLPLKRCSVVGNGGVLKHSGC 133
Cdd:cd23989    1 TAVEAFRKLLEDCCDPKRLFAVTKHNSPLGKNLWFDGEFLHSHTVDNETYSLFPQDTPLQLPLKKCSVVGNGGILKNSGC 80

                         90
                 ....*....|..
gi 125995402 134 GNEIDRADFIMR 145
Cdd:cd23989   81 GQQIDRADFVMR 92

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125995402  54 TAVELYRKLLTDCCNPKRMFAVTKENSPLGKVLWYDGEFYHYHTVTNETYPIFVQDTPLQLPLKRCSVVGNGGVLKHSGC 133
Cdd:cd23989    1 TAVEAFRKLLEDCCDPKRLFAVTKHNSPLGKNLWFDGEFLHSHTVDNETYSLFPQDTPLQLPLKKCSVVGNGGILKNSGC 80

                         90
                 ....*....|..
gi 125995402 134 GNEIDRADFIMR 145
Cdd:cd23989   81 GQQIDRADFVMR 92

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125995402  54 TAVELYRKLLTDCCNPKRMFaVTKENSPLGKVLWYDGEFYHYHTVTNETYPIFVQDTPL-QLPLKRCSVVGNGGVLKHSG 132
Cdd:cd23963    1 TALDKFRKELERLLNTRKLF-LTQKNTPLGDVLYYSYFKKKTFKITKSLYELLPKTSPFsHKRYKTCAVVGNSGILLGSG 79

                         90
                 ....*....|...
gi 125995402 133 CGNEIDRADFIMR 145
Cdd:cd23963   80 CGKEIDSHDFVIR 92

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 125995402   75 VTKENSPLGKVLWYdGEFYHYHTVTNETYPIFVQDTPLQ-LPLKRCSVVGNGGVLKHSGCGNEIDRADFIMR 145
Cdd:pfam00777   2 LTKENFPLGEWIRY-SEWWLPFTVTEELLELLPKVSPFDnKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIR 72

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125995402  52 NQTAVELYRKLLTDCCNPKRMFAVTKENSPLGKVLWYDgefYHYHTVTNETYPIFVQDTPLQLPL-----KRCSVVGNGG 126
Cdd:cd23970    2 NKTALLHQRKEIRQYFDVIKNISLTKKDVRIGQLMHFD---YSSHKYVFSISPNLRSLLPEVSPFqnkhyNTCAVVGNSG 78

                         90
                 ....*....|....*....
gi 125995402 127 VLKHSGCGNEIDRADFIMR 145
Cdd:cd23970   79 ILTNSQCGNEIDKSDFVFR 97

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.

                         10        20
                 ....*....|....*....|....*..
gi 125995402 119 CSVVGNGGVLKHSGCGNEIDRADFIMR 145
Cdd:cd19952    1 CAVVGNSGILLGSEYGKEIDSHDAVFR 27

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125995402  54 TAVELYRKLLTDCCNPKRMFAVTKENSPLGKVLWYDGEFYHYHTVTNETYPIFVQDTPLQ-LPLKRCSVVGNGGVLKHSG 132
Cdd:cd23988    1 SLVLEIRKDILRFLDAERDVSVVKSSFKPGDVIHYVLDRRRTLNISQNLHSLLPEVSPMKnRRFKTCAVVGNSGILLDSG 80

                         90
                 ....*....|...
gi 125995402 133 CGNEIDRADFIMR 145
Cdd:cd23988   81 CGKEIDSHDFVIR 93

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 125995402  60 RKLLTDCCNPKRMFAVTKENSPLGKVLWYDGEFYHYHTVTNETYPIFVQDTPLQ-LPLKRCSVVGNGGVLKHSGCGNEID 138
Cdd:cd23987    7 RKQILKFLDAERDISVLKGTLKPGDVIHYVFDRDSTMNISQNLYELLPRTSPLKnKHFKTCAIVGNSGILLNSGCGREID 86

                 ....*..
gi 125995402 139 RADFIMR 145
Cdd:cd23987   87 SHDFVIR 93

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).

                         10        20
                 ....*....|....*....|....*...
gi 125995402 118 RCSVVGNGGVLKHSGCGNEIDRADFIMR 145
Cdd:cd23974   86 RCAVVGNGGILNGSRMGAEIDGHDYVFR 113

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).

                         10        20
                 ....*....|....*....|....*...
gi 125995402 118 RCSVVGNGGVLKHSGCGNEIDRADFIMR 145
Cdd:cd23973   85 RCAVVGNGGILNGSKMGQEIDSHDYVFR 112

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).

                         10        20        30
                 ....*....|....*....|....*....|.
gi 125995402 115 PLKRCSVVGNGGVLKHSGCGNEIDRADFIMR 145
Cdd:cd23984    1 SCKKCVVVGNGGVLRNKSLGKKIDSYDVIIR 31

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).

                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 125995402 111 PLQLPLK--RCSVVGNGGVLKHSGCGNEIDRADFIMR 145
Cdd:cd23972   75 PRDTPGKciRCAVVGNGGILNGSRQGRAIDAHDYVFR 111

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).

                         10        20
                 ....*....|....*....|....*....
gi 125995402 117 KRCSVVGNGGVLKHSGCGNEIDRADFIMR 145
Cdd:cd23981    3 RRCIIVGNGGVLANKSLGSKIDDYDVVVR 31

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).

                         10        20        30
                 ....*....|....*....|....*....|.
gi 125995402 115 PLKRCSVVGNGGVLKHSGCGNEIDRADFIMR 145
Cdd:cd23982    1 RCRRCVVVGNGHNLKNSSLGDVIDSYDVVIR 31