igfbp1b insulin-like growth factor binding protein 1b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: igfbp1bprovided by ZNC
Official Full Name: insulin-like growth factor binding protein 1bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-081210-3
See related: Ensembl:ENSDARG00000038666 AllianceGenome:ZFIN:ZDB-GENE-081210-3
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Enables insulin-like growth factor I binding activity and insulin-like growth factor II binding activity. Predicted to be involved in regulation of insulin-like growth factor receptor signaling pathway. Predicted to be located in extracellular region and membrane. Predicted to be active in extracellular space. Is expressed in digestive system; female organism; and male organism. Human ortholog(s) of this gene implicated in diabetic angiopathy. Orthologous to human IGFBP1 (insulin like growth factor binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 2

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (124433..129689, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (135384..138896, complement)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

G47512 (e-PCR)
- UniSTS:108288

G46273 (e-PCR)
- UniSTS:107075

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables growth factor binding	IEA Inferred from Electronic Annotation more info
enables insulin-like growth factor I binding	IBA Inferred from Biological aspect of Ancestor more info
enables insulin-like growth factor I binding	IDA Inferred from Direct Assay more info	PubMed
enables insulin-like growth factor II binding	IBA Inferred from Biological aspect of Ancestor more info
enables insulin-like growth factor II binding	IDA Inferred from Direct Assay more info	PubMed
enables insulin-like growth factor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of insulin-like growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: insulin-like growth factor-binding protein 1b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001098257.2 → NP_001091727.1 insulin-like growth factor-binding protein 1b precursor

See identical proteins and their annotated locations for NP_001091727.1

Status: VALIDATED

Source sequence(s)

BC135095

UniProtKB/TrEMBL

A0A8M1NEP6, A4IGH0, A4K8J2

Related

ENSDARP00000056452.5, ENSDART00000056453.7

Conserved Domains (2) summary

smart00121
Location:29 → 106

IB; Insulin growth factor-binding protein homologues

pfam00086
Location:163 → 238

Thyroglobulin_1; Thyroglobulin type-1 repeat