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igfbp1b insulin-like growth factor binding protein 1b [ Danio rerio (zebrafish) ]

Gene ID: 793907, updated on 9-Dec-2024

Summary

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Official Symbol
igfbp1bprovided by ZNC
Official Full Name
insulin-like growth factor binding protein 1bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-081210-3
See related
Ensembl:ENSDARG00000038666 AllianceGenome:ZFIN:ZDB-GENE-081210-3
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Enables insulin-like growth factor I binding activity and insulin-like growth factor II binding activity. Predicted to be involved in regulation of insulin-like growth factor receptor signaling pathway. Predicted to be located in extracellular region and membrane. Predicted to be active in extracellular space. Is expressed in digestive system; female organism; and male organism. Human ortholog(s) of this gene implicated in diabetic angiopathy. Orthologous to human IGFBP1 (insulin like growth factor binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See igfbp1b in Genome Data Viewer
Location:
chromosome: 2
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (124433..129689, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (135384..138896, complement)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene FGGY carbohydrate kinase domain containing Neighboring gene zinc finger-like gene 2a Neighboring gene adenylate cyclase 1b Neighboring gene Mov10 like RNA helicase 1 Neighboring gene zgc:113518

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Duplication and diversification of the hypoxia-inducible IGFBP-1 gene in zebrafish. Kamei H, et al. PLoS One, 2008 Aug 28. PMID 18769480, Free PMC Article
  2. Hyperactivation of Wnt/β-catenin and Jak/Stat3 pathways in human and zebrafish foetal growth restriction models: Implications for pharmacological rescue. Risato G, et al. Front Cell Dev Biol, 2022. PMID 36051436, Free PMC Article
  3. Acute stress is detrimental to heart regeneration in zebrafish. Sallin P, et al. Open Biol, 2016 Mar. PMID 27030176, Free PMC Article
  4. Integrating multiple genome annotation databases improves the interpretation of microarray gene expression data. Yin J, et al. BMC Genomics, 2010 Jan 20. PMID 20089164, Free PMC Article
  5. Research resource: whole transcriptome RNA sequencing detects multiple 1α,25-dihydroxyvitamin D(3)-sensitive metabolic pathways in developing zebrafish. Craig TA, et al. Mol Endocrinol, 2012 Sep. PMID 22734042, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables growth factor binding  
enables insulin-like growth factor I binding  
enables insulin-like growth factor I binding PubMed 
enables insulin-like growth factor II binding  
enables insulin-like growth factor II binding PubMed 
enables insulin-like growth factor binding  
Process Evidence Code Pubs
involved_in regulation of insulin-like growth factor receptor signaling pathway  
Component Evidence Code Pubs
located_in extracellular region  
is_active_in extracellular space  
located_in membrane  

General protein information

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Preferred Names
insulin-like growth factor-binding protein 1b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098257.2 → NP_001091727.1  insulin-like growth factor-binding protein 1b precursor

    See identical proteins and their annotated locations for NP_001091727.1

    Status: VALIDATED

    Source sequence(s)
    BC135095
    UniProtKB/TrEMBL
    A0A8M1NEP6, A4IGH0, A4K8J2
    Related
    ENSDARP00000056452.5, ENSDART00000056453.7
    Conserved Domains (2) summary
    smart00121
    Location:29 → 106
    IB; Insulin growth factor-binding protein homologues
    pfam00086
    Location:163 → 238
    Thyroglobulin_1; Thyroglobulin type-1 repeat

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    124433..129689 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068212908.1 → XP_068069009.1  insulin-like growth factor-binding protein 1b isoform X1

    UniProtKB/TrEMBL
    A0A8M1NEP6, A4IGH0, A4K8J2

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