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    tag-68 Mothers against decapentaplegic homolog [ Caenorhabditis elegans ]

    Gene ID: 172930, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tag-68
    Official Full Name
    Mothers against decapentaplegic homolog
    Primary source
    WormBase:WBGene00006445
    Locus tag
    CELE_F37D6.6
    See related
    AllianceGenome:WB:WBGene00006445
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable I-SMAD binding activity and transcription regulator inhibitor activity. Predicted to be involved in several processes, including SMAD protein signal transduction; cell differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleus. Predicted to be part of heteromeric SMAD protein complex. Is expressed in head neurons; intestine; and ventral nerve cord. Human ortholog(s) of this gene implicated in aortic valve disease 2; colorectal cancer; craniosynostosis 7; pancreatic adenocarcinoma; and radioulnar synostosis. Orthologous to human SMAD6 (SMAD family member 6) and SMAD7 (SMAD family member 7). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tag-68 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    9
    Sequence:
    Chromosome: I; NC_003279.8 (10501585..10505949)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Intraflagellar transport protein che-13 Neighboring gene Glycosyltransferase family 92 protein F59C6.8

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lysine conservation and context in TGFbeta and Wnt signaling suggest new targets and general themes for posttranslational modification. Konikoff CE, et al. J Mol Evol, 2008 Oct. PMID 18797952, Free PMC Article
    2. Molecular evolution of a developmental pathway: phylogenetic analyses of transforming growth factor-beta family ligands, receptors and Smad signal transducers. Newfeld SJ, et al. Genetics, 1999 Jun. PMID 10353918, Free PMC Article
    3. High-throughput behavioral analysis in C. elegans. Swierczek NA, et al. Nat Methods, 2011 Jun 5. PMID 21642964, Free PMC Article
    4. TGF-beta signaling. Savage-Dunn C. WormBook, 2005 Sep 9. PMID 18050404, Free PMC Article
    5. A 4D single-cell protein atlas of transcription factors delineates spatiotemporal patterning during embryogenesis. Ma X, et al. Nat Methods, 2021 Aug. PMID 34312566

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables I-SMAD binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription regulator inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in SMAD protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in anatomical structure morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in post-embryonic development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of developmental process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of multicellular organismal process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of heteromeric SMAD protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mothers against decapentaplegic homolog
    NP_492746.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      10501585..10505949
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060345.4 → NP_492746.2  Mothers against decapentaplegic homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492746.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EDS9
      Conserved Domains (2) summary
      cd10489
      Location:14 → 152
      MH1_SMAD_6_7; N-terminal Mad Homology 1 (MH1) domain in SMAD6 and SMAD7
      cl00056
      Location:251 → 415
      MH2; C-terminal Mad Homology 2 (MH2) domain
    Nucleotide Protein
    Heading Accession and Version

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