tnr tenascin R (restrictin, janusin) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tnrprovided by ZNC
Official Full Name: tenascin R (restrictin, janusin)provided by ZNC
Primary source: ZFIN:ZDB-GENE-030804-1
See related: Ensembl:ENSDARG00000020771 AllianceGenome:ZFIN:ZDB-GENE-030804-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Acts upstream of or within axon guidance. Predicted to be located in extracellular region. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in brain; head; and heart. Orthologous to human TNR (tenascin R). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (35240887..35479018)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (35258155..35492951)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tenascin-R may guide newly added and regenerating optic axons by a contact-repellent mechanism in the optic pathway of adult fish.
Title: Tenascin-R as a repellent guidance molecule for newly growing and regenerating optic axons in adult zebrafish.
role of tenascin-R in axon pathfinding was studied in the developing optic system of zebrafish
Title: Tenascin-R as a repellent guidance molecule for developing optic axons in zebrafish.

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General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
acts_upstream_of_or_within axon guidance	IDA Inferred from Direct Assay more info	PubMed
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tenascin-R

Names: janusin; restrictin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_194383.1 → NP_919364.1 tenascin-R precursor

See identical proteins and their annotated locations for NP_919364.1

Status: PROVISIONAL

Source sequence(s)

AY286489

UniProtKB/TrEMBL

Q7T3T6

Related

ENSDARP00000010406.7, ENSDART00000015827.9

Conserved Domains (6) summary

smart00060
Location:859 → 935

FN3; Fibronectin type 3 domain

cd00063
Location:590 → 674

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00087
Location:1126 → 1336

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

pfam00041
Location:682 → 754

fn3; Fibronectin type III domain

pfam01683
Location:234 → 283

EB; EB module

pfam07974
Location:294 → 318

EGF_2; EGF-like domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007113.7 Reference GRCz11 Primary Assembly

Range

35240887..35479018

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005171279.5 → XP_005171336.1 tenascin-R isoform X2

UniProtKB/TrEMBL

A0A8M2BIJ4

Conserved Domains (5) summary

cd00063
Location:590 → 674

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00087
Location:1037 → 1247

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

pfam00041
Location:682 → 754

fn3; Fibronectin type III domain

pfam01683
Location:234 → 283

EB; EB module

pfam07974
Location:294 → 318

EGF_2; EGF-like domain
XM_068223258.1 → XP_068079359.1 tenascin-R isoform X1

Related

ENSDARP00000147658.1, ENSDART00000179804.1
XM_068223257.1 → XP_068079358.1 tenascin-R isoform X1