dgcr8 DGCR8 microprocessor complex subunit [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dgcr8provided by ZNC
Official Full Name: DGCR8 microprocessor complex subunitprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-3421
See related: Ensembl:ENSDARG00000035564 AllianceGenome:ZFIN:ZDB-GENE-030131-3421
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: sb:eu827; sb:eu832; wu:fc23f08; wu:fc38f06; si:ch211-106a19.4
Summary: Predicted to enable double-stranded RNA binding activity and primary miRNA binding activity. Predicted to be involved in primary miRNA processing. Predicted to be part of microprocessor complex. Is expressed in ovary. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human DGCR8 (DGCR8 microprocessor complex subunit). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (24520437..24532386)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (24016637..24028586)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Drosha associated with DGCR8, and both were required to cleave pri-miRNAs. The Drosha/DGCR8 holoenzyme preferred pri-miRNAs with a large terminal loop, an extended duplex region, and flanking single stranded RNAs.
Title: Cloning, expression, and characterization of the zebrafish Dicer and Drosha enzymes.
DiGeorge syndrome critical region gene 8 (dgcr8) in zebrafish germ line was deleted and demonstrated that the maternal-zygotic dgcr8 (MZdgcr8) embryos exhibit MZdicer-like phenotypes with morphological defects which could be rescued by miR-430.
Title: Germline-specific dgcr8 knockout in zebrafish using a BACK approach.

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General gene information

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Markers

fi29d05.x1 (e-PCR)
- UniSTS:197204

fc23f08.x1 (e-PCR)
- UniSTS:193160

fc23f08.x1 (e-PCR)
- UniSTS:187841

fc06d09.x1 (e-PCR)
- UniSTS:192249

fc06d09.x1 (e-PCR)
- UniSTS:192250

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables double-stranded RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables primary miRNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in primary miRNA processing	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within primary miRNA processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of microprocessor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of microprocessor complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: microprocessor complex subunit DGCR8

Names: DiGeorge syndrome critical region gene 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001122749.1 → NP_001116221.1 microprocessor complex subunit DGCR8

Status: VALIDATED

Source sequence(s)

BX088551

UniProtKB/TrEMBL

A0A8M1NI63, A2BEG3

Related

ENSDARP00000113375.1, ENSDART00000144560.2

Conserved Domains (2) summary

smart00456
Location:293 → 323

WW; Domain with 2 conserved Trp (W) residues

pfam00035
Location:522 → 585

dsrm; Double-stranded RNA binding motif