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dgcr8 DGCR8 microprocessor complex subunit [ Danio rerio (zebrafish) ]

Gene ID: 563963, updated on 9-Dec-2024

Summary

Official Symbol
dgcr8provided by ZNC
Official Full Name
DGCR8 microprocessor complex subunitprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-3421
See related
Ensembl:ENSDARG00000035564 AllianceGenome:ZFIN:ZDB-GENE-030131-3421
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
sb:eu827; sb:eu832; wu:fc23f08; wu:fc38f06; si:ch211-106a19.4
Summary
Predicted to enable double-stranded RNA binding activity and primary miRNA binding activity. Predicted to be involved in primary miRNA processing. Predicted to be part of microprocessor complex. Is expressed in ovary. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human DGCR8 (DGCR8 microprocessor complex subunit). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See dgcr8 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (24520437..24532386)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (24016637..24028586)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137495588 Neighboring gene cytotoxic granule-associated RNA binding protein 1, like Neighboring gene microRNA mir-1306 Neighboring gene tRNA methyltransferase 2 homolog A Neighboring gene ATPase H+ transporting V0 subunit a2b

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

General gene information

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables RNA binding  
enables double-stranded RNA binding  
enables heme binding  
enables identical protein binding  
enables primary miRNA binding  
Process Evidence Code Pubs
involved_in primary miRNA processing  
acts_upstream_of_or_within primary miRNA processing  
Component Evidence Code Pubs
part_of microprocessor complex  
part_of microprocessor complex  

General protein information

Preferred Names
microprocessor complex subunit DGCR8
Names
DiGeorge syndrome critical region gene 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122749.1NP_001116221.1  microprocessor complex subunit DGCR8

    Status: VALIDATED

    Source sequence(s)
    BX088551
    UniProtKB/TrEMBL
    A0A8M1NI63, A2BEG3
    Related
    ENSDARP00000113375.1, ENSDART00000144560.2
    Conserved Domains (2) summary
    smart00456
    Location:293323
    WW; Domain with 2 conserved Trp (W) residues
    pfam00035
    Location:522585
    dsrm; Double-stranded RNA binding motif

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    24520437..24532386
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394576.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    216447..228281
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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