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    ACO3 aconitase 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 815120, updated on 18-Sep-2024

    Summary

    Official Symbol
    ACO3
    Official Full Name
    aconitase 3
    Primary source
    TAIR:AT2G05710
    Locus tag
    AT2G05710
    See related
    Araport:AT2G05710
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    aconitase 3; T3P4.5; T3P4_5
    Summary
    Encodes an aconitase that can catalyze the conversion of citrate to isocitrate through a cis-aconitate intermediate, indicating that it may participate in the TCA cycle and other primary metabolic pathways. The protein is believed to accumulate in the mitochondria and the cytosol. It affects CSD2 (At2g28190 - a superoxide dismutase) transcript levels and may play a role in the response to oxidative stress. One member of the family (ACO1 - At35830) was shown to specifically bind to the 5' UTR of CSD2 in vitro. ACO3 is tyrosine-phosphorylated and its phosphorylation state is modulated in response to ABA in Arabidopsis thaliana seeds.
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    Genomic context

    See ACO3 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    19
    Sequence:
    Chromosome: 2; NC_003071.7 (2141329..2146678)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene pseudo Neighboring gene miscRNA Neighboring gene Transducin/WD40 repeat-like superfamily protein Neighboring gene miscRNA

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    NM_126589.3

    Gene Ontology Provided by TAIR

    General protein information

    Preferred Names
    aconitase 3
    NP_178634.2
    • aconitase 3 (ACO3); FUNCTIONS IN: aconitate hydratase activity, copper ion binding, ATP binding; INVOLVED IN: in 6 processes; LOCATED IN: cytosol, mitochondrion, cell wall, plasma membrane, chloroplast; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha (InterPro:IPR001030), Aconitase family, 4Fe-4S cluster binding site (InterPro:IPR018136), Aconitase A/isopropylmalate dehydratase small subunit, swivel (InterPro:IPR000573), Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 2 (InterPro:IPR015932), Aconitase/Iron regulatory protein 2/2-methylisocitrate dehydratase (InterPro:IPR015934), Aconitase-like core (InterPro:IPR015937), Aconitase/3-isopropylmalate dehydratase, swivel (InterPro:IPR015928), Aconitase/iron regulatory protein 2 (InterPro:IPR006249), Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3 (InterPro:IPR015931); BEST Arabidopsis thaliana protein match is: aconitase 1 (TAIR:AT4G35830.1); Has 20552 Blast hits to 20369 proteins in 2575 species: Archae - 558; Bacteria - 10777; Metazoa - 503; Fungi - 660; Plants - 232; Viruses - 0; Other Eukaryotes - 7822 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      2141329..2146678
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_126589.3 → NP_178634.2  aconitase 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_178634.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8L784, Q9SIB9
      UniProtKB/TrEMBL
      A0A178VV24, A0A5S9WXC8
      Conserved Domains (1) summary
      PLN00070
      Location:59 → 990
      PLN00070; aconitate hydratase
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