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    TCP4 TCP family transcription factor 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820732, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TCP4
    Official Full Name
    TCP family transcription factor 4
    Primary source
    TAIR:AT3G15030
    Locus tag
    AT3G15030
    See related
    Araport:AT3G15030
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    maternal effect embryo arrest 35; MEE35; TCP family transcription factor 4
    Summary
    Arabidopsis thaliana TCP family transcription factor. Regulated by miR319. Involved in heterchronic regulation of leaf differentiation.
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    Genomic context

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    See TCP4 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    2
    Sequence:
    Chromosome: 3; NC_003074.8 (5061681..5064152)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene cobalt ion binding protein Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein Neighboring gene Lactate/malate dehydrogenase family protein Neighboring gene senescence regulator (Protein of unknown function, DUF584) Neighboring gene IQ-domain 10

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A double-negative feedback loop between miR319c and JAW-TCPs establishes growth pattern in incipient leaf primordia in Arabidopsis thaliana. Shankar N, et al. PLoS Genet, 2023 Sep. PMID 37769020, Free PMC Article
    2. Hyper-activation of the TCP4 transcription factor in Arabidopsis thaliana accelerates multiple aspects of plant maturation. Sarvepalli K, et al. Plant J, 2011 Aug. PMID 21518050
    3. The TCP4 transcription factor of Arabidopsis blocks cell division in yeast at G1→S transition. Aggarwal P, et al. Biochem Biophys Res Commun, 2011 Jul 1. PMID 21658370
    4. Interaction of TCP4-mediated growth module with phytohormones. Sarvepalli K, et al. Plant Signal Behav, 2011 Oct. PMID 21904111, Free PMC Article
    5. Identification of specific DNA binding residues in the TCP family of transcription factors in Arabidopsis. Aggarwal P, et al. Plant Cell, 2010 Apr. PMID 20363772, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Arabidopsis transcription factor TCP4 controls the identity of the apical gynoecium.
      Title: Arabidopsis transcription factor TCP4 controls the identity of the apical gynoecium.
    2. Arabidopsis TCP4 transcription factor inhibits high temperature-induced homeotic conversion of ovules.
      Title: Arabidopsis TCP4 transcription factor inhibits high temperature-induced homeotic conversion of ovules.
    3. The function of the WRI1-TCP4 regulatory module in lipid biosynthesis.
      Title: The function of the WRI1-TCP4 regulatory module in lipid biosynthesis.
    4. TEOSINTE BRANCHED1/CYCLOIDEA/PROLIFERATING CELL FACTOR4 Interacts with WRINKLED1 to Mediate Seed Oil Biosynthesis.
      Title: TEOSINTE BRANCHED1/CYCLOIDEA/PROLIFERATING CELL FACTOR4 Interacts with WRINKLED1 to Mediate Seed Oil Biosynthesis.
    5. De Novo Shoot Regeneration Controlled by HEN1 and TCP3/4 in Arabidopsis.
      Title: De Novo Shoot Regeneration Controlled by HEN1 and TCP3/4 in Arabidopsis.
    6. The TCP4 Transcription Factor Directly Activates TRICHOMELESS1 and 2 and Suppresses Trichome Initiation.
      Title: The TCP4 Transcription Factor Directly Activates TRICHOMELESS1 and 2 and Suppresses Trichome Initiation.
    7. The study reveals that the interplay between light-responsive factors PIFs and the developmental regulator TCP4 determines the cotyledon-specific light regulation of SAUR16 and SAUR50, which contributes to cotyledon closure and opening before and after de-etiolation.
      Title: The Transcription Factors TCP4 and PIF3 Antagonistically Regulate Organ-Specific Light Induction of SAUR Genes to Modulate Cotyledon Opening during De-Etiolation in Arabidopsis.
    8. We induced a microRNA-resistant form of TCP4 at various developmental stages of leaf primordium that lacked the activity of TCP4 and its homologues and followed its effect on growth kinematics. By combining this with spatio-temporal gene expression analysis, we show that TCP4 commits leaf cells within the transition zone to exit proliferation and enter differentiation.
      Title: The CIN-TCP transcription factors promote commitment to differentiation in Arabidopsis leaf pavement cells via both auxin-dependent and independent pathways.
    9. Detailed genetic analyses show that GIS and TCP4 work in same pathway and GIS function is required for TCP4-mediated regulation of trichome differentiation.
      Title: The TCP4 transcription factor regulates trichome cell differentiation by directly activating GLABROUS INFLORESCENCE STEMS in Arabidopsis thaliana.
    10. Mutations in MIR319 and gain-of-function mutations in the TCP4 gene conferred resistance against miR319 and impaired the cotyledon boundary and leaf serration formation. Taken together, these findings demonstrate that the MIR319 and TCP gene families underlie robust and multilayer control of leaf development.
      Title: Roles of miR319 and TCP Transcription Factors in Leaf Development.
    Submit: New GeneRIF Correction See all GeneRIFs (20)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001202967.1
    NM_001338148.1
    NM_112365.4
    NM_180258.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables DNA-binding transcription activator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within cotyledon development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cotyledon morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within embryo development ending in seed dormancy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf senescence IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of development, heterochronic IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    TCP family transcription factor 4
    NP_001189896.1
    • TCP family transcription factor 4 (TCP4); FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: in 6 processes; LOCATED IN: cellular_component unknown; EXPRESSED IN: 19 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: Transcription factor, TCP (InterPro:IPR005333), Transcription factor TCP subgroup (InterPro:IPR017887); BEST Arabidopsis thaliana protein match is: TEOSINTE BRANCHED 1, cycloidea and PCF transcription factor 3 (TAIR:AT1G53230.1).
    NP_001319557.1
    • TCP family transcription factor 4 (TCP4); CONTAINS InterPro DOMAIN/s: Transcription factor, TCP (InterPro:IPR005333), Transcription factor TCP subgroup (InterPro:IPR017887); BEST Arabidopsis thaliana protein match is: TEOSINTE BRANCHED 1, cycloidea and PCF transcription factor 3 (TAIR:AT1G53230.1); Has 1577 Blast hits to 1575 proteins in 330 species: Archae - 0; Bacteria - 0; Metazoa - 88; Fungi - 13; Plants - 1470; Viruses - 0; Other Eukaryotes - 6 (source: NCBI BLink).
    NP_850589.1
    • TCP family transcription factor 4 (TCP4); CONTAINS InterPro DOMAIN/s: Transcription factor, TCP (InterPro:IPR005333), Transcription factor TCP subgroup (InterPro:IPR017887); BEST Arabidopsis thaliana protein match is: TEOSINTE BRANCHED 1, cycloidea and PCF transcription factor 3 (TAIR:AT1G53230.1); Has 1577 Blast hits to 1575 proteins in 330 species: Archae - 0; Bacteria - 0; Metazoa - 88; Fungi - 13; Plants - 1470; Viruses - 0; Other Eukaryotes - 6 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      5061681..5064152
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001338148.1 → NP_001319557.1  TCP family transcription factor 4 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A178VD44, B9DFB4, Q8LPR5, Q9LKA2
      UniProtKB/TrEMBL
      A0A384KY84, A0A654F7B2
      Conserved Domains (1) summary
      cl23822
      Location:43 → 104
      TCP; TCP family transcription factor

    2. NM_112365.4 → NP_188121.1  TCP family transcription factor 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_188121.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A178VD44, B9DFB4, Q8LPR5, Q9LKA2
      UniProtKB/TrEMBL
      A0A384KY84, A0A654F7B2
      Conserved Domains (1) summary
      cl23822
      Location:43 → 104
      TCP; TCP family transcription factor

    3. NM_001202967.1 → NP_001189896.1  TCP family transcription factor 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001189896.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A178VD44, B9DFB4, Q8LPR5, Q9LKA2
      UniProtKB/TrEMBL
      A0A384KY84, A0A654F7B2
      Conserved Domains (1) summary
      cl23822
      Location:43 → 104
      TCP; TCP family transcription factor

    4. NM_180258.3 → NP_850589.1  TCP family transcription factor 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850589.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A178VD44, B9DFB4, Q8LPR5, Q9LKA2
      UniProtKB/TrEMBL
      A0A384KY84, A0A654F7B2
      Conserved Domains (1) summary
      cl23822
      Location:43 → 104
      TCP; TCP family transcription factor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8LPR5.1

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