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    MOS6 ARM repeat superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 827472, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MOS6
    Official Full Name
    ARM repeat superfamily protein
    Primary source
    TAIR:AT4G02150
    Locus tag
    AT4G02150
    See related
    Araport:AT4G02150
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    6; ATIMPALPHA3; IMPA-3; IMPORTIN ALPHA 3; IMPORTIN ALPHA ISOFORM 3; MODIFIER OF SNC1; T10M13.16; T10M13_16
    Summary
    Encodes IMPORTIN ALPHA 3. Mutant plants act as suppressors of snc1 response and salicylic acid accumulation. Located in the nucleus. Involved in protein import. Protein interacts with Agrobacterium proteins VirD2 and VirE2. Is not individually essential for Agrobacterium-mediated root transformation, but when overexpressed can rescue the impa-4 decreased transformation susceptibility phenotype.
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    Genomic context

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    See MOS6 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    10
    Sequence:
    Chromosome: 4; NC_003075.7 (950546..953690, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene CTP synthase family protein Neighboring gene galacturonosyltransferase 6 Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene cotton fiber protein Neighboring gene cotton fiber protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Probing formation of cargo/importin-α transport complexes in plant cells using a pathogen effector. Wirthmueller L, et al. Plant J, 2015 Jan. PMID 25284001, Free PMC Article
    2. An importin alpha homolog, MOS6, plays an important role in plant innate immunity. Palma K, et al. Curr Biol, 2005 Jun 21. PMID 15964279
    3. Functional requirement of the Arabidopsis importin-α nuclear transport receptor family in autoimmunity mediated by the NLR protein SNC1. Lüdke D, et al. Plant J, 2021 Feb. PMID 33210758
    4. The truncated NLR protein TIR-NBS13 is a MOS6/IMPORTIN-α3 interaction partner required for plant immunity. Roth C, et al. Plant J, 2017 Dec. PMID 28901644
    5. Pleiotropic control of glucose and hormone responses by PRL1, a nuclear WD protein, in Arabidopsis. Németh K, et al. Genes Dev, 1998 Oct 1. PMID 9765207, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Functional requirement of the Arabidopsis importin-alpha nuclear transport receptor family in autoimmunity mediated by the NLR protein SNC1.
      Title: Functional requirement of the Arabidopsis importin-α nuclear transport receptor family in autoimmunity mediated by the NLR protein SNC1.
    2. MOS6, identified by positional cloning, encodes importin alpha3, one of eight alpha importins in Arabidopsis [MOS6]
      Title: An importin alpha homolog, MOS6, plays an important role in plant innate immunity.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001340367.1
    NM_116447.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables nuclear import signal receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ARM repeat superfamily protein
    NP_192124.1
    • MODIFIER OF SNC1, 6 (MOS6); FUNCTIONS IN: protein transporter activity, binding; INVOLVED IN: intracellular protein transport, defense response; LOCATED IN: nucleus; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Importin-alpha-like, importin-beta-binding domain (InterPro:IPR002652), Armadillo-like helical (InterPro:IPR011989), Armadillo (InterPro:IPR000225), Armadillo-type fold (InterPro:IPR016024); BEST Arabidopsis thaliana protein match is: importin alpha isoform 6 (TAIR:AT1G02690.1); Has 4718 Blast hits to 3432 proteins in 305 species: Archae - 4; Bacteria - 22; Metazoa - 2034; Fungi - 556; Plants - 1321; Viruses - 0; Other Eukaryotes - 781 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      950546..953690 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_116447.3 → NP_192124.1  ARM repeat superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_192124.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04255, O04294, O49601, Q4JHM3, Q94F55
      UniProtKB/TrEMBL
      A0A178V578, A0A5S9XP37, A0A654FL77
      Conserved Domains (2) summary
      COG5064
      Location:10 → 529
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      sd00043
      Location:247 → 272
      ARM; armadillo repeat [structural motif]

    2. NM_001340367.1 → NP_001328074.1  ARM repeat superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B3H5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O04294.2

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