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    FAH2 fatty acid hydroxylase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 827835, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FAH2
    Official Full Name
    fatty acid hydroxylase 2
    Primary source
    TAIR:AT4G20870
    Locus tag
    AT4G20870
    See related
    Araport:AT4G20870
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS FATTY ACID HYDROXYLASE 2; ATFAH2; fatty acid hydroxylase 2; T13K14.30; T13K14_30
    Summary
    encodes a fatty acid hydroxylase, required for the AtBI-1-mediated suppression of programmed cell death.
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    Genomic context

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    See FAH2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    7
    Sequence:
    Chromosome: 4; NC_003075.7 (11174450..11176881, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene FAD-binding Berberine family protein Neighboring gene tripeptidyl peptidase ii Neighboring gene FAD-binding Berberine family protein Neighboring gene miscRNA Neighboring gene miscRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Defective FA2H leads to a novel form of neurodegeneration with brain iron accumulation (NBIA). Kruer MC, et al. Ann Neurol, 2010 Nov. PMID 20853438, Free PMC Article
    2. Arabidopsis mutants of sphingolipid fatty acid α-hydroxylases accumulate ceramides and salicylates. König S, et al. New Phytol, 2012 Dec. PMID 23025549
    3. Arabidopsis sphingolipid fatty acid 2-hydroxylases (AtFAH1 and AtFAH2) are functionally differentiated in fatty acid 2-hydroxylation and stress responses. Nagano M, et al. Plant Physiol, 2012 Jul. PMID 22635113, Free PMC Article
    4. Functional association of cell death suppressor, Arabidopsis Bax inhibitor-1, with fatty acid 2-hydroxylation through cytochrome b₅. Nagano M, et al. Plant J, 2009 Apr. PMID 19054355
    5. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FAH2 enzyme is capable of forming alpha-hydroxylated ceramides.
      Title: Arabidopsis mutants of sphingolipid fatty acid α-hydroxylases accumulate ceramides and salicylates.
    2. AtFAH1 and AtFAH2 had fatty acid 2-hydroxylase activity, and the interaction with Arabidopsis cytochrome b5 was needed for the sufficient activity.
      Title: Arabidopsis sphingolipid fatty acid 2-hydroxylases (AtFAH1 and AtFAH2) are functionally differentiated in fatty acid 2-hydroxylation and stress responses.
    3. the present study identifies mutations in FA2H as a cause of NBIA
      Title: Defective FA2H leads to a novel form of neurodegeneration with brain iron accumulation (NBIA).
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001341459.1
    NM_118205.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables fatty acid 2-hydroxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fatty acid 2-hydroxylase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of programmed cell death IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    fatty acid hydroxylase 2
    NP_193819.1
    • fatty acid hydroxylase 2 (FAH2); CONTAINS InterPro DOMAIN/s: Fatty acid hydroxylase (InterPro:IPR006694); BEST Arabidopsis thaliana protein match is: fatty acid hydroxylase 1 (TAIR:AT2G34770.1); Has 806 Blast hits to 806 proteins in 373 species: Archae - 0; Bacteria - 413; Metazoa - 105; Fungi - 141; Plants - 78; Viruses - 0; Other Eukaryotes - 69 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      11174450..11176881 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_118205.2 → NP_193819.1  fatty acid hydroxylase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_193819.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SUC5
      UniProtKB/TrEMBL
      A0A178V550, A0A7G2EZQ1
      Conserved Domains (1) summary
      PLN02434
      Location:1 → 237
      PLN02434; fatty acid hydroxylase

    2. NM_001341459.1 → NP_001328972.1  fatty acid hydroxylase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SUC5
      UniProtKB/TrEMBL
      A0A178V550, A0A7G2EZQ1
      Conserved Domains (1) summary
      PLN02434
      Location:1 → 237
      PLN02434; fatty acid hydroxylase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SUC5.1

    Gene LinkOut

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