U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    RAD54 DNA repair/recombination protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821455, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    RAD54
    Official Full Name
    DNA repair/recombination protein
    Primary source
    TAIR:AT3G19210
    Locus tag
    AT3G19210
    See related
    Araport:AT3G19210
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATRAD54; CHR25; homolog of RAD54
    Summary
    Encodes RAD54, a member of the SWI2/SNF2 family of DNA-stimulated ATPases. Functions in DNA repair via homologous recombination.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See RAD54 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    21
    Sequence:
    Chromosome: 3; NC_003074.8 (6652695..6658988, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene autophagy 2 Neighboring gene uncharacterized protein Neighboring gene protein disulfide isomerase Neighboring gene Leucine-rich repeat (LRR) family protein Neighboring gene tRNA-Arg

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. RAD54 forms DNA repair foci in response to DNA damage in living plant cells. Hirakawa T, et al. Plant J, 2017 Apr. PMID 28155243
    2. Homologous recombination in Arabidopsis seeds along the track of energetic carbon ions. Wang T, et al. Mutat Res, 2012 Sep 1. PMID 22683605
    3. RAD54 is essential for RAD51-mediated repair of meiotic DSB in Arabidopsis. Hernandez Sanchez-Rebato M, et al. PLoS Genet, 2021 May. PMID 34003859, Free PMC Article
    4. LSD1-LIKE1-Mediated H3K4me2 Demethylation Is Required for Homologous Recombination Repair. Hirakawa T, et al. Plant Physiol, 2019 Oct. PMID 31366719, Free PMC Article
    5. Isolation and characterization of the RAD54 gene from Arabidopsis thaliana. Osakabe K, et al. Plant J, 2006 Dec. PMID 17227544

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SOG1 and BRCA1 Interdependently Regulate RAD54 Expression for Repairing Salinity-Induced DNA Double-Strand Breaks in Arabidopsis.
      Title: SOG1 and BRCA1 Interdependently Regulate RAD54 Expression for Repairing Salinity-Induced DNA Double-Strand Breaks in Arabidopsis.
    2. RAD54 is essential for RAD51-mediated repair of meiotic DSB in Arabidopsis.
      Title: RAD54 is essential for RAD51-mediated repair of meiotic DSB in Arabidopsis.
    3. LSD1-LIKE1-Mediated H3K4me2 Demethylation Is Required for Homologous Recombination Repair.
      Title: LSD1-LIKE1-Mediated H3K4me2 Demethylation Is Required for Homologous Recombination Repair.
    4. The appearance of RAD54 foci was dependent on the ATAXIA-TELANGIECTASIA MUTATED-SUPPRESSOR OF GAMMA RESPONSE 1 pathway, and RAD54 foci were co-localized with gammaH2AX signals. Laser irradiation of a subnuclear area demonstrated that in living cells RAD54 was specifically accumulated at the damaged site. In addition, the formation of RAD54 foci showed specificity for cell type and region. We conclude that RAD54 foci co...
      Title: RAD54 forms DNA repair foci in response to DNA damage in living plant cells.
    5. Study identified a host factor, RAD54, in a screen for replication initiator protein (Rep)-interacting partners and observed its role in DNA replication of the geminivirus mungbean yellow mosaic India virus (MYMIV).
      Title: A novel role for RAD54: this host protein modulates geminiviral DNA replication.
    6. The trans-species compatibility of Rad54 functions, is reported.
      Title: Functional conservation of the yeast and Arabidopsis RAD54-like genes.
    7. findings point to an important role for Rad54 in homologous recombination repair in plants [Rad54]
      Title: Isolation and characterization of the RAD54 gene from Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    NM_001203004.1
    NM_001338387.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP-dependent chromatin remodeler activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological process involved in interaction with host IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in cellular response to gamma radiation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to metal ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within double-strand break repair via homologous recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within double-strand break repair via synthesis-dependent strand annealing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in double-strand break repair via synthesis-dependent strand annealing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to gamma radiation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    DNA repair/recombination protein
    NP_001189933.1
    • homolog of RAD54 (RAD54); FUNCTIONS IN: helicase activity, DNA binding, nucleic acid binding, ATP binding; INVOLVED IN: DNA repair, response to gamma radiation, double-strand break repair via homologous recombination; LOCATED IN: cellular_component unknown; EXPRESSED IN: style (sensu Poaceae), hydathode, root, petiole; CONTAINS InterPro DOMAIN/s: DEAD-like helicase, N-terminal (InterPro:IPR014001), DNA/RNA helicase, C-terminal (InterPro:IPR001650), Helicase, superfamily 1/2, ATP-binding domain (InterPro:IPR014021), SNF2-related (InterPro:IPR000330); BEST Arabidopsis thaliana protein match is: switch 2 (TAIR:AT1G03750.1).
    NP_188552.3
    • homolog of RAD54 (RAD54); FUNCTIONS IN: helicase activity, DNA binding, nucleic acid binding, ATP binding; INVOLVED IN: DNA repair, response to gamma radiation, double-strand break repair via homologous recombination; LOCATED IN: cellular_component unknown; EXPRESSED IN: style (sensu Poaceae), hydathode, root, petiole, cultured cell; CONTAINS InterPro DOMAIN/s: DEAD-like helicase, N-terminal (InterPro:IPR014001), DNA/RNA helicase, C-terminal (InterPro:IPR001650), Helicase, superfamily 1/2, ATP-binding domain (InterPro:IPR014021), SNF2-related (InterPro:IPR000330); BEST Arabidopsis thaliana protein match is: P-loop containing nucleoside triphosphate hydrolases superfamily protein (TAIR:AT1G08600.2); Has 18387 Blast hits to 15591 proteins in 2067 species: Archae - 120; Bacteria - 5826; Metazoa - 3647; Fungi - 4163; Plants - 1557; Viruses - 140; Other Eukaryotes - 2934 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      6652695..6658988 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_112808.4 → NP_188552.3  DNA repair/recombination protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_188552.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4JB43, Q0PCS3, Q9LJK7
      UniProtKB/TrEMBL
      A0A178VKI0, A0A5S9XDT6, A0A654F8N7
      Conserved Domains (2) summary
      COG0553
      Location:180 → 708
      HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
      cd18004
      Location:180 → 421
      DEXHc_RAD54; DEXH-box helicase domain of RAD54

    2. NM_001203004.1 → NP_001189933.1  DNA repair/recombination protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001189933.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654F8N7
      Conserved Domains (3) summary
      cd00046
      Location:205 → 353
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:183 → 487
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:531 → 647
      Helicase_C; Helicase conserved C-terminal domain

    3. NM_001338387.1 → NP_001325757.1  DNA repair/recombination protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LM75, A0A654F8N7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0PCS3.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools