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Conserved domains on  [gi|145338703|ref|NP_188552|]
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DNA repair/recombination protein [Arabidopsis thaliana]

Protein Classification

DEAD/DEAH box helicase( domain architecture ID 13029066)

DEAD/DEAH box containing ATP-dependent helicase catalyzes the unwinding of DNA or RNA; such as human DNA excision repair protein ERCC-6-like and DNA repair and recombination protein RAD54-like

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
DEXHc_RAD54 cd18004
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ...
180-421 2.40e-134

DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


:

Pssm-ID: 350762 [Multi-domain]  Cd Length: 240  Bit Score: 401.28  E-value: 2.40e-134
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 180 LRPHQREGVQFMFDCVSGlHGSANINGCILADDMGLGKTLQSITLLYTLLCQGFDGTPMVKKAIIVTPTSLVSNWEAEIK 259
Cdd:cd18004    1 LRPHQREGVQFLYDCLTG-RRGYGGGGAILADEMGLGKTLQAIALVWTLLKQGPYGKPTAKKALIVCPSSLVGNWKAEFD 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 260 KWVGD-RIQLIALCESTRDDVLSGIdsFTRPRSALQVLIISYETFRMHSSKFCQSESCDLLICDEAHRLKNDQTLTNRAL 338
Cdd:cd18004   80 KWLGLrRIKVVTADGNAKDVKASLD--FFSSASTYPVLIISYETLRRHAEKLSKKISIDLLICDEGHRLKNSESKTTKAL 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 339 ASLTCKRRVLLSGTPMQNDLEEFFAMVNFTNPGSLGDAAHFRHYYEAPIICGREPTATEEEKNLAADRSAELSSKVNQFI 418
Cdd:cd18004  158 NSLPCRRRLLLTGTPIQNDLDEFFALVDFVNPGILGSLASFRKVFEEPILRSRDPDASEEDKELGAERSQELSELTSRFI 237

                 ...
gi 145338703 419 LRR 421
Cdd:cd18004  238 LRR 240
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ...
180-679 7.11e-120

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];


:

Pssm-ID: 440319 [Multi-domain]  Cd Length: 682  Bit Score: 379.95  E-value: 7.11e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 180 LRPHQREGVQFM-FDCVSGLhgsaninGCILADDMGLGKTLQSITLLYTLLCQGfdgtpMVKKAIIVTPTSLVSNWEAEI 258
Cdd:COG0553  242 LRPYQLEGAAWLlFLRRLGL-------GGLLADDMGLGKTIQALALLLELKERG-----LARPVLIVAPTSLVGNWQREL 309
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 259 KKWvGDRIQLIALCESTRDDVLsgidsfTRPRSALQVLIISYETFRMHSSKFCQSEScDLLICDEAHRLKNDQTLTNRAL 338
Cdd:COG0553  310 AKF-APGLRVLVLDGTRERAKG------ANPFEDADLVITSYGLLRRDIELLAAVDW-DLVILDEAQHIKNPATKRAKAV 381
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 339 ASLTCKRRVLLSGTPMQNDLEEFFAMVNFTNPGSLGDAAHFRHYYEAPIICGREptateeeknlaaDRSAELSSKVNQFI 418
Cdd:COG0553  382 RALKARHRLALTGTPVENRLEELWSLLDFLNPGLLGSLKAFRERFARPIEKGDE------------EALERLRRLLRPFL 449
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 419 LRRTNALLSNHLPPKIIEVVCCKMTTLQSTLY--------NHFISSKNLKRaladnakQTKVLAYITALKKLCNHPKLIY 490
Cdd:COG0553  450 LRRTKEDVLKDLPEKTEETLYVELTPEQRALYeavleylrRELEGAEGIRR-------RGLILAALTRLRQICSHPALLL 522
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 491 DTIKSgnpgtvgfencleffpaemFSGRsgawtggdgawvelSGKMHVLSRLLANLRRKtDDRIVLVSNYTQTLDLFAQL 570
Cdd:COG0553  523 EEGAE-------------------LSGR--------------SAKLEALLELLEELLAE-GEKVLVFSQFTDTLDLLEER 568
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 571 CRERRYPFLRLDGSTTISKRQKLVNRLNDptKDEF-AFLLSSKAGGCGLNLIGANRLVLFDPDWNPANDKQAAARVWRDG 649
Cdd:COG0553  569 LEERGIEYAYLHGGTSAEERDELVDRFQE--GPEApVFLISLKAGGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIG 646
                        490       500       510
                 ....*....|....*....|....*....|
gi 145338703 650 QKKRVYVYRFLSTGTIEEKVYQRQMSKEGL 679
Cdd:COG0553  647 QTRDVQVYKLVAEGTIEEKILELLEEKRAL 676
 
Name Accession Description Interval E-value
DEXHc_RAD54 cd18004
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ...
180-421 2.40e-134

DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350762 [Multi-domain]  Cd Length: 240  Bit Score: 401.28  E-value: 2.40e-134
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 180 LRPHQREGVQFMFDCVSGlHGSANINGCILADDMGLGKTLQSITLLYTLLCQGFDGTPMVKKAIIVTPTSLVSNWEAEIK 259
Cdd:cd18004    1 LRPHQREGVQFLYDCLTG-RRGYGGGGAILADEMGLGKTLQAIALVWTLLKQGPYGKPTAKKALIVCPSSLVGNWKAEFD 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 260 KWVGD-RIQLIALCESTRDDVLSGIdsFTRPRSALQVLIISYETFRMHSSKFCQSESCDLLICDEAHRLKNDQTLTNRAL 338
Cdd:cd18004   80 KWLGLrRIKVVTADGNAKDVKASLD--FFSSASTYPVLIISYETLRRHAEKLSKKISIDLLICDEGHRLKNSESKTTKAL 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 339 ASLTCKRRVLLSGTPMQNDLEEFFAMVNFTNPGSLGDAAHFRHYYEAPIICGREPTATEEEKNLAADRSAELSSKVNQFI 418
Cdd:cd18004  158 NSLPCRRRLLLTGTPIQNDLDEFFALVDFVNPGILGSLASFRKVFEEPILRSRDPDASEEDKELGAERSQELSELTSRFI 237

                 ...
gi 145338703 419 LRR 421
Cdd:cd18004  238 LRR 240
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ...
180-679 7.11e-120

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];


Pssm-ID: 440319 [Multi-domain]  Cd Length: 682  Bit Score: 379.95  E-value: 7.11e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 180 LRPHQREGVQFM-FDCVSGLhgsaninGCILADDMGLGKTLQSITLLYTLLCQGfdgtpMVKKAIIVTPTSLVSNWEAEI 258
Cdd:COG0553  242 LRPYQLEGAAWLlFLRRLGL-------GGLLADDMGLGKTIQALALLLELKERG-----LARPVLIVAPTSLVGNWQREL 309
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 259 KKWvGDRIQLIALCESTRDDVLsgidsfTRPRSALQVLIISYETFRMHSSKFCQSEScDLLICDEAHRLKNDQTLTNRAL 338
Cdd:COG0553  310 AKF-APGLRVLVLDGTRERAKG------ANPFEDADLVITSYGLLRRDIELLAAVDW-DLVILDEAQHIKNPATKRAKAV 381
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 339 ASLTCKRRVLLSGTPMQNDLEEFFAMVNFTNPGSLGDAAHFRHYYEAPIICGREptateeeknlaaDRSAELSSKVNQFI 418
Cdd:COG0553  382 RALKARHRLALTGTPVENRLEELWSLLDFLNPGLLGSLKAFRERFARPIEKGDE------------EALERLRRLLRPFL 449
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 419 LRRTNALLSNHLPPKIIEVVCCKMTTLQSTLY--------NHFISSKNLKRaladnakQTKVLAYITALKKLCNHPKLIY 490
Cdd:COG0553  450 LRRTKEDVLKDLPEKTEETLYVELTPEQRALYeavleylrRELEGAEGIRR-------RGLILAALTRLRQICSHPALLL 522
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 491 DTIKSgnpgtvgfencleffpaemFSGRsgawtggdgawvelSGKMHVLSRLLANLRRKtDDRIVLVSNYTQTLDLFAQL 570
Cdd:COG0553  523 EEGAE-------------------LSGR--------------SAKLEALLELLEELLAE-GEKVLVFSQFTDTLDLLEER 568
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 571 CRERRYPFLRLDGSTTISKRQKLVNRLNDptKDEF-AFLLSSKAGGCGLNLIGANRLVLFDPDWNPANDKQAAARVWRDG 649
Cdd:COG0553  569 LEERGIEYAYLHGGTSAEERDELVDRFQE--GPEApVFLISLKAGGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIG 646
                        490       500       510
                 ....*....|....*....|....*....|
gi 145338703 650 QKKRVYVYRFLSTGTIEEKVYQRQMSKEGL 679
Cdd:COG0553  647 QTRDVQVYKLVAEGTIEEKILELLEEKRAL 676
SNF2-rel_dom pfam00176
SNF2-related domain; This domain is found in proteins involved in a variety of processes ...
183-489 4.13e-76

SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.


Pssm-ID: 425504 [Multi-domain]  Cd Length: 289  Bit Score: 250.29  E-value: 4.13e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703  183 HQREGVQFMFDCVSGLHgsaniNGCILADDMGLGKTLQSITLLYTLL-CQGFDGTPmvkkAIIVTPTSLVSNWEAEIKKW 261
Cdd:pfam00176   1 YQIEGVNWMLSLENNLG-----RGGILADEMGLGKTLQTISLLLYLKhVDKNWGGP----TLIVVPLSLLHNWMNEFERW 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703  262 VGDRiQLIALCESTRDDVLSGIDSFTRPRSALQVLIISYETFRMHSSKFcqsESCD--LLICDEAHRLKNDQTLTNRALA 339
Cdd:pfam00176  72 VSPP-ALRVVVLHGNKRPQERWKNDPNFLADFDVVITTYETLRKHKELL---KKVHwhRIVLDEGHRLKNSKSKLSKALK 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703  340 SLTCKRRVLLSGTPMQNDLEEFFAMVNFTNPGSLGDAAHFRHYYEAPIicgreptateeEKNLAADRSAELSSKVNQFIL 419
Cdd:pfam00176 148 SLKTRNRWILTGTPLQNNLEELWALLNFLRPGPFGSLSTFRNWFDRPI-----------ERGGGKKGVSRLHKLLKPFLL 216
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 145338703  420 RRTNALLSNHLPPKIIEVVCCKMTTLQSTLYNHFISSKNL---KRALADNAKQTKVLAYITALKKLCNHPKLI 489
Cdd:pfam00176 217 RRTKKDVEKSLPPKVEYILFCRLSKLQRKLYQTFLLKKDLnaiKTGEGGREIKASLLNILMRLRKICNHPGLI 289
PLN03142 PLN03142
Probable chromatin-remodeling complex ATPase chain; Provisional
132-684 6.47e-69

Probable chromatin-remodeling complex ATPase chain; Provisional


Pssm-ID: 215601 [Multi-domain]  Cd Length: 1033  Bit Score: 248.56  E-value: 6.47e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703  132 ASTNIERDEEEEVVclppdieplvlwQSEEDGMSNV--TTIMVHSVLVK-FLRPHQREGVQFM---FDcvsglHGsanIN 205
Cdd:PLN03142  131 ASKLTEEEEDEEYL------------KEEEDGLGGSggTRLLVQPSCIKgKMRDYQLAGLNWLirlYE-----NG---IN 190
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703  206 GcILADDMGLGKTLQSITLL-YTLLCQGFDGTPMVkkaiiVTPTSLVSNWEAEIKKWV---------GD----RIQLIAL 271
Cdd:PLN03142  191 G-ILADEMGLGKTLQTISLLgYLHEYRGITGPHMV-----VAPKSTLGNWMNEIRRFCpvlravkfhGNpeerAHQREEL 264
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703  272 CESTRDDVLsgIDSFtrprsalQVLIISYETFRMHSSKFCqsescdllICDEAHRLKNDQTLTNRALASLTCKRRVLLSG 351
Cdd:PLN03142  265 LVAGKFDVC--VTSF-------EMAIKEKTALKRFSWRYI--------IIDEAHRIKNENSLLSKTMRLFSTNYRLLITG 327
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703  352 TPMQNDLEEFFAMVNFTNPGSLGDAAHFRHYYEapiicgrepTATEEEKnlaADRSAELSSKVNQFILRRTNALLSNHLP 431
Cdd:PLN03142  328 TPLQNNLHELWALLNFLLPEIFSSAETFDEWFQ---------ISGENDQ---QEVVQQLHKVLRPFLLRRLKSDVEKGLP 395
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703  432 PKIIEVVCCKMTTLQSTLYNHFISsKNLKrALADNAKQTKVLAYITALKKLCNHPKLIydtiKSGNPGTvgfencleffp 511
Cdd:PLN03142  396 PKKETILKVGMSQMQKQYYKALLQ-KDLD-VVNAGGERKRLLNIAMQLRKCCNHPYLF----QGAEPGP----------- 458
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703  512 aemfsgrsgAWTGGDgAWVELSGKMHVLSRLLANLRRKtDDRIVLVSNYTQTLDLFAQLCRERRYPFLRLDGSTTISKRQ 591
Cdd:PLN03142  459 ---------PYTTGE-HLVENSGKMVLLDKLLPKLKER-DSRVLIFSQMTRLLDILEDYLMYRGYQYCRIDGNTGGEDRD 527
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703  592 KLVNRLNDPTKDEFAFLLSSKAGGCGLNLIGANRLVLFDPDWNPANDKQAAARVWRDGQKKRVYVYRFLSTGTIEEKVYQ 671
Cdd:PLN03142  528 ASIDAFNKPGSEKFVFLLSTRAGGLGINLATADIVILYDSDWNPQVDLQAQDRAHRIGQKKEVQVFRFCTEYTIEEKVIE 607
                         570
                  ....*....|....
gi 145338703  672 RQMSKEGLQK-VIQ 684
Cdd:PLN03142  608 RAYKKLALDAlVIQ 621
SF2_C_SNF cd18793
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ...
532-660 4.17e-54

C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350180 [Multi-domain]  Cd Length: 135  Bit Score: 183.83  E-value: 4.17e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 532 LSGKMHVLSRLLANLRrKTDDRIVLVSNYTQTLDLFAQLCRERRYPFLRLDGSTTISKRQKLVNRLNDPtKDEFAFLLSS 611
Cdd:cd18793    9 VSGKLEALLELLEELR-EPGEKVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNED-PDIRVFLLST 86
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 145338703 612 KAGGCGLNLIGANRLVLFDPDWNPANDKQAAARVWRDGQKKRVYVYRFL 660
Cdd:cd18793   87 KAGGVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
DEXDc smart00487
DEAD-like helicases superfamily;
178-371 5.33e-27

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 109.12  E-value: 5.33e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703   178 KFLRPHQREGVQFMFDcvsglhgsaNINGCILADDMGLGKTLQSITLLYTLLCQGFDgtpmvKKAIIVTPT-SLVSNWEA 256
Cdd:smart00487   7 EPLRPYQKEAIEALLS---------GLRDVILAAPTGSGKTLAALLPALEALKRGKG-----GRVLVLVPTrELAEQWAE 72
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703   257 EIKKWVGDrIQLIALCESTRDDVLSGIDSFTRPRSalQVLIISYETF-RMHSSKFCQSESCDLLICDEAHRLKND---QT 332
Cdd:smart00487  73 ELKKLGPS-LGLKVVGLYGGDSKREQLRKLESGKT--DILVTTPGRLlDLLENDKLSLSNVDLVILDEAHRLLDGgfgDQ 149
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 145338703   333 LTNRALASLTCKRRVLLSGTP---MQNDLEEFFAMVNFTNPG 371
Cdd:smart00487 150 LEKLLKLLPKNVQLLLLSATPpeeIENLLELFLNDPVFIDVG 191
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
534-649 4.45e-23

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 94.58  E-value: 4.45e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703  534 GKMHVLSRLLanlRRKTDDRIVLVSNYTQTLDLfAQLCRERRYPFLRLDGSTTISKRQKLVNRLNDPTKDefaFLLSSKA 613
Cdd:pfam00271   1 EKLEALLELL---KKERGGKVLIFSQTKKTLEA-ELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKID---VLVATDV 73
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 145338703  614 GGCGLNLIGANRLVLFDPDWNPANDKQAAARVWRDG 649
Cdd:pfam00271  74 AERGLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
HELICc smart00490
helicase superfamily c-terminal domain;
565-649 2.15e-18

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 80.33  E-value: 2.15e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703   565 DLFAQLCRERRYPFLRLDGSTTISKRQKLVNRLNdptKDEFAFLLSSKAGGCGLNLIGANRLVLFDPDWNPANDKQAAAR 644
Cdd:smart00490   1 EELAELLKELGIKVARLHGGLSQEEREEILDKFN---NGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGR 77

                   ....*
gi 145338703   645 VWRDG 649
Cdd:smart00490  78 AGRAG 82
SSL2 COG1061
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
180-353 4.20e-10

Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];


Pssm-ID: 440681 [Multi-domain]  Cd Length: 566  Bit Score: 63.51  E-value: 4.20e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 180 LRPHQREGVQFMFDCVSGLHGsaniNGCILADdMGLGKTLQSITLLYTLLCqgfdgtpmVKKAIIVTPT-SLVSNWEAEI 258
Cdd:COG1061   81 LRPYQQEALEALLAALERGGG----RGLVVAP-TGTGKTVLALALAAELLR--------GKRVLVLVPRrELLEQWAEEL 147
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 259 KKWVGDRIqlialcestrddvlsgiDSFTRPRSALQVLIISYETF--RMHSSKFcqSESCDLLICDEAHRLKNDQTLtnR 336
Cdd:COG1061  148 RRFLGDPL-----------------AGGGKKDSDAPITVATYQSLarRAHLDEL--GDRFGLVIIDEAHHAGAPSYR--R 206
                        170
                 ....*....|....*..
gi 145338703 337 ALASLTCKRRVLLSGTP 353
Cdd:COG1061  207 ILEAFPAAYRLGLTATP 223
 
Name Accession Description Interval E-value
DEXHc_RAD54 cd18004
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ...
180-421 2.40e-134

DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350762 [Multi-domain]  Cd Length: 240  Bit Score: 401.28  E-value: 2.40e-134
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 180 LRPHQREGVQFMFDCVSGlHGSANINGCILADDMGLGKTLQSITLLYTLLCQGFDGTPMVKKAIIVTPTSLVSNWEAEIK 259
Cdd:cd18004    1 LRPHQREGVQFLYDCLTG-RRGYGGGGAILADEMGLGKTLQAIALVWTLLKQGPYGKPTAKKALIVCPSSLVGNWKAEFD 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 260 KWVGD-RIQLIALCESTRDDVLSGIdsFTRPRSALQVLIISYETFRMHSSKFCQSESCDLLICDEAHRLKNDQTLTNRAL 338
Cdd:cd18004   80 KWLGLrRIKVVTADGNAKDVKASLD--FFSSASTYPVLIISYETLRRHAEKLSKKISIDLLICDEGHRLKNSESKTTKAL 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 339 ASLTCKRRVLLSGTPMQNDLEEFFAMVNFTNPGSLGDAAHFRHYYEAPIICGREPTATEEEKNLAADRSAELSSKVNQFI 418
Cdd:cd18004  158 NSLPCRRRLLLTGTPIQNDLDEFFALVDFVNPGILGSLASFRKVFEEPILRSRDPDASEEDKELGAERSQELSELTSRFI 237

                 ...
gi 145338703 419 LRR 421
Cdd:cd18004  238 LRR 240
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ...
180-679 7.11e-120

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];


Pssm-ID: 440319 [Multi-domain]  Cd Length: 682  Bit Score: 379.95  E-value: 7.11e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 180 LRPHQREGVQFM-FDCVSGLhgsaninGCILADDMGLGKTLQSITLLYTLLCQGfdgtpMVKKAIIVTPTSLVSNWEAEI 258
Cdd:COG0553  242 LRPYQLEGAAWLlFLRRLGL-------GGLLADDMGLGKTIQALALLLELKERG-----LARPVLIVAPTSLVGNWQREL 309
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 259 KKWvGDRIQLIALCESTRDDVLsgidsfTRPRSALQVLIISYETFRMHSSKFCQSEScDLLICDEAHRLKNDQTLTNRAL 338
Cdd:COG0553  310 AKF-APGLRVLVLDGTRERAKG------ANPFEDADLVITSYGLLRRDIELLAAVDW-DLVILDEAQHIKNPATKRAKAV 381
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 339 ASLTCKRRVLLSGTPMQNDLEEFFAMVNFTNPGSLGDAAHFRHYYEAPIICGREptateeeknlaaDRSAELSSKVNQFI 418
Cdd:COG0553  382 RALKARHRLALTGTPVENRLEELWSLLDFLNPGLLGSLKAFRERFARPIEKGDE------------EALERLRRLLRPFL 449
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 419 LRRTNALLSNHLPPKIIEVVCCKMTTLQSTLY--------NHFISSKNLKRaladnakQTKVLAYITALKKLCNHPKLIY 490
Cdd:COG0553  450 LRRTKEDVLKDLPEKTEETLYVELTPEQRALYeavleylrRELEGAEGIRR-------RGLILAALTRLRQICSHPALLL 522
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 491 DTIKSgnpgtvgfencleffpaemFSGRsgawtggdgawvelSGKMHVLSRLLANLRRKtDDRIVLVSNYTQTLDLFAQL 570
Cdd:COG0553  523 EEGAE-------------------LSGR--------------SAKLEALLELLEELLAE-GEKVLVFSQFTDTLDLLEER 568
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 571 CRERRYPFLRLDGSTTISKRQKLVNRLNDptKDEF-AFLLSSKAGGCGLNLIGANRLVLFDPDWNPANDKQAAARVWRDG 649
Cdd:COG0553  569 LEERGIEYAYLHGGTSAEERDELVDRFQE--GPEApVFLISLKAGGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIG 646
                        490       500       510
                 ....*....|....*....|....*....|
gi 145338703 650 QKKRVYVYRFLSTGTIEEKVYQRQMSKEGL 679
Cdd:COG0553  647 QTRDVQVYKLVAEGTIEEKILELLEEKRAL 676
DEXHc_RAD54A cd18067
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as ...
180-421 5.59e-92

DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as RAD54L or RAD54, plays a role in homologous recombination related repair of DNA double-strand breaks. RAD54A is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350825 [Multi-domain]  Cd Length: 243  Bit Score: 290.91  E-value: 5.59e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 180 LRPHQREGVQFMFDCVSGLHgSANINGCILADDMGLGKTLQSITLLYTLLCQGFDGTPMVKKAIIVTPTSLVSNWEAEIK 259
Cdd:cd18067    1 LRPHQREGVKFLYRCVTGRR-IRGSHGCIMADEMGLGKTLQCITLMWTLLRQSPQCKPEIDKAIVVSPSSLVKNWANELG 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 260 KWVGDRIQLIALCESTRDDVLSGIDSFTRPRSA---LQVLIISYETFRMHSSKFCQSEsCDLLICDEAHRLKNDQTLTNR 336
Cdd:cd18067   80 KWLGGRLQPLAIDGGSKKEIDRKLVQWASQQGRrvsTPVLIISYETFRLHVEVLQKGE-VGLVICDEGHRLKNSDNQTYQ 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 337 ALASLTCKRRVLLSGTPMQNDLEEFFAMVNFTNPGSLGDAAHFRHYYEAPIICGREPTATEEEKNLAADRSAELSSKVNQ 416
Cdd:cd18067  159 ALDSLNTQRRVLLSGTPIQNDLSEYFSLVNFVNPGILGTAAEFKKNFELPILKGRDADASEKERQLGEEKLQELISIVNR 238

                 ....*
gi 145338703 417 FILRR 421
Cdd:cd18067  239 CIIRR 243
DEXHc_RAD54B cd18066
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as ...
180-421 1.23e-80

DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as RDH54, binds to double-stranded DNA, displays ATPase activity in the presence of DNA, and may have a role in meiotic and mitotic recombination. RAD54B is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350824 [Multi-domain]  Cd Length: 235  Bit Score: 260.55  E-value: 1.23e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 180 LRPHQREGVQFMFDCVSGLHGSANInGCILADDMGLGKTLQSITLLYTLLCQGFDGT-PMVKKAIIVTPTSLVSNWEAEI 258
Cdd:cd18066    1 LRPHQREGIEFLYECVMGMRVNERF-GAILADEMGLGKTLQCISLIWTLLRQGPYGGkPVIKRALIVTPGSLVKNWKKEF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 259 KKWVG-DRIQLIALcestrdDVLSGIDSFTRPrSALQVLIISYETFrMHSSKFCQSESCDLLICDEAHRLKNDQTLTNRA 337
Cdd:cd18066   80 QKWLGsERIKVFTV------DQDHKVEEFIAS-PLYSVLIISYEML-LRSLDQISKLNFDLVICDEGHRLKNTSIKTTTA 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 338 LASLTCKRRVLLSGTPMQNDLEEFFAMVNFTNPGSLGDAAHFRHYYEAPIICGREPTATEEEKNLAADRSAELSSKVNQF 417
Cdd:cd18066  152 LTSLSCERRIILTGTPIQNDLQEFFALIDFVNPGILGSLSTYRKVYEEPIVRSREPTATPEEKKLGEARAAELTRLTGLF 231

                 ....
gi 145338703 418 ILRR 421
Cdd:cd18066  232 ILRR 235
SNF2-rel_dom pfam00176
SNF2-related domain; This domain is found in proteins involved in a variety of processes ...
183-489 4.13e-76

SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.


Pssm-ID: 425504 [Multi-domain]  Cd Length: 289  Bit Score: 250.29  E-value: 4.13e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703  183 HQREGVQFMFDCVSGLHgsaniNGCILADDMGLGKTLQSITLLYTLL-CQGFDGTPmvkkAIIVTPTSLVSNWEAEIKKW 261
Cdd:pfam00176   1 YQIEGVNWMLSLENNLG-----RGGILADEMGLGKTLQTISLLLYLKhVDKNWGGP----TLIVVPLSLLHNWMNEFERW 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703  262 VGDRiQLIALCESTRDDVLSGIDSFTRPRSALQVLIISYETFRMHSSKFcqsESCD--LLICDEAHRLKNDQTLTNRALA 339
Cdd:pfam00176  72 VSPP-ALRVVVLHGNKRPQERWKNDPNFLADFDVVITTYETLRKHKELL---KKVHwhRIVLDEGHRLKNSKSKLSKALK 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703  340 SLTCKRRVLLSGTPMQNDLEEFFAMVNFTNPGSLGDAAHFRHYYEAPIicgreptateeEKNLAADRSAELSSKVNQFIL 419
Cdd:pfam00176 148 SLKTRNRWILTGTPLQNNLEELWALLNFLRPGPFGSLSTFRNWFDRPI-----------ERGGGKKGVSRLHKLLKPFLL 216
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 145338703  420 RRTNALLSNHLPPKIIEVVCCKMTTLQSTLYNHFISSKNL---KRALADNAKQTKVLAYITALKKLCNHPKLI 489
Cdd:pfam00176 217 RRTKKDVEKSLPPKVEYILFCRLSKLQRKLYQTFLLKKDLnaiKTGEGGREIKASLLNILMRLRKICNHPGLI 289
PLN03142 PLN03142
Probable chromatin-remodeling complex ATPase chain; Provisional
132-684 6.47e-69

Probable chromatin-remodeling complex ATPase chain; Provisional


Pssm-ID: 215601 [Multi-domain]  Cd Length: 1033  Bit Score: 248.56  E-value: 6.47e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703  132 ASTNIERDEEEEVVclppdieplvlwQSEEDGMSNV--TTIMVHSVLVK-FLRPHQREGVQFM---FDcvsglHGsanIN 205
Cdd:PLN03142  131 ASKLTEEEEDEEYL------------KEEEDGLGGSggTRLLVQPSCIKgKMRDYQLAGLNWLirlYE-----NG---IN 190
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703  206 GcILADDMGLGKTLQSITLL-YTLLCQGFDGTPMVkkaiiVTPTSLVSNWEAEIKKWV---------GD----RIQLIAL 271
Cdd:PLN03142  191 G-ILADEMGLGKTLQTISLLgYLHEYRGITGPHMV-----VAPKSTLGNWMNEIRRFCpvlravkfhGNpeerAHQREEL 264
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703  272 CESTRDDVLsgIDSFtrprsalQVLIISYETFRMHSSKFCqsescdllICDEAHRLKNDQTLTNRALASLTCKRRVLLSG 351
Cdd:PLN03142  265 LVAGKFDVC--VTSF-------EMAIKEKTALKRFSWRYI--------IIDEAHRIKNENSLLSKTMRLFSTNYRLLITG 327
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703  352 TPMQNDLEEFFAMVNFTNPGSLGDAAHFRHYYEapiicgrepTATEEEKnlaADRSAELSSKVNQFILRRTNALLSNHLP 431
Cdd:PLN03142  328 TPLQNNLHELWALLNFLLPEIFSSAETFDEWFQ---------ISGENDQ---QEVVQQLHKVLRPFLLRRLKSDVEKGLP 395
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703  432 PKIIEVVCCKMTTLQSTLYNHFISsKNLKrALADNAKQTKVLAYITALKKLCNHPKLIydtiKSGNPGTvgfencleffp 511
Cdd:PLN03142  396 PKKETILKVGMSQMQKQYYKALLQ-KDLD-VVNAGGERKRLLNIAMQLRKCCNHPYLF----QGAEPGP----------- 458
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703  512 aemfsgrsgAWTGGDgAWVELSGKMHVLSRLLANLRRKtDDRIVLVSNYTQTLDLFAQLCRERRYPFLRLDGSTTISKRQ 591
Cdd:PLN03142  459 ---------PYTTGE-HLVENSGKMVLLDKLLPKLKER-DSRVLIFSQMTRLLDILEDYLMYRGYQYCRIDGNTGGEDRD 527
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703  592 KLVNRLNDPTKDEFAFLLSSKAGGCGLNLIGANRLVLFDPDWNPANDKQAAARVWRDGQKKRVYVYRFLSTGTIEEKVYQ 671
Cdd:PLN03142  528 ASIDAFNKPGSEKFVFLLSTRAGGLGINLATADIVILYDSDWNPQVDLQAQDRAHRIGQKKEVQVFRFCTEYTIEEKVIE 607
                         570
                  ....*....|....
gi 145338703  672 RQMSKEGLQK-VIQ 684
Cdd:PLN03142  608 RAYKKLALDAlVIQ 621
DEXHc_ATRX-like cd18007
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ...
180-406 2.59e-65

DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350765 [Multi-domain]  Cd Length: 239  Bit Score: 219.09  E-value: 2.59e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 180 LRPHQREGVQFMFD-CVSGLHGSANINGCILADDMGLGKTLQSITLLYTLLCQgfdgTPMVKKAIIVTPTSLVSNWEAEI 258
Cdd:cd18007    1 LKPHQVEGVRFLWSnLVGTDVGSDEGGGCILAHTMGLGKTLQVITFLHTYLAA----APRRSRPLVLCPASTLYNWEDEF 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 259 KKWVGD--RIQLIALCESTRDDVLSGIDSFTRPRSALQVLIISYETFR-------------MHSSKFCQSESCDLLICDE 323
Cdd:cd18007   77 KKWLPPdlRPLLVLVSLSASKRADARLRKINKWHKEGGVLLIGYELFRnlasnattdprlkQEFIAALLDPGPDLLVLDE 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 324 AHRLKNDQTLTNRALASLTCKRRVLLSGTPMQNDLEEFFAMVNFTNPGSLGDAAHFRHYYEAPIICGREPTATEEEKNLA 403
Cdd:cd18007  157 GHRLKNEKSQLSKALSKVKTKRRILLTGTPLQNNLKEYWTMVDFARPKYLGTLKEFKKKFVKPIEAGQCVDSTEEDVRLM 236

                 ...
gi 145338703 404 ADR 406
Cdd:cd18007  237 LKR 239
DEXHc_Snf cd17919
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ...
180-370 1.34e-57

DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350677 [Multi-domain]  Cd Length: 182  Bit Score: 195.48  E-value: 1.34e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 180 LRPHQREGVQFMFDCVSglhgsaNINGCILADDMGLGKTLQSITLLYTLLCQGfdgtPMVKKAIIVTPTSLVSNWEAEIK 259
Cdd:cd17919    1 LRPYQLEGLNFLLELYE------NGPGGILADEMGLGKTLQAIAFLAYLLKEG----KERGPVLVVCPLSVLENWEREFE 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 260 KWVGDrIQLIALCESTRDDVLsgIDSFTRPRSAlQVLIISYETFRMHSSKFCqSESCDLLICDEAHRLKNDQTLTNRALA 339
Cdd:cd17919   71 KWTPD-LRVVVYHGSQRERAQ--IRAKEKLDKF-DVVLTTYETLRRDKASLR-KFRWDLVVVDEAHRLKNPKSQLSKALK 145
                        170       180       190
                 ....*....|....*....|....*....|.
gi 145338703 340 SLTCKRRVLLSGTPMQNDLEEFFAMVNFTNP 370
Cdd:cd17919  146 ALRAKRRLLLTGTPLQNNLEELWALLDFLDP 176
DEXHc_ERCC6L2 cd18005
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as ...
180-421 8.35e-57

DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350763 [Multi-domain]  Cd Length: 245  Bit Score: 195.68  E-value: 8.35e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 180 LRPHQREGVQFMFDCVSGLHGsaningCILADDMGLGKTLQSITLLYTLLcqGFDGT--------PMVKK---------- 241
Cdd:cd18005    1 LRDYQREGVEFMYDLYKNGRG------GILGDDMGLGKTVQVIAFLAAVL--GKTGTrrdrennrPRFKKkppassakkp 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 242 AIIVTPTSLVSNWEAEIKKWvgDRIQLIALCESTRDDVLSGidsfTRPRSALQVLIISYETFRMHSSKFCQSEsCDLLIC 321
Cdd:cd18005   73 VLIVAPLSVLYNWKDELDTW--GHFEVGVYHGSRKDDELEG----RLKAGRLEVVVTTYDTLRRCIDSLNSIN-WSAVIA 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 322 DEAHRLKNDQTLTNRALASLTCKRRVLLSGTPMQNDLEEFFAMVNFTNPGSLGDAAHFRHYYEAPIICGREPTATEEEKN 401
Cdd:cd18005  146 DEAHRIKNPKSKLTQAMKELKCKVRIGLTGTLLQNNMKELWCLLDWAVPGALGSRSQFKKHFSEPIKRGQRHTATARELR 225
                        250       260
                 ....*....|....*....|
gi 145338703 402 LAADRSAELSSKVNQFILRR 421
Cdd:cd18005  226 LGRKRKQELAVKLSKFFLRR 245
SF2_C_SNF cd18793
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ...
532-660 4.17e-54

C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350180 [Multi-domain]  Cd Length: 135  Bit Score: 183.83  E-value: 4.17e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 532 LSGKMHVLSRLLANLRrKTDDRIVLVSNYTQTLDLFAQLCRERRYPFLRLDGSTTISKRQKLVNRLNDPtKDEFAFLLSS 611
Cdd:cd18793    9 VSGKLEALLELLEELR-EPGEKVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNED-PDIRVFLLST 86
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 145338703 612 KAGGCGLNLIGANRLVLFDPDWNPANDKQAAARVWRDGQKKRVYVYRFL 660
Cdd:cd18793   87 KAGGVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
DEXQc_arch_SWI2_SNF2 cd18012
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ...
180-422 1.73e-50

DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350770 [Multi-domain]  Cd Length: 218  Bit Score: 176.99  E-value: 1.73e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 180 LRPHQREGVQFM-FDCVSGLhgsaninGCILADDMGLGKTLQSITLLYTLLCQGfdgtpMVKKAIIVTPTSLVSNWEAEI 258
Cdd:cd18012    5 LRPYQKEGFNWLsFLRHYGL-------GGILADDMGLGKTLQTLALLLSRKEEG-----RKGPSLVVAPTSLIYNWEEEA 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 259 KKWVGD-RIQLIALCESTRddvlsgidSFTRPRSALQVLIISYETFRmHSSKFCQSESCDLLICDEAHRLKNDQTLTNRA 337
Cdd:cd18012   73 AKFAPElKVLVIHGTKRKR--------EKLRALEDYDLVITSYGLLR-RDIELLKEVKFHYLVLDEAQNIKNPQTKTAKA 143
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 338 LASLTCKRRVLLSGTPMQNDLEEFFAMVNFTNPGSLGDAAHFRHYYEAPIicgreptateeEKNLAADRSAELSSKVNQF 417
Cdd:cd18012  144 VKALKADHRLALTGTPIENHLGELWSIFDFLNPGLLGSYKRFKKRFAKPI-----------EKDGDEEALEELKKLISPF 212

                 ....*
gi 145338703 418 ILRRT 422
Cdd:cd18012  213 ILRRL 217
DEXHc_ATRX cd18068
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha ...
180-406 2.57e-44

DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) is involved in transcriptional regulation and chromatin remodeling. Mutations in humans cause mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1) and alpha-thalassemia myelodysplasia syndrome (ATMDS). ATRX is part of the a DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350826 [Multi-domain]  Cd Length: 246  Bit Score: 160.44  E-value: 2.57e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 180 LRPHQREGVQFMFDC----VSGLHGSANiNGCILADDMGLGKTLQSITLLYT-LLCQGFDGtpmVKKAIIVTPTSLVSNW 254
Cdd:cd18068    1 LKPHQVDGVQFMWDCccesLKKTKKSPG-SGCILAHCMGLGKTLQVVTFLHTvLLCEKLEN---FSRVLVVCPLNTVLNW 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 255 EAEIKKWVGDriqlialceSTRDDVL--SGIDSFTRP---RSALQ-------VLIISYETFRMHSS-------------- 308
Cdd:cd18068   77 LNEFEKWQEG---------LKDEEKIevNELATYKRPqerSYKLQrwqeeggVMIIGYDMYRILAQernvksreklkeif 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 309 -KFCQSESCDLLICDEAHRLKNDQTLTNRALASLTCKRRVLLSGTPMQNDLEEFFAMVNFTNPGSLGDAAHFRHYYEAPI 387
Cdd:cd18068  148 nKALVDPGPDFVVCDEGHILKNEASAVSKAMNSIRTKRRIVLTGTPLQNNLIEYHCMVNFVKPNLLGTIKEFRNRFVNPI 227
                        250
                 ....*....|....*....
gi 145338703 388 ICGREPTATEEEKNLAADR 406
Cdd:cd18068  228 QNGQCADSTLVDVRVMKKR 246
DEXHc_ERCC6L cd18001
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ...
180-421 2.63e-44

DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350759 [Multi-domain]  Cd Length: 232  Bit Score: 159.84  E-value: 2.63e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 180 LRPHQREGVQFMFdcvsGLHgsANINGCILADDMGLGKTLQSITLLYTLLCQGFdgtpmVKKAIIVTPTSLVSNWEAEIK 259
Cdd:cd18001    1 LYPHQREGVAWLW----SLH--DGGKGGILADDMGLGKTVQICAFLSGMFDSGL-----IKSVLVVMPTSLIPHWVKEFA 69
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 260 KW-VGDRIQLI-ALCESTRDDVLsgiDSFTRPRSAL----QVLIISYETFrmhSSKFCQSESCDLLICDEAHRLKNDQTL 333
Cdd:cd18001   70 KWtPGLRVKVFhGTSKKERERNL---ERIQRGGGVLlttyGMVLSNTEQL---SADDHDEFKWDYVILDEGHKIKNSKTK 143
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 334 TNRALASLTCKRRVLLSGTPMQNDLEEFFAMVNFTNPGS-LGDAAHFRHYYEAPIICGREPTATEEEKNLAADRSAELSS 412
Cdd:cd18001  144 SAKSLREIPAKNRIILTGTPIQNNLKELWALFDFACNGSlLGTRKTFKMEFENPITRGRDKDATQGEKALGSEVAENLRQ 223

                 ....*....
gi 145338703 413 KVNQFILRR 421
Cdd:cd18001  224 IIKPYFLRR 232
DEXHc_ARIP4 cd18069
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called ...
180-406 8.36e-42

DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called RAD54 like 2 or RAD54L2 ) modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. ARIP4 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350827 [Multi-domain]  Cd Length: 227  Bit Score: 152.66  E-value: 8.36e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 180 LRPHQREGVQFMFD----CVSGLHGSANInGCILADDMGLGKTLQSITLLYTLL-CQGfdgtpmVKKAIIVTPTSLVSNW 254
Cdd:cd18069    1 LKPHQIGGIRFLYDniieSLERYKGSSGF-GCILAHSMGLGKTLQVISFLDVLLrHTG------AKTVLAIVPVNTLQNW 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 255 EAEIKKWVGDRIQL-IALCESTRDDVLSGIDSFTRPRSAL--------QVLIISYETFRMHSSKfcqsescDLLICDEAH 325
Cdd:cd18069   74 LSEFNKWLPPPEALpNVRPRPFKVFILNDEHKTTAARAKViedwvkdgGVLLMGYEMFRLRPGP-------DVVICDEGH 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 326 RLKNDQTLTNRALASLTCKRRVLLSGTPMQNDLEEFFAMVNFTNPGSLGDAAHFRHYYEAPIICGREPTATEEEKNLAAD 405
Cdd:cd18069  147 RIKNCHASTSQALKNIRSRRRIVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMFERPILNGQCVDSTPQDVKLMRY 226

                 .
gi 145338703 406 R 406
Cdd:cd18069  227 R 227
DEXHc_Mot1 cd17999
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in ...
180-421 4.35e-38

DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in eukaryotes) regulates transcription in association with TATA binding protein (TBP). Mot1, Ino80C, and NC2 function coordinately to regulate pervasive transcription in yeast and mammals. Mot1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350757 [Multi-domain]  Cd Length: 232  Bit Score: 142.10  E-value: 4.35e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 180 LRPHQREGVQFM-FDCVSGLHGsaningcILADDMGLGKTLQSITLLYT---LLCQGFDGTPMVkkAIIVTPTSLVSNWE 255
Cdd:cd17999    1 LRPYQQEGINWLaFLNKYNLHG-------ILCDDMGLGKTLQTLCILASdhhKRANSFNSENLP--SLVVCPPTLVGHWV 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 256 AEIKKWVGDRIQLIALCESTRDDVLSGIDSFTRPRsalqVLIISYETFRmHSSKFCQSESCDLLICDEAHRLKNDQTLTN 335
Cdd:cd17999   72 AEIKKYFPNAFLKPLAYVGPPQERRRLREQGEKHN----VIVASYDVLR-NDIEVLTKIEWNYCVLDEGHIIKNSKTKLS 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 336 RALASLTCKRRVLLSGTPMQNDLEEFFAMVNFTNPGSLGDAAHFRHYYEAPIICGREPTATEEEKNLAADRSAELSSKVN 415
Cdd:cd17999  147 KAVKQLKANHRLILSGTPIQNNVLELWSLFDFLMPGYLGTEKQFQRRFLKPILASRDSKASAKEQEAGALALEALHKQVL 226

                 ....*.
gi 145338703 416 QFILRR 421
Cdd:cd17999  227 PFLLRR 232
DEXHc_CHD6_7_8_9 cd17995
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; ...
180-379 3.44e-36

DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; Chromodomain-helicase-DNA-binding protein 6-9 (CHD6, CHD7, CHD8, and CHD9) are members of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350753 [Multi-domain]  Cd Length: 223  Bit Score: 136.22  E-value: 3.44e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 180 LRPHQREGVQFMFDCVSglhgsaNINGCILADDMGLGKTLQSITLLYTLLCQGFDGTPmvkkAIIVTPTSLVSNWEAEIK 259
Cdd:cd17995    1 LRDYQLEGVNWLLFNWY------NRRNCILADEMGLGKTIQSIAFLEHLYQVEGIRGP----FLVIAPLSTIPNWQREFE 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 260 KWV----------GDRIQLIALCESTRDD----VLSGIDSFtrprsalQVLIISYETFrMHSSKFCQSESCDLLICDEAH 325
Cdd:cd17995   71 TWTdmnvvvyhgsGESRQIIQQYEMYFKDaqgrKKKGVYKF-------DVLITTYEMV-IADAEELRKIPWRVVVVDEAH 142
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 145338703 326 RLKNDQTLTNRALASLTCKRRVLLSGTPMQNDLEEFFAMVNFTNPGSLGDAAHF 379
Cdd:cd17995  143 RLKNRNSKLLQGLKKLTLEHKLLLTGTPLQNNTEELWSLLNFLEPEKFPSSEEF 196
DEXDc_SHPRH-like cd18008
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the ...
180-421 1.92e-35

DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350766 [Multi-domain]  Cd Length: 241  Bit Score: 134.72  E-value: 1.92e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 180 LRPHQREGVQFMfdcvsglhgsaNINGCILADDMGLGKTLQSITLLYTLLCQGFD-------------GTPMVKKAIIVT 246
Cdd:cd18008    1 LLPYQKQGLAWM-----------LPRGGILADEMGLGKTIQALALILATRPQDPKipeeleenssdpkKLYLSKTTLIVV 69
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 247 PTSLVSNWEAEIKKwvgdriqliaLCESTRDDVL--SGIDSFTRPRSALQ--VLIISYETFRMHSSKF--------CQSE 314
Cdd:cd18008   70 PLSLLSQWKDEIEK----------HTKPGSLKVYvyHGSKRIKSIEELSDydIVITTYGTLASEFPKNkkgggrdsKEKE 139
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 315 SCDLL-------ICDEAHRLKNDQTLTNRALASLTCKRRVLLSGTPMQNDLEEFFAMVNFTNPGSLGDAAHFRHYYEAPI 387
Cdd:cd18008  140 ASPLHrirwyrvILDEAHNIKNRSTKTSRAVCALKAERRWCLTGTPIQNSLDDLYSLLRFLRVEPFGDYPWFNSDISKPF 219
                        250       260       270
                 ....*....|....*....|....*....|....
gi 145338703 388 icgreptatEEEKNLAADRsaeLSSKVNQFILRR 421
Cdd:cd18008  220 ---------SKNDRKALER---LQALLKPILLRR 241
DEXQc_SRCAP cd18003
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ...
180-421 4.56e-33

DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350761 [Multi-domain]  Cd Length: 223  Bit Score: 127.47  E-value: 4.56e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 180 LRPHQREGVQFMFdcvsGLHgSANINGcILADDMGLGKTLQSITLLYTLLCQGFDGTPMvkkaIIVTPTSLVSNWEAEIK 259
Cdd:cd18003    1 LREYQHIGLDWLA----TLY-EKNLNG-ILADEMGLGKTIQTIALLAHLACEKGNWGPH----LIVVPTSVMLNWEMEFK 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 260 KWvgdriqlialCESTRddVLSGIDS----------FTRPrSALQVLIISYETFrMHSSKFCQSESCDLLICDEAHRLKN 329
Cdd:cd18003   71 RW----------CPGFK--ILTYYGSakerklkrqgWMKP-NSFHVCITSYQLV-VQDHQVFKRKKWKYLILDEAHNIKN 136
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 330 DQTLTNRALASLTCKRRVLLSGTPMQNDLEEFFAMVNFTNPGSLGDAAHFRHYYEAPiicgrEPTATEEEKNLAADRSAE 409
Cdd:cd18003  137 FKSQRWQTLLNFNTQRRLLLTGTPLQNSLMELWSLMHFLMPHIFQSHQEFKEWFSNP-----LTAMSEGSQEENEELVRR 211
                        250
                 ....*....|..
gi 145338703 410 LSSKVNQFILRR 421
Cdd:cd18003  212 LHKVLRPFLLRR 223
DEXHc_CHD1L cd18006
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, ...
180-421 3.58e-32

DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, also known as ALC1) is involved in DNA repair by regulating chromatin relaxation following DNA damage. CHD1L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350764 [Multi-domain]  Cd Length: 216  Bit Score: 124.47  E-value: 3.58e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 180 LRPHQREGVQFMFDCVsglhgsANINGCILADDMGLGKTLQSITLLYTLLCQGFDGTPMvkkaIIVTPTSLVSNWEAEIK 259
Cdd:cd18006    1 LRPYQLEGVNWLLQCR------AEQHGCILGDEMGLGKTCQTISLLWYLAGRLKLLGPF----LVLCPLSVLDNWKEELN 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 260 ---------KWVGDRIQLIALCESTRDDvlsgidsftrprSALQVLIISYETFRMHSSkFCQSESCDLLICDEAHRLKND 330
Cdd:cd18006   71 rfapdlsviTYMGDKEKRLDLQQDIKST------------NRFHVLLTTYEICLKDAS-FLKSFPWASLVVDEAHRLKNQ 137
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 331 QTLTNRALASLTCKRRVLLSGTPMQNDLEEFFAMVNFTNPG--SLGDAAHFRHYYEapiicgreptATEEEKNLAadrsA 408
Cdd:cd18006  138 NSLLHKTLSEFSVDFRLLLTGTPIQNSLQELYALLSFIEPNvfPKDKLDDFIKAYS----------ETDDESETV----E 203
                        250
                 ....*....|...
gi 145338703 409 ELSSKVNQFILRR 421
Cdd:cd18006  204 ELHLLLQPFLLRR 216
DEXHc_HELLS_SMARCA6 cd18009
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or ...
180-421 5.47e-32

DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or SMARCA6) is a major epigenetic regulator crucial for normal heterochromatin structure and function. HELLS is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350767 [Multi-domain]  Cd Length: 236  Bit Score: 124.81  E-value: 5.47e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 180 LRPHQREGVQFMFDCV-SGLHGsaningcILADDMGLGKTLQSITLLYTLLCQGFDGtPMvkkaIIVTPTSLVSNWEAEI 258
Cdd:cd18009    4 MRPYQLEGMEWLRMLWeNGING-------ILADEMGLGKTIQTIALLAHLRERGVWG-PF----LVIAPLSTLPNWVNEF 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 259 KKWVGD-RIQLIALCESTRDDVLSGIDSFTRPRSALQVLIISYETFrMHSSKFCQSESCDLLICDEAHRLKNDQTLTNRA 337
Cdd:cd18009   72 ARFTPSvPVLLYHGTKEERERLRKKIMKREGTLQDFPVVVTSYEIA-MRDRKALQHYAWKYLIVDEGHRLKNLNCRLIQE 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 338 LASLTCKRRVLLSGTPMQNDLEEFFAMVNFTNPGSLGDAAHFRHYYEAPIICGREPTATEEEKNLAADRSAELSSKVNQF 417
Cdd:cd18009  151 LKTFNSDNRLLLTGTPLQNNLSELWSLLNFLLPDVFDDLSSFESWFDFSSLSDNAADISNLSEEREQNIVHMLHAILKPF 230

                 ....
gi 145338703 418 ILRR 421
Cdd:cd18009  231 LLRR 234
DEXHc_SMARCA1_SMARCA5 cd17997
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin ...
180-422 1.58e-28

DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 and 5 (SMARCA1 and SMARCA5) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350755 [Multi-domain]  Cd Length: 222  Bit Score: 114.34  E-value: 1.58e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 180 LRPHQREGVQFMfdcVSGLHgsANINGcILADDMGLGKTLQSITLL-YTLLCQGFDGTPMvkkaiIVTPTSLVSNWEAEI 258
Cdd:cd17997    4 MRDYQIRGLNWL---ISLFE--NGING-ILADEMGLGKTLQTISLLgYLKHYKNINGPHL-----IIVPKSTLDNWMREF 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 259 KKWVGD--RIQLIALCEsTRDDVLsgidsftrpRSALQ-----VLIISYETFRMHSSKFCQSeSCDLLICDEAHRLKNDQ 331
Cdd:cd17997   73 KRWCPSlrVVVLIGDKE-ERADII---------RDVLLpgkfdVCITSYEMVIKEKTVLKKF-NWRYIIIDEAHRIKNEK 141
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 332 TLTNRALASLTCKRRVLLSGTPMQNDLEEFFAMVNFTNPGSLGDAAHFRHYYEapiicgreptaTEEEKNLAADRSAELS 411
Cdd:cd17997  142 SKLSQIVRLFNSRNRLLLTGTPLQNNLHELWALLNFLLPDVFTSSEDFDEWFN-----------VNNCDDDNQEVVQRLH 210
                        250
                 ....*....|.
gi 145338703 412 SKVNQFILRRT 422
Cdd:cd17997  211 KVLRPFLLRRI 221
DEXHc_CHD1_2 cd17993
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and ...
180-421 3.01e-28

DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and similar proteins; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as the substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but is also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. Both are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350751 [Multi-domain]  Cd Length: 218  Bit Score: 113.22  E-value: 3.01e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 180 LRPHQREGVQFMfdcvsgLHGSANINGCILADDMGLGKTLQSITLLYTLlcqgFDGTPMVKKAIIVTPTSLVSNWEAEIK 259
Cdd:cd17993    2 LRDYQLTGLNWL------AHSWCKGNNGILADEMGLGKTVQTISFLSYL----FHSQQQYGPFLVVVPLSTMPAWQREFA 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 260 KWVGDRIQLIALCESTRDDVLSGIDSFTRPRSALQ--VLIISYEtFRMHSSKFCQSESCDLLICDEAHRLKNDQTLTNRA 337
Cdd:cd17993   72 KWAPDMNVIVYLGDIKSRDTIREYEFYFSQTKKLKfnVLLTTYE-IILKDKAFLGSIKWQYLAVDEAHRLKNDESLLYEA 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 338 LASLTCKRRVLLSGTPMQNDLEEFFAMVNFTNPGSLGDAAHFrhyyeapiicgreptatEEEKNLAADRS-AELSSKVNQ 416
Cdd:cd17993  151 LKEFKTNNRLLITGTPLQNSLKELWALLHFLMPGKFDIWEEF-----------------EEEHDEEQEKGiADLHKELEP 213

                 ....*
gi 145338703 417 FILRR 421
Cdd:cd17993  214 FILRR 218
DEXHc_CHD3_4_5 cd17994
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; ...
180-379 3.56e-28

DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD3, CHD4, and CHD5 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350752 [Multi-domain]  Cd Length: 196  Bit Score: 112.53  E-value: 3.56e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 180 LRPHQREGVQFMfdcvsgLHGSANINGCILADDMGLGKTLQSITLLYTLLCQGFDGTPMvkkaIIVTPTSLVSNWEAEIK 259
Cdd:cd17994    1 LHPYQLEGLNWL------RFSWAQGTDTILADEMGLGKTIQTIVFLYSLYKEGHSKGPF----LVSAPLSTIINWEREFE 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 260 KWVGDRIqlialcestrddVLSGIDSftrprsalQVLIISYETFRMHSSKFcQSESCDLLICDEAHRLKNDQTLTNRALA 339
Cdd:cd17994   71 MWAPDFY------------VVTYVGD--------HVLLTSYELISIDQAIL-GSIDWAVLVVDEAHRLKNNQSKFFRILN 129
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 145338703 340 SLTCKRRVLLSGTPMQNDLEEFFAMVNFTNPGSLGDAAHF 379
Cdd:cd17994  130 SYKIGYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLQGF 169
DEXHc_ERCC6 cd18000
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, ...
180-370 1.14e-27

DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, also known Cockayne syndrome group B (CSB), Rad26 in Saccharomyces cerevisiae, and Rhp26 in Schizosaccharomyces pombe) is a DNA-binding protein that is important in transcription-coupled excision repair. ERCC6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350758 [Multi-domain]  Cd Length: 193  Bit Score: 110.88  E-value: 1.14e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 180 LRPHQREGVQFMFDcvsgLHGSANinGCILADDMGLGKTLQSITLLYTLLCQGFDGTPmvkkAIIVTPTSLVSNWEAEIK 259
Cdd:cd18000    1 LFKYQQTGVQWLWE----LHCQRV--GGILGDEMGLGKTIQIIAFLAALHHSKLGLGP----SLIVCPATVLKQWVKEFH 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 260 KWVGD-RIQLI-ALCESTRDD--VLSGIDSFTRPRSALQ---VLIISYETFRMHSsKFCQSESCDLLICDEAHRLKNDQt 332
Cdd:cd18000   71 RWWPPfRVVVLhSSGSGTGSEekLGSIERKSQLIRKVVGdggILITTYEGFRKHK-DLLLNHNWQYVILDEGHKIRNPD- 148
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 145338703 333 ltnrALASLTCKR-----RVLLSGTPMQNDLEEFFAMVNFTNP 370
Cdd:cd18000  149 ----AEITLACKQlrtphRLILSGTPIQNNLKELWSLFDFVFP 187
DEXHc_HARP_SMARCAL1 cd18010
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ...
180-402 4.37e-27

DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350768 [Multi-domain]  Cd Length: 213  Bit Score: 109.99  E-value: 4.37e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 180 LRPHQREGVQFmfdcvsglhGSANiNG-CILADDMGLGKTLQSITLLYtllcqgfdgtpMVKK---AIIVTPTSLVSNWE 255
Cdd:cd18010    1 LLPFQREGVCF---------ALRR-GGrVLIADEMGLGKTVQAIAIAA-----------YYREewpLLIVCPSSLRLTWA 59
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 256 AEIKKWVG----DRIQLIAlcesTRDDVLSGIDSftrprsalQVLIISYETFRMHSSKFcQSESCDLLICDEAHRLKNDQ 331
Cdd:cd18010   60 DEIERWLPslppDDIQVIV----KSKDGLRDGDA--------KVVIVSYDLLRRLEKQL-LARKFKVVICDESHYLKNSK 126
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 145338703 332 TLTNRALASLT--CKRRVLLSGTPMQNDLEEFFAMVNFTNPGSLGDAAHFRHYYEAPIICGREPTAT-----EEEKNL 402
Cdd:cd18010  127 AKRTKAALPLLkrAKRVILLSGTPALSRPIELFTQLDALDPKLFGRFHDFGRRYCAAKQGGFGWDYSgssnlEELHLL 204
DEXDc smart00487
DEAD-like helicases superfamily;
178-371 5.33e-27

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 109.12  E-value: 5.33e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703   178 KFLRPHQREGVQFMFDcvsglhgsaNINGCILADDMGLGKTLQSITLLYTLLCQGFDgtpmvKKAIIVTPT-SLVSNWEA 256
Cdd:smart00487   7 EPLRPYQKEAIEALLS---------GLRDVILAAPTGSGKTLAALLPALEALKRGKG-----GRVLVLVPTrELAEQWAE 72
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703   257 EIKKWVGDrIQLIALCESTRDDVLSGIDSFTRPRSalQVLIISYETF-RMHSSKFCQSESCDLLICDEAHRLKND---QT 332
Cdd:smart00487  73 ELKKLGPS-LGLKVVGLYGGDSKREQLRKLESGKT--DILVTTPGRLlDLLENDKLSLSNVDLVILDEAHRLLDGgfgDQ 149
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 145338703   333 LTNRALASLTCKRRVLLSGTP---MQNDLEEFFAMVNFTNPG 371
Cdd:smart00487 150 LEKLLKLLPKNVQLLLLSATPpeeIENLLELFLNDPVFIDVG 191
DEXHc_SMARCA2_SMARCA4 cd17996
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin ...
180-421 7.03e-27

DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, members 2 and 4 (SMARCA2 and SMARCA4) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350754 [Multi-domain]  Cd Length: 233  Bit Score: 109.77  E-value: 7.03e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 180 LRPHQREGVQFMfdcVSgLHGSaNINGcILADDMGLGKTLQSITLLYTLLCQGFDGTPMvkkaIIVTPTSLVSNWEAEIK 259
Cdd:cd17996    4 LKEYQLKGLQWM---VS-LYNN-NLNG-ILADEMGLGKTIQTISLITYLMEKKKNNGPY----LVIVPLSTLSNWVSEFE 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 260 KWVgDRIQLIALCESTrdDVLSGIDSFTRPrSALQVLIISYEtFRMHSSKFCQSESCDLLICDEAHRLKNDQTLTNRALA 339
Cdd:cd17996   74 KWA-PSVSKIVYKGTP--DVRKKLQSQIRA-GKFNVLLTTYE-YIIKDKPLLSKIKWKYMIIDEGHRMKNAQSKLTQTLN 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 340 SLTC-KRRVLLSGTPMQNDLEEFFAMVNFTNPGSLGDAAHFRHYYEAP--IICGREPTATEEEKNLAADRsaELSSKVNQ 416
Cdd:cd17996  149 TYYHaRYRLLLTGTPLQNNLPELWALLNFLLPKIFKSCKTFEQWFNTPfaNTGEQVKIELNEEETLLIIR--RLHKVLRP 226

                 ....*
gi 145338703 417 FILRR 421
Cdd:cd17996  227 FLLRR 231
DEXHc_CHD6 cd18058
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; ...
180-379 7.59e-27

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6 (CHD6) is a DNA-dependent ATPase that plays a role in chromatin remodeling. It regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. It activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.2 and acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. CHD6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350816 [Multi-domain]  Cd Length: 222  Bit Score: 109.36  E-value: 7.59e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 180 LRPHQREGVQFMfdcvsgLHGSANINGCILADDMGLGKTLQSITLLYTLLCQGFDGtPMvkkaIIVTPTSLVSNWEAEIK 259
Cdd:cd18058    1 LREYQLEGMNWL------LFNWYNRKNCILADEMGLGKTIQSITFLSEIFLMGIRG-PF----LIIAPLSTITNWEREFR 69
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 260 KWV--------GDRI--QLIALCESTRDD----VLSGIDSFtrprsalQVLIISYETFRMHSSKFCQSE-SCdlLICDEA 324
Cdd:cd18058   70 TWTemnaivyhGSQIsrQMIQQYEMYYRDeqgnPLSGIFKF-------QVVITTFEMILADCPELKKINwSC--VIIDEA 140
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 145338703 325 HRLKNDQTLTNRALASLTCKRRVLLSGTPMQNDLEEFFAMVNFTNPGSLGDAAHF 379
Cdd:cd18058  141 HRLKNRNCKLLEGLKLMALEHKVLLTGTPLQNSVEELFSLLNFLEPSQFPSETTF 195
DEXDc_RapA cd18011
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated ...
180-380 1.63e-26

DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350769 [Multi-domain]  Cd Length: 207  Bit Score: 108.15  E-value: 1.63e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 180 LRPHQREGVQFMFDcvsglHGsanINGCILADDMGLGKTLQSITLLYTLLCQGfdgtpMVKKAIIVTPTSLVSNWEAEIK 259
Cdd:cd18011    1 PLPHQIDAVLRALR-----KP---PVRLLLADEVGLGKTIEAGLIIKELLLRG-----DAKRVLILCPASLVEQWQDELQ 67
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 260 KWVGDRIQLIalcesTRDDVLSGIDSFTRPRSALQVLIISYETFRM--HSSKFCQSESCDLLICDEAHRLKN----DQTL 333
Cdd:cd18011   68 DKFGLPFLIL-----DRETAAQLRRLIGNPFEEFPIVIVSLDLLKRseERRGLLLSEEWDLVVVDEAHKLRNsgggKETK 142
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 145338703 334 TNRALASL--TCKRRVLLSGTPMQNDLEEFFAMVNFTNPGSLGDAAHFR 380
Cdd:cd18011  143 RYKLGRLLakRARHVLLLTATPHNGKEEDFRALLSLLDPGRFAVLGRFL 191
DEXHc_SMARCAD1 cd17998
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent ...
207-370 4.36e-25

DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1, also known as ATP-dependent helicase 1 or Hel1) possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for both DNA repair and heterochromatin organization. SMARCAD1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350756 [Multi-domain]  Cd Length: 187  Bit Score: 103.23  E-value: 4.36e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 207 CILADDMGLGKTLQSITLLYTLLCQGFDGTpmvkkAIIVTPTSLVSNWEAEIKKW------------VGDRIQLialces 274
Cdd:cd17998   22 GILADEMGLGKTIQVIAFLAYLKEIGIPGP-----HLVVVPSSTLDNWLREFKRWcpslkvepyygsQEERKHL------ 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 275 tRDDVLSGIDSFtrprsalQVLIISYE--TFRMHSSKFCQSESCDLLICDEAHRLKNDQTLTNRALASLTCKRRVLLSGT 352
Cdd:cd17998   91 -RYDILKGLEDF-------DVIVTTYNlaTSNPDDRSFFKRLKLNYVVYDEGHMLKNMTSERYRHLMTINANFRLLLTGT 162
                        170
                 ....*....|....*...
gi 145338703 353 PMQNDLEEFFAMVNFTNP 370
Cdd:cd17998  163 PLQNNLLELMSLLNFIMP 180
DEXHc_CHD5 cd18057
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; ...
180-379 4.50e-25

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350815 [Multi-domain]  Cd Length: 232  Bit Score: 104.76  E-value: 4.50e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 180 LRPHQREGVQFM-FDCVSGlhgsaniNGCILADDMGLGKTLQSITLLYTLLCQGFDGTPMvkkaIIVTPTSLVSNWEAEI 258
Cdd:cd18057    1 LHPYQLEGLNWLrFSWAQG-------TDTILADEMGLGKTVQTIVFLYSLYKEGHSKGPY----LVSAPLSTIINWEREF 69
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 259 KKW---------VGDRIQLIALCE---STRDDVL-SGIDSFTRPRSA---LQVLIISYETFRMHSSKFCQSE-SCdlLIC 321
Cdd:cd18057   70 EMWapdfyvvtyTGDKESRSVIREnefSFEDNAIrSGKKVFRMKKEAqikFHVLLTSYELITIDQAILGSIEwAC--LVV 147
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 145338703 322 DEAHRLKNDQTLTNRALASLTCKRRVLLSGTPMQNDLEEFFAMVNFTNPGSLGDAAHF 379
Cdd:cd18057  148 DEAHRLKNNQSKFFRVLNSYKIDYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGF 205
DEXHc_CHD4 cd18056
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; ...
180-370 8.88e-25

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. CHD4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350814 [Multi-domain]  Cd Length: 232  Bit Score: 103.99  E-value: 8.88e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 180 LRPHQREGVQFM-FDCVSGlhgsaniNGCILADDMGLGKTLQSITLLYTLLCQGFDGTPMvkkaIIVTPTSLVSNWEAEI 258
Cdd:cd18056    1 LHPYQLEGLNWLrFSWAQG-------TDTILADEMGLGKTVQTAVFLYSLYKEGHSKGPF----LVSAPLSTIINWEREF 69
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 259 KKW---------VGDRIQLIALCE---STRDDVLSGIDSFTRPRS----ALQVLIISYETFRMHSSKFCQSE-SCdlLIC 321
Cdd:cd18056   70 EMWapdmyvvtyVGDKDSRAIIREnefSFEDNAIRGGKKASRMKKeasvKFHVLLTSYELITIDMAILGSIDwAC--LIV 147
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 145338703 322 DEAHRLKNDQTLTNRALASLTCKRRVLLSGTPMQNDLEEFFAMVNFTNP 370
Cdd:cd18056  148 DEAHRLKNNQSKFFRVLNGYSLQHKLLLTGTPLQNNLEELFHLLNFLTP 196
DEXHc_CHD7 cd18059
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; ...
180-379 2.39e-24

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; Chromodomain-helicase-DNA-binding protein 7 (CHD7) is a probable transcription regulator. It may be involved in the 45S precursor rRNA production. CHD7 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350817 [Multi-domain]  Cd Length: 222  Bit Score: 102.42  E-value: 2.39e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 180 LRPHQREGVQFMfdcvsgLHGSANINGCILADDMGLGKTLQSITLLYTLLCQGFDGTPMVkkaiiVTPTSLVSNWEAEIK 259
Cdd:cd18059    1 LREYQLEGVNWL------LFNWYNTRNCILADEMGLGKTIQSITFLYEIYLKGIHGPFLV-----IAPLSTIPNWEREFR 69
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 260 KWVGDRIQLIALCESTRDDVLSGIDSFTRPRSAL-------QVLIISYETFRMHSSKFcQSESCDLLICDEAHRLKNDQT 332
Cdd:cd18059   70 TWTELNVVVYHGSQASRRTIQLYEMYFKDPQGRVikgsykfHAIITTFEMILTDCPEL-RNIPWRCVVIDEAHRLKNRNC 148
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 145338703 333 LTNRALASLTCKRRVLLSGTPMQNDLEEFFAMVNFTNPGSLGDAAHF 379
Cdd:cd18059  149 KLLEGLKMMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSRFPSETTF 195
DEXHc_SMARCA5 cd18064
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent ...
180-433 8.81e-24

DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (SMARCA5, also called SNF2H) is the catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. SMARCA5 plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding SMARCA5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350822 [Multi-domain]  Cd Length: 244  Bit Score: 101.28  E-value: 8.81e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 180 LRPHQREGVQFMFDCVSGlhgsaNINGcILADDMGLGKTLQSITLL-YTLLCQGFDGTPMVkkaiiVTPTSLVSNWEAEI 258
Cdd:cd18064   16 LRDYQVRGLNWLISLYEN-----GING-ILADEMGLGKTLQTISLLgYMKHYRNIPGPHMV-----LVPKSTLHNWMAEF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 259 KKWV---------GDRIQLIALcesTRDDVLSGidsftrprsALQVLIISYETFRMHSSKFcQSESCDLLICDEAHRLKN 329
Cdd:cd18064   85 KRWVptlravcliGDKDQRAAF---VRDVLLPG---------EWDVCVTSYEMLIKEKSVF-KKFNWRYLVIDEAHRIKN 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 330 DQTLTNRALASLTCKRRVLLSGTPMQNDLEEFFAMVNFTNPGSLGDAAHFRHYYEAPIICGREPTAteeeknlaadrsAE 409
Cdd:cd18064  152 EKSKLSEIVREFKTTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSAEDFDSWFDTNNCLGDQKLV------------ER 219
                        250       260
                 ....*....|....*....|....
gi 145338703 410 LSSKVNQFILRRTNALLSNHLPPK 433
Cdd:cd18064  220 LHMVLRPFLLRRIKADVEKSLPPK 243
DEXHc_CHD8 cd18060
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; ...
180-379 1.05e-23

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; Chromodomain-helicase-DNA-binding protein 8 (CHD8) is a DNA helicase that acts as a chromatin remodeling factor and regulates transcription. It also acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. It suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity and of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. It also acts as a negative regulator of Wnt signaling pathway and CTNNB1-targeted gene expression. CHD8 is also involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. It also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. CHD8 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350818 [Multi-domain]  Cd Length: 222  Bit Score: 100.51  E-value: 1.05e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 180 LRPHQREGVQFMfdcvsgLHGSANINGCILADDMGLGKTLQSITLLYTLLCQGFDGTPMvkkaiIVTPTSLVSNWEAEIK 259
Cdd:cd18060    1 LREYQLEGVNWL------LFNWYNRQNCILADEMGLGKTIQSIAFLQEVYNVGIHGPFL-----VIAPLSTITNWEREFN 69
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 260 KW-----------VGDRiQLIA----LCESTRDDVLSGIDSFtrprsalQVLIISYETFRMHSSKFCQSE-SCdlLICDE 323
Cdd:cd18060   70 TWtemntivyhgsLASR-QMIQqyemYCKDSRGRLIPGAYKF-------DALITTFEMILSDCPELREIEwRC--VIIDE 139
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 145338703 324 AHRLKNDQTLTNRALASLTCKRRVLLSGTPMQNDLEEFFAMVNFTNPGSLGDAAHF 379
Cdd:cd18060  140 AHRLKNRNCKLLDSLKHMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSQFPSESEF 195
DEXHc_CHD3 cd18055
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; ...
208-370 1.13e-23

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. CHD3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350813 [Multi-domain]  Cd Length: 232  Bit Score: 100.47  E-value: 1.13e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 208 ILADDMGLGKTLQSITLLYTLLCQGFDGTPMVKKAiivtPTSLVSNWEAEIKKW---------VGDRIQ--LIALCESTR 276
Cdd:cd18055   23 ILADEMGLGKTIQTIVFLYSLYKEGHTKGPFLVSA----PLSTIINWEREFQMWapdfyvvtyTGDKDSraIIRENEFSF 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 277 DD--VLSGIDSFTRPRSA---LQVLIISYETFRMHSSKFcQSESCDLLICDEAHRLKNDQTLTNRALASLTCKRRVLLSG 351
Cdd:cd18055   99 DDnaVKGGKKAFKMKREAqvkFHVLLTSYELVTIDQAAL-GSIRWACLVVDEAHRLKNNQSKFFRVLNGYKIDHKLLLTG 177
                        170
                 ....*....|....*....
gi 145338703 352 TPMQNDLEEFFAMVNFTNP 370
Cdd:cd18055  178 TPLQNNLEELFHLLNFLTP 196
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
534-649 4.45e-23

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 94.58  E-value: 4.45e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703  534 GKMHVLSRLLanlRRKTDDRIVLVSNYTQTLDLfAQLCRERRYPFLRLDGSTTISKRQKLVNRLNDPTKDefaFLLSSKA 613
Cdd:pfam00271   1 EKLEALLELL---KKERGGKVLIFSQTKKTLEA-ELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKID---VLVATDV 73
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 145338703  614 GGCGLNLIGANRLVLFDPDWNPANDKQAAARVWRDG 649
Cdd:pfam00271  74 AERGLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
DEXHc_CHD2 cd18054
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; ...
180-370 6.71e-23

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. CHD2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350812 [Multi-domain]  Cd Length: 237  Bit Score: 98.54  E-value: 6.71e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 180 LRPHQREGVQFMfdcvsgLHGSANINGCILADDMGLGKTLQSITLLYTLLCQGFDGTPMvkkaIIVTPTSLVSNWEAEIK 259
Cdd:cd18054   21 LRDYQLEGLNWL------AHSWCKNNSVILADEMGLGKTIQTISFLSYLFHQHQLYGPF----LLVVPLSTLTSWQREFE 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 260 KWVGDRIQLIALCESTRDDVLSGIDsFTRPRSA---LQVLIISYETFrMHSSKFCQSESCDLLICDEAHRLKNDQTLTNR 336
Cdd:cd18054   91 IWAPEINVVVYIGDLMSRNTIREYE-WIHSQTKrlkFNALITTYEIL-LKDKTVLGSINWAFLGVDEAHRLKNDDSLLYK 168
                        170       180       190
                 ....*....|....*....|....*....|....
gi 145338703 337 ALASLTCKRRVLLSGTPMQNDLEEFFAMVNFTNP 370
Cdd:cd18054  169 TLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMP 202
DEXHc_SMARCA2 cd18063
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent ...
180-421 7.62e-23

DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, also known as brahma homolog) is a component of the BAF complex. SMARCA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350821 [Multi-domain]  Cd Length: 251  Bit Score: 98.60  E-value: 7.62e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 180 LRPHQREGVQFMFDCVSGlhgsaNINGcILADDMGLGKTLQSITLLYTLLCQGFDGTPMvkkaIIVTPTSLVSNWEAEIK 259
Cdd:cd18063   24 LKHYQLQGLEWMVSLYNN-----NLNG-ILADEMGLGKTIQTIALITYLMEHKRLNGPY----LIIVPLSTLSNWTYEFD 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 260 KWVGDRIQLI-----ALCESTRDDVLSGidsftrprsALQVLIISYEtFRMHSSKFCQSESCDLLICDEAHRLKNDQTLT 334
Cdd:cd18063   94 KWAPSVVKISykgtpAMRRSLVPQLRSG---------KFNVLLTTYE-YIIKDKHILAKIRWKYMIVDEGHRMKNHHCKL 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 335 NRALAS-LTCKRRVLLSGTPMQNDLEEFFAMVNFTNPGSLGDAAHFRHYYEAPI-ICGREPTATEEEKNLAADRsaeLSS 412
Cdd:cd18063  164 TQVLNThYVAPRRILLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFaMTGERVDLNEEETILIIRR---LHK 240

                 ....*....
gi 145338703 413 KVNQFILRR 421
Cdd:cd18063  241 VLRPFLLRR 249
DEXHc_CHD1 cd18053
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; ...
180-421 2.00e-22

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350811 [Multi-domain]  Cd Length: 237  Bit Score: 97.04  E-value: 2.00e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 180 LRPHQREGVQFMfdcvsgLHGSANINGCILADDMGLGKTLQSITLLYTLlcqgFDGTPMVKKAIIVTPTSLVSNWEAEIK 259
Cdd:cd18053   21 LRDYQLNGLNWL------AHSWCKGNSCILADEMGLGKTIQTISFLNYL----FHEHQLYGPFLLVVPLSTLTSWQREIQ 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 260 KWVGDRIQLIALCESTRDDVLSgIDSFTRP---RSALQVLIISYETFrMHSSKFCQSESCDLLICDEAHRLKNDQTLTNR 336
Cdd:cd18053   91 TWAPQMNAVVYLGDINSRNMIR-THEWMHPqtkRLKFNILLTTYEIL-LKDKSFLGGLNWAFIGVDEAHRLKNDDSLLYK 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 337 ALASLTCKRRVLLSGTPMQNDLEEFFAMVNFTNPGSLGDAAHFrhyyeapiicgreptatEEEKNLAADRS-AELSSKVN 415
Cdd:cd18053  169 TLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFSSWEDF-----------------EEEHGKGREYGyASLHKELE 231

                 ....*.
gi 145338703 416 QFILRR 421
Cdd:cd18053  232 PFLLRR 237
DEXHc_CHD9 cd18061
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; ...
180-370 3.47e-22

DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; Chromodomain-helicase-DNA-binding protein 9 (CHD9) acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. It is proposed to be a ATP-dependent chromatin remodeling protein. CHD9 has DNA-dependent ATPase activity and binds to A/T-rich DNA. It also associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis. CHD9 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350819 [Multi-domain]  Cd Length: 222  Bit Score: 95.84  E-value: 3.47e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 180 LRPHQREGVQFMfdcvsgLHGSANINGCILADDMGLGKTLQSITLLYTLLCQGFDGtPMvkkaIIVTPTSLVSNWEAEIK 259
Cdd:cd18061    1 LREYQLEGLNWL------LFNWYNRRNCILADEMGLGKTIQSITFLYEILLTGIRG-PF----LIIAPLSTIANWEREFR 69
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 260 KWVGDRI--------------QLIALCESTRDDVLSGIDSFtrprsalQVLIISYETFrMHSSKFCQSESCDLLICDEAH 325
Cdd:cd18061   70 TWTDLNVvvyhgslisrqmiqQYEMYFRDSQGRIIRGAYRF-------QAIITTFEMI-LGGCPELNAIDWRCVIIDEAH 141
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 145338703 326 RLKNDQTLTNRALASLTCKRRVLLSGTPMQNDLEEFFAMVNFTNP 370
Cdd:cd18061  142 RLKNKNCKLLEGLKLMNLEHKVLLTGTPLQNTVEELFSLLHFLEP 186
DEXQc_INO80 cd18002
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 ...
180-421 8.03e-22

DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 chromatin remodeling complex. INO80 removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1. INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. INO80 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350760 [Multi-domain]  Cd Length: 229  Bit Score: 95.26  E-value: 8.03e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 180 LRPHQREGVQFMFDCVSglhgsANINGcILADDMGLGKTLQSITLLYTLLCQGFDGTPMvkkaIIVTPTSLVSNWEAEIK 259
Cdd:cd18002    1 LKEYQLKGLNWLANLYE-----QGING-ILADEMGLGKTVQSIAVLAHLAEEHNIWGPF----LVIAPASTLHNWQQEIS 70
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 260 KWVGDrIQLIALCESTRD-DVLSGI---DSFTRPRSALQVLIISYETFrMHSSKFCQSESCDLLICDEAHRLKNDQTLTN 335
Cdd:cd18002   71 RFVPQ-FKVLPYWGNPKDrKVLRKFwdrKNLYTRDAPFHVVITSYQLV-VQDEKYFQRVKWQYMVLDEAQAIKSSSSSRW 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 336 RALASLTCKRRVLLSGTPMQNDLEEFFAMVNFTNPGSLGDAAHFRHYYEAPIicgrEPTAtEEEKNLAADRSAELSSKVN 415
Cdd:cd18002  149 KTLLSFHCRNRLLLTGTPIQNSMAELWALLHFIMPTLFDSHDEFNEWFSKDI----ESHA-ENKTGLNEHQLKRLHMILK 223

                 ....*.
gi 145338703 416 QFILRR 421
Cdd:cd18002  224 PFMLRR 229
DEXHc_SMARCA4 cd18062
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent ...
168-421 1.26e-21

DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4, also known as transcription activator BRG1) is a component of the CREST-BRG1 complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF complexes, contributes to a range of malignancies and neurologic disorders. SMARCA4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350820 [Multi-domain]  Cd Length: 251  Bit Score: 95.11  E-value: 1.26e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 168 TTIMVHSVLvkflRPHQREGVQFMFDCVSGlhgsaNINGcILADDMGLGKTLQSITLLYTLLCQGFDGTPMvkkaIIVTP 247
Cdd:cd18062   16 SSLLVNGVL----KQYQIKGLEWLVSLYNN-----NLNG-ILADEMGLGKTIQTIALITYLMEHKRINGPF----LIIVP 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 248 TSLVSNWEAEIKKWVGDRIQL-IALCESTRDDVLSGIDSftrprSALQVLIISYEtFRMHSSKFCQSESCDLLICDEAHR 326
Cdd:cd18062   82 LSTLSNWVYEFDKWAPSVVKVsYKGSPAARRAFVPQLRS-----GKFNVLLTTYE-YIIKDKQILAKIRWKYMIVDEGHR 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 327 LKNDQTLTNRALAS-LTCKRRVLLSGTPMQNDLEEFFAMVNFTNPGSLGDAAHFRHYYEAPIICGREPTATEEEKNLAAD 405
Cdd:cd18062  156 MKNHHCKLTQVLNThYVAPRRLLLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMTGEKVDLNEEETILII 235
                        250
                 ....*....|....*.
gi 145338703 406 RsaELSSKVNQFILRR 421
Cdd:cd18062  236 R--RLHKVLRPFLLRR 249
DEXHc_SMARCA1 cd18065
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent ...
180-384 1.38e-20

DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (SMARCA1, also called SNF2L) is a component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes which promote the perturbation of chromatin structure in an ATP-dependent manner. SMARCA1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350823 [Multi-domain]  Cd Length: 233  Bit Score: 91.62  E-value: 1.38e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 180 LRPHQREGVQFMFDCVSGlhgsaNINGcILADDMGLGKTLQSITLL-YTLLCQGFDGTPMVkkaiiVTPTSLVSNWEAEI 258
Cdd:cd18065   16 LRDYQVRGLNWMISLYEN-----GVNG-ILADEMGLGKTLQTIALLgYLKHYRNIPGPHMV-----LVPKSTLHNWMNEF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 259 KKWVGdriQLIALCESTRDDVLSGIDSFTRPRSALQVLIISYETFRMHSSKFcQSESCDLLICDEAHRLKNDQTLTNRAL 338
Cdd:cd18065   85 KRWVP---SLRAVCLIGDKDARAAFIRDVMMPGEWDVCVTSYEMVIKEKSVF-KKFNWRYLVIDEAHRIKNEKSKLSEIV 160
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 145338703 339 ASLTCKRRVLLSGTPMQNDLEEFFAMVNFTNPGSLGDAAHFRHYYE 384
Cdd:cd18065  161 REFKTTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSADDFDSWFD 206
DEXHc_HLTF1_SMARC3 cd18071
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as ...
202-421 1.27e-19

DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as HIP116 or SMARCA3) has both helicase and E3 ubiquitin ligase activities and ATP-dependent nucleosome-remodeling activity. HLTF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350829 [Multi-domain]  Cd Length: 239  Bit Score: 89.07  E-value: 1.27e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 202 ANINGCILADDMGLGKTLQSITLLYTllcqgfdgtpmvKKAIIVTPTSLVSNWEAEIKKWV------------GDRIQLI 269
Cdd:cd18071   46 ELVRGGILADDMGLGKTLTTISLILA------------NFTLIVCPLSVLSNWETQFEEHVkpgqlkvytyhgGERNRDP 113
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 270 ALcestrddvLSGIDsftrprsalqVLIISYETFrmhSSKFCQSESCDL-------LICDEAHRLKNDQTLTNRALASLT 342
Cdd:cd18071  114 KL--------LSKYD----------IVLTTYNTL---ASDFGAKGDSPLhtinwlrVVLDEGHQIRNPNAQQTKAVLNLS 172
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 145338703 343 CKRRVLLSGTPMQNDLEEFFAMVNFTNPGSLGDAAHFRHYYEAPIICGrEPTAteeeknlaadrSAELSSKVNQFILRR 421
Cdd:cd18071  173 SERRWVLTGTPIQNSPKDLGSLLSFLHLKPFSNPEYWRRLIQRPLTMG-DPTG-----------LKRLQVLMKQITLRR 239
HELICc smart00490
helicase superfamily c-terminal domain;
565-649 2.15e-18

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 80.33  E-value: 2.15e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703   565 DLFAQLCRERRYPFLRLDGSTTISKRQKLVNRLNdptKDEFAFLLSSKAGGCGLNLIGANRLVLFDPDWNPANDKQAAAR 644
Cdd:smart00490   1 EELAELLKELGIKVARLHGGLSQEEREEILDKFN---NGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGR 77

                   ....*
gi 145338703   645 VWRDG 649
Cdd:smart00490  78 AGRAG 82
DEXHc_TTF2 cd18072
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called ...
180-369 6.60e-15

DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called Forkhead-box E1/FOXE1 ) is a transcription termination factor that couples ATP hydrolysis with the removal of RNA polymerase II from the DNA template. Single nucleotide polymorphism (SNP) within the 5'-UTR of TTF2 is associated with thyroid cancer risk.TTF2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350830 [Multi-domain]  Cd Length: 241  Bit Score: 75.21  E-value: 6.60e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 180 LRPHQREGVQFMFdcvsgLHGSANINGCILADDMGLGKTLQSITLLytlLCQGF------------DGTPMVKKA----- 242
Cdd:cd18072    1 LLLHQKQALAWLL-----WRERQKPRGGILADDMGLGKTLTMIALI---LAQKNtqnrkeeekekaLTEWESKKDstlvp 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 243 ----IIVTPTSLVSNWEAEIKKWVgdRIQLIALC------ESTRDDVLSGIDsftrprsalqVLIISYETF-RMHSSKFC 311
Cdd:cd18072   73 sagtLVVCPASLVHQWKNEVESRV--ASNKLRVClyhgpnRERIGEVLRDYD----------IVITTYSLVaKEIPTYKE 140
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 145338703 312 QSESCDLL-------ICDEAHRLKNDQTLTNRALASLTCKRRVLLSGTPMQNDLEEFFAMVNFTN 369
Cdd:cd18072  141 ESRSSPLFriawariILDEAHNIKNPKVQASIAVCKLRAHARWALTGTPIQNNLLDMYSLLKFLR 205
DEXQc_SHPRH cd18070
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously ...
180-367 7.60e-13

DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously expressed protein that contains motifs characteristic of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 and is involved in DNA repair. SHPRH is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350828 [Multi-domain]  Cd Length: 257  Bit Score: 69.68  E-value: 7.60e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 180 LRPHQREGVQFMFdcvsglhgsanINGCILADDMGLGKTLQSITLLYT-------LLCQGFDGTPMV------------- 239
Cdd:cd18070    1 LLPYQRRAVNWML-----------VPGGILADEMGLGKTVEVLALILLhprpdndLDAADDDSDEMVccpdclvaetpvs 69
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 240 -KKAIIVTPTSLVSNWEAEIKKWVGDriqlialceSTRDDVLSGI--DSFTRPRSA-----LQVLIISYET--------- 302
Cdd:cd18070   70 sKATLIVCPSAILAQWLDEINRHVPS---------SLKVLTYQGVkkDGALASPAPeilaeYDIVVTTYDVlrtelhyae 140
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 145338703 303 -FRMHSSKFCQSE----SCDLLIC-------DEAHRLKNDQTLTNRALASLTCKRRVLLSGTPMQNDLEEFFAMVNF 367
Cdd:cd18070  141 aNRSNRRRRRQKRyeapPSPLVLVewwrvclDEAQMVESSTSKAAEMARRLPRVNRWCVSGTPIQRGLDDLFGLLSF 217
DEXQc_bact_SNF2 cd18013
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 ...
180-388 1.91e-11

DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprise a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. The bacterial SNF2 present in this family are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350771 [Multi-domain]  Cd Length: 218  Bit Score: 64.68  E-value: 1.91e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 180 LRPHQREGVQFMFDcvsglhgsaNINGCILADdMGLGKTLQSITLLYTLLCQGFdgtpmVKKAIIVTPTSLVSN-WEAEI 258
Cdd:cd18013    1 PHPYQKVAINFIIE---------HPYCGLFLD-MGLGKTVTTLTALSDLQLDDF-----TRRVLVIAPLRVARStWPDEV 65
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 259 KKWvgdriqlialcESTRDDVLSGIDSFTRPRSAL-----QVLIISYETFRMHSSKFCQSESCDLLICDEAHRLKNDQTL 333
Cdd:cd18013   66 EKW-----------NHLRNLTVSVAVGTERQRSKAantpaDLYVINRENLKWLVNKSGDPWPFDMVVIDELSSFKSPRSK 134
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 145338703 334 TNRALASL--TCKRRVLLSGTPMQNDLEEFFAMVNFTNPG-SLGDA-AHFRHYYEAPII 388
Cdd:cd18013  135 RFKALRKVrpVIKRLIGLTGTPSPNGLMDLWAQIALLDQGeRLGRSiTAYRERWFDPDK 193
SSL2 COG1061
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
180-353 4.20e-10

Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];


Pssm-ID: 440681 [Multi-domain]  Cd Length: 566  Bit Score: 63.51  E-value: 4.20e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 180 LRPHQREGVQFMFDCVSGLHGsaniNGCILADdMGLGKTLQSITLLYTLLCqgfdgtpmVKKAIIVTPT-SLVSNWEAEI 258
Cdd:COG1061   81 LRPYQQEALEALLAALERGGG----RGLVVAP-TGTGKTVLALALAAELLR--------GKRVLVLVPRrELLEQWAEEL 147
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 259 KKWVGDRIqlialcestrddvlsgiDSFTRPRSALQVLIISYETF--RMHSSKFcqSESCDLLICDEAHRLKNDQTLtnR 336
Cdd:COG1061  148 RRFLGDPL-----------------AGGGKKDSDAPITVATYQSLarRAHLDEL--GDRFGLVIIDEAHHAGAPSYR--R 206
                        170
                 ....*....|....*..
gi 145338703 337 ALASLTCKRRVLLSGTP 353
Cdd:COG1061  207 ILEAFPAAYRLGLTATP 223
DEXHc_RE cd17926
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ...
180-353 7.11e-08

DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350684 [Multi-domain]  Cd Length: 146  Bit Score: 52.31  E-value: 7.11e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 180 LRPHQREGVQFMFDCVSGLHGSaningCILAddMGLGKTLQSITLLYTLlcqgfdgtpMVKKAIIVTPT-SLVSNWEAEI 258
Cdd:cd17926    1 LRPYQEEALEAWLAHKNNRRGI-----LVLP--TGSGKTLTALALIAYL---------KELRTLIVVPTdALLDQWKERF 64
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 259 KKWVGDRIqlIALCESTRDDVLSGIDsftrprsalqVLIISYET--FRMHSSKFCQSEsCDLLICDEAHRLKNDQtlTNR 336
Cdd:cd17926   65 EDFLGDSS--IGLIGGGKKKDFDDAN----------VVVATYQSlsNLAEEEKDLFDQ-FGLLIVDEAHHLPAKT--FSE 129
                        170
                 ....*....|....*..
gi 145338703 337 ALASLTCKRRVLLSGTP 353
Cdd:cd17926  130 ILKELNAKYRLGLTATP 146
SF2-N cd00046
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ...
205-352 9.65e-06

N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.


Pssm-ID: 350668 [Multi-domain]  Cd Length: 146  Bit Score: 46.24  E-value: 9.65e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 205 NGCILADDMGLGKTLQ-SITLLYTLLCQGfdgtpmvKKAIIVTPT-SLVSNWEAEIKKWvgdriqliaLCESTRDDVLSG 282
Cdd:cd00046    2 ENVLITAPTGSGKTLAaLLAALLLLLKKG-------KKVLVLVPTkALALQTAERLREL---------FGPGIRVAVLVG 65
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 283 IDSFTRPRSA----LQVLIISYETFRM---HSSKFCQSEScDLLICDEAHRLKNDQ------TLTNRALASLTCkRRVLL 349
Cdd:cd00046   66 GSSAEEREKNklgdADIIIATPDMLLNlllREDRLFLKDL-KLIIVDEAHALLIDSrgalilDLAVRKAGLKNA-QVILL 143

                 ...
gi 145338703 350 SGT 352
Cdd:cd00046  144 SAT 146
ResIII pfam04851
Type III restriction enzyme, res subunit;
180-353 1.84e-05

Type III restriction enzyme, res subunit;


Pssm-ID: 398492 [Multi-domain]  Cd Length: 162  Bit Score: 45.74  E-value: 1.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703  180 LRPHQREGVqfmfDCVSGLHGSANINGCIladDM--GLGKTLQSITLLYTLLCQGFdgtpmVKKAIIVTPT-SLVSNWEA 256
Cdd:pfam04851   4 LRPYQIEAI----ENLLESIKNGQKRGLI---VMatGSGKTLTAAKLIARLFKKGP-----IKKVLFLVPRkDLLEQALE 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703  257 EIKKWVGDRIQLIalcestrdDVLSGiDSFTRPRSALQVLIISYETFRMHSSKFCQ---SESCDLLICDEAHRLkNDQTL 333
Cdd:pfam04851  72 EFKKFLPNYVEIG--------EIISG-DKKDESVDDNKIVVTTIQSLYKALELASLellPDFFDVIIIDEAHRS-GASSY 141
                         170       180
                  ....*....|....*....|
gi 145338703  334 TNrALASLTCKRRVLLSGTP 353
Cdd:pfam04851 142 RN-ILEYFKPAFLLGLTATP 160
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
214-353 2.48e-03

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 39.53  E-value: 2.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703  214 GLGKTLqsITLLYtlLCQGFDGTPMVKKAIIVTPT-SLVSNWEAEIKKWvGDRIQLIALCESTRDDVLSGIDSFTRPrsa 292
Cdd:pfam00270  24 GSGKTL--AFLLP--ALEALDKLDNGPQALVLAPTrELAEQIYEELKKL-GKGLGLKVASLLGGDSRKEQLEKLKGP--- 95
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 145338703  293 lQVLIISYETFRMHSSKFCQSESCDLLICDEAHRLKND--QTLTNRALASLTCKRR-VLLSGTP 353
Cdd:pfam00270  96 -DILVGTPGRLLDLLQERKLLKNLKLLVLDEAHRLLDMgfGPDLEEILRRLPKKRQiLLLSATL 158
DEXHc_XPB cd18029
DEXH-box helicase domain of TFIIH XPB subunit and similar proteins; TFIIH basal transcription ...
180-327 2.84e-03

DEXH-box helicase domain of TFIIH XPB subunit and similar proteins; TFIIH basal transcription factor complex helicase XPB subunit (also known as DNA excision repair protein ERCC-3 or TFIIH 89 kDa subunit) is the ATP-dependent 3'-5' DNA helicase component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. XPB is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350787 [Multi-domain]  Cd Length: 169  Bit Score: 39.59  E-value: 2.84e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145338703 180 LRPHQREGVQFMFDcvSGLHGSANIngcILAddMGLGKTLQSITLLYTllcqgfdgtpmVKKAIIVTPTSLVS--NWEAE 257
Cdd:cd18029    9 LRPYQEKALSKMFG--NGRARSGVI---VLP--CGAGKTLVGITAACT-----------IKKSTLVLCTSAVSveQWRRQ 70
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 145338703 258 IKKWVgdRIQLIALCESTRddvlsgiDSFTRPRSALQVL----IISYETFRMHSSK----FCQSESCDLLICDEAHRL 327
Cdd:cd18029   71 FLDWT--TIDDEQIGRFTS-------DKKEIFPEAGVTVstysMLANTRKRSPESEkfmeFITEREWGLIILDEVHVV 139
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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