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    LZF1 light-regulated zinc finger protein 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 844196, updated on 18-Sep-2024

    Summary

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    Official Symbol
    LZF1
    Official Full Name
    light-regulated zinc finger protein 1
    Primary source
    TAIR:AT1G78600
    Locus tag
    AT1G78600
    See related
    Araport:AT1G78600
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    B-box domain protein 22; BBX22; DBB3; DOUBLE B-BOX 3; light-regulated zinc finger protein 1; SALT TOLERANCE HOMOLOG 3; STH3; T30F21.7; T30F21_7
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    Genomic context

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    See LZF1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    4
    Sequence:
    Chromosome: 1; NC_003070.9 (29566863..29568931)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene trehalose-6-phosphate synthase Neighboring gene ncRNA Neighboring gene NAD(H) kinase 3 Neighboring gene mechanosensitive channel of small conductance-like 6 Neighboring gene integral membrane protein (Protein of unknown function DUF92, transmembrane)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Function of B-BOX under shade. Crocco CD, et al. Plant Signal Behav, 2011 Jan. PMID 21301219, Free PMC Article
    2. COP1-mediated degradation of BBX22/LZF1 optimizes seedling development in Arabidopsis. Chang CS, et al. Plant Physiol, 2011 May. PMID 21427283, Free PMC Article
    3. AtBBX21 and COP1 genetically interact in the regulation of shade avoidance. Crocco CD, et al. Plant J, 2010 Nov. PMID 21070414
    4. LZF1, a HY5-regulated transcriptional factor, functions in Arabidopsis de-etiolation. Chang CS, et al. Plant J, 2008 Apr. PMID 18182030
    5. Identification of BBX proteins as rate-limiting cofactors of HY5. Bursch K, et al. Nat Plants, 2020 Aug. PMID 32661279

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of BBX proteins as rate-limiting cofactors of HY5.
      Title: Identification of BBX proteins as rate-limiting cofactors of HY5.
    2. Analysis of BBX22 degradation kinetics shows that it has a short half-life under both dark and light conditions. COP1 mediates the BBX22 degradation in the dark. Although dispensable in the dark, HY5 contributes to the BBX22 degradation in the light.
      Title: COP1-mediated degradation of BBX22/LZF1 optimizes seedling development in Arabidopsis.
    3. Data suggest that BBX25 (At2g31380) and BBX24 (At1g06040) function as transcriptional corepressors, probably by forming inactive heterodimers with HY5 (At5g11260) downregulating BBX22 (AT1G78600) expression for the light-mediated seedling development.
      Title: The Arabidopsis B-BOX protein BBX25 interacts with HY5, negatively regulating BBX22 expression to suppress seedling photomorphogenesis.
    4. Results identified STH3 {LIGHT-REGULATED ZINC FINGER1/SALT TOLERANCE HOMOLOG3) as a positive regulator of photomorphogenesis acting in concert with STH2 and HY5, while also being a target of COP1-mediated ubiquitination. [STH3]
      Title: LZF1/SALT TOLERANCE HOMOLOG3, an Arabidopsis B-box protein involved in light-dependent development and gene expression, undergoes COP1-mediated ubiquitination.
    5. The isolation and characterization of light-regulated zinc finger protein 1 (LZF1), a HY5-regulated factor, is reported.
      Title: LZF1, a HY5-regulated transcriptional factor, functions in Arabidopsis de-etiolation.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    NM_001198499.1
    NM_106507.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within anthocyanin-containing compound biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within chlorophyll biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within chloroplast organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of photomorphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within shade avoidance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within shade avoidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    light-regulated zinc finger protein 1
    NP_001185428.1
    • light-regulated zinc finger protein 1 (LZF1); CONTAINS InterPro DOMAIN/s: Zinc finger, B-box (InterPro:IPR000315); BEST Arabidopsis thaliana protein match is: B-box zinc finger family protein (TAIR:AT1G06040.1).
    NP_565183.1
    • light-regulated zinc finger protein 1 (LZF1); CONTAINS InterPro DOMAIN/s: Zinc finger, B-box (InterPro:IPR000315); BEST Arabidopsis thaliana protein match is: B-box zinc finger family protein (TAIR:AT1G06040.1); Has 1826 Blast hits to 1364 proteins in 120 species: Archae - 0; Bacteria - 0; Metazoa - 16; Fungi - 0; Plants - 1701; Viruses - 0; Other Eukaryotes - 109 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      29566863..29568931
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_106507.4 → NP_565183.1  light-regulated zinc finger protein 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565183.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8RWG4, Q9SYM2
      UniProtKB/TrEMBL
      A0A178W7F6, A0A5S9WVH9
      Conserved Domains (1) summary
      cd19821
      Location:5 → 47
      Bbox1_BBX-like; B-box-type 1 zinc finger found in B-box (BBX) family of plant transcription factors and similar proteins

    2. NM_001198499.1 → NP_001185428.1  light-regulated zinc finger protein 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001185428.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654EQC4, F4IBS4
      Conserved Domains (1) summary
      cd19821
      Location:5 → 47
      Bbox1_BBX-like; B-box-type 1 zinc finger found in B-box (BBX) family of plant transcription factors and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SYM2.2

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