B-box-type 1 zinc finger found in B-box (BBX) family of plant transcription factors and similar proteins; The BBX family includes a group of zinc finger transcription factors that contain one or two B-box motifs, and sometimes also feature a CCT (CONSTANS, CO-like, and TOC1) domain. They play important roles in plant growth and development, including seedling photomorphogenesis, photoperiodic regulation of flowering, shade avoidance, and responses to biotic and abiotic stresses. Their B-box motifs show high sequence similarity with B-Box-type 1 zinc finger found in tripartite motif-containing proteins (TRIMs) and are involved in mediating transcriptional regulation and protein-protein interaction in plant signaling. The type 1 B-box (Bbox1) zinc finger is characterized by a C6H2 zinc-binding consensus motif; this family contains a modified motif, C3XC2H2, where X can be D, E, C or H.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 18412037   5 CNVCEAAEATVLCCADEAALCWACDEKIHAANKLAGKHQRVPL 47
Cdd:cd19821   2 CDSCESAPAVVYCRADRASLCRACDAKVHSANKLASRHQRVPL 44

B-box-type 1 zinc finger found in B-box (BBX) family of plant transcription factors and similar proteins; The BBX family includes a group of zinc finger transcription factors that contain one or two B-box motifs, and sometimes also feature a CCT (CONSTANS, CO-like, and TOC1) domain. They play important roles in plant growth and development, including seedling photomorphogenesis, photoperiodic regulation of flowering, shade avoidance, and responses to biotic and abiotic stresses. Their B-box motifs show high sequence similarity with B-Box-type 1 zinc finger found in tripartite motif-containing proteins (TRIMs) and are involved in mediating transcriptional regulation and protein-protein interaction in plant signaling. The type 1 B-box (Bbox1) zinc finger is characterized by a C6H2 zinc-binding consensus motif; this family contains a modified motif, C3XC2H2, where X can be D, E, C or H.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 18412037   5 CNVCEAAEATVLCCADEAALCWACDEKIHAANKLAGKHQRVPL 47
Cdd:cd19821   2 CDSCESAPAVVYCRADRASLCRACDAKVHSANKLASRHQRVPL 44

B-Box-type zinc finger;

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 18412037     55 PKCDICQEASGFFFCLQDRALLCRKCDVAIHtvnphvSAHQRFLL 99
Cdd:smart00336   4 PKCDSHGDEPAEFFCEECGALLCRTCDEAEH------RGHTVVLL 42

B-box zinc finger;

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 18412037     5 CNVCEAAEATVLCCADEAALCWACDEKIHAanklagKHQRVPL 47
Cdd:pfam00643   6 CPEHEEEPLTLYCNDCQELLCEECSVGEHR------GHTVVPL 42

B-box-type 1 zinc finger found in B-box (BBX) family of plant transcription factors and similar proteins; The BBX family includes a group of zinc finger transcription factors that contain one or two B-box motifs, and sometimes also feature a CCT (CONSTANS, CO-like, and TOC1) domain. They play important roles in plant growth and development, including seedling photomorphogenesis, photoperiodic regulation of flowering, shade avoidance, and responses to biotic and abiotic stresses. Their B-box motifs show high sequence similarity with B-Box-type 1 zinc finger found in tripartite motif-containing proteins (TRIMs) and are involved in mediating transcriptional regulation and protein-protein interaction in plant signaling. The type 1 B-box (Bbox1) zinc finger is characterized by a C6H2 zinc-binding consensus motif; this family contains a modified motif, C3XC2H2, where X can be D, E, C or H.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 18412037   5 CNVCEAAEATVLCCADEAALCWACDEKIHAANKLAGKHQRVPL 47
Cdd:cd19821   2 CDSCESAPAVVYCRADRASLCRACDAKVHSANKLASRHQRVPL 44

B-Box-type zinc finger;

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 18412037     55 PKCDICQEASGFFFCLQDRALLCRKCDVAIHtvnphvSAHQRFLL 99
Cdd:smart00336   4 PKCDSHGDEPAEFFCEECGALLCRTCDEAEH------RGHTVVLL 42

B-box-type 1 zinc finger (Bbox1); The B-box-type zinc finger is a short zinc binding domain of around 40 amino acid residues in length. It has been found in transcription factors, ribonucleoproteins and proto-oncoproteins, such as in TRIM (tripartite motif) proteins that consist of an N-terminal RING finger (originally called an A-box), followed by 1-2 B-box domains and a coiled-coil domain (also called RBCC for Ring, B-box, Coiled-Coil). The B-box-type zinc finger often presents in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain, in functionally unrelated proteins, most likely mediating protein-protein interactions. Based on different consensus sequences and the spacing of the 7-8 zinc-binding residues, the B-box-type zinc fingers can be divided into two groups, type 1 (Bbox1: C6H2) and type 2 (Bbox2: CHC3H2). This family corresponds to the type 1 B-box (Bbox1).

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 18412037   4 QCNVCEAAEATVLCCADEAALCWACDEKIHAANKLAGKHQRVPL 47
Cdd:cd19757   1 LCDECEEREATVYCLECEEFLCDDCSDAIHRRGKLTRSHKLVPL 44

first B-box-type 2 zinc finger found in tripartite motif-containing protein 23 (TRIM23) and similar proteins; TRIM23, also known as ADP-ribosylation factor domain-containing protein 1, GTP-binding protein ARD-1, or RING finger protein 46 (RNF46), is an E3 ubiquitin-protein ligase belonging to the C-IX subclass of TRIM (tripartite motif) family of proteins that are defined by an N-terminal RBCC (RING, Bbox, and coiled coil) domains, including three consecutive zinc-binding domains, a RING finger, two Bbox2, and a coiled coil region, as well as C-terminal ADP ribosylation factor (ARF) domains. The type 2 B-box (Bbox2) zinc finger is characterized by a CHC3H2 zinc-binding consensus motif. TRIM23 is involved in nuclear factor (NF)-kappaB activation. It mediates atypical lysine 27 (K27)-linked polyubiquitin conjugation to NF-kappaB essential modulator NEMO, also known as IKKgamma, which plays an important role in the NF-kappaB pathway, and this conjugation is essential for TLR3- and RIG-I/MDA5-mediated antiviral innate and inflammatory responses. It also regulates adipocyte differentiation via stabilization of the adipogenic activator peroxisome proliferator-activated receptor gamma (PPARgamma) through atypical ubiquitin conjugation to PPARgamma. Moreover, TRIM23 interacts with and polyubiquitinates yellow fever virus (YFV) NS5 to promote its binding to STAT2 and trigger type I interferon (IFN-I) signaling inhibition.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 18412037   3 IQCNVCEAAEATVLCCADEAALCWACDEKIHAANKLAgKHQRVPLS 48
Cdd:cd19773   3 IPCDENEDHEATLYCTVCSTNLCEECFTSTHSTKTLS-KHRRVPLS 47

B-box-type 1 zinc finger found in HOIL-1-interacting protein (HOIP) and similar proteins; HOIP, also termed RING finger protein 31 (RNF31), or zinc in-between-RING-finger ubiquitin-associated domain protein, together with HOIL-1 and SHARPIN, forms the E3-ligase complex (also known as linear-ubiquitin-chain assembly complex LUBAC) that regulates NF-kappaB activity and apoptosis. It also interacts with the atypical mammalian orphan receptor DAX-1, trigger DAX-1 ubiquitination and stabilization, and participate in repressing steroidogenic gene expression. HOIP contains a B-box motif that shows high sequence similarity with B-Box-type 1 zinc finger found in tripartite motif-containing proteins (TRIMs). The type 1 B-box (Bbox1) zinc finger is characterized by a C6H2 zinc-binding consensus motif.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 18412037   4 QCNVCEAAEATVLCCADEAALCWACDEKIHAANKLAGkHQRVPL 47
Cdd:cd19815   1 LCDLCGEAAASVFCASCEDKLCLSCDDLYHKHPARRS-HHRQPI 43