CLASP CLIP-associated protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: CLASP
Official Full Name: CLIP-associated protein
Primary source: TAIR:AT2G20190
Locus tag: AT2G20190
See related: Araport:AT2G20190
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATCLASP; CLIP-associated protein; CLIP-ASSOCIATED PROTEIN; T2G17.1; T2G17_1
Summary: Encodes a microtubule-associated protein that is involved in both cell division and cell expansion. It likely promotes microtubule stability.
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Genomic context

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See CLASP in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 21

Sequence:: Chromosome: 2; NC_003071.7 (8711579..8719115, complement)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

KATANIN and CLASP function at different spatial scales to mediate microtubule response to mechanical stress in Arabidopsis cotyledons.
Title: KATANIN and CLASP function at different spatial scales to mediate microtubule response to mechanical stress in Arabidopsis cotyledons.
The conserved protein CLASP is a potent stabilizer of new plus ends created by katanin severing in plant cells.
Title: CLASP stabilization of plus ends created by severing promotes microtubule creation and reorientation.
CLASP plays a critical role in cellular morphogenesis through actions on new microtubules that facilitate array transitions.
Title: CLASP Facilitates Transitions between Cortical Microtubule Array Patterns.
These findings mechanistically link SABRE to CLASP-dependent microtubule organization, shedding new light on the function of SABRE-related proteins in eukaryotes.
Title: Arabidopsis SABRE and CLASP interact to stabilize cell division plane orientation and planar polarity.
the microtubule-associated protein CLASP interacts with the retromer component sorting nexin 1 (SNX1) to mediate an association between endosomes and microtubules.
Title: CLASP interacts with sorting nexin 1 to link microtubules and auxin transport via PIN2 recycling in Arabidopsis thaliana.
Edge-induced microtubule depolymerization, is overcome by the CLASP proteins which accumulates at specific cell edges.
Title: A CLASP-modulated cell edge barrier mechanism drives cell-wide cortical microtubule organization in Arabidopsis.
A novel mechanism where modulation of CLASP activity governs microtubule-cortex attachment, thereby contributing to self-organization of cortical microtubules, is identified.
Title: CLASP modulates microtubule-cortex interaction during self-organization of acentrosomal microtubules.
Arabidopsis thaliana CLASP protein is a microtubule-associated protein that is involved in both cell division and cell expansion.[CLASP]
Title: The Arabidopsis CLASP gene encodes a microtubule-associated protein involved in cell expansion and division.
findings show that AtCLASP is enriched at the plus ends of microtubules where it localizes behind the AtEB1b protein; AtCLASP is required for cell morphogenesis and cell division
Title: CLASP localizes in two discrete patterns on cortical microtubules and is required for cell morphogenesis and cell division in Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_179666.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables microtubule plus-end binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cortical microtubule organization	IDA Inferred from Direct Assay more info	PubMed
involved_in cortical microtubule organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of microtubule depolymerization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cell division	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein stabilization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within unidimensional cell growth	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISM Inferred from Sequence Model more info
NOT located_in cytosol	RCA inferred from Reviewed Computational Analysis more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in phragmoplast	IDA Inferred from Direct Assay more info	PubMed
located_in plasmodesma	HDA more info	PubMed
located_in spindle microtubule	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: CLIP-associated protein

NP_849997.2

CLIP-associated protein (CLASP); FUNCTIONS IN: binding; INVOLVED IN: mitosis, protein stabilization, cell growth; LOCATED IN: spindle microtubule, plasma membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: HEAT (InterPro:IPR000357), Armadillo-like helical (InterPro:IPR011989), HEAT, type 2 (InterPro:IPR021133), Armadillo-type fold (InterPro:IPR016024); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

8711579..8719115 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_179666.5 → NP_849997.2 CLIP-associated protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_849997.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0WVK2, Q8RWY6, Q9SK81, Q9SL62

UniProtKB/TrEMBL

A0A178VPD0, A0A5S9WZQ7, A0A654EVP1

Conserved Domains (4) summary

COG5181
Location:1249 → 1434

HSH155; U2 snRNP spliceosome subunit [RNA processing and modification]

sd00044
Location:796 → 818

HEAT; HEAT repeat [structural motif]

pfam12348
Location:283 → 501

CLASP_N; CLASP N terminal

pfam13513
Location:60 → 102

HEAT_EZ; HEAT-like repeat